#K-731
【日本人HF入院中のMRA開始とCV転帰/J Cardiol】Sep.28

日本、MRA服用歴なくHF入院の2,792例 [平均73歳] 解析——

・731日間の「CV死亡・HF入院」発生率は25%。
・入院中にMRA「開始」[可能] 例 [48%] では「非開始」例に比 
 べ、HRが0.75の有意低値。
(著明減少は「HF入院」。「CV死亡」HRは0.97)。
・eGFR「≧30」かつ血清K「<5,0」 mmol/L群と「<30、≧5.0」
 群に分けて比較しても結果は同様(有意な交互作用は認めず)。

抄録🔗. x.gd/qhLc5
Association of in-hospital mineralocorticoid receptor antagonist initiation with outcomes according to guideline-defined eGFR and potassium eligibility in patients with heart failure
Evidence on the use of mineralocorticoid receptor antagonists (MRAs) in patients hospitalized for heart failure (HF) with concomitant advanced chronic kidney disease or hyperkalemia remains limited. W...
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September 29, 2026 at 10:41 PM
September 27, 2026 at 3:03 PM
私はその本のせいでナチスに異常な興味を持つ小学生になってしまい、そこから南京大虐殺や731部隊やKKKなど「人間はどこまで残虐になれるのか」みたいな興味がどんどん広がっていった。その年にNHKで『映像の世紀』が放送開始したのも影響した。
図書館でそういう本を借りてきては読みふけっている私を両親は心配しただろう。間違いなく近現代史にはまった原点の一つでもある。
美人のK先生、たぶん今54歳くらいだと思われるがお元気かな。
August 20, 2026 at 6:32 AM
August 12, 2026 at 1:43 PM
August 11, 2026 at 9:14 AM
The bot 'Elon Musk' just killed the player 'Kilchek' (k/d: 0/1) with LinkGun -- Current Map : DM-Entropic -- Current score : [#TeamElon - 731] [#TeamEarth - 1056] #UnrealTournament2004 #UT2k4
July 31, 2026 at 4:38 AM
A non-classical biosynthetic route enables tocopherol synthesis in bacteria
Schneider, C. Chemistry and biology of vitamin E. Mol. Nutr. Food Res. 49, 7–30 (2005). Müller, L., Theile, K. & Böhm, V. In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma. Mol. Nutr. Food Res. 54, 731–742 (2010). Valentin, H. E. & Qi, Q. Biotechnological production and application of vitamin E: current state and prospects. Appl. Microbiol. Biotechnol. 68, 436–444 (2005). Yuan, P. et al. Metabolic engineering for the production of fat-soluble vitamins: advances and perspectives. Appl. Microbiol. Biotechnol. 104, 935–951 (2019). KamalEldin, A. & Appelqvist, L. A. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31, 671–701 (1996). Constantinou, C., Papas, A. & Constantinou, A. I. Vitamin E and cancer: an insight into the anticancer activities of vitamin E isomers and analogs. Int. J. Cancer 123, 739–752 (2008). La Fata, G., Weber, P. & Mohajeri, M. H. Effects of vitamin E on cognitive performance during ageing and in Alzheimer’s disease. Nutrients 6, 5453–5472 (2014). Sozen, E., Demirel, T. & Ozer, N. K. Vitamin E: regulatory role in the cardiovascular system. Iubmb. Life 71, 507–515 (2019). Ye, Z. et al. Revolution of vitamin E production by...
www.nature.com
July 28, 2026 at 4:30 AM
Last night's Voidstar Productions' High Voltage Circumcision Show on WZBC can be heard at spinitron.com/WZBC/pl/2265... with
Bob Familiar
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Pas Musique
Somatic Responses
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Neptune
Torture Gallery
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Unit 731
Murderous Vision
Voidstar Productions' High Voltage Circumcision Show Mon Jun 29 with DVJ Deftly-D on WZBC 90.3 FM Newton
All things dark hard rhythmic noise and other
spinitron.com
June 30, 2026 at 6:05 PM
#otdJan6Attack

#otdJune12th 2024

#Jan6PressReleases
24-507

“Florida Man Sentenced on Felony Charge for Actions During Jan. 6 Capitol Breach”

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June 13, 2026 at 4:27 AM
Autophagy modulation in cancer
Galluzzi, L., Yamazaki, T. & Kroemer, G. Linking cellular stress responses to systemic homeostasis. Nat. Rev. Mol. Cell Biol. 19, 731–745 (2018). Groelly, F. J., Fawkes, M., Dagg, R. A., Blackford, A. N. & Tarsounas, M. Targeting DNA damage response pathways in cancer. Nat. Rev. Cancer 23, 78–94 (2023). Chen, X. & Cubillos-Ruiz, J. R. Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat. Rev. Cancer 21, 71–88 (2021). Debnath, J., Gammoh, N. & Ryan, K. M. Autophagy and autophagy-related pathways in cancer. Nat. Rev. Mol. Cell Biol. 24, 560–575 (2023). Yamamoto, H., Zhang, S. & Mizushima, N. Autophagy genes in biology and disease. Nat. Rev. Genet. 24, 382–400 (2023). Wang, L., Klionsky, D. J. & Shen, H. M. The emerging mechanisms and functions of microautophagy. Nat. Rev. Mol. Cell Biol. 24, 186–203 (2023). Kaushik, S. & Cuervo, A. M. The coming of age of chaperone-mediated autophagy. Nat. Rev. Mol. Cell Biol. 19, 365–381 (2018). Zhao, Y. G., Codogno, P. & Zhang, H. Machinery, regulation and pathophysiological implications of autophagosome maturation. Nat. Rev. Mol. Cell Biol. 22, 733–750 (2021). Zhang, H. The genetics of autophagy in multicellular organisms. Annu. Rev. Genet. 56, 17–39 (2022). Levine, B. & Kroemer,...
www.nature.com
May 18, 2026 at 3:31 PM
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May 12, 2026 at 6:30 AM
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Available in the iOS app store now!
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May 12, 2026 at 5:29 AM
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May 9, 2026 at 9:20 AM
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#epsteinweb #efta00056236
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April 19, 2026 at 9:51 PM
GIS-based AHP multi-criteria mapping of potential solar PV power plant development
Abonomi, A. Collaborative Planning for the Environmental Sustainability of the Hajj (Victoria University, 2022). Abonomi, A., De Lacy, T. & Pyke, J. Environmental impact of the hajj. Int. J. Religious Tourism Pilgrimage. 10 (1), 12 (2022). Adeyeye, K., Ijumba, N. & Colton, J. Exploring the environmental and economic impacts of wind energy: A cost-benefit perspective. Int. J. Sustainable Dev. World Ecol. 27 (8), 718–731 (2020). Ahmed, Q. A., Arabi, Y. M. & Memish, Z. A. Health risks at the Hajj. Lancet 367 (9515), 1008–1015 (2006). Akkas, O. P., Erten, M. Y., Cam, E. & Inanc, N. Optimal site selection for a solar power plant in the Central Anatolian Region of Turkey. Int. J. Photoenergy. 2017 (1), 7452715 (2017). Al-Awadhi, T., Ramimi, A., Jabri, W. A., Abulibdeh, A. & K., & Solar farms suitability analysis using GIS-Based Analytic Hierarchy Process (AHP) multi-criteria: A case study of Al Duqm–Oman. Renew. energy. 241, 122295 (2025). Al-Shammari, S., Ko, W., Al Ammar, E. A., Alotaibi, M. A. & Choi, H. J. Optimal decision-making in photovoltaic system selection in Saudi Arabia. Energies 14 (2), 357 (2021). Al Garni, H. Z. & Awasthi, A. Solar PV power plant site selection using a GIS-AHP based approach with...
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April 12, 2026 at 1:11 PM
Rätsel #731: 85 Punkte mit 7 Wörtern erreicht (🔥 Top-Score) und 1 Isogramm entdeckt

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April 11, 2026 at 7:54 PM
Rätsel #731: 81 Punkte mit 8 Wörtern erreicht und 2 Isogramme entdeckt

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April 11, 2026 at 2:15 PM