All expression constructs for the KANK1-4 ankyrin repeat domains and pathogenic variants used in this study are now available from @addgene.bsky.social.
We hope they prove useful to others working on KANK biology, adhesions and microtubule regulation.
www.addgene.org/browse/artic...
We hope they prove useful to others working on KANK biology, adhesions and microtubule regulation.
www.addgene.org/browse/artic...
Addgene: The KN domain of KANK proteins contains separable talin-binding and intramolecular interaction modules
www.addgene.org
June 11, 2026 at 1:24 PM
All expression constructs for the KANK1-4 ankyrin repeat domains and pathogenic variants used in this study are now available from @addgene.bsky.social.
We hope they prove useful to others working on KANK biology, adhesions and microtubule regulation.
www.addgene.org/browse/artic...
We hope they prove useful to others working on KANK biology, adhesions and microtubule regulation.
www.addgene.org/browse/artic...
CCDC66 couples actin-microtubule crosslinking to KANK1-associated microtubule targeting and focal adhesion turnover
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
May 21, 2026 at 11:24 AM
CCDC66 couples actin-microtubule crosslinking to KANK1-associated microtubule targeting and focal adhesion turnover
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
CCDC66 couples actin-microtubule crosslinking to KANK1-associated microtubule targeting and focal adhesion turnover https://www.biorxiv.org/content/10.64898/2026.05.19.723697v1
May 21, 2026 at 6:30 AM
CCDC66 couples actin-microtubule crosslinking to KANK1-associated microtubule targeting and focal adhesion turnover https://www.biorxiv.org/content/10.64898/2026.05.19.723697v1
CCDC66 couples actin-microtubule crosslinking to KANK1-associated microtubule targeting and focal adhesion turnover https://www.biorxiv.org/content/10.64898/2026.05.19.723697v1
May 21, 2026 at 6:30 AM
CCDC66 couples actin-microtubule crosslinking to KANK1-associated microtubule targeting and focal adhesion turnover https://www.biorxiv.org/content/10.64898/2026.05.19.723697v1
In our last week's #journalclub, we looked at how the dynein light chain LC8 stablises the disordered domain of KANK1, transforming it into a rigid, hinged rod that can span the cortex–microtubule gap and recruit kinesin-4 to cortical microtubule plus ends.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 20, 2026 at 10:49 AM
In our last week's #journalclub, we looked at how the dynein light chain LC8 stablises the disordered domain of KANK1, transforming it into a rigid, hinged rod that can span the cortex–microtubule gap and recruit kinesin-4 to cortical microtubule plus ends.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New collaborative preprint!
A striking result: a disordered linker in KANK1 binds as many as 15 LC8 dimers, forming a protein rod that bridges cell membranes and microtubules!
www.biorxiv.org/content/10.1...
A striking result: a disordered linker in KANK1 binds as many as 15 LC8 dimers, forming a protein rod that bridges cell membranes and microtubules!
www.biorxiv.org/content/10.1...
January 8, 2026 at 3:07 PM
New collaborative preprint!
A striking result: a disordered linker in KANK1 binds as many as 15 LC8 dimers, forming a protein rod that bridges cell membranes and microtubules!
www.biorxiv.org/content/10.1...
A striking result: a disordered linker in KANK1 binds as many as 15 LC8 dimers, forming a protein rod that bridges cell membranes and microtubules!
www.biorxiv.org/content/10.1...
January 7, 2026 at 6:09 PM
New collaborative preprint!
A striking result: a disordered linker in KANK1 binds as many as 15 LC8 dimers, forming a protein rod that bridges cell membranes and microtubules!
www.biorxiv.org/content/10.1...
A striking result: a disordered linker in KANK1 binds as many as 15 LC8 dimers, forming a protein rod that bridges cell membranes and microtubules!
www.biorxiv.org/content/10.1...
We also performed an exome-wide scan for novel genes associated with misalignment...
♀️Age at Menopause: We identified KANK1 as a gene associated with later-than-expected age at menopause, suggesting a potential protective role against primary ovarian insufficiency.
♀️Age at Menopause: We identified KANK1 as a gene associated with later-than-expected age at menopause, suggesting a potential protective role against primary ovarian insufficiency.
January 6, 2026 at 6:31 PM
We also performed an exome-wide scan for novel genes associated with misalignment...
♀️Age at Menopause: We identified KANK1 as a gene associated with later-than-expected age at menopause, suggesting a potential protective role against primary ovarian insufficiency.
♀️Age at Menopause: We identified KANK1 as a gene associated with later-than-expected age at menopause, suggesting a potential protective role against primary ovarian insufficiency.
Identification of co-segregating RUBCN and KANK1 mutations in a UK ALS kindred https://www.medrxiv.org/content/10.1101/2025.07.23.25331426v1
July 23, 2025 at 10:40 PM
Identification of co-segregating RUBCN and KANK1 mutations in a UK ALS kindred https://www.medrxiv.org/content/10.1101/2025.07.23.25331426v1
Weak Motifs, Strong Complex: KANK1 Uses Cooperative Multivalency with the Hub-Protein LC8 to Bridge Cytoskeletal Complexes https://www.biorxiv.org/content/10.1101/2025.07.16.665182v1
July 21, 2025 at 11:47 AM
Weak Motifs, Strong Complex: KANK1 Uses Cooperative Multivalency with the Hub-Protein LC8 to Bridge Cytoskeletal Complexes https://www.biorxiv.org/content/10.1101/2025.07.16.665182v1
Weak Motifs, Strong Complex: KANK1 Uses Cooperative Multivalency with the Hub-Protein LC8 to Bridge Cytoskeletal Complexes https://www.biorxiv.org/content/10.1101/2025.07.16.665182v1
July 21, 2025 at 11:47 AM
Weak Motifs, Strong Complex: KANK1 Uses Cooperative Multivalency with the Hub-Protein LC8 to Bridge Cytoskeletal Complexes https://www.biorxiv.org/content/10.1101/2025.07.16.665182v1
Actus Mer/Sea News: A Shuttling Protein Kank1 Plays Important Role in the Sex Determination in Yellow Drum - @FrontMarineSci http://dlvr.it/SPls4g
January 25, 2025 at 3:56 AM
Actus Mer/Sea News: A Shuttling Protein Kank1 Plays Important Role in the Sex Determination in Yellow Drum - @FrontMarineSci http://dlvr.it/SPls4g