ME/CFS Autopsy Study Finds a Wrecked HPA Axis: The 2025 IACFS/ME Conference Report #3 www.healthrising.org/blog/2025/12... #MECFS
ME/CFS Autopsy Study Finds a Wrecked HPA Axis: The 2025 IACFS/ME Conference Report #3 - Health Rising
A Dutch ME/CFS autopsy report findings multiple severe problems in the HPA axis of ME/CFS patients.
www.healthrising.org
December 13, 2025 at 9:21 PM
ME/CFS Autopsy Study Finds a Wrecked HPA Axis: The 2025 IACFS/ME Conference Report #3 www.healthrising.org/blog/2025/12... #MECFS
Health Rising: “ME/CFS Autopsy Study Finds a Wrecked HPA Axis: The 2025 IACFS/ME Conference Report #3”
“.. they found almost no CRH producing neurons in the ME/CFS patients. That suggested that a general suppression of the hypothalamus…”
www.healthrising.org/blog/2025/12...
“.. they found almost no CRH producing neurons in the ME/CFS patients. That suggested that a general suppression of the hypothalamus…”
www.healthrising.org/blog/2025/12...
ME/CFS Autopsy Study Finds a Wrecked HPA Axis: The 2025 IACFS/ME Conference Report #3 - Health Rising
A Dutch ME/CFS autopsy report findings multiple severe problems in the HPA axis of ME/CFS patients.
www.healthrising.org
December 5, 2025 at 12:04 AM
Health Rising: “ME/CFS Autopsy Study Finds a Wrecked HPA Axis: The 2025 IACFS/ME Conference Report #3”
“.. they found almost no CRH producing neurons in the ME/CFS patients. That suggested that a general suppression of the hypothalamus…”
www.healthrising.org/blog/2025/12...
“.. they found almost no CRH producing neurons in the ME/CFS patients. That suggested that a general suppression of the hypothalamus…”
www.healthrising.org/blog/2025/12...
Acute responses can be immune activation, endothelial and metabolic stress, or HPA/autonomic responses can be early results of triggers.
Then the failure of resolution (IMO the most mysterious): persistent antigens or lingering infection, continual activation of immune responses or HPA axis, etc.
Then the failure of resolution (IMO the most mysterious): persistent antigens or lingering infection, continual activation of immune responses or HPA axis, etc.
September 23, 2026 at 6:13 PM
Acute responses can be immune activation, endothelial and metabolic stress, or HPA/autonomic responses can be early results of triggers.
Then the failure of resolution (IMO the most mysterious): persistent antigens or lingering infection, continual activation of immune responses or HPA axis, etc.
Then the failure of resolution (IMO the most mysterious): persistent antigens or lingering infection, continual activation of immune responses or HPA axis, etc.
We have met the enemy and it is the HPA axis
March 11, 2026 at 4:42 PM
We have met the enemy and it is the HPA axis
ME Research UK:
Review study concludes that chronic stress may contribute to brain fog in ME/CFS by disrupting the Hypothalamic Pituitary Adrenal (HPA) axis and adversely affecting a part of the brain called the hippocampus.
Find out more: tinyurl.com/4r5rjjde
#MEcfs #pwme #cfs
1/
Review study concludes that chronic stress may contribute to brain fog in ME/CFS by disrupting the Hypothalamic Pituitary Adrenal (HPA) axis and adversely affecting a part of the brain called the hippocampus.
Find out more: tinyurl.com/4r5rjjde
#MEcfs #pwme #cfs
1/
June 29, 2026 at 7:24 PM
ME Research UK:
Review study concludes that chronic stress may contribute to brain fog in ME/CFS by disrupting the Hypothalamic Pituitary Adrenal (HPA) axis and adversely affecting a part of the brain called the hippocampus.
Find out more: tinyurl.com/4r5rjjde
#MEcfs #pwme #cfs
1/
Review study concludes that chronic stress may contribute to brain fog in ME/CFS by disrupting the Hypothalamic Pituitary Adrenal (HPA) axis and adversely affecting a part of the brain called the hippocampus.
Find out more: tinyurl.com/4r5rjjde
#MEcfs #pwme #cfs
1/
Association of childhood adversity with HPA axis activity in children and adolescents: A systematic review and meta-analysis www.sciencedirect.com/science/arti...
April 2, 2025 at 2:10 PM
Association of childhood adversity with HPA axis activity in children and adolescents: A systematic review and meta-analysis www.sciencedirect.com/science/arti...
Nature research paper: Androgen loss accelerates brain tumour growth via HPA axis activation
go.nature.com/4ncUDfY
go.nature.com/4ncUDfY
Androgen loss accelerates brain tumour growth via HPA axis activation - Nature
Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.
go.nature.com
May 13, 2026 at 8:46 AM
Nature research paper: Androgen loss accelerates brain tumour growth via HPA axis activation
go.nature.com/4ncUDfY
go.nature.com/4ncUDfY
The y-axis limits on Apple Weather’s pressure forecasts are frustrating. Fixed at 975–1065 hPa for a 24h period means most fluctuations are hard to discern. Further, <975 hPa is *much* more likely than >1065 hPa! (UK record is a sniff over 1050) Central point of the axis is 1020 hPa — a bit high.
March 16, 2025 at 12:22 PM
The y-axis limits on Apple Weather’s pressure forecasts are frustrating. Fixed at 975–1065 hPa for a 24h period means most fluctuations are hard to discern. Further, <975 hPa is *much* more likely than >1065 hPa! (UK record is a sniff over 1050) Central point of the axis is 1020 hPa — a bit high.
🧬Science Wednesdays: HPA axis
The hypothalamus-pituitary-adrenal (HPA) axis is the communication between three organs: the hypothalamus region of the brain, the pituitary gland, and the adrenal gland. The HPA axis is a major part of the body’s stress management system.
The hypothalamus-pituitary-adrenal (HPA) axis is the communication between three organs: the hypothalamus region of the brain, the pituitary gland, and the adrenal gland. The HPA axis is a major part of the body’s stress management system.
August 6, 2025 at 2:28 PM
🧬Science Wednesdays: HPA axis
The hypothalamus-pituitary-adrenal (HPA) axis is the communication between three organs: the hypothalamus region of the brain, the pituitary gland, and the adrenal gland. The HPA axis is a major part of the body’s stress management system.
The hypothalamus-pituitary-adrenal (HPA) axis is the communication between three organs: the hypothalamus region of the brain, the pituitary gland, and the adrenal gland. The HPA axis is a major part of the body’s stress management system.
Happy to share Bryan Jenkins' latest work published in @psychopharmacology.bsky.social: Cannabidiol potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice link.springer.com/article/10.1.... Bryan truly led this project!
Cannabidiol (CBD) potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice - Psychopharmacology
Rationale Clinical literature indicates there may be a therapeutic use of cannabidiol (CBD) for stress-related disorders. Preclinical literature remains conflicted regarding the underlying neurobehavi...
link.springer.com
January 4, 2025 at 4:56 PM
Happy to share Bryan Jenkins' latest work published in @psychopharmacology.bsky.social: Cannabidiol potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice link.springer.com/article/10.1.... Bryan truly led this project!
From ME Research UK:
A review by Noé López-Amador explores the potential role of the hypothalamic-pituitary-adrenal (HPA) axis and orexin system in ME/CFS.
Read more: tinyurl.com/ajbtrmua
#MECFS
A review by Noé López-Amador explores the potential role of the hypothalamic-pituitary-adrenal (HPA) axis and orexin system in ME/CFS.
Read more: tinyurl.com/ajbtrmua
#MECFS
September 4, 2025 at 10:14 PM
From ME Research UK:
A review by Noé López-Amador explores the potential role of the hypothalamic-pituitary-adrenal (HPA) axis and orexin system in ME/CFS.
Read more: tinyurl.com/ajbtrmua
#MECFS
A review by Noé López-Amador explores the potential role of the hypothalamic-pituitary-adrenal (HPA) axis and orexin system in ME/CFS.
Read more: tinyurl.com/ajbtrmua
#MECFS
9) The second part of the presentation wasn't about the HPA axis or stress system but about microglia, the immune cells in the brain.
February 7, 2026 at 1:54 PM
9) The second part of the presentation wasn't about the HPA axis or stress system but about microglia, the immune cells in the brain.
7) CRH is the key that starts the Hypothalamic-Pituitary-Adrenal (HPA) axis, the body’s primary stress response system.
It goes something like this: Hypothalamus -> CRH -> Pituitary gland -> ACTH -> Adrenal glands -> Cortisol.
It goes something like this: Hypothalamus -> CRH -> Pituitary gland -> ACTH -> Adrenal glands -> Cortisol.
February 7, 2026 at 1:54 PM
7) CRH is the key that starts the Hypothalamic-Pituitary-Adrenal (HPA) axis, the body’s primary stress response system.
It goes something like this: Hypothalamus -> CRH -> Pituitary gland -> ACTH -> Adrenal glands -> Cortisol.
It goes something like this: Hypothalamus -> CRH -> Pituitary gland -> ACTH -> Adrenal glands -> Cortisol.
Does sugar affect how you deal with stress? 🍪
I am excited to share that I received funding from the @dfg.de to study the links between acute and chronic glucose intake and HPA axis regulation. I will be hiring one PhD student soon (more infos will follow). (1/3)
I am excited to share that I received funding from the @dfg.de to study the links between acute and chronic glucose intake and HPA axis regulation. I will be hiring one PhD student soon (more infos will follow). (1/3)
July 29, 2026 at 9:32 AM
Does sugar affect how you deal with stress? 🍪
I am excited to share that I received funding from the @dfg.de to study the links between acute and chronic glucose intake and HPA axis regulation. I will be hiring one PhD student soon (more infos will follow). (1/3)
I am excited to share that I received funding from the @dfg.de to study the links between acute and chronic glucose intake and HPA axis regulation. I will be hiring one PhD student soon (more infos will follow). (1/3)
Disturbance history alters the development of the HPA axis in altricial nestling birds | peerj.com/articles/1... | @peerj.bsky.social | #ornithology 🪶
March 3, 2025 at 5:24 AM
Disturbance history alters the development of the HPA axis in altricial nestling birds | peerj.com/articles/1... | @peerj.bsky.social | #ornithology 🪶
Don't miss the latest Endocrine Feedback Loop podcast!
EFL057 - Weaning #Glucocorticoids and #HPA Recovery.
In iatrogenic adrenal insufficiency, how often does HPA-axis recovery occur? Guests Felix Beuschlein and Salila Kurra.
@endocrinesociety.bsky.social #JCEM
www.endocrine.org/journals/end...
EFL057 - Weaning #Glucocorticoids and #HPA Recovery.
In iatrogenic adrenal insufficiency, how often does HPA-axis recovery occur? Guests Felix Beuschlein and Salila Kurra.
@endocrinesociety.bsky.social #JCEM
www.endocrine.org/journals/end...
EFL057 - Weaning Glucocorticoids and HPA Recovery
In iatrogenic adrenal insufficiency, how often does HPA-axis recovery occur, and what is the best approach to encourage that recovery? Find out more in this episode!
www.endocrine.org
January 16, 2025 at 10:16 PM
Don't miss the latest Endocrine Feedback Loop podcast!
EFL057 - Weaning #Glucocorticoids and #HPA Recovery.
In iatrogenic adrenal insufficiency, how often does HPA-axis recovery occur? Guests Felix Beuschlein and Salila Kurra.
@endocrinesociety.bsky.social #JCEM
www.endocrine.org/journals/end...
EFL057 - Weaning #Glucocorticoids and #HPA Recovery.
In iatrogenic adrenal insufficiency, how often does HPA-axis recovery occur? Guests Felix Beuschlein and Salila Kurra.
@endocrinesociety.bsky.social #JCEM
www.endocrine.org/journals/end...
Long COVID identified through immune profiling (Putrino, Iwasaki) buff.ly/3PShYEJ
Clinical surveys were 94% accurate to diagnose LC.
People with Long COVID had
⬇️ cortisol (HPA axis defect?)
⬆️ activated B and cytokine-secreting T cells
⬆️ anti-Spike IgG Ab
⬆️ EBV reactive Abs
🩺
Clinical surveys were 94% accurate to diagnose LC.
People with Long COVID had
⬇️ cortisol (HPA axis defect?)
⬆️ activated B and cytokine-secreting T cells
⬆️ anti-Spike IgG Ab
⬆️ EBV reactive Abs
🩺
September 28, 2023 at 9:35 PM
Long COVID identified through immune profiling (Putrino, Iwasaki) buff.ly/3PShYEJ
Clinical surveys were 94% accurate to diagnose LC.
People with Long COVID had
⬇️ cortisol (HPA axis defect?)
⬆️ activated B and cytokine-secreting T cells
⬆️ anti-Spike IgG Ab
⬆️ EBV reactive Abs
🩺
Clinical surveys were 94% accurate to diagnose LC.
People with Long COVID had
⬇️ cortisol (HPA axis defect?)
⬆️ activated B and cytokine-secreting T cells
⬆️ anti-Spike IgG Ab
⬆️ EBV reactive Abs
🩺
Timing matters for maternal effects on offspring HPA-axis in wild macaque. New paper out from the Assamese macaque Project at Phu Khieo Wildlife Sanctuary!
link here 👇👇
tinyurl.com/yc6k5dvf
@primatenzentrum.bsky.social @unigoettingen.bsky.social @primatecognition.bsky.social @dfg.de
link here 👇👇
tinyurl.com/yc6k5dvf
@primatenzentrum.bsky.social @unigoettingen.bsky.social @primatecognition.bsky.social @dfg.de
January 24, 2025 at 2:15 PM
Timing matters for maternal effects on offspring HPA-axis in wild macaque. New paper out from the Assamese macaque Project at Phu Khieo Wildlife Sanctuary!
link here 👇👇
tinyurl.com/yc6k5dvf
@primatenzentrum.bsky.social @unigoettingen.bsky.social @primatecognition.bsky.social @dfg.de
link here 👇👇
tinyurl.com/yc6k5dvf
@primatenzentrum.bsky.social @unigoettingen.bsky.social @primatecognition.bsky.social @dfg.de
(now 11) autopsies show severe HPA axis dysfunction, specifically a massive reduction in neurons producing the CRH hormone, alongside signs of dystrophic, rather than inflamed, microglia.
www.healthrising.org/blog/2025/12...
Should we inform them?
www.healthrising.org/blog/2025/12...
Should we inform them?
ME/CFS Autopsy Study Finds a Wrecked HPA Axis: The 2025 IACFS/ME Conference Report #3 - Health Rising
A Dutch ME/CFS autopsy report findings multiple severe problems in the HPA axis of ME/CFS patients.
www.healthrising.org
May 2, 2026 at 5:48 AM
(now 11) autopsies show severe HPA axis dysfunction, specifically a massive reduction in neurons producing the CRH hormone, alongside signs of dystrophic, rather than inflamed, microglia.
www.healthrising.org/blog/2025/12...
Should we inform them?
www.healthrising.org/blog/2025/12...
Should we inform them?
Chronic sleep restriction disrupts the HPA axis differently in males and females, impacting health risks and opioid relapse vulnerability.
by Everson CA, Szabo A (...) Raff H et 2 al. in Sleep #MedSky
👉 get more here
📖 read the article:
by Everson CA, Szabo A (...) Raff H et 2 al. in Sleep #MedSky
👉 get more here
📖 read the article:
The effects of chronic sleep restriction on the hypothalamic-pituitary-adrenal axis and its interaction with abstinence from opioid use
AbstractStudy objectives. The hypothalamic-pituitary-adrenal (HPA) axis is critical in regulating responses to physiological and psychological disturbances
academic.oup.com
April 29, 2025 at 8:39 AM
🧬 Gut Microbiota & Brain Development 🧠
Exploring how the gut–brain axis influences neurogenesis, microglial maturation, HPA-axis regulation, myelination & neuroplasticity.
🌍 GMC 2027 | May 11–12 | Boston, USA
⏳ Early Bird Deadline: Sept 30, 2026
🔗 microbiomecongress.org/registrations/
#Microbiome
Exploring how the gut–brain axis influences neurogenesis, microglial maturation, HPA-axis regulation, myelination & neuroplasticity.
🌍 GMC 2027 | May 11–12 | Boston, USA
⏳ Early Bird Deadline: Sept 30, 2026
🔗 microbiomecongress.org/registrations/
#Microbiome
September 26, 2026 at 6:25 AM
🧬 Gut Microbiota & Brain Development 🧠
Exploring how the gut–brain axis influences neurogenesis, microglial maturation, HPA-axis regulation, myelination & neuroplasticity.
🌍 GMC 2027 | May 11–12 | Boston, USA
⏳ Early Bird Deadline: Sept 30, 2026
🔗 microbiomecongress.org/registrations/
#Microbiome
Exploring how the gut–brain axis influences neurogenesis, microglial maturation, HPA-axis regulation, myelination & neuroplasticity.
🌍 GMC 2027 | May 11–12 | Boston, USA
⏳ Early Bird Deadline: Sept 30, 2026
🔗 microbiomecongress.org/registrations/
#Microbiome
new out in Nature www.nature.com/articles/s41...
Androgen loss accelerates brain tumour growth via HPA axis activation - Nature
Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.
www.nature.com
May 7, 2026 at 6:46 AM
new out in Nature www.nature.com/articles/s41...
5) Correa da Silva said they looked at the HPA axis because low cortisol has been linked to ME/CFS symptoms. But: “The magnitude of the changes in the brains of people with ME seem to be very high, much more than we expected initially.”
February 7, 2026 at 1:54 PM
5) Correa da Silva said they looked at the HPA axis because low cortisol has been linked to ME/CFS symptoms. But: “The magnitude of the changes in the brains of people with ME seem to be very high, much more than we expected initially.”