We've made remarkable progress in the science of aging (geroscience) with readiness to apply this for "precision geromedicine."
A brilliant new review @cellpress.bsky.social
www.cell.com/cell/fulltex...
A brilliant new review @cellpress.bsky.social
www.cell.com/cell/fulltex...
April 19, 2025 at 4:07 PM
We've made remarkable progress in the science of aging (geroscience) with readiness to apply this for "precision geromedicine."
A brilliant new review @cellpress.bsky.social
www.cell.com/cell/fulltex...
A brilliant new review @cellpress.bsky.social
www.cell.com/cell/fulltex...
The most exciting idea in medicine right now? Targeting aging itself, not just the diseases it causes. 🧪
This is a great intro to geroscience, but what did they miss?
Some of the best interventions!
🏋️ Exercise
💊 SGLT2 inhibitors
🍽 Acarbose
(More on these in future posts.)
Now, what did I miss?
This is a great intro to geroscience, but what did they miss?
Some of the best interventions!
🏋️ Exercise
💊 SGLT2 inhibitors
🍽 Acarbose
(More on these in future posts.)
Now, what did I miss?
Is Human Aging Reversible?
The geroscience hypothesis holds that targeting molecular pathways that drive aging can give us more healthy years. Evidence is mounting
www.scientificamerican.com
April 4, 2025 at 1:46 PM
The most exciting idea in medicine right now? Targeting aging itself, not just the diseases it causes. 🧪
This is a great intro to geroscience, but what did they miss?
Some of the best interventions!
🏋️ Exercise
💊 SGLT2 inhibitors
🍽 Acarbose
(More on these in future posts.)
Now, what did I miss?
This is a great intro to geroscience, but what did they miss?
Some of the best interventions!
🏋️ Exercise
💊 SGLT2 inhibitors
🍽 Acarbose
(More on these in future posts.)
Now, what did I miss?
Long COVID affects 400M+ people globally — and its symptoms mirror accelerated aging: cognitive decline, fatigue, autonomic dysfunction, microvascular damage.
📄 Read free: www.nature.com/articles/s43...
#LongCOVID #Geroscience #AgingResearch #Healthspan
📄 Read free: www.nature.com/articles/s43...
#LongCOVID #Geroscience #AgingResearch #Healthspan
May 4, 2026 at 3:28 PM
Long COVID affects 400M+ people globally — and its symptoms mirror accelerated aging: cognitive decline, fatigue, autonomic dysfunction, microvascular damage.
📄 Read free: www.nature.com/articles/s43...
#LongCOVID #Geroscience #AgingResearch #Healthspan
📄 Read free: www.nature.com/articles/s43...
#LongCOVID #Geroscience #AgingResearch #Healthspan
If you haven't heard about them yet, I want to introduce you to the Canadian Translational Geroscience Network (CTGN).
The CTGN is a multidisciplinary organization dedicated to applying geroscience principles—connecting the biology of aging with chronic disease prevention—to extend healthspan and
The CTGN is a multidisciplinary organization dedicated to applying geroscience principles—connecting the biology of aging with chronic disease prevention—to extend healthspan and
September 24, 2026 at 8:51 PM
If you haven't heard about them yet, I want to introduce you to the Canadian Translational Geroscience Network (CTGN).
The CTGN is a multidisciplinary organization dedicated to applying geroscience principles—connecting the biology of aging with chronic disease prevention—to extend healthspan and
The CTGN is a multidisciplinary organization dedicated to applying geroscience principles—connecting the biology of aging with chronic disease prevention—to extend healthspan and
We were thrilled to hear from our keynote speaker, Susan Ozanne of the University of Cambridge, yesterday at the 2026 Geroscience Symposium!
@ozannelab.bsky.social
Thank you for a wonderful lecture! #GeroscienceSymposium2026
@ozannelab.bsky.social
Thank you for a wonderful lecture! #GeroscienceSymposium2026
September 23, 2026 at 7:47 PM
We were thrilled to hear from our keynote speaker, Susan Ozanne of the University of Cambridge, yesterday at the 2026 Geroscience Symposium!
@ozannelab.bsky.social
Thank you for a wonderful lecture! #GeroscienceSymposium2026
@ozannelab.bsky.social
Thank you for a wonderful lecture! #GeroscienceSymposium2026
Finally answered the "should we start a podcast" call that waits for us all...
Episode 1 of Inside Geroscience is out now! Tune in for conversations about the biology of ageing with leading scientists in the field. Brought to you by the Academy of Geroscience, available on all podcast platforms.
Episode 1 of Inside Geroscience is out now! Tune in for conversations about the biology of ageing with leading scientists in the field. Brought to you by the Academy of Geroscience, available on all podcast platforms.
Nature vs. Nurture with Uri Alon
open.spotify.com
May 8, 2026 at 11:04 PM
Finally answered the "should we start a podcast" call that waits for us all...
Episode 1 of Inside Geroscience is out now! Tune in for conversations about the biology of ageing with leading scientists in the field. Brought to you by the Academy of Geroscience, available on all podcast platforms.
Episode 1 of Inside Geroscience is out now! Tune in for conversations about the biology of ageing with leading scientists in the field. Brought to you by the Academy of Geroscience, available on all podcast platforms.
Out in print in Geroscience by @rosealsaadi.bsky.social: Pro‑longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan. Most interventions that help hermaphrodites also improve male lifespan, not necessarily reproductive heathspan. link.springer.com/epdf/10.1007...
February 17, 2026 at 9:25 PM
Out in print in Geroscience by @rosealsaadi.bsky.social: Pro‑longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan. Most interventions that help hermaphrodites also improve male lifespan, not necessarily reproductive heathspan. link.springer.com/epdf/10.1007...
“We found that having COVID-19 during the 3-year study period significantly increased the progress of aging,” particularly among females.
Associations of epigenetic aging and COVID-19: A 3-year longitudinal study
link.springer.com/article/10.1...
Associations of epigenetic aging and COVID-19: A 3-year longitudinal study
link.springer.com/article/10.1...
Associations of epigenetic aging and COVID- 19: A 3-year longitudinal study - GeroScience
Aging and COVID- 19 are known to influence DNA methylation, potentially affecting the rate of aging and the risk of disease. The physiological functions of 54 volunteers—including maximal oxygen uptak...
link.springer.com
April 13, 2025 at 5:19 AM
“We found that having COVID-19 during the 3-year study period significantly increased the progress of aging,” particularly among females.
Associations of epigenetic aging and COVID-19: A 3-year longitudinal study
link.springer.com/article/10.1...
Associations of epigenetic aging and COVID-19: A 3-year longitudinal study
link.springer.com/article/10.1...
Here for the biology of aging/longevity and related news #geroscience #aging #longevity #biogerontology
October 24, 2024 at 3:54 PM
Here for the biology of aging/longevity and related news #geroscience #aging #longevity #biogerontology
Anyone know of a good ageing biology starter pack on here?
Hashtag soup to catch anyone who might know of one: #ageing #aging #longevity #agingbiology #ageingbiology #longevityscience #biogerontology #geroscience :)
Hashtag soup to catch anyone who might know of one: #ageing #aging #longevity #agingbiology #ageingbiology #longevityscience #biogerontology #geroscience :)
August 21, 2024 at 10:21 AM
Anyone know of a good ageing biology starter pack on here?
Hashtag soup to catch anyone who might know of one: #ageing #aging #longevity #agingbiology #ageingbiology #longevityscience #biogerontology #geroscience :)
Hashtag soup to catch anyone who might know of one: #ageing #aging #longevity #agingbiology #ageingbiology #longevityscience #biogerontology #geroscience :)
Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin
www.aging-us.com/article/2061...
www.aging-us.com/article/2061...
Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin | Aging
Aging | doi:10.18632/aging.206189. David A. Barzilai
www.aging-us.com
January 14, 2025 at 12:40 AM
Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin
www.aging-us.com/article/2061...
www.aging-us.com/article/2061...
Thank you to everyone who joined us for the 2026 Geroscience Symposium! We’re grateful to our speakers, attendees, and collaborators for making this a great event and for advancing conversations around aging research. We appreciate you being part of it! #GeroscienceSymposium2026
September 23, 2026 at 7:58 PM
Thank you to everyone who joined us for the 2026 Geroscience Symposium! We’re grateful to our speakers, attendees, and collaborators for making this a great event and for advancing conversations around aging research. We appreciate you being part of it! #GeroscienceSymposium2026
The Dog Aging Project, the largest and longest-running canine aging study in the world, published a finding in the journal GeroScience that changes the way we understand aging in dogs and, potentially, in humans as well.
The Dog Aging Project reveals that combining chronic diseases doubles the risk of death in dogs - Sinaptica
The Dog Aging Project, the largest and longest-running canine aging study in the world, published a finding in the journal GeroScience that changes the way we u
sinapti.ca
August 31, 2026 at 10:19 PM
The Dog Aging Project, the largest and longest-running canine aging study in the world, published a finding in the journal GeroScience that changes the way we understand aging in dogs and, potentially, in humans as well.
Taking place in Vancouver, BC on October 22nd & 23rd, the third annual scientific meeting of the Canadian Translational Geroscience Network promises to be a great opportunity to find out more about longevity research in Canada.
September 25, 2026 at 5:48 PM
Taking place in Vancouver, BC on October 22nd & 23rd, the third annual scientific meeting of the Canadian Translational Geroscience Network promises to be a great opportunity to find out more about longevity research in Canada.
📈 As the US population ages, the incidence of #stroke, #heartfailure, #dementia, and other age-related health issues is expected to increase.
Learn more about geroscience interventions designed to slow #aging in this Review.
ja.ma/3UQRlld
Learn more about geroscience interventions designed to slow #aging in this Review.
ja.ma/3UQRlld
August 9, 2025 at 3:00 PM
📈 As the US population ages, the incidence of #stroke, #heartfailure, #dementia, and other age-related health issues is expected to increase.
Learn more about geroscience interventions designed to slow #aging in this Review.
ja.ma/3UQRlld
Learn more about geroscience interventions designed to slow #aging in this Review.
ja.ma/3UQRlld
„Diese 3-Jahres-Studie zeigt, dass eine Infektion mit COVID-19 den Fortschritt der Alterung signifikant erhöhte. Die Daten deuten darauf hin, dass COVID-19 eine leichte Langzeitwirkung auf die epigenetische Alterung haben könnte.“
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Associations of epigenetic aging and COVID- 19: A 3-year longitudinal study - GeroScience
Aging and COVID- 19 are known to influence DNA methylation, potentially affecting the rate of aging and the risk of disease. The physiological functions of 54 volunteers—including maximal oxygen uptak...
link.springer.com
April 12, 2025 at 3:45 PM
„Diese 3-Jahres-Studie zeigt, dass eine Infektion mit COVID-19 den Fortschritt der Alterung signifikant erhöhte. Die Daten deuten darauf hin, dass COVID-19 eine leichte Langzeitwirkung auf die epigenetische Alterung haben könnte.“
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Patients are asking for time with family, time in full cognition, time in independence, and time living on their own terms.
That is why geroscience should be judged not only by survival, but by whether it extends life by extending health.
My Editorial:
www.linkedin.com/posts/agingd...
That is why geroscience should be judged not only by survival, but by whether it extends life by extending health.
My Editorial:
www.linkedin.com/posts/agingd...
The future of geroscience should not be framed as a choice between lifespan and healthspan.
In my new editorial, “Healthy life extension: Geroscience’s north star,” I argue that this is the wrong… | ...
The future of geroscience should not be framed as a choice between lifespan and healthspan.
In my new editorial, “Healthy life extension: Geroscience’s north star,” I argue that this is the wrong deb...
www.linkedin.com
March 18, 2026 at 1:33 PM
Patients are asking for time with family, time in full cognition, time in independence, and time living on their own terms.
That is why geroscience should be judged not only by survival, but by whether it extends life by extending health.
My Editorial:
www.linkedin.com/posts/agingd...
That is why geroscience should be judged not only by survival, but by whether it extends life by extending health.
My Editorial:
www.linkedin.com/posts/agingd...
📊🩺 This study from GeroScience suggests that longer durations of smoking cessation are associated with more favorable biological aging profiles, adding biological evidence for the long-term health benefits of sustained cessation for healthy aging.🛟 #EpiSky #PrevMed
Duration of smoking cessation and DNA methylation aging clocks among US adults: potential reversibility of smoking-induced biological aging - GeroScience
Tobacco smoking is a critical modifiable risk factor for age-related diseases and mortality. Although smoking cessation is known to improve health outcomes, whether smoking-induced biological aging is reversible upon cessation remains unclear. We investigated the associations of smoking status and cessation duration with epigenetic age acceleration (EAA) using multi-generational DNA methylation clocks. We analyzed data from 1,911 adults aged 50–84 years in the National Health and Nutrition Examination Survey (NHANES) 1999–2002. Participants were classified as never, former, or current smokers, with former smokers further categorized by cessation duration (< 10, 10– < 20, and ≥ 20 years). EAA was evaluated across six validated DNA methylation clocks: first-generation (HorvathAge, HannumAge, SkinBloodAge), second-generation (PhenoAge, GrimAge2), and third-generation (DunedinPoAm). In survey-weighted regression, current smokers exhibited the highest EAA across all clocks. Among former smokers, a longer duration of cessation was associated with a dose–response reduction in EAA, with the strongest associations observed for GrimAge2 and DunedinPoAm. Former smokers with ≥ 20 years of cessation showed a substantial reduction in GrimAge2 acceleration (β = -12.66 years; 95% CI: -14.56, -10.75), approaching the levels observed among never smokers (β = -13.88 years; 95% CI: -15.70, -12.05). Restricted cubic spline analysis revealed rapid initial declines in EAA during the first decade post-cessation, with continuous declines observed beyond 20 years for GrimAge2 and DunedinPoAm. These findings suggest that longer durations of smoking cessation are associated with more favorable biological aging profiles, adding biological evidence for the long-term health benefits of sustained cessation for healthy aging.
bit.ly
September 24, 2026 at 10:00 PM
Really looking forward to the #FusionAging25 meeting in Malta - stunning location and stellar science 💕#geroscience
November 26, 2024 at 7:07 PM
Really looking forward to the #FusionAging25 meeting in Malta - stunning location and stellar science 💕#geroscience
We are thrilled to announce a new publication regarding the data collection infrastructure developed for the precision cohort. Check it out here: link.springer.com/article/10.1...
#geroscience #canine #longevity
#geroscience #canine #longevity
March 6, 2025 at 10:23 PM
We are thrilled to announce a new publication regarding the data collection infrastructure developed for the precision cohort. Check it out here: link.springer.com/article/10.1...
#geroscience #canine #longevity
#geroscience #canine #longevity
SARS-CoV-2 infection can cause cerebrovascular pathologies, with the development of chronic neurological manifestations associated with #LongCovid
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health - GeroScience
Long COVID (also known as post-acute sequelae of SARS-CoV-2 infection [PASC] or post-COVID syndrome) is characterized by persistent symptoms that extend beyond the acute phase of SARS-CoV-2 infection,...
link.springer.com
January 12, 2025 at 12:52 PM
SARS-CoV-2 infection can cause cerebrovascular pathologies, with the development of chronic neurological manifestations associated with #LongCovid
link.springer.com/article/10.1...
link.springer.com/article/10.1...
📈 As the US population ages, the incidence of #stroke, #heartfailure, #dementia, and other age-related health issues is expected to increase.
Learn more about geroscience interventions designed to slow #aging and improve health outcomes in this Review.
ja.ma/4mPqoKB
Learn more about geroscience interventions designed to slow #aging and improve health outcomes in this Review.
ja.ma/4mPqoKB
September 23, 2025 at 4:20 PM
📈 As the US population ages, the incidence of #stroke, #heartfailure, #dementia, and other age-related health issues is expected to increase.
Learn more about geroscience interventions designed to slow #aging and improve health outcomes in this Review.
ja.ma/4mPqoKB
Learn more about geroscience interventions designed to slow #aging and improve health outcomes in this Review.
ja.ma/4mPqoKB
#Geroscience can't agree what #aging is
www.nature.com/articles/d41...
Even more problematic:
Each geroscientist is convinced that they themselves know what aging is
What do you think aging is?
— Loss of function?
— Accumulated damage?
— A disease?
— A continuation of development?
www.nature.com/articles/d41...
Even more problematic:
Each geroscientist is convinced that they themselves know what aging is
What do you think aging is?
— Loss of function?
— Accumulated damage?
— A disease?
— A continuation of development?
What is ageing? Even the field’s researchers can’t agree
Survey of scientists who study ageing finds no consensus on the fundamentals.
www.nature.com
December 4, 2024 at 2:21 AM
#Geroscience can't agree what #aging is
www.nature.com/articles/d41...
Even more problematic:
Each geroscientist is convinced that they themselves know what aging is
What do you think aging is?
— Loss of function?
— Accumulated damage?
— A disease?
— A continuation of development?
www.nature.com/articles/d41...
Even more problematic:
Each geroscientist is convinced that they themselves know what aging is
What do you think aging is?
— Loss of function?
— Accumulated damage?
— A disease?
— A continuation of development?