#VascularMalformation

Tie2+ or Apln+ Endothelial Cell Tie2 R848W (activating variant)🐭
👉Vascular lesions (CD34-hi, αSMA+) in🫁(E18.5)
👉⏬Retinal radial vascular outgrowth (P7)
👉⏫Retinal capillary αSMA+ Pericytes

TRAIL/TNFSF10 Angiocrine to mural cell🤔

#IntJMedSci 2025
www.medsci.org/v22p2518.htm