And more exciting work on what we do and don't know about making functional #genedrive is about to drop!
Natural genetic variation can silently undermine gene drive performance.
In our new study, we used a split homing drive in Culex quinquefasciatus and found that target-site heterology of less than 10% reduced homing efficiency by up to 54%.
doi.org/10.1093/gene...
In our new study, we used a split homing drive in Culex quinquefasciatus and found that target-site heterology of less than 10% reduced homing efficiency by up to 54%.
doi.org/10.1093/gene...
March 4, 2026 at 11:32 AM
And more exciting work on what we do and don't know about making functional #genedrive is about to drop!
pissing off both american and european retro gamers by insisting it's actually called the sega megasis. sometimes spicing it up with genedrive
January 14, 2026 at 9:12 AM
pissing off both american and european retro gamers by insisting it's actually called the sega megasis. sometimes spicing it up with genedrive
Drs @mlwilde.bsky.social Sarah Farrell, Christopher Goodman & @fad1.bsky.social review novel techniques for disrupting #malaria #transmission. #Plasmodium #Mosquito #GeneDrive #Paratransgenesis
authors.elsevier.com/a/1lPdi_XTJP...
authors.elsevier.com/a/1lPdi_XTJP...
July 11, 2025 at 7:29 AM
Drs @mlwilde.bsky.social Sarah Farrell, Christopher Goodman & @fad1.bsky.social review novel techniques for disrupting #malaria #transmission. #Plasmodium #Mosquito #GeneDrive #Paratransgenesis
authors.elsevier.com/a/1lPdi_XTJP...
authors.elsevier.com/a/1lPdi_XTJP...
megasis or genedrive
June 6, 2024 at 10:22 PM
megasis or genedrive
genedrive reads like some kind of late-80's/early-90's mecha anime title. Science Soldier Genedrive or some shit
January 14, 2026 at 9:17 AM
genedrive reads like some kind of late-80's/early-90's mecha anime title. Science Soldier Genedrive or some shit
Excited to be a part of this new paper with Alphey Lab- out in pre-print.
Multiplexing overrides resistance for #genedrive in Anopheles stephensi
www.biorxiv.org/content/10.1...
Multiplexing overrides resistance for #genedrive in Anopheles stephensi
www.biorxiv.org/content/10.1...
August 21, 2025 at 8:46 AM
Excited to be a part of this new paper with Alphey Lab- out in pre-print.
Multiplexing overrides resistance for #genedrive in Anopheles stephensi
www.biorxiv.org/content/10.1...
Multiplexing overrides resistance for #genedrive in Anopheles stephensi
www.biorxiv.org/content/10.1...
This is the first formal analysis of the field. So please share it widely - hope this is a tool of wide use to the #genedrive community.
New pre-print!
Excited to share our new paper — the first meta-analysis of CRISPR-based homing gene drives! Analysing nearly one million scored progeny across 42 studies and 10 species.
www.biorxiv.org/content/10.6...
@sebaldv.bsky.social @nikiwind.bsky.social
@eivimeycook.bsky.social
Excited to share our new paper — the first meta-analysis of CRISPR-based homing gene drives! Analysing nearly one million scored progeny across 42 studies and 10 species.
www.biorxiv.org/content/10.6...
@sebaldv.bsky.social @nikiwind.bsky.social
@eivimeycook.bsky.social
March 6, 2026 at 10:43 AM
This is the first formal analysis of the field. So please share it widely - hope this is a tool of wide use to the #genedrive community.
Bill Gates talking about #genedrive as one of the tools in the pipeline that could help end #malaria in the next 20 years @transmission-zero.bsky.social @targetmalaria.org
May 8, 2025 at 4:51 PM
Bill Gates talking about #genedrive as one of the tools in the pipeline that could help end #malaria in the next 20 years @transmission-zero.bsky.social @targetmalaria.org
Tomorrow, hear from T0's George Christophides at the Johns Hopkins Malaria Research Institute’s World Malaria Day Symposium, “Building Better Mosquitoes”!
If you’re at the symposium, we hope you can join us!
#WorldMalariaDay2025 #GeneDrive #Malaria
@gkchris.bsky.social @jhmrimalaria.bsky.social
If you’re at the symposium, we hope you can join us!
#WorldMalariaDay2025 #GeneDrive #Malaria
@gkchris.bsky.social @jhmrimalaria.bsky.social
April 24, 2025 at 4:34 PM
Tomorrow, hear from T0's George Christophides at the Johns Hopkins Malaria Research Institute’s World Malaria Day Symposium, “Building Better Mosquitoes”!
If you’re at the symposium, we hope you can join us!
#WorldMalariaDay2025 #GeneDrive #Malaria
@gkchris.bsky.social @jhmrimalaria.bsky.social
If you’re at the symposium, we hope you can join us!
#WorldMalariaDay2025 #GeneDrive #Malaria
@gkchris.bsky.social @jhmrimalaria.bsky.social
🚨New pre-print🚨
Natural DNA variation can slash CRISPR gene drive efficiency by up to 54% in Culex quinquefasciatus, a major West Nile virus mosquito vector.
<10% mismatch at the target site disrupts copying.
#GeneDrive #CRISPR
(with Tim Harvey-Samuel and Alphey Lab)
doi.org/10.1101/2025...
Natural DNA variation can slash CRISPR gene drive efficiency by up to 54% in Culex quinquefasciatus, a major West Nile virus mosquito vector.
<10% mismatch at the target site disrupts copying.
#GeneDrive #CRISPR
(with Tim Harvey-Samuel and Alphey Lab)
doi.org/10.1101/2025...
August 5, 2025 at 8:14 AM
🚨New pre-print🚨
Natural DNA variation can slash CRISPR gene drive efficiency by up to 54% in Culex quinquefasciatus, a major West Nile virus mosquito vector.
<10% mismatch at the target site disrupts copying.
#GeneDrive #CRISPR
(with Tim Harvey-Samuel and Alphey Lab)
doi.org/10.1101/2025...
Natural DNA variation can slash CRISPR gene drive efficiency by up to 54% in Culex quinquefasciatus, a major West Nile virus mosquito vector.
<10% mismatch at the target site disrupts copying.
#GeneDrive #CRISPR
(with Tim Harvey-Samuel and Alphey Lab)
doi.org/10.1101/2025...
While we are working on an oral contraceptive for grey squirrels, the @roslininstitute.bsky.social & European Squirrel Initiative are looking into #genedrive technology. This Confor article from a few years ago provides a useful overview: www.confor.org.uk/media/267820... #genetics #wildlife
December 15, 2025 at 9:44 AM
While we are working on an oral contraceptive for grey squirrels, the @roslininstitute.bsky.social & European Squirrel Initiative are looking into #genedrive technology. This Confor article from a few years ago provides a useful overview: www.confor.org.uk/media/267820... #genetics #wildlife
Probably don't have the reach on here yet - BUT:
I have a fully-funded four year PhD studentship available - the deadline is soon - November 25th - so please share if you can.
And let's connect if you are interested in #genedrive #pestcontrol #evobio
biodtp.norwichresearchpark.ac.uk/projects/new...
I have a fully-funded four year PhD studentship available - the deadline is soon - November 25th - so please share if you can.
And let's connect if you are interested in #genedrive #pestcontrol #evobio
biodtp.norwichresearchpark.ac.uk/projects/new...
New strategies for pest insect control by population suppression | Doctoral Training Partnership
CHAPMAN_U25DTP1
biodtp.norwichresearchpark.ac.uk
November 15, 2024 at 2:08 PM
Probably don't have the reach on here yet - BUT:
I have a fully-funded four year PhD studentship available - the deadline is soon - November 25th - so please share if you can.
And let's connect if you are interested in #genedrive #pestcontrol #evobio
biodtp.norwichresearchpark.ac.uk/projects/new...
I have a fully-funded four year PhD studentship available - the deadline is soon - November 25th - so please share if you can.
And let's connect if you are interested in #genedrive #pestcontrol #evobio
biodtp.norwichresearchpark.ac.uk/projects/new...
Gene drive mosquitoes could transform malaria control, but tracking them usually requires lab equipment. We propose a low-cost Rapid Diagnostic Test (RDT) to detect & track gene drives directly in the field.
Read the paper: rdcu.be/fv59Q
#GlobalHealth #Malaria #CRISPR #GeneDrive
Read the paper: rdcu.be/fv59Q
#GlobalHealth #Malaria #CRISPR #GeneDrive
A target product profile for a rapid diagnostic test to monitor mosquito gene drive presence and frequency
rdcu.be
July 26, 2026 at 10:01 PM
Gene drive mosquitoes could transform malaria control, but tracking them usually requires lab equipment. We propose a low-cost Rapid Diagnostic Test (RDT) to detect & track gene drives directly in the field.
Read the paper: rdcu.be/fv59Q
#GlobalHealth #Malaria #CRISPR #GeneDrive
Read the paper: rdcu.be/fv59Q
#GlobalHealth #Malaria #CRISPR #GeneDrive
Genedrive does
August 22, 2025 at 5:50 PM
Genedrive does
I am going to try and get back into posting a bit more regularly. Probably like most people twitter left me a bit bruised and jaded...
Anyway I am interested in #highered #rstats #genedrive #biology if you are too let's connect!
Anyway I am interested in #highered #rstats #genedrive #biology if you are too let's connect!
November 13, 2024 at 9:51 AM
I am going to try and get back into posting a bit more regularly. Probably like most people twitter left me a bit bruised and jaded...
Anyway I am interested in #highered #rstats #genedrive #biology if you are too let's connect!
Anyway I am interested in #highered #rstats #genedrive #biology if you are too let's connect!
#GDR
Good news for them .
Genedrive PLC - CE-certification #GDR @genedriveplc www.voxmarkets.co.uk/rns/announce... #voxmarkets #investing #shares #RNS via @voxmarkets
Good news for them .
Genedrive PLC - CE-certification #GDR @genedriveplc www.voxmarkets.co.uk/rns/announce... #voxmarkets #investing #shares #RNS via @voxmarkets
Genedrive PLC - CE-certification - Vox Markets
RNS Number: 6765 K Genedrive PLC 30 May 2025 genedrive plc. Genedrive ® CYP2C19 ID Kit receives CE-certification under the European In Vitro Diagnostics Regulation. genedrive plc, the point of care ph...
www.voxmarkets.co.uk
May 30, 2025 at 6:37 AM
#GDR
Good news for them .
Genedrive PLC - CE-certification #GDR @genedriveplc www.voxmarkets.co.uk/rns/announce... #voxmarkets #investing #shares #RNS via @voxmarkets
Good news for them .
Genedrive PLC - CE-certification #GDR @genedriveplc www.voxmarkets.co.uk/rns/announce... #voxmarkets #investing #shares #RNS via @voxmarkets
Science Soldier Genedrive would get a singular tie-in game on the famicom and be mixed up with other 4/10 titles published by Banpresto
January 14, 2026 at 9:36 AM
Science Soldier Genedrive would get a singular tie-in game on the famicom and be mixed up with other 4/10 titles published by Banpresto
Our new paper in @cp-trendsparasitol.bsky.social
Adapting Africa’s vector surveillance systems to monitor gene-drive mosquitoes in malaria control: www.cell.com/trends/paras...
Led by Prof #FredrosOkumu, Dr #LinaFinda, Dr #JoelOdero
@sbohvm.gla.ac.uk #IfakaraHealthInstitute
#OneHealth #GeneDrive
Adapting Africa’s vector surveillance systems to monitor gene-drive mosquitoes in malaria control: www.cell.com/trends/paras...
Led by Prof #FredrosOkumu, Dr #LinaFinda, Dr #JoelOdero
@sbohvm.gla.ac.uk #IfakaraHealthInstitute
#OneHealth #GeneDrive
Adapting Africa’s vector surveillance systems to monitor gene-drive mosquitoes in malaria control
Gene-drive mosquitoes could transform malaria control in Africa, but their rapid,
autonomous spread requires rigorous post-release monitoring. Most malaria-endemic
countries already conduct some entom...
www.cell.com
April 14, 2026 at 5:57 AM
Our new paper in @cp-trendsparasitol.bsky.social
Adapting Africa’s vector surveillance systems to monitor gene-drive mosquitoes in malaria control: www.cell.com/trends/paras...
Led by Prof #FredrosOkumu, Dr #LinaFinda, Dr #JoelOdero
@sbohvm.gla.ac.uk #IfakaraHealthInstitute
#OneHealth #GeneDrive
Adapting Africa’s vector surveillance systems to monitor gene-drive mosquitoes in malaria control: www.cell.com/trends/paras...
Led by Prof #FredrosOkumu, Dr #LinaFinda, Dr #JoelOdero
@sbohvm.gla.ac.uk #IfakaraHealthInstitute
#OneHealth #GeneDrive
Opinion piece: Here’s how to reduce the chances of gene drives causing collateral damage. In PNAS Front Matter: https://ow.ly/2oEl50XuOGg
#GeneDrive #TargetSpeciesComplex #RiskAssessment #PublicHealth #agriculture #malaria #mosquitoes #vector #AnophelesGambiae
#GeneDrive #TargetSpeciesComplex #RiskAssessment #PublicHealth #agriculture #malaria #mosquitoes #vector #AnophelesGambiae
November 22, 2025 at 6:00 PM
Opinion piece: Here’s how to reduce the chances of gene drives causing collateral damage. In PNAS Front Matter: https://ow.ly/2oEl50XuOGg
#GeneDrive #TargetSpeciesComplex #RiskAssessment #PublicHealth #agriculture #malaria #mosquitoes #vector #AnophelesGambiae
#GeneDrive #TargetSpeciesComplex #RiskAssessment #PublicHealth #agriculture #malaria #mosquitoes #vector #AnophelesGambiae
July 7, 2025 at 3:24 PM
Finally! Self-help in the only format I can stomach: crunchy genedrive cartridges
July 3, 2026 at 12:13 AM
Finally! Self-help in the only format I can stomach: crunchy genedrive cartridges
Check out our new study in An. stephensi:
Variable gene drive efficiency across 4 Pol III promoters (but up to 99.8%) - building essential knowledge for next-gen drives. Key challenges remain - maternal Cas9 causes high rates of early somatic editing. #genedrive www.nature.com/articles/s41...
Variable gene drive efficiency across 4 Pol III promoters (but up to 99.8%) - building essential knowledge for next-gen drives. Key challenges remain - maternal Cas9 causes high rates of early somatic editing. #genedrive www.nature.com/articles/s41...
Optimization of SgRNA expression with RNA pol III regulatory elements in Anopheles stephensi - Scientific Reports
Scientific Reports - Optimization of SgRNA expression with RNA pol III regulatory elements in Anopheles stephensi
www.nature.com
April 23, 2025 at 11:34 AM
Check out our new study in An. stephensi:
Variable gene drive efficiency across 4 Pol III promoters (but up to 99.8%) - building essential knowledge for next-gen drives. Key challenges remain - maternal Cas9 causes high rates of early somatic editing. #genedrive www.nature.com/articles/s41...
Variable gene drive efficiency across 4 Pol III promoters (but up to 99.8%) - building essential knowledge for next-gen drives. Key challenges remain - maternal Cas9 causes high rates of early somatic editing. #genedrive www.nature.com/articles/s41...