We hope our in situ findings bring exciting new insights to the centriole & centrosome field! Would love to hear thoughts from the community: #Centriole #cryoET #InSituStructuralBiology @centriolelab.bsky.social @cellarchlab.com @computingcaitie.bsky.social @alanbrownhms.bsky.social
1/4 Following our 2023 ELI-TriScope work (@NatMethods), we’ve focused on the in situ architectures of native centrosomes & basal bodies (BBs).
October 10, 2026 at 1:28 AM
We hope our in situ findings bring exciting new insights to the centriole & centrosome field! Would love to hear thoughts from the community: #Centriole #cryoET #InSituStructuralBiology @centriolelab.bsky.social @cellarchlab.com @computingcaitie.bsky.social @alanbrownhms.bsky.social
The new Leopard-EM software package for 2D template matching has been written with extensibility at the forefront #InSituStructuralBiology #CryoEM #CryoET doi.org/10.1107/S205...
March 17, 2026 at 3:21 PM
The new Leopard-EM software package for 2D template matching has been written with extensibility at the forefront #InSituStructuralBiology #CryoEM #CryoET doi.org/10.1107/S205...
Matthew D. Giammar et al.: Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology ##InSituStructuralBiology##CryoEM##CryoET@usc...##IUCrhttps://journals.iucr.org/paper?S2059798325009982
Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology
In situ cryo-EM coupled with 2D template matching (2DTM) holds the potential to visualize the cellular structureome in context, but further developments are required to make this a reality. We describe Leopard-EM (Location and orientation of particles found using two-dimensional tEmplate Matching), an extensible Python package for 2DTM to accelerate in situ structural biology.
journals.iucr.org
December 9, 2025 at 1:00 AM
Matthew D. Giammar et al.: Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology ##InSituStructuralBiology##CryoEM##CryoET@usc...##IUCrhttps://journals.iucr.org/paper?S2059798325009982