What happens to a macrophage that is infected for a long time? Senescence!

Once we clear those senescent cells with senolytics, the bacterial burden drops.

This is a new way to tackle
infections without using antibiotics.

Link in comment!
#ICSAPaperOfTheMonth
@edoardoscarpanti.bsky.social

In the #ICSAPaperOfTheMonth, the Passos and @adamsbioaging.bsky.social lab reveal how mitochondrial metabolism controls the SASP through epigenetic regulation. Targeting mitochondrial citrate transport reduces inflammation and improves healthspan in aged mice.

Link 👉 www.nature.com/articles/s41...

🏆 #ICSAPaperOfTheMonth
Telomere shortening has long been considered a cause of cellular senescence. Fabrizio d'Adda and team now show telomeric DNA damage signalling is itself a causal driver of hematopoietic decline.
www.nature.com/articles/s43...
@nataging.nature.com

The ICSA paper of the month is by @amor-lab.bsky.social & beyazlab ‼️ Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness. #ICSAPaperOfTheMonth @cshlnews.bsky.social
🔗 www.nature.com/articles/s43...

#ICSAPaperOfTheMonth. sin-lncRNA interacts with the TCA enzyme DLST to maintain metabolic balance during senescence. Depletion of sin-lncRNA causes DLST translocation to the nucleus triggering transcriptional changes that lead to metabolic reprogramming in senescence.

#ICSAPaperOfTheMonth In this Neuron paper, Graves et al find that p16 expression—particularly in microglia (the brain resident immune cells) and endothelial cells (the primary component of blood vessels)—is necessary for tau-based neurodegenerative disease in mice.
www.cell.com/neuron/fullt...

#ICSAPaperOfTheMonth Breast cancer cells resist chemotherapy by entering a transient senescent state and evading immune detection. Instead of dying, they persist and can later escape senescence to drive relapse. Disrupting this cycle could lead to new treatment strategies.