'Carnivore' or 'Cholesterol' hands photographed on a 40 year old man following the carnivore diet 😫 👎
These lesions are consistent with xanthelasma, likely resulting from severe hypercholesterolemia associated with a high-fat carnivore diet. Total cholesterol levels of the man exceeded 1000 mg/dL.
These lesions are consistent with xanthelasma, likely resulting from severe hypercholesterolemia associated with a high-fat carnivore diet. Total cholesterol levels of the man exceeded 1000 mg/dL.
September 28, 2026 at 10:03 PM
'Carnivore' or 'Cholesterol' hands photographed on a 40 year old man following the carnivore diet 😫 👎
These lesions are consistent with xanthelasma, likely resulting from severe hypercholesterolemia associated with a high-fat carnivore diet. Total cholesterol levels of the man exceeded 1000 mg/dL.
These lesions are consistent with xanthelasma, likely resulting from severe hypercholesterolemia associated with a high-fat carnivore diet. Total cholesterol levels of the man exceeded 1000 mg/dL.
One practitioner, Colonel Wriothesley Featherstonehaugh, originally from a rural community in Saskatchewan, was already suffering from Strongyloidiasis and immediately developed hypercholesterolemia.
3/7
3/7
September 17, 2026 at 11:15 AM
One practitioner, Colonel Wriothesley Featherstonehaugh, originally from a rural community in Saskatchewan, was already suffering from Strongyloidiasis and immediately developed hypercholesterolemia.
3/7
3/7
David's lab invented two major upgrades to genome editing - base (Alexis Komor, Nicole Gaudelli) and prime editing (Andrew Anzalone).
While originating in an "academic" lab, both resonated loudly in the for-profit sector (Verve trial for hypercholesterolemia and Beam's - for A1AT deficiency).
While originating in an "academic" lab, both resonated loudly in the for-profit sector (Verve trial for hypercholesterolemia and Beam's - for A1AT deficiency).
David Liu receives Breakthrough Prize in Life Sciences.
Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine. www.broadinstitute.org/news/david-l...
Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine. www.broadinstitute.org/news/david-l...
David Liu receives Breakthrough Prize in Life Sciences
Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine.
www.broadinstitute.org
April 6, 2025 at 1:22 PM
David's lab invented two major upgrades to genome editing - base (Alexis Komor, Nicole Gaudelli) and prime editing (Andrew Anzalone).
While originating in an "academic" lab, both resonated loudly in the for-profit sector (Verve trial for hypercholesterolemia and Beam's - for A1AT deficiency).
While originating in an "academic" lab, both resonated loudly in the for-profit sector (Verve trial for hypercholesterolemia and Beam's - for A1AT deficiency).
🧪 Atorvastatin (Lipitor) is "the best-selling drug in history. Approved by the FDA in 1996, this small molecule revolutionized the treatment of hypercholesterolemia and the prevention of cardiovascular diseases,"
A blog looking at how this, and other statins, were developed ⬇️
A blog looking at how this, and other statins, were developed ⬇️
I have a new blog devoted to medicinal chemistry in which I will mainly focus on classic papers.
My first installment describes the design and discovery of the amazing atorvastatin: a triumph of simple modeling, dogged synthesis and leadership decisions medchemash.substack.com/p/classics-i...
My first installment describes the design and discovery of the amazing atorvastatin: a triumph of simple modeling, dogged synthesis and leadership decisions medchemash.substack.com/p/classics-i...
Classics in Medicinal Chemistry #1: Atorvastatin
Lipitor
medchemash.substack.com
January 19, 2025 at 12:16 AM
🧪 Atorvastatin (Lipitor) is "the best-selling drug in history. Approved by the FDA in 1996, this small molecule revolutionized the treatment of hypercholesterolemia and the prevention of cardiovascular diseases,"
A blog looking at how this, and other statins, were developed ⬇️
A blog looking at how this, and other statins, were developed ⬇️
The only person I've ever wished for hypercholesterolemia to hurry the fuck up and do it's job.
January 13, 2025 at 2:17 PM
The only person I've ever wished for hypercholesterolemia to hurry the fuck up and do it's job.
Homozygous Familial Hypercholesterolemia Epidemiology Market | WiseGuyReports www.wiseguyreports.com/reports/homo...
Homozygous Familial Hypercholesterolemia Epidemiology Market
The Homozygous Familial Hypercholesterolemia Epidemiology Market is expected to grow from 800 USD Million in 2025 to 1,500 USD Million by 2035. The Homozygous Familial Hypercholesterolemia Epidemiolog...
www.wiseguyreports.com
September 25, 2026 at 11:17 AM
Homozygous Familial Hypercholesterolemia Epidemiology Market | WiseGuyReports www.wiseguyreports.com/reports/homo...
In addition to a good description of the new gene-editing technologies it brought to my attention the very recent clinical trial using mRNA-based in vivo gene editing to treat familial hypercholesterolemia. Fascinating! 🧪 ir.vervetx.com/news-release...
The 1st approval for genome editing is a historic medical milestone. But it's indirect, disruptive, & rudimentary—just getting started. David Liu gave a master class on genome editing's future. With transcript, relevant external links & explainer Figures
erictopol.substack.com/p/david-liu-...
erictopol.substack.com/p/david-liu-...
December 11, 2023 at 9:00 AM
In addition to a good description of the new gene-editing technologies it brought to my attention the very recent clinical trial using mRNA-based in vivo gene editing to treat familial hypercholesterolemia. Fascinating! 🧪 ir.vervetx.com/news-release...
Surprise, surprise.
60 years ago, there was no early detection of hypertension, diabetes, hypercholesterolemia, colon cancer or breast cancer.
People did not survive their stroke, heart attack or cancer for long.
Today we can have a good,long life with those deseases an medication
60 years ago, there was no early detection of hypertension, diabetes, hypercholesterolemia, colon cancer or breast cancer.
People did not survive their stroke, heart attack or cancer for long.
Today we can have a good,long life with those deseases an medication
April 25, 2025 at 1:01 PM
Surprise, surprise.
60 years ago, there was no early detection of hypertension, diabetes, hypercholesterolemia, colon cancer or breast cancer.
People did not survive their stroke, heart attack or cancer for long.
Today we can have a good,long life with those deseases an medication
60 years ago, there was no early detection of hypertension, diabetes, hypercholesterolemia, colon cancer or breast cancer.
People did not survive their stroke, heart attack or cancer for long.
Today we can have a good,long life with those deseases an medication
The patients usually do not have traditional atherosclerotic risk factors, though there is a comparable prevalence of hypertension and hypercholesterolemia.
A Canadian cohort study suggested that migraines (33%), anxiety (20%), and depression (20%) were relevant comorbid associations.
A Canadian cohort study suggested that migraines (33%), anxiety (20%), and depression (20%) were relevant comorbid associations.
November 10, 2024 at 2:12 PM
The patients usually do not have traditional atherosclerotic risk factors, though there is a comparable prevalence of hypertension and hypercholesterolemia.
A Canadian cohort study suggested that migraines (33%), anxiety (20%), and depression (20%) were relevant comorbid associations.
A Canadian cohort study suggested that migraines (33%), anxiety (20%), and depression (20%) were relevant comorbid associations.
“Impact of a whole food, plant-based diet on LDL-cholesterol and cardiovascular risk factors in adults with heterozygous familial hypercholesterolemia: a randomized, two-period, two-treatment, crossover, fully controlled feeding trial.” May 20, 2026, Nature Communications doi.org/10.1038/s414...
Impact of a whole food, plant-based diet on LDL-cholesterol and cardiovascular risk factors in adults with heterozygous familial hypercholesterolemia: a randomized, two-period, two-treatment, crossove...
Whole food, plant-based diets are recommended worldwide for their cardioprotective properties but evidence regarding their effects in heterozygous familial hypercholesterolemia remains unavailable. He...
doi.org
July 20, 2026 at 3:26 PM
“Impact of a whole food, plant-based diet on LDL-cholesterol and cardiovascular risk factors in adults with heterozygous familial hypercholesterolemia: a randomized, two-period, two-treatment, crossover, fully controlled feeding trial.” May 20, 2026, Nature Communications doi.org/10.1038/s414...
Carlos Bustamante is giving a master class on identifying new mutations for familial hypercholesterolemia across diverse populations and developing ancestry-specific polygenic risk scores. @dbdsstanford.bsky.social
January 16, 2025 at 6:26 PM
Carlos Bustamante is giving a master class on identifying new mutations for familial hypercholesterolemia across diverse populations and developing ancestry-specific polygenic risk scores. @dbdsstanford.bsky.social
New @implementsci.bsky.social reporting patient and clinician perspectives on FH care pathway. Work in partnership with Family Heart Foundation, @pennmedicine.bsky.social @pennchibe.bsky.social @nufeinbergmed.bsky.social #impsci implementationsciencecomms.biomedcentral.com/articles/10....
A qualitative study of perceptions of the care pathway for familial hypercholesterolemia: screening, diagnosis, treatment, and family cascade screening - Implementation Science Communications
Background Familial hypercholesterolemia (FH) is an autosomal dominant genetic condition that carries increased risk for premature atherosclerotic cardiovascular disease, cardiovascular events, and de...
implementationsciencecomms.biomedcentral.com
December 3, 2024 at 2:51 PM
New @implementsci.bsky.social reporting patient and clinician perspectives on FH care pathway. Work in partnership with Family Heart Foundation, @pennmedicine.bsky.social @pennchibe.bsky.social @nufeinbergmed.bsky.social #impsci implementationsciencecomms.biomedcentral.com/articles/10....
Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social
May 29, 2025 at 2:10 PM
Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social
🟡 Huge news in Nature Communications: A new fully controlled trial shows a whole food, plant-based diet robustly lowers LDL-cholesterol even in adults with heterozygous familial hypercholesterolemia (genetically high cholesterol).
#Vegan #PlantBased
www.nature.com/articles/s41...
#Vegan #PlantBased
www.nature.com/articles/s41...
Impact of a whole food, plant-based diet on LDL-cholesterol and cardiovascular risk factors in adults with heterozygous familial hypercholesterolemia: a randomized, two-period, two-treatment, crossove...
Whole food, plant-based diets are recommended worldwide for their cardioprotective properties but evidence regarding their effects in heterozygous familial hypercholesterolemia remains unavailable. He...
www.nature.com
June 4, 2026 at 10:46 PM
🟡 Huge news in Nature Communications: A new fully controlled trial shows a whole food, plant-based diet robustly lowers LDL-cholesterol even in adults with heterozygous familial hypercholesterolemia (genetically high cholesterol).
#Vegan #PlantBased
www.nature.com/articles/s41...
#Vegan #PlantBased
www.nature.com/articles/s41...
you just say LDL without context, twelve minutes ago it was HDL. what part of familial hypercholesterolemia is salient in your mind. where were you when the strokes started en masse
May 26, 2025 at 7:14 PM
you just say LDL without context, twelve minutes ago it was HDL. what part of familial hypercholesterolemia is salient in your mind. where were you when the strokes started en masse
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR
The low-density lipoprotein receptor (LDLR) is responsible for cholesterol concentrations in your blood.
www.science.org/doi/...
1/2
The low-density lipoprotein receptor (LDLR) is responsible for cholesterol concentrations in your blood.
www.science.org/doi/...
1/2
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR
Variants in the familial hypercholesterolemia gene LDLR—the most important genetic driver of cardiovascular disease—can raise circulating low-density lipoprotein (LDL) cholesterol concentrations and increase the risk of premature atherosclerosis. ...
www.science.org
October 30, 2025 at 9:09 PM
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR
The low-density lipoprotein receptor (LDLR) is responsible for cholesterol concentrations in your blood.
www.science.org/doi/...
1/2
The low-density lipoprotein receptor (LDLR) is responsible for cholesterol concentrations in your blood.
www.science.org/doi/...
1/2
Apparently RFK Jr is set to lay out the latest MAHA metabolic trainwreck, er sorry, "dietary guidelines" in January.
My guess: double down on red meat (one of the worst things possible, down there with soft drinks), everybody with familial hypercholesterolemia dies in five years.
My guess: double down on red meat (one of the worst things possible, down there with soft drinks), everybody with familial hypercholesterolemia dies in five years.
December 29, 2025 at 11:55 PM
Apparently RFK Jr is set to lay out the latest MAHA metabolic trainwreck, er sorry, "dietary guidelines" in January.
My guess: double down on red meat (one of the worst things possible, down there with soft drinks), everybody with familial hypercholesterolemia dies in five years.
My guess: double down on red meat (one of the worst things possible, down there with soft drinks), everybody with familial hypercholesterolemia dies in five years.
The FDA has approved Merck & Co.’s cyclic peptide enlicitide decanoate for the reduction of low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia.
#chemsky 🧪
#chemsky 🧪
FDA approves first oral PCSK9 inhibitor for managing cholesterol
Merck & Co.'s macrocyclic peptide enlicitide to be marketed as Lipfendra
cen.acs.org
July 17, 2026 at 6:08 PM
The FDA has approved Merck & Co.’s cyclic peptide enlicitide decanoate for the reduction of low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia.
#chemsky 🧪
#chemsky 🧪
I have hereditary hypercholesterolemia & a strong family history of ischemic heart disease; exercise, diet & statins have helped, but not enough, so I’m excited
Also, crucially: “Cardiologists not associated with Merck applauded the FDA approval & the drug’s price”
www.nytimes.com/2026/07/16/s...
Also, crucially: “Cardiologists not associated with Merck applauded the FDA approval & the drug’s price”
www.nytimes.com/2026/07/16/s...
The F.D.A. Approves a New Pill to Slash Cholesterol Levels
The new pills can lower cholesterol levels far below what can be achieved with statins, clinical trials have shown.
www.nytimes.com
July 16, 2026 at 4:27 PM
I have hereditary hypercholesterolemia & a strong family history of ischemic heart disease; exercise, diet & statins have helped, but not enough, so I’m excited
Also, crucially: “Cardiologists not associated with Merck applauded the FDA approval & the drug’s price”
www.nytimes.com/2026/07/16/s...
Also, crucially: “Cardiologists not associated with Merck applauded the FDA approval & the drug’s price”
www.nytimes.com/2026/07/16/s...
9) Because much is already known about hypercholesterolemia and rheumatoid arthritis, these applications could present their goals, targets, and deliverables in more certain terms than medical conditions that are truly under-researched.
January 11, 2025 at 10:27 AM
9) Because much is already known about hypercholesterolemia and rheumatoid arthritis, these applications could present their goals, targets, and deliverables in more certain terms than medical conditions that are truly under-researched.
🧪🫀In this "Picture in Science" we recreated the cellular process happening in plaques to model #atherosclerosis in a dish.
www.lbscience.org/en/2024/09/1...
#microscopy #macrophages #hypercholesterolemia
www.lbscience.org/en/2024/09/1...
#microscopy #macrophages #hypercholesterolemia
An Immune Cell Swallowing “Bad” Cholesterol - Little, Big Science
In atherosclerosis, fatty deposits containing cholesterol molecules carried by proteins form on the walls of blood vessels. One of these protein-cholesterol structures is LDL, which is colloquially ca...
www.lbscience.org
July 11, 2025 at 10:25 PM
🧪🫀In this "Picture in Science" we recreated the cellular process happening in plaques to model #atherosclerosis in a dish.
www.lbscience.org/en/2024/09/1...
#microscopy #macrophages #hypercholesterolemia
www.lbscience.org/en/2024/09/1...
#microscopy #macrophages #hypercholesterolemia