In the paper, “Encapsulating GSH/NQO1-responsive SN38 prodrug micelles with Timosaponin AIII-based multifunctional liposomes for tumor-targeted chemotherapy,” researchers developed a novel micelle-liposome composite carrier by integrating GSH/NQO1 dual-responsive SN38 prodrug polymer micelles (PEG-SS-SN38-QPA, abbreviated as PSSQ) with TAIII-based multifunctional liposomes (TLP).  Results point to a promising, targeted therapeutic strategy for treating colorectal cancer with enhanced intratumoral […]

Read the full paper: Tricin‐Loaded Liposomes as a Passive Targeting Nanodelivery System for Enhanced Gastric Cancer Therapy

Stable cnidarian–dinoflagellate symbioses provide the trophic foundation of coral reef ecosystems. Understanding nutrient exchange underpinning this symbiosis, and the need for interventions to improv...

Nature Nanotechnology, Published online: 13 October 2026; doi:10.1038/s41565-026-02287-xCuriosity-driven studies of lipid organization and lipid asymmetry in biological membranes led to scalable methods for making liposomes, efficient loading of drugs and ionizable cationic lipids. In turn, these advances led to lipid nanoparticles enabling the RNA medicine Onpattro and the COVID-19 mRNA vaccines, and they are now facilitating gene therapies that can potentially treat most human diseases.

This protocol outlines an extracellular vesicle detection approach in which reagent-loaded liposomes fuse with extracellular vesicles directly in patient blood to sensitively detect RNA within the extracellular vesicles.

Turkish researchers have shown that liposomes loaded with cinnamon and clove extracts can keep bread free of fungal growth for up to 21 days while boosting its antioxidant content.

The position of biomineralization peptides within liposomes can influence how gold nanoparticles grow. Peptides localized at the membrane interface promote branched structures, while those confined to the liposome interior favor spherical nanoparticles. The findings offer a new strategy for controlling nanoscale reaction environments in nanoparticle synthesis.

The findings could help researchers make local anesthetics last longer in people. Patients recovering from surgery may need pain relief beyond the eight to 12 hours, or about a day at most, that most local anesthetics provide. Seeking a longer-lasting option, researchers at Boston Children’s Hospital have redesigned liposomes, microscopic carriers made from fatty molecules, [...]

Contrary to expectations that unsaturation accelerates release, unsaturated phospholipid liposomes showed 3-fold higher loading and markedly reduced initial and sustained release due to multilamellar–...

Cerebrospinal fluid (CSF) drains along the perivascular space, known as the glymphatic system, to the meninges, where meningeal lymphatic vessels (MLVs) remove toxic products with excess CSF from the brain. Macrophages are widely present in the leptomeninges and dura mater of meninges. However, whether leptomeningeal and dural macrophages play the same or distinct roles in maintaining optimal CSF drainage remains unclear. By intra-cisterna magna (i.c.m.) injection of clodronate liposomes (CLL...

Nature Biomedical Engineering, Published online: 23 September 2026; doi:10.1038/s41551-026-01791-8Unsaturated phospholipids unexpectedly form multilamellar, multivesicular liposomes that efficiently encapsulate hydrophilic drugs and suppress burst release. These structures enable ultra-slow drug release and produce weeks-long sciatic nerve block with tetrodotoxin in rats.

Nature Biomedical Engineering, Published online: 23 September 2026; doi:10.1038/s41551-026-01793-6Contrary to expectations that unsaturation accelerates release, unsaturated phospholipid liposomes showed 3-fold higher loading and markedly reduced initial and sustained release due to multilamellar–multivesicular structure.