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Background: Target trial emulation (TTE) studies are increasingly important for regulatory decision‑making and health technology assessments (HTAs), but current risk-of-bias (RoB) tools are not specifically tailored to assess biases central to TTE studies—such as immortal time bias, misaligned eligibility criteria, and prevalent user bias. RoB assessment for TTE studies thus remains difficult, and it is unclear which tools and adaptations #Researchers currently use or how well they work. Objective: This #Study aims to analyze the RoB assessment of TTE studies at regulatory and policy decision points along the medical product life cycle by providing a systematic overview of tools developed, used, adapted, or evaluated for TTE studies and the perceived importance and feasibility of assessing TTE studies by HTA assessors, regulators, systematic reviewers, and methods experts. Methods: This is a #Protocol for a scoping review and online survey among systematic reviewers, methods experts, European HTA organizations, and regulators. We will collect data on the name, description, and feasibility of RoB tools used, adapted, and developed for TTE studies, as well as RoB assessment results and the RoB sources relevant for TTE studies. Two authors will use qualitative content analysis to analyze the data independently. The systematic search for published and gray literature in 4 electronic databases (PubMed, Scopus, Web of Science, and the Cochrane Library), on relevant websites (eg, Cochrane, HTA and regulatory agencies), and through reference list checking was conducted in May to June 2026. Results: As of August 25, 2026, screening is ongoing, and 78 references have been preliminarily included in the scoping review. We will analyze the scoping review and survey data and provide an overview of the types, feasibility, and assessment results of RoB tools currently used, adapted, or developed for TTE studies, as well as the RoB sources considered relevant for TTE studies by HTA assessors, regulators, systematic reviewers, and methods experts. Analysis results of the literature review and survey are expected in September 2026 and November 2026, respectively. Conclusions: The analysis of the scoping review and survey data will inform users of TTE evidence about the feasibility of RoB tools; future development and training needs; and the perceived value of assessing the RoB in HTAs, regulatory decisions, and systematic reviews.

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I can't say for sure but I think this is the only western that opens with a quote from Mao about revolutions. For a movie that was written with a title Duck, You Asshole it has a massive epic scope. H...

Surrogate outcomes play an important role in modern healthcare research. Join us for this webinar where our experts will focus on methods and guidelines for establishing surrogate outcomes and how the...

Learn how new frameworks for HTAs can better capture the full value of medical innovations, including broader social impacts.

An increasing investment in health technology assessment (HTA) in low-income and middle-income countries has generated greater interest from policy-makers about the value and return on investment (ROI...

Strengthen the foundation of your systematic reviews, HTAs, guidelines, and other evidence syntheses with Searching for Systematic Reviews: Advanced Design Methods, an online Instats seminar for PhD students, clinicians, information specialists/librarians, and professional researchers. Led by Julie Glanville and Carol Lefebvre, each with 30 years of expertise in evidence searching and training, this workshop explores advanced techniques for designing robust, transparent, and reproducible search strategies across a range of review types. Participants will learn how to translate PICO and non-PICO questions into effective searches, use text mining, AI, and machine learning tools to support study identification, apply search filters, address complex or hard-to-define topics, use citation analysis to improve search completeness, and identify retractions, errata, and comments to support evidence integrity. The seminar includes opportunities for discussion, questions, and sharing best practices, with Zoom recordings, materials, take-home skill challenges, and instructor support available for 30 days. An official Instats certificate of completion is provided, with 1 ECTS equivalent point available for European students. This seminar can be taken on its own or as part of the two-part course Searching for Systematic Reviews: Where and How to Search, with a 10% discount when both seminars are purchased together. #Psychology #Sociology #SocialWork #PublicPolicy #Epidemiology #PublicHealth #ClinicalorLaboratoryScience #PharmaceuticalScience #Psychiatry #Ophthalmology #Neuroscience #Immunology #Pharmacology #BiomedicalEngineering #DataScience #InformationScience #Medicine #Education #Research #ResearchTraining #Instats

Join our online seminar on methodological search filters (or "hedges") to learn how to find, appraise and apply filters that focus searches on study designs such as randomized controlled trials—an essential skill for anyone conducting systematic reviews, HTAs, guidelines or other evidence syntheses. Taught by Carol and Julie (each with 30 years’ experience as filter developers and trainers), this practical Zoom workshop covers choosing sensitive vs. specific filters, adapting filters across databases, ethical considerations, staying up to date, and hands-on exercises to build your skills; all sessions, slides and materials will be available for 30 days after the seminar and an online chat forum will be monitored for questions during that time, with an Instats certificate of completion provided. Register now and save 10% if you sign up for this seminar together with "Finding Unpublished Clinical Trial Data" at https://instats.org/course/key-search-issues-finding-trials-using1. #Psychology #Sociology #SocialWork #Epidemiology #PublicHealth #Biostatistics #ClinicalorLaboratoryScience #Psychiatry #InformationScience #Medicine #Education #SocialTheory #Research #ResearchTraining #Instats

Join our online workshop on methodological search filters (hedges) — essential tools for limiting search results to specific study designs and improving the quality and efficiency of systematic searches used in evidence syntheses, HTAs, guidelines and clinical research. Led by Carol and Julie, each with 30 years’ experience as filter developers and trainers, this practical Zoom seminar (with hands-on exercises) will teach you how to find, appraise, adapt and use filters across databases, navigate ethical issues, stay up to date, and avoid common pitfalls — ideal for clinicians, information specialists, librarians and researchers. All sessions and materials will be available for 30 days after the seminar, a monitored chat forum will be open for follow-up questions, and an Instats certificate of completion is provided. Sign up for this seminar and "Finding Unpublished Clinical Trial Data" at the same time to save 10% on both: https://instats.org/course/key-search-issues-finding-trials-using1. Register now to secure your place. #Psychology #Sociology #SocialWork #Epidemiology #PublicHealth #Biostatistics #ClinicalorLaboratoryScience #Psychiatry #InformationScience #Medicine #Education #SocialTheory #Research #ResearchTraining #Instats

Join our online workshop on methodological search filters (hedges)—essential tools for narrowing searches to study designs (e.g., RCTs) used in systematic reviews, HTAs, guidelines and other evidence syntheses—taught by Carol and Julie, each with 30 years’ experience as filter developers and trainers. This practical, hands-on seminar is ideal for clinicians, information specialists/librarians and researchers who want to learn how to find, appraise, adapt and use filters effectively (including disease/search blocks), navigate common challenges and ethical issues, and stay up to date with new filters. The course is delivered via Zoom, includes exercises, an online chat forum monitored during and for 30 days after the seminar, and all recordings and materials (including slides) will be available for 30 days; an official Instats certificate of completion is provided. Sign up for this seminar and "Finding Unpublished Clinical Trial Data" at the same time to save 10% on both: https://instats.org/course/key-search-issues-finding-trials-using1 #Psychology #Sociology #SocialWork #Epidemiology #PublicHealth #Biostatistics #ClinicalorLaboratoryScience #Psychiatry #InformationScience #Medicine #Education #Research #ResearchTraining #Instats

The infamous US-Israeli Gaza Humanitarian Foundation (GHF) proposed building what it called “Humanitarian Transit Areas” (HTAs) inside and possibly outside Gaza, according to documents reviewed by Reu...

From: Di Tanna Gian Luca Subject: Call for paper on Methods for Systematic Reviews of Health Economic Evaluations Themed Issue: Methods for Systematic Reviews of Health Economic Evaluations Decision-analytic model-based and alongside-trial cost-effectiveness/utility and budget impact analyses are becoming increasingly critical for health technology assessments (HTAs) and reimbursement decisions in healthcare systems worldwide. As healthcare budgets face growing constraints, methodologically rigorous approaches to synthesising health economic evidence have become essential for evidence-based health policy decision-making. The methodological landscape for conducting systematic reviews of health economic evaluations (SR-HEEs) faces unique challenges not encountered in systematic reviews of clinical effectiveness. These [...]