Meet SQUARNA 3.0, our tool for #RNA secondary structure prediction:
pypi.org/project/SQUA...
Now with options for @rfamdb.bsky.social Rfam template search and G-quadruplex pattern recognition!
Currently, as CLI and Python API, and soon, a web version.
#Rfam #G4 #Gquadruplex #Bioinformatics
pypi.org/project/SQUA...
Now with options for @rfamdb.bsky.social Rfam template search and G-quadruplex pattern recognition!
Currently, as CLI and Python API, and soon, a web version.
#Rfam #G4 #Gquadruplex #Bioinformatics
February 18, 2026 at 12:28 PM
Meet SQUARNA 3.0, our tool for #RNA secondary structure prediction:
pypi.org/project/SQUA...
Now with options for @rfamdb.bsky.social Rfam template search and G-quadruplex pattern recognition!
Currently, as CLI and Python API, and soon, a web version.
#Rfam #G4 #Gquadruplex #Bioinformatics
pypi.org/project/SQUA...
Now with options for @rfamdb.bsky.social Rfam template search and G-quadruplex pattern recognition!
Currently, as CLI and Python API, and soon, a web version.
#Rfam #G4 #Gquadruplex #Bioinformatics
Another collaboration published! Have a look at this work on targeting TERRA RNA G-quadruplexes with small molecules and their role in ALT-associated telomere maintenance.
Full text: onlinelibrary.wiley.com/doi/epdf/10....
#RNA #GQuadruplex #Targeting #NMR
Full text: onlinelibrary.wiley.com/doi/epdf/10....
#RNA #GQuadruplex #Targeting #NMR
Small Molecule Modulation of TERRA RNA Quadruplex Reprograms ALT‐Telomere Maintenance
The telomeric lncRNA TERRA forms RNA G-quadruplex structures that regulate telomere integrity. An indoloquinoxaline ligand (IQ4) selectively binds and stabilizes the TERRA rG4, disrupts the TERRA–TRF...
onlinelibrary.wiley.com
September 22, 2026 at 3:16 PM
Another collaboration published! Have a look at this work on targeting TERRA RNA G-quadruplexes with small molecules and their role in ALT-associated telomere maintenance.
Full text: onlinelibrary.wiley.com/doi/epdf/10....
#RNA #GQuadruplex #Targeting #NMR
Full text: onlinelibrary.wiley.com/doi/epdf/10....
#RNA #GQuadruplex #Targeting #NMR
Check out our latest publication on DNA G-quadruplexes! We show how the ligand Phen-DC3 modulates the folding of the human telomeric repeat 23TAG DNA, providing insights into the modulation of G4 folding.
Read more here 👉 doi.org/10.1002/chem...
#DNA #GQuadruplex #folding #kinetics #realtime #NMR
Read more here 👉 doi.org/10.1002/chem...
#DNA #GQuadruplex #folding #kinetics #realtime #NMR
Exploring the modulation of the complex folding landscape of Human Telomeric DNA by low molecular weight ligands
Telomeric DNA forms G-quadruplex (G4) structures. These G4s structures are crucial for genomic stability and therapeutic targeting. Using time-resolved NMR and CD spectroscopies, we investigated how ...
doi.org
April 22, 2025 at 2:38 PM
Check out our latest publication on DNA G-quadruplexes! We show how the ligand Phen-DC3 modulates the folding of the human telomeric repeat 23TAG DNA, providing insights into the modulation of G4 folding.
Read more here 👉 doi.org/10.1002/chem...
#DNA #GQuadruplex #folding #kinetics #realtime #NMR
Read more here 👉 doi.org/10.1002/chem...
#DNA #GQuadruplex #folding #kinetics #realtime #NMR
Learned about using an oligo pull down assay to show that the zinc finger domain of transcription factor #Mig1 binds to #GQuadruplex DNA from #MeenuSharma from lab of #NayunKim #UTAustinCollegeOfPharmacy #Yeast26 @genetics-gsa.bsky.social #G4
June 16, 2026 at 4:31 PM
Learned about using an oligo pull down assay to show that the zinc finger domain of transcription factor #Mig1 binds to #GQuadruplex DNA from #MeenuSharma from lab of #NayunKim #UTAustinCollegeOfPharmacy #Yeast26 @genetics-gsa.bsky.social #G4
I had a great time at #G4thering 2025 in Minneapolis earlier this month.
I gave a talk at the Young Scholar Forum and was awarded a travel grant by the G4 society - very grateful for the chance to present and connect with the G4 community!
#Gquadruplex #PhDLife #YoungScientist
I gave a talk at the Young Scholar Forum and was awarded a travel grant by the G4 society - very grateful for the chance to present and connect with the G4 community!
#Gquadruplex #PhDLife #YoungScientist
June 16, 2025 at 2:34 PM
I had a great time at #G4thering 2025 in Minneapolis earlier this month.
I gave a talk at the Young Scholar Forum and was awarded a travel grant by the G4 society - very grateful for the chance to present and connect with the G4 community!
#Gquadruplex #PhDLife #YoungScientist
I gave a talk at the Young Scholar Forum and was awarded a travel grant by the G4 society - very grateful for the chance to present and connect with the G4 community!
#Gquadruplex #PhDLife #YoungScientist
Just out - @PrietoTayler, @McquaidKane and I are honouring the pioneering nucleic acid structural work of Stephen Neidle with our review of G-quadruplex metal complex sructures. #G4 #openaccess #DNA #Gquadruplex #Xray #NMR https://link.springer.com/article/10.1007/s00044-024-03309-w
Structural insights into G-quadruplex binding by metal co...
G-quadruplex DNA secondary structures are formed in guani...
link.springer.com
November 22, 2024 at 11:23 AM
Just out - @PrietoTayler, @McquaidKane and I are honouring the pioneering nucleic acid structural work of Stephen Neidle with our review of G-quadruplex metal complex sructures. #G4 #openaccess #DNA #Gquadruplex #Xray #NMR https://link.springer.com/article/10.1007/s00044-024-03309-w
Study finds nuclear microRNA-9 drives G-quadruplex formation, impacting 3D genome structure during TGF-β-induced transcription, suggesting a role in enhancer-promoter loops. #Genome #Gquadruplex PMID:39706840, Nat Commun 2024, @NatureComms doi.org/10.1038/s414...
Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-β-induced transcription - Nature Communications
Three-dimensional genome organization is important for transcription regulation. Here the authors show that microRNA 9 mediates the formation of G-quadruplexes and the looping of promoters and super-e...
doi.org
December 27, 2024 at 12:20 AM
Study finds nuclear microRNA-9 drives G-quadruplex formation, impacting 3D genome structure during TGF-β-induced transcription, suggesting a role in enhancer-promoter loops. #Genome #Gquadruplex PMID:39706840, Nat Commun 2024, @NatureComms doi.org/10.1038/s414...
Mappati gli enigmatici nodi del Dna. Sono 50mila, potrebbero avere un ruolo contro tumori e infezioni. #DNAumano #gquadruplex #imotifs
September 3, 2024 at 5:56 PM
Mappati gli enigmatici nodi del Dna. Sono 50mila, potrebbero avere un ruolo contro tumori e infezioni. #DNAumano #gquadruplex #imotifs
#research #Gquadruplex #DNA #NMR
NMR screen reveals the diverse structural landscape of a G-quadruplex library (Curtis) -
Chemistry – A European Journal : doi.org/10.1002/chem...
@iocbprague.bsky.social #CAS #CzechScience
NMR screen reveals the diverse structural landscape of a G-quadruplex library (Curtis) -
Chemistry – A European Journal : doi.org/10.1002/chem...
@iocbprague.bsky.social #CAS #CzechScience
September 16, 2024 at 11:11 AM
#research #Gquadruplex #DNA #NMR
NMR screen reveals the diverse structural landscape of a G-quadruplex library (Curtis) -
Chemistry – A European Journal : doi.org/10.1002/chem...
@iocbprague.bsky.social #CAS #CzechScience
NMR screen reveals the diverse structural landscape of a G-quadruplex library (Curtis) -
Chemistry – A European Journal : doi.org/10.1002/chem...
@iocbprague.bsky.social #CAS #CzechScience
DFT Analysis of Stacking Interactions and Cyclic H-Bond Cooperativity in G-Quadruplexes.
E, Soorya et al.
Paper
Details
#GQuadruplex #StackingInteractions #HydrogenBondCooperativity
E, Soorya et al.
Paper
Details
#GQuadruplex #StackingInteractions #HydrogenBondCooperativity
December 15, 2025 at 9:02 AM
DFT Analysis of Stacking Interactions and Cyclic H-Bond Cooperativity in G-Quadruplexes.
E, Soorya et al.
Paper
Details
#GQuadruplex #StackingInteractions #HydrogenBondCooperativity
E, Soorya et al.
Paper
Details
#GQuadruplex #StackingInteractions #HydrogenBondCooperativity
Very happy to share lovely work of @McquaidKane
Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex https://pubs.acs.org/doi/10.1021/jacs.2c00178#.YjzksPkYnbo.twitter
Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex https://pubs.acs.org/doi/10.1021/jacs.2c00178#.YjzksPkYnbo.twitter
November 22, 2024 at 1:59 PM