A longstanding mystery in Parkinson's disease research has been why some individuals carrying pathogenic variants that increase their risk of PD go on to develop the disease, while others who also carry such variants do not. #neuroskyence #Parkinson #Lysosomaldysfunction
New key genes in Parkinson's disease identified using CRISPR technology
A longstanding mystery in Parkinson's disease research has been why some individuals carrying pathogenic variants that increase their risk of PD go on to develop the disease, while others who also car...
www.sciencedaily.com
April 20, 2025 at 3:07 AM
A longstanding mystery in Parkinson's disease research has been why some individuals carrying pathogenic variants that increase their risk of PD go on to develop the disease, while others who also carry such variants do not. #neuroskyence #Parkinson #Lysosomaldysfunction
GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis.
Bogacki, Erin C et al.
Paper
Details
#GPNMB #lysosomaldysfunction #LRRK2
Bogacki, Erin C et al.
Paper
Details
#GPNMB #lysosomaldysfunction #LRRK2
December 19, 2025 at 9:01 AM
GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis.
Bogacki, Erin C et al.
Paper
Details
#GPNMB #lysosomaldysfunction #LRRK2
Bogacki, Erin C et al.
Paper
Details
#GPNMB #lysosomaldysfunction #LRRK2
To examine the implications of CMA dysfunction, rPeptide’s Tau-441 was used to assess #Tau behavior under these impaired conditions.
t.ly/2bKKW
This provides insight into the molecular links between #lysosomaldysfunction and #proteinaccumulation in #Parkinsons and #Alzheimers diseases.
t.ly/2bKKW
This provides insight into the molecular links between #lysosomaldysfunction and #proteinaccumulation in #Parkinsons and #Alzheimers diseases.
Tau-441
Recombinant Tau-441 from rPeptide. High quality, >90% purity, batch to batch consistency. In stock and ready to ship - order online today.
www.rpeptide.com
August 11, 2025 at 1:59 PM
To examine the implications of CMA dysfunction, rPeptide’s Tau-441 was used to assess #Tau behavior under these impaired conditions.
t.ly/2bKKW
This provides insight into the molecular links between #lysosomaldysfunction and #proteinaccumulation in #Parkinsons and #Alzheimers diseases.
t.ly/2bKKW
This provides insight into the molecular links between #lysosomaldysfunction and #proteinaccumulation in #Parkinsons and #Alzheimers diseases.
Biomarkers of LRRK2 and lysosomal dysfunction in Progressive Supranuclear Palsy
Allinson, K. S. et al.
Paper
Details
#LRRK2 #lysosomaldysfunction #PSP
Allinson, K. S. et al.
Paper
Details
#LRRK2 #lysosomaldysfunction #PSP
December 9, 2025 at 9:02 AM
Biomarkers of LRRK2 and lysosomal dysfunction in Progressive Supranuclear Palsy
Allinson, K. S. et al.
Paper
Details
#LRRK2 #lysosomaldysfunction #PSP
Allinson, K. S. et al.
Paper
Details
#LRRK2 #lysosomaldysfunction #PSP