Niche topic alert 😀: macroscopic examination of mandibular resections performed for odontogenic tumors

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More recent paper describes a non-canonical fusion

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Parasagittal section through total laryngectomy specimen resected for advanced stage squamous cell carcinoma. Curious finding in the blue box

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Submandibular sialolith is a gross-only specimen for us. However…the interesting surface texture piqued my interest. Intact appearance, sectioned, faxitron (in our lab) and low mag histology with arrows highlighting the textured region.

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Laryngeal biopsy. What would you call this squamous cell proliferation?
🤔
A) hyperplasia
B) dysplasia
C) carcinoma
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🔬 tumourclassification.iarc.who.int/Viewer/Index...

✅ Verrucous Carcinoma
✅Characteristic broad, "pushing" invasive front combined with deceptively bland cytology
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🔬 tumourclassification.iarc.who.int/Viewer/Index...

Squamous cell carcinoma of the edentulous alveolar ridge and palate. Cut surface (ms=maxillary sinus; nc=nasal cavity); corresponding low mag image; endophytic (arrow) with cystic cuniculatum-like growth; additional cystic change in scca.

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❌ Adenosquamous Carcinoma
Requires TWO distinct malignant components:
1) SCC
2) adenocarcinoma (true glands, often mucin-producing)
🔬 tumourclassification.iarc.who.int/Viewer/Index...
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Here is a closer look at the luminal spaces, what do they contain?
A) squamous cells
B) mucin
C) both
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Tonsilar lesion. Is it #TooFarToDiagnose?
🧐🧐
A) Squamous cell carcinoma
B) Adenocarcinoma
C) Both
D) Neither
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rosai.secondslide.com/view/sem1142...

Will find SNP tissue (arrows in these two low magnification examples) near fungiform, foliate and/or circumvallate papillae of the tongue.

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