🦠Bacteria serve as an amazing reservoir of immune genes for eukaryotes but also of essential cellular functions!
⬇️New exaptation example : euk RNA-guided RNA modification originated from "bridge RNA" IS110 transposons.
Led by @hugovaysset.bsky.social and C. Meers from Sternberg lab! rdcu.be/d5ovZ
⬇️New exaptation example : euk RNA-guided RNA modification originated from "bridge RNA" IS110 transposons.
Led by @hugovaysset.bsky.social and C. Meers from Sternberg lab! rdcu.be/d5ovZ
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons
Nature Microbiology - Structural and phylogenetic analyses show that programmable RNA modifications ubiquitous in archaea and eukarya arose from bacterial transposons.
rdcu.be
January 6, 2025 at 10:24 AM
🦠Bacteria serve as an amazing reservoir of immune genes for eukaryotes but also of essential cellular functions!
⬇️New exaptation example : euk RNA-guided RNA modification originated from "bridge RNA" IS110 transposons.
Led by @hugovaysset.bsky.social and C. Meers from Sternberg lab! rdcu.be/d5ovZ
⬇️New exaptation example : euk RNA-guided RNA modification originated from "bridge RNA" IS110 transposons.
Led by @hugovaysset.bsky.social and C. Meers from Sternberg lab! rdcu.be/d5ovZ
OUT NOW: Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons
by Samuel Sternberg, @audeber.bsky.social & co
www.nature.com/articles/s41...
by Samuel Sternberg, @audeber.bsky.social & co
www.nature.com/articles/s41...
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons - Nature Microbiology
Structural and phylogenetic analyses show that programmable RNA modifications ubiquitous in archaea and eukarya arose from bacterial transposons.
www.nature.com
January 2, 2025 at 5:23 PM
OUT NOW: Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons
by Samuel Sternberg, @audeber.bsky.social & co
www.nature.com/articles/s41...
by Samuel Sternberg, @audeber.bsky.social & co
www.nature.com/articles/s41...
#TEsky Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons doi.org/10.1038/s415...
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons - Nature Microbiology
Structural and phylogenetic analyses show that programmable RNA modifications ubiquitous in archaea and eukarya arose from bacterial transposons.
doi.org
January 2, 2025 at 1:29 PM
#TEsky Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons doi.org/10.1038/s415...
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons www.nature.com/articles/s41... #jcampubs
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons - Nature Microbiology
Structural and phylogenetic analyses show that programmable RNA modifications ubiquitous in archaea and eukarya arose from bacterial transposons.
www.nature.com
January 2, 2025 at 4:29 PM
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons www.nature.com/articles/s41... #jcampubs
Such natural IS110 diversity may expand our genome-editing toolbox. We validated an active 843-bp IS110 encoding a 201-aa recombinase, which is the most compact IS110 system shown to catalyze targeted insertion.
August 18, 2026 at 5:45 PM
Such natural IS110 diversity may expand our genome-editing toolbox. We validated an active 843-bp IS110 encoding a 201-aa recombinase, which is the most compact IS110 system shown to catalyze targeted insertion.
🧬🌉Online @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...
Programmable genome editing in human cells using RNA-guided bridge recombinases
Site-specific insertion of gene-sized DNA fragments remains an unmet need in the genome editing field. IS110-family serine recombinases have recently been shown to mediate programmable DNA recombinati...
www.science.org
February 6, 2026 at 12:12 AM
🧬🌉Online @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...
Added a photo set of Janeen Gzesch from 2002 #hogtied on the bed wearing a #satin #blouse, #silk #skirt, #pantyhose & #heels to the Encore section of the ImagoStudios.com Members' Club.
This scene is from IS110 "10 Hogtied Damsels!" video: www.bondagewarehouse.com/downloadcart...
This scene is from IS110 "10 Hogtied Damsels!" video: www.bondagewarehouse.com/downloadcart...
May 30, 2026 at 3:03 AM
Added a photo set of Janeen Gzesch from 2002 #hogtied on the bed wearing a #satin #blouse, #silk #skirt, #pantyhose & #heels to the Encore section of the ImagoStudios.com Members' Club.
This scene is from IS110 "10 Hogtied Damsels!" video: www.bondagewarehouse.com/downloadcart...
This scene is from IS110 "10 Hogtied Damsels!" video: www.bondagewarehouse.com/downloadcart...
Excited to share our latest preprint from the lab! 🧬
We found that IS110 elements, typically considered small, can grow into large elements that carry cargo and disseminate antimicrobial resistance. We also experimentally validated the smallest and largest IS110s characterized to date.
We found that IS110 elements, typically considered small, can grow into large elements that carry cargo and disseminate antimicrobial resistance. We also experimentally validated the smallest and largest IS110s characterized to date.
Canonically minimal RNA-guided insertion sequences expand into large elements that disseminate antimicrobial resistance https://www.biorxiv.org/content/10.64898/2026.08.14.744561v1
August 18, 2026 at 5:32 PM
Excited to share our latest preprint from the lab! 🧬
We found that IS110 elements, typically considered small, can grow into large elements that carry cargo and disseminate antimicrobial resistance. We also experimentally validated the smallest and largest IS110s characterized to date.
We found that IS110 elements, typically considered small, can grow into large elements that carry cargo and disseminate antimicrobial resistance. We also experimentally validated the smallest and largest IS110s characterized to date.
Added IS110 - "Captured Damsels" to the Archive Video section of imagostudios.com Members’ Club.
This video will be available for free to Members for 30 days or it can be purchased individually at: bondagewarehouse.com/downloadcart...
This video will be available for free to Members for 30 days or it can be purchased individually at: bondagewarehouse.com/downloadcart...
October 1, 2026 at 11:11 PM
Added IS110 - "Captured Damsels" to the Archive Video section of imagostudios.com Members’ Club.
This video will be available for free to Members for 30 days or it can be purchased individually at: bondagewarehouse.com/downloadcart...
This video will be available for free to Members for 30 days or it can be purchased individually at: bondagewarehouse.com/downloadcart...
IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways: Molecular Cell https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00315-1?rss=yes
IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways
Sun et al. show that IS110 transposons utilize two independent RNA-guided transposition pathways: a top-strand copy-out mechanism and a direct top-strand transfer to new targets. These findings redefine IS110 transposition and reconcile prior discrepancies, which provides insight into programmable, RNA-guided genome modification without double-strand DNA breaks.
www.cell.com
June 1, 2026 at 10:39 PM
IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways: Molecular Cell https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00315-1?rss=yes
Online Now: IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways Online now:
IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways
Sun et al. show that IS110 transposons utilize two independent RNA-guided transposition pathways: a top-strand copy-out mechanism and a direct top-strand transfer to new targets. These findings redefine IS110 transposition and reconcile prior discrepancies, which provides insight into programmable, RNA-guided genome modification without double-strand DNA breaks.
dlvr.it
June 1, 2026 at 7:14 PM
Online Now: IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways Online now:
August 1 SALE VIDEOS at BondageWarehouse.com!
IS-BW0165: Cydel Jimenez
IS110: Molly, Naleyja, Katarina, Lainie, Holly, Dina & Salem
QT0378: Bethany & Stevie
Sale videos change on the 1st & 15th of the month - at least 6 videos on sale! Use Member & Flash Sale coupons to save more!
IS-BW0165: Cydel Jimenez
IS110: Molly, Naleyja, Katarina, Lainie, Holly, Dina & Salem
QT0378: Bethany & Stevie
Sale videos change on the 1st & 15th of the month - at least 6 videos on sale! Use Member & Flash Sale coupons to save more!
August 2, 2025 at 8:26 AM
August 1 SALE VIDEOS at BondageWarehouse.com!
IS-BW0165: Cydel Jimenez
IS110: Molly, Naleyja, Katarina, Lainie, Holly, Dina & Salem
QT0378: Bethany & Stevie
Sale videos change on the 1st & 15th of the month - at least 6 videos on sale! Use Member & Flash Sale coupons to save more!
IS-BW0165: Cydel Jimenez
IS110: Molly, Naleyja, Katarina, Lainie, Holly, Dina & Salem
QT0378: Bethany & Stevie
Sale videos change on the 1st & 15th of the month - at least 6 videos on sale! Use Member & Flash Sale coupons to save more!
@science.org publishes a new study from Martin Jinek’s lab presenting the novel #bridge genome editing system from IS110 ISCro4 of Citrobacter, capable of delivering scar-free diverse types of editions with significant efficiencies in human cells. 🌉⬇️
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Programmable genome editing in human cells using RNA-guided bridge recombinases
Site-specific insertion of gene-sized DNA fragments remains an unmet need in the field of genome editing. IS110-family serine recombinases have recently been shown to mediate programmable DNA recombin...
www.science.org
March 14, 2026 at 7:53 AM
@science.org publishes a new study from Martin Jinek’s lab presenting the novel #bridge genome editing system from IS110 ISCro4 of Citrobacter, capable of delivering scar-free diverse types of editions with significant efficiencies in human cells. 🌉⬇️
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Our results suggest IS110s are dynamic genetic elements that can grow, acquire adaptive cargo, and help spread antimicrobial resistance between bacteria. 🧬🦠
🔗 Full preprint here: www.biorxiv.org/content/10.6...
#Microbiology #Genomics #AMR #MobileGeneticElements #IS110
🔗 Full preprint here: www.biorxiv.org/content/10.6...
#Microbiology #Genomics #AMR #MobileGeneticElements #IS110
Canonically minimal RNA-guided insertion sequences expand into large elements that disseminate antimicrobial resistance
IS110 has emerged as a powerful genome-editing tool because it is the smallest RNA-guided system capable of diverse programmable insertions. Naturally existing elements are conventionally modeled as c...
www.biorxiv.org
August 18, 2026 at 5:50 PM
Our results suggest IS110s are dynamic genetic elements that can grow, acquire adaptive cargo, and help spread antimicrobial resistance between bacteria. 🧬🦠
🔗 Full preprint here: www.biorxiv.org/content/10.6...
#Microbiology #Genomics #AMR #MobileGeneticElements #IS110
🔗 Full preprint here: www.biorxiv.org/content/10.6...
#Microbiology #Genomics #AMR #MobileGeneticElements #IS110
We found that natural IS110 systems can span from ~800 bp to nearly 100 kb, which is far beyond the canonical ~1.5-kb model.
August 18, 2026 at 5:35 PM
We found that natural IS110 systems can span from ~800 bp to nearly 100 kb, which is far beyond the canonical ~1.5-kb model.
Two papers in Nature describe a new genome editing technique that enables the insertion, inversion and deletion of long DNA sequences at user-specified genome positions. A single-step approach could provide an easier method of genome editing.
go.nature.com/4cuvTtq
go.nature.com/3RECskL 🧪
go.nature.com/4cuvTtq
go.nature.com/3RECskL 🧪
June 26, 2024 at 4:23 PM
Two papers in Nature describe a new genome editing technique that enables the insertion, inversion and deletion of long DNA sequences at user-specified genome positions. A single-step approach could provide an easier method of genome editing.
go.nature.com/4cuvTtq
go.nature.com/3RECskL 🧪
go.nature.com/4cuvTtq
go.nature.com/3RECskL 🧪
IS110 elements can gradually grow by repeatedly gaining new DNA and duplicating parts, or even all, of the element, which allows them to accumulate cargo over time.
August 18, 2026 at 5:41 PM
IS110 elements can gradually grow by repeatedly gaining new DNA and duplicating parts, or even all, of the element, which allows them to accumulate cargo over time.
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons https://www.biorxiv.org/content/10.1101/2024.06.21.599552v1
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons https://www.biorxiv.org/content/10.1101/2024.06.21.599552v1
Transposase genes are ubiquitous in all domains of life and provide a rich reservoir for the evoluti
www.biorxiv.org
June 22, 2024 at 5:32 AM
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons https://www.biorxiv.org/content/10.1101/2024.06.21.599552v1
Wow, this is incredible!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bridge RNAs direct programmable recombination of target and donor DNA - Nature
A bispecific non-coding RNA expressed by the IS110 family of mobile genetic elements forms the basis of a programmable genome-editing system that enables the insertion, excision or inversion of s...
www.nature.com
June 27, 2024 at 2:29 AM
Wow, this is incredible!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways
IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways
Sun et al. show that IS110 transposons utilize two independent RNA-guided transposition pathways: a top-strand copy-out mechanism and a direct top-strand transfer to new targets. These findings redefine IS110 transposition and reconcile prior discrepancies, which provides insight into programmable, RNA-guided genome modification without double-strand DNA breaks.
dlvr.it
July 20, 2026 at 11:32 AM
IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways
DNA tabanlı bakteriyel parazit tamamen yeni bir DNA düzenleme yöntemi kullanıyor.
CRISPR'a rakip olma potansiyeline sahip yeni bir genom düzenleme aracı keşfedildi. IS110, bakteriyel bir DNA parazitine dayanan sistem.
arstechnica.com/science/2024...
CRISPR'a rakip olma potansiyeline sahip yeni bir genom düzenleme aracı keşfedildi. IS110, bakteriyel bir DNA parazitine dayanan sistem.
arstechnica.com/science/2024...
DNA-based bacterial parasite uses completely new DNA-editing method
Its error rates are too high for safe use but might be improved.
arstechnica.com
June 28, 2024 at 9:32 AM
DNA tabanlı bakteriyel parazit tamamen yeni bir DNA düzenleme yöntemi kullanıyor.
CRISPR'a rakip olma potansiyeline sahip yeni bir genom düzenleme aracı keşfedildi. IS110, bakteriyel bir DNA parazitine dayanan sistem.
arstechnica.com/science/2024...
CRISPR'a rakip olma potansiyeline sahip yeni bir genom düzenleme aracı keşfedildi. IS110, bakteriyel bir DNA parazitine dayanan sistem.
arstechnica.com/science/2024...
Expanded IS110s can also move across different bacterial lineages. We found about 30,000 cases of nearly identical IS110s in different species, especially among Klebsiella, Enterobacter, Escherichia, and Salmonella. Much of the DNA accumulated by IS110 appeared to come from plasmids.
August 18, 2026 at 5:37 PM
Expanded IS110s can also move across different bacterial lineages. We found about 30,000 cases of nearly identical IS110s in different species, especially among Klebsiella, Enterobacter, Escherichia, and Salmonella. Much of the DNA accumulated by IS110 appeared to come from plasmids.
IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways https://www.biorxiv.org/content/10.1101/2025.10.25.684509v1
October 25, 2025 at 8:16 PM
IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways https://www.biorxiv.org/content/10.1101/2025.10.25.684509v1
A programmable seeker RNA guides target selection by IS1111 and IS110 type insertion sequences. https://www.biorxiv.org/content/10.1101/2024.04.26.591405v1
A programmable seeker RNA guides target selection by IS1111 and IS110 type insertion sequences. https://www.biorxiv.org/content/10.1101/2024.04.26.591405v1
IS1111 and IS110 insertion sequence (IS) family members encode an unusual DEDD transposase type and
www.biorxiv.org
April 28, 2024 at 6:16 AM
A programmable seeker RNA guides target selection by IS1111 and IS110 type insertion sequences. https://www.biorxiv.org/content/10.1101/2024.04.26.591405v1
Older Prusa Mk3. Just be sure the plate is clean, Z calibration is110% spot on, and the filament is good.
March 26, 2025 at 3:10 PM
Older Prusa Mk3. Just be sure the plate is clean, Z calibration is110% spot on, and the filament is good.