New @nature.com study: Hypoxia drives colorectal cancer stemness & drug resistance. Our HypoxyLab provided precise low-O2 conditions, confirming ↑ stemness markers (OCT4/NANOG) & chemo resistance. Vital for modeling tumor microenvironments.
#CancerResearch #Hypoxia #CRC #StemCell #Research
#CancerResearch #Hypoxia #CRC #StemCell #Research
Interplay between ALK2R206H mutant receptor and autophagy signaling regulates receptor stability and its chondrogenic functions - Cell Death Discovery
Cell Death Discovery - Interplay between ALK2R206H mutant receptor and autophagy signaling regulates receptor stability and its chondrogenic functions
www.nature.com
April 11, 2025 at 3:20 PM
New @nature.com study: Hypoxia drives colorectal cancer stemness & drug resistance. Our HypoxyLab provided precise low-O2 conditions, confirming ↑ stemness markers (OCT4/NANOG) & chemo resistance. Vital for modeling tumor microenvironments.
#CancerResearch #Hypoxia #CRC #StemCell #Research
#CancerResearch #Hypoxia #CRC #StemCell #Research
Stop guessing pericellular oxygen and just measure it.
Guide to dissolved O2 in hypoxia chambers: think in mmHg, verify in media pO2, track stability with #OxyLite and #HypoxyLab.
Read here: www.oxford-optronix.com/resources/in...
#pO2 #Hypoxia #ResearchTools
Guide to dissolved O2 in hypoxia chambers: think in mmHg, verify in media pO2, track stability with #OxyLite and #HypoxyLab.
Read here: www.oxford-optronix.com/resources/in...
#pO2 #Hypoxia #ResearchTools
In Vitro Dissolved Oxygen Monitoring in Hypoxia Chambers
Explore how an in vitro system that can be utilized within hypoxic chambers ensures precise dissolved oxygen control in cell cultures and media. Hypoxia chambers are used worldwide by research investi...
www.oxford-optronix.com
October 31, 2025 at 3:02 PM
Stop guessing pericellular oxygen and just measure it.
Guide to dissolved O2 in hypoxia chambers: think in mmHg, verify in media pO2, track stability with #OxyLite and #HypoxyLab.
Read here: www.oxford-optronix.com/resources/in...
#pO2 #Hypoxia #ResearchTools
Guide to dissolved O2 in hypoxia chambers: think in mmHg, verify in media pO2, track stability with #OxyLite and #HypoxyLab.
Read here: www.oxford-optronix.com/resources/in...
#pO2 #Hypoxia #ResearchTools
What if antiviral screening at 21% O₂ misses part of the biology?
A new ACS Infectious Diseases study found LAVR-289 strongly inhibited Marek’s disease virus at nanomolar levels.
Using #HypoxyLab, researchers tested 1% O₂ and showed antiviral activity remained under hypoxia.
#Hypoxia #Virology
A new ACS Infectious Diseases study found LAVR-289 strongly inhibited Marek’s disease virus at nanomolar levels.
Using #HypoxyLab, researchers tested 1% O₂ and showed antiviral activity remained under hypoxia.
#Hypoxia #Virology
Acyclic Nucleoside Phosphonate Prodrug LAVR-289 Inhibits Marek’s Disease Virus Replication
Since the 1970s, numerous antivirals targeting human herpesviruses have been developed, yet their application in veterinary medicine remains limited due to poor bioavailability and significant toxicit...
pubs.acs.org
May 7, 2026 at 7:56 PM
What if antiviral screening at 21% O₂ misses part of the biology?
A new ACS Infectious Diseases study found LAVR-289 strongly inhibited Marek’s disease virus at nanomolar levels.
Using #HypoxyLab, researchers tested 1% O₂ and showed antiviral activity remained under hypoxia.
#Hypoxia #Virology
A new ACS Infectious Diseases study found LAVR-289 strongly inhibited Marek’s disease virus at nanomolar levels.
Using #HypoxyLab, researchers tested 1% O₂ and showed antiviral activity remained under hypoxia.
#Hypoxia #Virology
FLASH question: is it oxygen depletion, or radicals recombining too fast to react with O₂?
This study used ESR + oxygen tracking and saw reduced O₂ depletion and spin-probe signal at UHDR. Oxygen conditions were set with HypoxyLab and validated with OxyLite.
#FLASHradiotherapy #Radiobiology
This study used ESR + oxygen tracking and saw reduced O₂ depletion and spin-probe signal at UHDR. Oxygen conditions were set with HypoxyLab and validated with OxyLite.
#FLASHradiotherapy #Radiobiology
Electron spin resonance measurements of radiation-induced radicals under conventional and ultra-high dose rate electron irradiation
Electron spin resonance measurements of radiation-induced radicals under conventional and ultra-high dose rate electron irradiation, Pehlivan, Johanna, Beyreuther, Elke, Horst, Felix, Nasse, Michael J...
doi.org
January 12, 2026 at 4:06 PM
FLASH question: is it oxygen depletion, or radicals recombining too fast to react with O₂?
This study used ESR + oxygen tracking and saw reduced O₂ depletion and spin-probe signal at UHDR. Oxygen conditions were set with HypoxyLab and validated with OxyLite.
#FLASHradiotherapy #Radiobiology
This study used ESR + oxygen tracking and saw reduced O₂ depletion and spin-probe signal at UHDR. Oxygen conditions were set with HypoxyLab and validated with OxyLite.
#FLASHradiotherapy #Radiobiology
We recently partnered with MycoFog to offer a simple-to-use decontamination device for cell incubators and workstations (HypoxyLab included).
Read this article to reduce contamination risk and keep experiments on track:
www.oxford-optronix.com/resources/ke...
#LabSafety #CellCulture #CleanLab
Read this article to reduce contamination risk and keep experiments on track:
www.oxford-optronix.com/resources/ke...
#LabSafety #CellCulture #CleanLab
Keeping incubators and workstations contamination-free
Maintain good laboratory practice by keeping CO₂ incubators and hypoxia workstations contamination-free with tools like MycoFog™, for greater confidence in experimental results
www.oxford-optronix.com
September 11, 2025 at 5:06 PM
We recently partnered with MycoFog to offer a simple-to-use decontamination device for cell incubators and workstations (HypoxyLab included).
Read this article to reduce contamination risk and keep experiments on track:
www.oxford-optronix.com/resources/ke...
#LabSafety #CellCulture #CleanLab
Read this article to reduce contamination risk and keep experiments on track:
www.oxford-optronix.com/resources/ke...
#LabSafety #CellCulture #CleanLab
Can #Organoid data be oxygen-skewed. CO₂ incubators only offer hyperoxic conditions.
We make the case for physioxia and how to do it properly with by utilizing O₂ control in mmHg + real-time dissolved O₂ monitoring.
Read Here: www.oxford-optronix.com/resources/th...
#StemCell #CellCulture
We make the case for physioxia and how to do it properly with by utilizing O₂ control in mmHg + real-time dissolved O₂ monitoring.
Read Here: www.oxford-optronix.com/resources/th...
#StemCell #CellCulture
The Case for Physiological Oxygen in Organoid Research
Discover how partial-pressure-based physiological oxygen control improves organoid and spheroid viability, maturation and reproducibility, with HypoxyLab and OxyLite enabling precise pO₂ control and m...
www.oxford-optronix.com
December 17, 2025 at 7:26 PM
Can #Organoid data be oxygen-skewed. CO₂ incubators only offer hyperoxic conditions.
We make the case for physioxia and how to do it properly with by utilizing O₂ control in mmHg + real-time dissolved O₂ monitoring.
Read Here: www.oxford-optronix.com/resources/th...
#StemCell #CellCulture
We make the case for physioxia and how to do it properly with by utilizing O₂ control in mmHg + real-time dissolved O₂ monitoring.
Read Here: www.oxford-optronix.com/resources/th...
#StemCell #CellCulture
HIF-1α’s dual role in acrolein lung damage revealed by a @baylor.bsky.social team!
Study shows hypoxia via #HypoxyLab lets HIF-1α either worsen or protect cells, depending on exposure. Key for understanding smoke/pollution toxicity! #Hypoxia #LungHealth
www.sciencedirect.com/science/arti...
Study shows hypoxia via #HypoxyLab lets HIF-1α either worsen or protect cells, depending on exposure. Key for understanding smoke/pollution toxicity! #Hypoxia #LungHealth
www.sciencedirect.com/science/arti...
Hypoxia-inducible factor 1α modulates acrolein-induced cellular damage in bronchial epithelial cells
Acrolein, a highly reactive α,β-unsaturated aldehyde, is a widespread environmental pollutant. It is generated during the incomplete combustion of mat…
www.sciencedirect.com
April 21, 2025 at 5:57 PM
HIF-1α’s dual role in acrolein lung damage revealed by a @baylor.bsky.social team!
Study shows hypoxia via #HypoxyLab lets HIF-1α either worsen or protect cells, depending on exposure. Key for understanding smoke/pollution toxicity! #Hypoxia #LungHealth
www.sciencedirect.com/science/arti...
Study shows hypoxia via #HypoxyLab lets HIF-1α either worsen or protect cells, depending on exposure. Key for understanding smoke/pollution toxicity! #Hypoxia #LungHealth
www.sciencedirect.com/science/arti...
What if an oxygen level outside a 3D culture system do not reflect a cells experience inside?
A @tudresden.bsky.social team used HypoxyLab and OxyLite to control atmosphere and map oxygen inside a perfusion bioreactor model of a osteochondral niche.
#TissueEngineering #Hypoxia #Bioreactor
A @tudresden.bsky.social team used HypoxyLab and OxyLite to control atmosphere and map oxygen inside a perfusion bioreactor model of a osteochondral niche.
#TissueEngineering #Hypoxia #Bioreactor
Numerical and Experimental Assessment of Oxygen Distribution in a Perfusion Bioreactor to Mimic the Osteochondral Niche
Oxygen supply is a critical parameter in 3D cell cultivation using bioreactors. Since bioreactor designs often prioritise practical constraints, understanding the oxygen supply dynamics of the media ...
analyticalsciencejournals.onlinelibrary.wiley.com
June 3, 2026 at 4:43 PM
What if an oxygen level outside a 3D culture system do not reflect a cells experience inside?
A @tudresden.bsky.social team used HypoxyLab and OxyLite to control atmosphere and map oxygen inside a perfusion bioreactor model of a osteochondral niche.
#TissueEngineering #Hypoxia #Bioreactor
A @tudresden.bsky.social team used HypoxyLab and OxyLite to control atmosphere and map oxygen inside a perfusion bioreactor model of a osteochondral niche.
#TissueEngineering #Hypoxia #Bioreactor
What if FLASH response is tuned by oxygen and spheroid size?
In 3D models, UHDR matched conventional dose rates in ambient oxygen for small spheroids, but hypoxia increased the dose needed for control by about 7 to 14 percent.
#HypoxyLab maintained 8 mmHg O2 to model hypoxia.
#FLASH #Hypoxia
In 3D models, UHDR matched conventional dose rates in ambient oxygen for small spheroids, but hypoxia increased the dose needed for control by about 7 to 14 percent.
#HypoxyLab maintained 8 mmHg O2 to model hypoxia.
#FLASH #Hypoxia
Not All Tumors Are Alike: Varying Efficacy of FLASH Across Tumor Types and Oxygenation Status in Spheroid Models - PubMed
This preclinical study suggests that tumor iso-efficacy with UHDR may not hold true for all cancer types and is associated with oxygen level.
pubmed.ncbi.nlm.nih.gov
October 14, 2025 at 7:32 PM
What if FLASH response is tuned by oxygen and spheroid size?
In 3D models, UHDR matched conventional dose rates in ambient oxygen for small spheroids, but hypoxia increased the dose needed for control by about 7 to 14 percent.
#HypoxyLab maintained 8 mmHg O2 to model hypoxia.
#FLASH #Hypoxia
In 3D models, UHDR matched conventional dose rates in ambient oxygen for small spheroids, but hypoxia increased the dose needed for control by about 7 to 14 percent.
#HypoxyLab maintained 8 mmHg O2 to model hypoxia.
#FLASH #Hypoxia
What if tumor hypoxia is the switch for CD8⁺ T-cell exhaustion?
New Immunity paper shows chronic hypoxia drives ATF4 leading to mitochondrial stress & death. ISRIB restores T-cell fitness and PD-1 response.
The #HypoxyLab was set to 1.5% O₂ for 96 h to model cell stress.
#Hypoxia #Immunotherapy
New Immunity paper shows chronic hypoxia drives ATF4 leading to mitochondrial stress & death. ISRIB restores T-cell fitness and PD-1 response.
The #HypoxyLab was set to 1.5% O₂ for 96 h to model cell stress.
#Hypoxia #Immunotherapy
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4
Metabolic stress imposed by the tumor microenvironment (TME) promotes T cell dysfunction
and limits antitumor immunity. Alicea Pauneto et al. demonstrate the hypoxia within
the TME drives chronic acti...
www.cell.com
September 29, 2025 at 7:16 PM
What if tumor hypoxia is the switch for CD8⁺ T-cell exhaustion?
New Immunity paper shows chronic hypoxia drives ATF4 leading to mitochondrial stress & death. ISRIB restores T-cell fitness and PD-1 response.
The #HypoxyLab was set to 1.5% O₂ for 96 h to model cell stress.
#Hypoxia #Immunotherapy
New Immunity paper shows chronic hypoxia drives ATF4 leading to mitochondrial stress & death. ISRIB restores T-cell fitness and PD-1 response.
The #HypoxyLab was set to 1.5% O₂ for 96 h to model cell stress.
#Hypoxia #Immunotherapy
What helps prostate cancer cells adapt to the hypoxic bone niche?
Using HypoxyLab at 1% O₂, researchers found that hypoxia plus osteoblast-derived signals strongly increased GJA1-20k and shifted mitochondria toward the cell periphery.
#ProstateCancer #Hypoxia #BoneMetastasis #CancerMetabolism
Using HypoxyLab at 1% O₂, researchers found that hypoxia plus osteoblast-derived signals strongly increased GJA1-20k and shifted mitochondria toward the cell periphery.
#ProstateCancer #Hypoxia #BoneMetastasis #CancerMetabolism
www.sciencedirect.com
July 28, 2026 at 2:05 PM
What helps prostate cancer cells adapt to the hypoxic bone niche?
Using HypoxyLab at 1% O₂, researchers found that hypoxia plus osteoblast-derived signals strongly increased GJA1-20k and shifted mitochondria toward the cell periphery.
#ProstateCancer #Hypoxia #BoneMetastasis #CancerMetabolism
Using HypoxyLab at 1% O₂, researchers found that hypoxia plus osteoblast-derived signals strongly increased GJA1-20k and shifted mitochondria toward the cell periphery.
#ProstateCancer #Hypoxia #BoneMetastasis #CancerMetabolism
What if mild hypoxia disrupts brain development by stopping interneuron migration?
An eLife study found ~58% fewer migration events under hypoxia, while adrenomedullin restored movement.
HypoxyLab enabled controlled hypoxic conditions for cell growth.
#Organoids #Hypoxia
An eLife study found ~58% fewer migration events under hypoxia, while adrenomedullin restored movement.
HypoxyLab enabled controlled hypoxic conditions for cell growth.
#Organoids #Hypoxia
Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia
Exposure of human cortical interneurons to hypoxia leads to decreased migration, a process that is likely altered in preterm infants and contributes to the increased risk for neurodevelopmental proble...
doi.org
July 15, 2026 at 7:12 PM
What if mild hypoxia disrupts brain development by stopping interneuron migration?
An eLife study found ~58% fewer migration events under hypoxia, while adrenomedullin restored movement.
HypoxyLab enabled controlled hypoxic conditions for cell growth.
#Organoids #Hypoxia
An eLife study found ~58% fewer migration events under hypoxia, while adrenomedullin restored movement.
HypoxyLab enabled controlled hypoxic conditions for cell growth.
#Organoids #Hypoxia
What if a tissue-derived matrix could help the injured brain recover?
A new TBI study found a dural ECM hydrogel reduced oxidative stress in hypoxic astrocytes and improved motor recovery in mice.
The pivotal in vitro hypoxia work utilized #HypoxyLab.
#TraumaticBrainInjury #RegenerativeMedicine
A new TBI study found a dural ECM hydrogel reduced oxidative stress in hypoxic astrocytes and improved motor recovery in mice.
The pivotal in vitro hypoxia work utilized #HypoxyLab.
#TraumaticBrainInjury #RegenerativeMedicine
A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice
Current clinical treatment options for traumatic brain injury (TBI) to limit permanent tissue damage and secondary injury remain inadequate. Intraparenchymal transplantation of neural stem cells is a ...
pubs.acs.org
July 10, 2026 at 7:59 PM
What if a tissue-derived matrix could help the injured brain recover?
A new TBI study found a dural ECM hydrogel reduced oxidative stress in hypoxic astrocytes and improved motor recovery in mice.
The pivotal in vitro hypoxia work utilized #HypoxyLab.
#TraumaticBrainInjury #RegenerativeMedicine
A new TBI study found a dural ECM hydrogel reduced oxidative stress in hypoxic astrocytes and improved motor recovery in mice.
The pivotal in vitro hypoxia work utilized #HypoxyLab.
#TraumaticBrainInjury #RegenerativeMedicine
What if FLASH sparing only appears when oxygen is truly physiological?
A new preprint reports reduced DNA strand-breaks with ultra-high dose-rate irradiation at ~40 mmHg O₂, but not ambient O₂.
Samples were prepared in HypoxyLab and verified with OxyLite.
#FLASHRT #RadiationBiology #DNARepair
A new preprint reports reduced DNA strand-breaks with ultra-high dose-rate irradiation at ~40 mmHg O₂, but not ambient O₂.
Samples were prepared in HypoxyLab and verified with OxyLite.
#FLASHRT #RadiationBiology #DNARepair
Ultra-High Dose-Rate Irradiation Spares DNA under Physiological Oxygen and Salt Conditions
Cancer treatment with radiotherapy aims to kill tumor cells while sparing healthy tissue. Therefore,the experimentally observed sparing of healthy tissue by the FLASH effect during ultra-high dose rat...
www.researchsquare.com
June 22, 2026 at 12:58 PM
What if FLASH sparing only appears when oxygen is truly physiological?
A new preprint reports reduced DNA strand-breaks with ultra-high dose-rate irradiation at ~40 mmHg O₂, but not ambient O₂.
Samples were prepared in HypoxyLab and verified with OxyLite.
#FLASHRT #RadiationBiology #DNARepair
A new preprint reports reduced DNA strand-breaks with ultra-high dose-rate irradiation at ~40 mmHg O₂, but not ambient O₂.
Samples were prepared in HypoxyLab and verified with OxyLite.
#FLASHRT #RadiationBiology #DNARepair
CoCl₂ can stabilize HIF-1α, but it does not create true low-oxygen cell culture.
For metabolism, mitochondria, organoids, spheroids, drug response, and long-term culture, oxygen needs to be controlled and ideally measured.
HypoxyLab controls it. OxyLite helps verify it.
#Hypoxia #CellCulture
For metabolism, mitochondria, organoids, spheroids, drug response, and long-term culture, oxygen needs to be controlled and ideally measured.
HypoxyLab controls it. OxyLite helps verify it.
#Hypoxia #CellCulture
Chemical Hypoxia vs. True Oxygen Control in Cell Culture
Chemical hypoxia mimetics such as cobalt chloride can stabilize HIF-1 alpha, but they do not recreate true low-oxygen cell culture. Learn when to use CoCl2 and when controlled oxygen is the better mod...
www.oxford-optronix.com
May 25, 2026 at 8:29 PM
CoCl₂ can stabilize HIF-1α, but it does not create true low-oxygen cell culture.
For metabolism, mitochondria, organoids, spheroids, drug response, and long-term culture, oxygen needs to be controlled and ideally measured.
HypoxyLab controls it. OxyLite helps verify it.
#Hypoxia #CellCulture
For metabolism, mitochondria, organoids, spheroids, drug response, and long-term culture, oxygen needs to be controlled and ideally measured.
HypoxyLab controls it. OxyLite helps verify it.
#Hypoxia #CellCulture
Organoids are often cultured at oxygen levels far above what tissues experience in vivo.
This resource explains why physoxia matters, and how #HypoxyLab plus #OxyLite can help researchers control and verify oxygen in organoid workflows.
Better models start with controlled and measured conditions.
This resource explains why physoxia matters, and how #HypoxyLab plus #OxyLite can help researchers control and verify oxygen in organoid workflows.
Better models start with controlled and measured conditions.
The Case for Physiological Oxygen in Organoid Research
Discover how partial-pressure-based physiological oxygen control improves organoid and spheroid viability, maturation and reproducibility, with HypoxyLab and OxyLite enabling precise pO₂ control and m...
www.oxford-optronix.com
May 5, 2026 at 3:14 PM
Organoids are often cultured at oxygen levels far above what tissues experience in vivo.
This resource explains why physoxia matters, and how #HypoxyLab plus #OxyLite can help researchers control and verify oxygen in organoid workflows.
Better models start with controlled and measured conditions.
This resource explains why physoxia matters, and how #HypoxyLab plus #OxyLite can help researchers control and verify oxygen in organoid workflows.
Better models start with controlled and measured conditions.
What if low oxygen helps explain glioma treatment response?
In C6 glioma cells, amitriptyline reduced viability, proliferation, and PD-L1, but the response became more complex with temozolomide and radiation. HypoxyLab helped by maintaining cultures at 2.5% O2.
#Glioma #Hypoxia #CancerResearch
In C6 glioma cells, amitriptyline reduced viability, proliferation, and PD-L1, but the response became more complex with temozolomide and radiation. HypoxyLab helped by maintaining cultures at 2.5% O2.
#Glioma #Hypoxia #CancerResearch
Spandidos Publications: Molecular and Clinical Oncology
International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.
www.spandidos-publications.com
April 7, 2026 at 12:32 PM
What if low oxygen helps explain glioma treatment response?
In C6 glioma cells, amitriptyline reduced viability, proliferation, and PD-L1, but the response became more complex with temozolomide and radiation. HypoxyLab helped by maintaining cultures at 2.5% O2.
#Glioma #Hypoxia #CancerResearch
In C6 glioma cells, amitriptyline reduced viability, proliferation, and PD-L1, but the response became more complex with temozolomide and radiation. HypoxyLab helped by maintaining cultures at 2.5% O2.
#Glioma #Hypoxia #CancerResearch
What if oral etoposide could work better in a neuroblastoma with less toxicity?
New paper: oral solid lipid nanoparticles improved bioavailability, and slowed tumor growth.
The team used HypoxyLab + OxyLite to create and verify stable hypoxia in vitro.
#Neuroblastoma #Hypoxia #CancerResearch
New paper: oral solid lipid nanoparticles improved bioavailability, and slowed tumor growth.
The team used HypoxyLab + OxyLite to create and verify stable hypoxia in vitro.
#Neuroblastoma #Hypoxia #CancerResearch
Oral solid lipid nanoparticles of etoposide enable metronomic-like therapy with reduced toxicity in MYCN-amplified neuroblastoma
Therapeutic regimens for pediatric malignancies such as neuroblastoma remain complex and are often associated with severe systemic toxicity. The devel…
www.sciencedirect.com
March 30, 2026 at 6:09 PM
What if oral etoposide could work better in a neuroblastoma with less toxicity?
New paper: oral solid lipid nanoparticles improved bioavailability, and slowed tumor growth.
The team used HypoxyLab + OxyLite to create and verify stable hypoxia in vitro.
#Neuroblastoma #Hypoxia #CancerResearch
New paper: oral solid lipid nanoparticles improved bioavailability, and slowed tumor growth.
The team used HypoxyLab + OxyLite to create and verify stable hypoxia in vitro.
#Neuroblastoma #Hypoxia #CancerResearch
New J Med Chem: first dual inhibitors of NAMPT and CA IX/XII (hypoxia-linked pH control). In 3D spheroids, compound 45 reduced cumulative spheroid area ~10× vs single-target controls.
#HypoxyLab enabled controlled hypoxia (1% O2) + #GelCount 2 enabled automated sizing.
#CancerResearch #Hypoxia
#HypoxyLab enabled controlled hypoxia (1% O2) + #GelCount 2 enabled automated sizing.
#CancerResearch #Hypoxia
Targeting Metabolic and pH Regulatory Pathways in Cancer via Dual Inhibition of Nicotinamide Phosphoribosyltransferase and Carbonic Anhydrases IX and XII
We report the first dual inhibitors of the tumor-associated carbonic anhydrases (hCA IX and XII) and nicotinamide phosphoribosyltransferase (NAMPT), designed to target metabolic and pH-regulatory mechanisms critical for tumor growth and resistance. Enzymatic assays identified hits showing potent nanomolar inhibition of both targets and superior efficacy compared to reference inhibitors. Computational studies elucidated key ligand–target interactions and structure–activity relationship. In high-throughput screening cellular assays, several compounds outperformed monotherapies with strong antiproliferative effects against renal carcinoma, glioblastoma, and colorectal cancer cells under normoxic and hypoxic conditions, and limited toxicity toward nonmalignant cells. In three-dimensional (3D) spheroids, compound 45 reduced the cumulative spheroid area approximately 10-fold more than the single-target inhibitors FK866 or SLC-0111 and induced apoptosis through NAD depletion, mitochondrial dysfunction, and suppression of ERK/mTOR signaling. These results support dual hCA IX/XII–NAMPT inhibition as an effective strategy to impair tumor growth and survival under hypoxic stress.
pubs.acs.org
January 28, 2026 at 7:16 PM
New J Med Chem: first dual inhibitors of NAMPT and CA IX/XII (hypoxia-linked pH control). In 3D spheroids, compound 45 reduced cumulative spheroid area ~10× vs single-target controls.
#HypoxyLab enabled controlled hypoxia (1% O2) + #GelCount 2 enabled automated sizing.
#CancerResearch #Hypoxia
#HypoxyLab enabled controlled hypoxia (1% O2) + #GelCount 2 enabled automated sizing.
#CancerResearch #Hypoxia
What if oxygen is the switch for FLASH at the molecular scale?
At 5% O₂, UHDR yields fewer DNA strand breaks than LDR & at ~21% O₂ that advantage vanishes. #HypoxyLab set ~40 mmHg O₂ and #OxyLite confirmed O₂ and sealing to keep conditions true.
Read here👉 arxiv.org/pdf/2510.15478
At 5% O₂, UHDR yields fewer DNA strand breaks than LDR & at ~21% O₂ that advantage vanishes. #HypoxyLab set ~40 mmHg O₂ and #OxyLite confirmed O₂ and sealing to keep conditions true.
Read here👉 arxiv.org/pdf/2510.15478
arxiv.org
October 28, 2025 at 4:42 PM
What if oxygen is the switch for FLASH at the molecular scale?
At 5% O₂, UHDR yields fewer DNA strand breaks than LDR & at ~21% O₂ that advantage vanishes. #HypoxyLab set ~40 mmHg O₂ and #OxyLite confirmed O₂ and sealing to keep conditions true.
Read here👉 arxiv.org/pdf/2510.15478
At 5% O₂, UHDR yields fewer DNA strand breaks than LDR & at ~21% O₂ that advantage vanishes. #HypoxyLab set ~40 mmHg O₂ and #OxyLite confirmed O₂ and sealing to keep conditions true.
Read here👉 arxiv.org/pdf/2510.15478
What does hypoxia do to your RNA?
A new Nucleic Acids Research paper reveals that low oxygen impairs translation & reshapes RNA mods.
They used the HypoxyLab for precise O₂ control at 0.2% to compare to normoxic conditions.
Read here: academic.oup.com/nar/article/...
#Hypoxia #RNA #LabTech
A new Nucleic Acids Research paper reveals that low oxygen impairs translation & reshapes RNA mods.
They used the HypoxyLab for precise O₂ control at 0.2% to compare to normoxic conditions.
Read here: academic.oup.com/nar/article/...
#Hypoxia #RNA #LabTech
Rapid depletion and super-resolution microscopy reveal dual roles of SRSF5 in coordinating nuclear speckle–paraspeckle crosstalk during cellular stress
Abstract. Nuclear speckles (NS) and paraspeckles (PS) are adjacent yet distinct nuclear condensates that undergo stress-induced reorganization. Here, we id
academic.oup.com
August 6, 2025 at 5:18 PM
What does hypoxia do to your RNA?
A new Nucleic Acids Research paper reveals that low oxygen impairs translation & reshapes RNA mods.
They used the HypoxyLab for precise O₂ control at 0.2% to compare to normoxic conditions.
Read here: academic.oup.com/nar/article/...
#Hypoxia #RNA #LabTech
A new Nucleic Acids Research paper reveals that low oxygen impairs translation & reshapes RNA mods.
They used the HypoxyLab for precise O₂ control at 0.2% to compare to normoxic conditions.
Read here: academic.oup.com/nar/article/...
#Hypoxia #RNA #LabTech
Just dropped: a 2-min explainer on the #HypoxyLab — a sealed, mmHg-controlled hypoxia chamber used in cancer, stem cell, and neuroscience research. Come see our novel approach to an oxygen controlled workstation!
and yes, there’s a blooper at the end 👀
#hypoxia #researchtools #science #labtech
and yes, there’s a blooper at the end 👀
#hypoxia #researchtools #science #labtech
HypoxyLab product intro
YouTube video by Oxford Optronix Ltd., UK
www.youtube.com
July 10, 2025 at 7:33 PM
Just dropped: a 2-min explainer on the #HypoxyLab — a sealed, mmHg-controlled hypoxia chamber used in cancer, stem cell, and neuroscience research. Come see our novel approach to an oxygen controlled workstation!
and yes, there’s a blooper at the end 👀
#hypoxia #researchtools #science #labtech
and yes, there’s a blooper at the end 👀
#hypoxia #researchtools #science #labtech
How to evolve from ocean to soil? A genome explosion!
New Nature study reveals clitellates underwent massive chromosomal scrambling—shattering ancestral gene order.
The #HypoxyLab was key: its precise O₂ control validated #adaptive responses.
#Evolution #Ecology
🔗: www.nature.com/articles/s41...
New Nature study reveals clitellates underwent massive chromosomal scrambling—shattering ancestral gene order.
The #HypoxyLab was key: its precise O₂ control validated #adaptive responses.
#Evolution #Ecology
🔗: www.nature.com/articles/s41...
An episodic burst of massive genomic rearrangements and the origin of non-marine annelids - Nature Ecology & Evolution
An analysis of annelid genomes reveals massive reshuffling of chromosomes in the ancestral lineage leading to clitellates, a clade composed of non-marine annelids, with potential implications for the ...
www.nature.com
June 24, 2025 at 12:52 AM
How to evolve from ocean to soil? A genome explosion!
New Nature study reveals clitellates underwent massive chromosomal scrambling—shattering ancestral gene order.
The #HypoxyLab was key: its precise O₂ control validated #adaptive responses.
#Evolution #Ecology
🔗: www.nature.com/articles/s41...
New Nature study reveals clitellates underwent massive chromosomal scrambling—shattering ancestral gene order.
The #HypoxyLab was key: its precise O₂ control validated #adaptive responses.
#Evolution #Ecology
🔗: www.nature.com/articles/s41...
For teams needing assurance their workstation is completely free of any contamination - Oxford Optronix is thrilled to announce MycoFog, a convenient bio-decontamination device for use in our widely trusted HypoxyLab cell culture workstation.
Read more: www.oxford-optronix.com/news-events/...
Read more: www.oxford-optronix.com/news-events/...
Introducing MycoFog™ - a convenient bio-decontamination solution for HypoxyLab™
Dissolved Oxygen Monitors, Laser Doppler Blood Flow Monitors, Colony Counter, Hypoxia Workstation
www.oxford-optronix.com
April 1, 2025 at 5:19 PM
For teams needing assurance their workstation is completely free of any contamination - Oxford Optronix is thrilled to announce MycoFog, a convenient bio-decontamination device for use in our widely trusted HypoxyLab cell culture workstation.
Read more: www.oxford-optronix.com/news-events/...
Read more: www.oxford-optronix.com/news-events/...
Sterility in hypoxia chambers is vital for reliable cell culture. Our whitepaper outlines strategies to combat contamination and shows how the innovative #HypoxyLab system—with HEPA filtration, UV sterilization & a smart letterbox—protects your experiments.
#CellCulture #LabSafety #Innovation
#CellCulture #LabSafety #Innovation
Contamination Control in Hypoxia Chambers
Effective contamination control in hypoxia chambers is essential for reliable research. The HypoxyLab features a self-contained and sealed chamber that creates a stable low-oxygen environment while pr...
www.oxford-optronix.com
March 3, 2025 at 7:11 PM
Sterility in hypoxia chambers is vital for reliable cell culture. Our whitepaper outlines strategies to combat contamination and shows how the innovative #HypoxyLab system—with HEPA filtration, UV sterilization & a smart letterbox—protects your experiments.
#CellCulture #LabSafety #Innovation
#CellCulture #LabSafety #Innovation