#JORSpine
📢 Check out the work of #ISSLS member Svenja Illien-Junger et al. in #JORSpine on PHLPP1’s role in IVD degeneration & small molecule inhibitors. Full study 👉 onlinelibrary.wiley.com/doi/10.1002/...

#SpineResearch
Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health
Pharmacological inhibition of PHLPP via NSC45586 promotes nucleus pulposus cell health. NSC45586 is a potential drug candidate in treating IVD degeneration.
onlinelibrary.wiley.com
March 6, 2025 at 7:56 AM
Analysis of Key Differential Metabolites in Intervertebral Disc Degeneration Based on Untargeted Metabolomics #JORSpine #MassSpec onlinelibrary.wiley.com/doi/10.1002/...
Analysis of Key Differential Metabolites in Intervertebral Disc Degeneration Based on Untargeted Metabolomics
The results showed that 2-methyl-1,3-cyclohexadiene, SM(d16_1_24_1(15Z)), SM(d17_1_24_1(15Z)), SM(d18_1_16_0), SM(d18_1_24_1(15Z)), stearoyl sphingomyelin, the methylcysteine, L-methionine, cis, cis-...
onlinelibrary.wiley.com
January 9, 2025 at 9:06 PM