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Earlier stem cell transplants may improve survival for youth with Shwachman-Diamond syndrome when high-risk features emerge, according to a study led by an expert at Cincinnati Children's and publishe...

BackgroundAcute graft-vs.-host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), where allogene...

X-linked adrenoleukodystrophy (ALD) is a rare inherited neurological disorder that poses considerable challenges for clinical management throughout the lifespan. Although males are generally more seve...

Chronic active Epstein–Barr virus (EBV) disease (CAEBV) is an uncommon lethal infection involving EBV-infected T cells and/or natural killer (NK) cells, often complicated by hemophagocytic lymphohistiocytosis (HLH). Patients need curative hematopoietic cell transplantation (HCT), but the indication and timing remain unclear. This study aimed to assess the prognostic value of EBV-infected lymphocyte subsets.MethodsWe analyzed 52 pediatric/young-adult patients diagnosed with persistently EBV infection from 2003 to 2025 at a single tertiary center in Japan, excluding acute infectious mononucleosis and secondary immunodeficiencies. Dominant EBV-infected cell types (CD4+, CD8+, and γδ T cells; CD19+ B cells; and CD56+ NK cells) were determined at diagnosis of CAEBV (n = 21), EBV-HLH (n = 19), or inborn errors of immunity (IEI, n = 12). The long-term outcomes were analyzed by major infected cell types and treatment.ResultsCAEBV included 12 T-cell–dominant (6 CD4+, 4 CD8+, and 2 γδ) and 9 NK-cell–dominant infections. EBV-HLH and IEI exclusively involved CD8+ T-cell and B-cell infections, respectively. Thirteen CAEBV patients (62%) underwent HCT to control progression, including 5 patients who presented with HLH. The 3-year overall survival was 88%, although CD4+ T-cell disease (all CAEBV) showed a significantly lower survival rate. Posttransplant deaths occurred in 3 of 13 CAEBV patients and none of the EBV-HLH patients. Among 9 CAEBV patients with median 11-year progression-free survival without HCT, each one of CD4+ T-cell or NK-cell cases transformed to lymphoma or leukemia after being untreated for >10 years.ConclusionsEBV-infected lymphocyte profiling guided prolonged HCT-free control of CAEBV. CD4+ T-cell CAEBV requires a prompt rather than elective HCT to prevent progression and transformation.

Hematopoietic cell transplantation (HCT) can be curative for lymphoma, yet population-level HCT outcomes by HIV status are not well studied, contribut…

Hematopoietic cell transplant (HCT) is a potentially curative treatment for relapsed or refractory lymphoma, and population-level patterns of HCT util…

http://www.emediawire.com/releases/2005/6/emw249802.htm Cowboys – Need Not Apply; Teaching the Right Stuff – for Hostile Conditions HCT (Hostile Control Tactics, LLC) meets growing need for training PMCs (Private Military Contractors) and security…

‘The rules have changed’: has Russia begun to order assassinations on US soil?