#Kidney-Alone #Transplantation With s#iRNA Therapy in Primary Hyperoxaluria Type 1
#VisualAbstract by Elba Medina
https://www.kireports.org/article/S2468-0249(26)03349-8/fulltext
#VisualAbstract by Elba Medina
https://www.kireports.org/article/S2468-0249(26)03349-8/fulltext
November 2, 2026 at 2:00 PM
#Kidney-Alone #Transplantation With s#iRNA Therapy in Primary Hyperoxaluria Type 1
#VisualAbstract by Elba Medina
https://www.kireports.org/article/S2468-0249(26)03349-8/fulltext
#VisualAbstract by Elba Medina
https://www.kireports.org/article/S2468-0249(26)03349-8/fulltext
RRIDs were included in this in Journal of Inherited Metabolic Disease paper. Thanks for making your methods matter! #BetterScience #STMpublishing #RRID
Genetic Correction of the Most Common Mutation Causing Primary Hyperoxaluria Restores Enzyme Localization and Oxalate Metabolism
Read the full paper: Genetic Correction of the Most Common Mutation Causing Primary Hyperoxaluria Restores Enzyme Localization and Oxalate Metabolism
doi.org
November 1, 2026 at 7:00 AM
RRIDs were included in this in Journal of Inherited Metabolic Disease paper. Thanks for making your methods matter! #BetterScience #STMpublishing #RRID
RNA interference medication and transplantation procedures in patients with primary hyperoxaluria type 1
More info: academic.oup.com/ndt/article-...
@ndt-era.bsky.social, @hjanders.bsky.social
More info: academic.oup.com/ndt/article-...
@ndt-era.bsky.social, @hjanders.bsky.social
RNA interference medication and transplantation procedures in patients with primary hyperoxaluria type 1
ABSTRACTBackground and hypothesis. Defective hepatic alanine-glyoxylate aminotransferase (AGT) leads to oxalate overproduction in primary hyperoxaluria typ
academic.oup.com
September 1, 2026 at 1:15 PM
RNA interference medication and transplantation procedures in patients with primary hyperoxaluria type 1
More info: academic.oup.com/ndt/article-...
@ndt-era.bsky.social, @hjanders.bsky.social
More info: academic.oup.com/ndt/article-...
@ndt-era.bsky.social, @hjanders.bsky.social
#GazaGenocide, 30 Jul 2026
Ibrahim Abdullah, 5, suffers from the rare genetic disorder Primary Hyperoxaluria Type 1, which has destroyed both of his kidneys.
His seven-year-old sister, Naima, is also affected by the same genetic disease.
The two siblings urgently need a medical transfer out of Gaza.
Ibrahim Abdullah, 5, suffers from the rare genetic disorder Primary Hyperoxaluria Type 1, which has destroyed both of his kidneys.
His seven-year-old sister, Naima, is also affected by the same genetic disease.
The two siblings urgently need a medical transfer out of Gaza.
July 31, 2026 at 3:10 AM
#GazaGenocide, 30 Jul 2026
Ibrahim Abdullah, 5, suffers from the rare genetic disorder Primary Hyperoxaluria Type 1, which has destroyed both of his kidneys.
His seven-year-old sister, Naima, is also affected by the same genetic disease.
The two siblings urgently need a medical transfer out of Gaza.
Ibrahim Abdullah, 5, suffers from the rare genetic disorder Primary Hyperoxaluria Type 1, which has destroyed both of his kidneys.
His seven-year-old sister, Naima, is also affected by the same genetic disease.
The two siblings urgently need a medical transfer out of Gaza.
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: PHYOX3: Nedosiran Long-Term Safety and Efficacy in Patients With Primary Hyperoxaluria Type 1 www.kireports.org/ar...
July 18, 2025 at 6:00 AM
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: PHYOX3: Nedosiran Long-Term Safety and Efficacy in Patients With Primary Hyperoxaluria Type 1 www.kireports.org/ar...
Interesting new publication from the main journal looking at the use of siRNA based therapies in Hyperoxaluria, discussing why some may not work as well as we hoped they would.
Ronald Wanders, et al
https://doi.org/10.1002/jimd.12817
Ronald Wanders, et al
https://doi.org/10.1002/jimd.12817
November 29, 2024 at 7:24 AM
Interesting new publication from the main journal looking at the use of siRNA based therapies in Hyperoxaluria, discussing why some may not work as well as we hoped they would.
Ronald Wanders, et al
https://doi.org/10.1002/jimd.12817
Ronald Wanders, et al
https://doi.org/10.1002/jimd.12817
YOLT-203 is an in vivo gene-editing therapy targeting primary hyperoxaluria type 1, a rare inherited metabolic disorder.
YOLT-204, is designed to target the bone marrow with a simple IV infusion, which could provide a safer and more scalable treatment for blood disorders.
YOLT-204, is designed to target the bone marrow with a simple IV infusion, which could provide a safer and more scalable treatment for blood disorders.
May 20, 2025 at 8:07 AM
YOLT-203 is an in vivo gene-editing therapy targeting primary hyperoxaluria type 1, a rare inherited metabolic disorder.
YOLT-204, is designed to target the bone marrow with a simple IV infusion, which could provide a safer and more scalable treatment for blood disorders.
YOLT-204, is designed to target the bone marrow with a simple IV infusion, which could provide a safer and more scalable treatment for blood disorders.
@purvasharma821 presenting #Hyperoxaluria
December 9, 2024 at 3:11 PM
@purvasharma821 presenting #Hyperoxaluria
Living With Primary Hyperoxaluria Type 1: What Patients Should Know | The Mighty @DMalieckal @NorthwellHealth @HofNorthwellDOM https://themighty.com/2021/09/primary-hyperoxaluria-type-1-what-patients-should-know-rare-disease/
What Patients Should Know About Living With Primary Hyper...
Have you heard of this rare condition?
themighty.com
December 9, 2024 at 4:48 AM
Living With Primary Hyperoxaluria Type 1: What Patients Should Know | The Mighty @DMalieckal @NorthwellHealth @HofNorthwellDOM https://themighty.com/2021/09/primary-hyperoxaluria-type-1-what-patients-should-know-rare-disease/
A reliable LC-MS/MS method for urinary oxalate determination and its comparison with analogous assays #CCA www.sciencedirect.com/science/arti...
A reliable LC-MS/MS method for urinary oxalate determination and its comparison with analogous assays
The quantification of urinary oxalate is essential for the diagnosis of primary hyperoxaluria. This study sought to develop a liquid chromatography-ta…
www.sciencedirect.com
September 13, 2025 at 6:32 AM
A reliable LC-MS/MS method for urinary oxalate determination and its comparison with analogous assays #CCA www.sciencedirect.com/science/arti...
Primary Hyperoxaluria (PH) is a rare genetic disorder often disguised as recurring kidney stones. With UAB Medicine in collaboration with OHF Care Center Network, see how the future of PH treatment is being rewritten—one breakthrough at a time. #AUA25 youtu.be/TQN9EqQjfgc
From Genes to Care: The UAB OHF Story
YouTube video by WebsEdgeMedicine
youtu.be
April 28, 2025 at 2:36 PM
Primary Hyperoxaluria (PH) is a rare genetic disorder often disguised as recurring kidney stones. With UAB Medicine in collaboration with OHF Care Center Network, see how the future of PH treatment is being rewritten—one breakthrough at a time. #AUA25 youtu.be/TQN9EqQjfgc
So needless to say, I am going to drown myself in homemade kefir on the off chance I've grown the strain at home, and get back to my artsy to-do list so I can make that medicine happen!
I just threw all this info out there in case it helps the other rare hyperoxaluria patients out there. ☀️✨
I just threw all this info out there in case it helps the other rare hyperoxaluria patients out there. ☀️✨
October 15, 2025 at 12:12 AM
So needless to say, I am going to drown myself in homemade kefir on the off chance I've grown the strain at home, and get back to my artsy to-do list so I can make that medicine happen!
I just threw all this info out there in case it helps the other rare hyperoxaluria patients out there. ☀️✨
I just threw all this info out there in case it helps the other rare hyperoxaluria patients out there. ☀️✨
Having a rare disease (hyperoxaluria) means sometimes you figure things out about it as you go.
I learned the hard way antibiotics kill off a specific good bacteria needed for this condition (oxalobacter formigenes) which is why I've been outrageously sick lately! 😷
I learned the hard way antibiotics kill off a specific good bacteria needed for this condition (oxalobacter formigenes) which is why I've been outrageously sick lately! 😷
October 15, 2025 at 12:11 AM
Having a rare disease (hyperoxaluria) means sometimes you figure things out about it as you go.
I learned the hard way antibiotics kill off a specific good bacteria needed for this condition (oxalobacter formigenes) which is why I've been outrageously sick lately! 😷
I learned the hard way antibiotics kill off a specific good bacteria needed for this condition (oxalobacter formigenes) which is why I've been outrageously sick lately! 😷
Congrats to Dr. Matthew Breeggemann, UCSF Division of Nephrology, and Dept. of Urology! The UCSF Complex Kidney Stone Center has been recognized as the newest member of the Oxalosis and Hyperoxaluria Foundation Care Center Network of Excellence for the management of rare kidney stone disorders.
May 7, 2025 at 7:49 PM
Congrats to Dr. Matthew Breeggemann, UCSF Division of Nephrology, and Dept. of Urology! The UCSF Complex Kidney Stone Center has been recognized as the newest member of the Oxalosis and Hyperoxaluria Foundation Care Center Network of Excellence for the management of rare kidney stone disorders.
I've always assumed that people who drink ethylene glycol do it because they've internally asked themselves, "I wonder what it's like to have primary hyperoxaluria, types 1, 2, or 3?"
Ethylene glycol intoxication presents w/ anion gap metabolic acidosis & acute oxalate tubulopathy. Detection of urinary calcium oxalate monohydrate crystals helps in diagnosis [not classic dumbbell nor envelope shaped (dihydrate) but rather “cigar” shaped]. Slide courtesy of @jrseltzer.bsky.social
November 23, 2024 at 2:33 AM
I've always assumed that people who drink ethylene glycol do it because they've internally asked themselves, "I wonder what it's like to have primary hyperoxaluria, types 1, 2, or 3?"
Fun fact: cystinuria was the first of the genetic kidney stone diseases to be characterized. Garrod presented his findings at the 1908 Croonian Lectures in London. Primary hyperoxaluria was the next to be described, and that was in 1925 by Lepoutre.
Cystine crystals (bright field, x400).
Their presence in #urinarysediment is pathognomonic for #cystinuria, the most common kidney stone disease with Mendelian genetics.
While perfectly specific, the sensitivity of cystine crystalluria is quite low.
#nephsky #skyneph
Their presence in #urinarysediment is pathognomonic for #cystinuria, the most common kidney stone disease with Mendelian genetics.
While perfectly specific, the sensitivity of cystine crystalluria is quite low.
#nephsky #skyneph
November 19, 2024 at 11:10 PM
Fun fact: cystinuria was the first of the genetic kidney stone diseases to be characterized. Garrod presented his findings at the 1908 Croonian Lectures in London. Primary hyperoxaluria was the next to be described, and that was in 1925 by Lepoutre.
The fact that primary hyperoxaluria is the first kidney disease for which an RNA therapeutic has become available is a milestone for the field.
How does this change the treatment landscape? 🧵
How does this change the treatment landscape? 🧵
May 26, 2026 at 4:03 PM
The fact that primary hyperoxaluria is the first kidney disease for which an RNA therapeutic has become available is a milestone for the field.
How does this change the treatment landscape? 🧵
How does this change the treatment landscape? 🧵
Oh god jesus fuck do people have no conception of runaway redox catalysis? Also fucking cofactor depletion. Ahhhhhh. Dumbasses need more metabolic dieticians on board.
And yeah I have primary hyperoxaluria and it is worse than kidney ... excess C fucks up liver cycling of AGXT related proteins.
And yeah I have primary hyperoxaluria and it is worse than kidney ... excess C fucks up liver cycling of AGXT related proteins.
July 23, 2026 at 7:10 PM
Oh god jesus fuck do people have no conception of runaway redox catalysis? Also fucking cofactor depletion. Ahhhhhh. Dumbasses need more metabolic dieticians on board.
And yeah I have primary hyperoxaluria and it is worse than kidney ... excess C fucks up liver cycling of AGXT related proteins.
And yeah I have primary hyperoxaluria and it is worse than kidney ... excess C fucks up liver cycling of AGXT related proteins.
Today is Rare Disease Day ❤️
This includes my daughter and her Primary Hyperoxaluria Type 1 diagnosis.
Latest and updates, link below
gofund.me/ff84ceaa
This includes my daughter and her Primary Hyperoxaluria Type 1 diagnosis.
Latest and updates, link below
gofund.me/ff84ceaa
Donate to Our little dragon Maeve ❤️❤️, organized by Sara Shipp
It is a rare occasion I post on social media.
But I am here to ask you to consider making … Sara Shipp needs your support for Our little dragon Maeve ❤️❤️
gofund.me
February 28, 2025 at 3:47 PM
Today is Rare Disease Day ❤️
This includes my daughter and her Primary Hyperoxaluria Type 1 diagnosis.
Latest and updates, link below
gofund.me/ff84ceaa
This includes my daughter and her Primary Hyperoxaluria Type 1 diagnosis.
Latest and updates, link below
gofund.me/ff84ceaa
❄️🎄On the Nineth Day of Continuing Education, NKF gave to me…
an educational activity on Primary Hyperoxaluria Type 1. Learn diagnostic criteria, genetics, and pathophysiology.
FREE for all learners!
Supported by an educational grant from Novo Nordisk
an educational activity on Primary Hyperoxaluria Type 1. Learn diagnostic criteria, genetics, and pathophysiology.
FREE for all learners!
Supported by an educational grant from Novo Nordisk
CaseHippo
One platform for interactive learning, engagement and collaborative knowledge
bit.ly
December 21, 2025 at 2:01 PM
❄️🎄On the Nineth Day of Continuing Education, NKF gave to me…
an educational activity on Primary Hyperoxaluria Type 1. Learn diagnostic criteria, genetics, and pathophysiology.
FREE for all learners!
Supported by an educational grant from Novo Nordisk
an educational activity on Primary Hyperoxaluria Type 1. Learn diagnostic criteria, genetics, and pathophysiology.
FREE for all learners!
Supported by an educational grant from Novo Nordisk
New #ASNCJASN Podcast: Dr. Saland summarizes the main findings from his study on "Final Results of the ILLUMINATE-A Phase 3 Clinical Trial of Lumasiran for Primary Hyperoxaluria 1" Listen here: kidney.pub/CPOD0916
March 19, 2026 at 5:01 PM
New #ASNCJASN Podcast: Dr. Saland summarizes the main findings from his study on "Final Results of the ILLUMINATE-A Phase 3 Clinical Trial of Lumasiran for Primary Hyperoxaluria 1" Listen here: kidney.pub/CPOD0916
New in #ASNCJASN: Final Results of the ILLUMINATE-A Phase 3 Clinical Trial of Lumasiran for Primary Hyperoxaluria 1. Read the article here: kidney.pub/CJASN0916
December 15, 2025 at 5:00 PM
New in #ASNCJASN: Final Results of the ILLUMINATE-A Phase 3 Clinical Trial of Lumasiran for Primary Hyperoxaluria 1. Read the article here: kidney.pub/CJASN0916
Primary hyperoxaluria (PH) comprises a rare group of genetic disorders leading to the overproduction of oxalate. Could new RNA inhibitor drugs be the answer? Read more In #ASNKidneyNews: kidney.pub/KN1709-05
September 15, 2025 at 5:00 PM
Primary hyperoxaluria (PH) comprises a rare group of genetic disorders leading to the overproduction of oxalate. Could new RNA inhibitor drugs be the answer? Read more In #ASNKidneyNews: kidney.pub/KN1709-05