#WeekendRead! #LipidPower! Hugues, Sun &co show @natcomms.bsky.social that lymphatic endothelial cells #LECs modify cholesterol into oxysterols, blocking PPARg in intratumor macrophages & monocytes, making them more inflammatory thus potentiating anti-tumor T cell responses during immunotherapy!!
Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma - Nature Communications
VEGF-C induced lymphangiogenesis combined with immunotherapy approaches can promote anti-tumor immune responses. Here the authors report that lymphaticderived oxysterols promote anti-tumor immunity an...
www.nature.com
February 1, 2025 at 8:02 PM
#WeekendRead! #LipidPower! Hugues, Sun &co show @natcomms.bsky.social that lymphatic endothelial cells #LECs modify cholesterol into oxysterols, blocking PPARg in intratumor macrophages & monocytes, making them more inflammatory thus potentiating anti-tumor T cell responses during immunotherapy!!
#WeekendRead! #LipidPower! @miriammerad.bsky.social &co show @natimmunol.bsky.social that to get activated, #DCs steal from cell debris & produce their own cholesterol which is organized in plasma membrane lipid nanodomains! AXL reduces this process & its deletion augment anti-tumor immunity!
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer - Nature Immunology
To mature, dendritic cells collect and synthesize cholesterol to construct lipid nanodomains on their membranes. Obstructing this process impairs their ability to prime T cells.
doi.org
February 2, 2025 at 5:31 PM
#WeekendRead! #LipidPower! @miriammerad.bsky.social &co show @natimmunol.bsky.social that to get activated, #DCs steal from cell debris & produce their own cholesterol which is organized in plasma membrane lipid nanodomains! AXL reduces this process & its deletion augment anti-tumor immunity!