MILEI LIDERA UN GOBIERNO DE CLASE (ALTA) PARA DESTRUIR A LA CLASE MEDIA
La columna de @fedevazquez.bsky.social en #Segurola👇
www.youtube.com/watch?v=mDr1...
La columna de @fedevazquez.bsky.social en #Segurola👇
www.youtube.com/watch?v=mDr1...
MILEI LIDERA UN GOBIERNO DE CLASE (ALTA) PARA DESTRUIR A LA CLASE MEDIA | FEDE VAZQUEZ en SEGUROLA
YouTube video by Futurock FM
www.youtube.com
December 2, 2024 at 6:35 PM
MILEI LIDERA UN GOBIERNO DE CLASE (ALTA) PARA DESTRUIR A LA CLASE MEDIA
La columna de @fedevazquez.bsky.social en #Segurola👇
www.youtube.com/watch?v=mDr1...
La columna de @fedevazquez.bsky.social en #Segurola👇
www.youtube.com/watch?v=mDr1...
❤️🩹 for Kai Kai ❤️🩹
Get the MDR1 test done on your herding breed now. It’s an easy at-home cheek swab: prime.vetmed.wsu.edu/2022/08/29/m...
Get the MDR1 test done on your herding breed now. It’s an easy at-home cheek swab: prime.vetmed.wsu.edu/2022/08/29/m...
November 24, 2024 at 1:18 AM
❤️🩹 for Kai Kai ❤️🩹
Get the MDR1 test done on your herding breed now. It’s an easy at-home cheek swab: prime.vetmed.wsu.edu/2022/08/29/m...
Get the MDR1 test done on your herding breed now. It’s an easy at-home cheek swab: prime.vetmed.wsu.edu/2022/08/29/m...
Yup, I forgot to post this!
Gobutiko is featured in the Game Devs of Color Expo 2025
@gdocexpo.com
The Steam showcase is live! You can watch the GDoCExpo Direct at 1pm PT / 4pm ET / 8pm UTC.
🎉Support your indies🎉
🔗 Direct: www.youtube.com/watch?v=MdR1...
#Indiegame #GameDevsofColor
Gobutiko is featured in the Game Devs of Color Expo 2025
@gdocexpo.com
The Steam showcase is live! You can watch the GDoCExpo Direct at 1pm PT / 4pm ET / 8pm UTC.
🎉Support your indies🎉
🔗 Direct: www.youtube.com/watch?v=MdR1...
#Indiegame #GameDevsofColor
September 16, 2025 at 5:36 PM
Yup, I forgot to post this!
Gobutiko is featured in the Game Devs of Color Expo 2025
@gdocexpo.com
The Steam showcase is live! You can watch the GDoCExpo Direct at 1pm PT / 4pm ET / 8pm UTC.
🎉Support your indies🎉
🔗 Direct: www.youtube.com/watch?v=MdR1...
#Indiegame #GameDevsofColor
Gobutiko is featured in the Game Devs of Color Expo 2025
@gdocexpo.com
The Steam showcase is live! You can watch the GDoCExpo Direct at 1pm PT / 4pm ET / 8pm UTC.
🎉Support your indies🎉
🔗 Direct: www.youtube.com/watch?v=MdR1...
#Indiegame #GameDevsofColor
How is this possible? We found that PAC-1 is being effluxed by MDR1 - but PAC-1 bound to iron is effluxed much more rapidly than PAC-1 by itself. So, MDR1 activity doesn't protect cells - it accelerates iron starvation in MDR1-high cells by pumping out the drug-iron complex.
December 1, 2025 at 9:30 PM
How is this possible? We found that PAC-1 is being effluxed by MDR1 - but PAC-1 bound to iron is effluxed much more rapidly than PAC-1 by itself. So, MDR1 activity doesn't protect cells - it accelerates iron starvation in MDR1-high cells by pumping out the drug-iron complex.
Surprisingly, using PRISM, we found that the cells most sensitive to PAC-1 were over-expressing MDR1 (also called P-gp). MDR1 stands for MultiDrug Resistance 1: it’s an efflux pump that expels drugs from tumors. But our data suggested that MDR1 conferred PAC-1 sensitivity!
December 1, 2025 at 9:30 PM
Surprisingly, using PRISM, we found that the cells most sensitive to PAC-1 were over-expressing MDR1 (also called P-gp). MDR1 stands for MultiDrug Resistance 1: it’s an efflux pump that expels drugs from tumors. But our data suggested that MDR1 conferred PAC-1 sensitivity!
To confirm this association, we generated MDR1-KO clones and we verified that these cells were more sensitive to standard chemotherapies, as we expected. However, we also found that the chemo-resistant MDR1-high cells were much more sensitive to PAC-1 than the MDR1-KO cells!
December 1, 2025 at 9:30 PM
To confirm this association, we generated MDR1-KO clones and we verified that these cells were more sensitive to standard chemotherapies, as we expected. However, we also found that the chemo-resistant MDR1-high cells were much more sensitive to PAC-1 than the MDR1-KO cells!
I mean the most important thing is that she doesn’t have the MDR1 mutation but also: very funny that I got a purebred Shetland sheepdog for $200 in a McDonald’s parking lot
December 31, 2024 at 4:47 PM
I mean the most important thing is that she doesn’t have the MDR1 mutation but also: very funny that I got a purebred Shetland sheepdog for $200 in a McDonald’s parking lot
MDR1 mutations are most common in Maine Coons, but aren’t exclusive to them. I learned about this after internet microceleb Pot Roast died from it.
Many ectoparasite preventatives don’t contain eprinomectin. Please use those! Mosquito-borne heartworm infections are deadly & untreatable in cats. 2/3
Many ectoparasite preventatives don’t contain eprinomectin. Please use those! Mosquito-borne heartworm infections are deadly & untreatable in cats. 2/3
Cats with MDR1 mutation at risk of severe reactions to popular medication
A WSU study identified a risk of severe adverse effects in cats with the genetic mutation to eprinomectin, an active ingredient in top-selling parasite preventatives like NexGardCombo and Centragard.
news.wsu.edu
June 13, 2026 at 4:17 PM
MDR1 mutations are most common in Maine Coons, but aren’t exclusive to them. I learned about this after internet microceleb Pot Roast died from it.
Many ectoparasite preventatives don’t contain eprinomectin. Please use those! Mosquito-borne heartworm infections are deadly & untreatable in cats. 2/3
Many ectoparasite preventatives don’t contain eprinomectin. Please use those! Mosquito-borne heartworm infections are deadly & untreatable in cats. 2/3
Dozens of people replying to a DVM’s reel about flea/tick/heartworm preventatives getting expensive to say “and they gave my dog seizures; they’re all neurotoxins!!”
So it’s time to introduce the concept of MDR1 drug sensitivity, which is real and can be managed! www.vet.cornell.edu/departments-...
So it’s time to introduce the concept of MDR1 drug sensitivity, which is real and can be managed! www.vet.cornell.edu/departments-...
Drug sensitivity: MDR1
Overview Multidrug Resistance 1 (MDR1) drug sensitivity is the result of a genetic variant that can place dogs at risk of severe or life-threatening complications after taking particular medications a...
www.vet.cornell.edu
June 28, 2026 at 5:37 PM
Dozens of people replying to a DVM’s reel about flea/tick/heartworm preventatives getting expensive to say “and they gave my dog seizures; they’re all neurotoxins!!”
So it’s time to introduce the concept of MDR1 drug sensitivity, which is real and can be managed! www.vet.cornell.edu/departments-...
So it’s time to introduce the concept of MDR1 drug sensitivity, which is real and can be managed! www.vet.cornell.edu/departments-...
> estradiol
loratadine will increase the level or effect of estradiol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
loratadine will increase the level or effect of estradiol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
May 28, 2024 at 9:32 PM
> estradiol
loratadine will increase the level or effect of estradiol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
loratadine will increase the level or effect of estradiol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
Mein Hundemädchen hat es geschafft. 2 Spritzen, Medikamente und einmal Blutentnahme für den MDR1-Test, damit ich endlich Gewissheit habe. 💪
Ich hoffe es hilft, sonst muss ich in 3 Tagen noch einmal hin...
Ich hoffe es hilft, sonst muss ich in 3 Tagen noch einmal hin...
August 18, 2025 at 4:02 PM
Mein Hundemädchen hat es geschafft. 2 Spritzen, Medikamente und einmal Blutentnahme für den MDR1-Test, damit ich endlich Gewissheit habe. 💪
Ich hoffe es hilft, sonst muss ich in 3 Tagen noch einmal hin...
Ich hoffe es hilft, sonst muss ich in 3 Tagen noch einmal hin...
This was useful & informative for pet owners living in or near areas where screwworm has been found recently. One notable caveat: the product they recommend for cats, NexGuard Combo, can be highly toxic & even lethal for the ~1% of cats carrying MDR1 mutations. 1/3
Does your pet have screwworm? Know the signs and how to prevent it
Screwworms have not reached Central Texas, but officials urge pet owners to watch for symptoms and protect animals..
www.statesman.com
June 13, 2026 at 4:17 PM
This was useful & informative for pet owners living in or near areas where screwworm has been found recently. One notable caveat: the product they recommend for cats, NexGuard Combo, can be highly toxic & even lethal for the ~1% of cats carrying MDR1 mutations. 1/3
We also found that we could use PAC-1 to reverse this process: we took chemo-resistant, MDR1-high cells and cultured them in PAC-1 for a few weeks, and we found that this resulted in a 20-fold decrease in MDR1 expression and a 7-fold increase in chemotherapy sensitivity.
December 1, 2025 at 9:30 PM
We also found that we could use PAC-1 to reverse this process: we took chemo-resistant, MDR1-high cells and cultured them in PAC-1 for a few weeks, and we found that this resulted in a 20-fold decrease in MDR1 expression and a 7-fold increase in chemotherapy sensitivity.
A blinded ML prediction challenge on live, real-world drug discovery data, with possibly (one of) the largest MDR1-MDCKII cell permeability datasets to boot? What more do you need?
🦠 We’re excited to announce our first competition in partnership with @asapdiscovery.bsky.social and @omsf.io!
Test your skills across three sub-challenges revolving around SARS-CoV-2 and MERS-CoV Mpro🧵
Full details: polarishub.io/competitions
Blog: polarishub.io/blog/antivir...
Test your skills across three sub-challenges revolving around SARS-CoV-2 and MERS-CoV Mpro🧵
Full details: polarishub.io/competitions
Blog: polarishub.io/blog/antivir...
December 3, 2024 at 3:35 PM
A blinded ML prediction challenge on live, real-world drug discovery data, with possibly (one of) the largest MDR1-MDCKII cell permeability datasets to boot? What more do you need?
⚠️ Before you give ivermectin—or any medication—to your pet, STOP. ⚠️
Some dogs and cats carry a genetic mutation (called MDR1) that can make everyday drugs toxic. 🧬
Some dogs and cats carry a genetic mutation (called MDR1) that can make everyday drugs toxic. 🧬
November 5, 2025 at 4:14 PM
⚠️ Before you give ivermectin—or any medication—to your pet, STOP. ⚠️
Some dogs and cats carry a genetic mutation (called MDR1) that can make everyday drugs toxic. 🧬
Some dogs and cats carry a genetic mutation (called MDR1) that can make everyday drugs toxic. 🧬
Ich hab übrigens in 5 Jahren nicht einen einzigen mit Nebenwirkungen gehabt (mdr1 sollte aber abgeklärt sein!) aber dafür jede Menge mit teils schweren Zeckenerkrankungen mit fatalen Folgen. Find ich keine schwierige Entscheidung.
September 16, 2024 at 7:31 AM
Ich hab übrigens in 5 Jahren nicht einen einzigen mit Nebenwirkungen gehabt (mdr1 sollte aber abgeklärt sein!) aber dafür jede Menge mit teils schweren Zeckenerkrankungen mit fatalen Folgen. Find ich keine schwierige Entscheidung.
Additionally, we think that PAC-1 could have significant utility as part of a broader combination-therapy regimen, to delay or reverse MDR1 activation and enhance tumor sensitivity to SOC chemotherapies.
December 1, 2025 at 9:30 PM
Additionally, we think that PAC-1 could have significant utility as part of a broader combination-therapy regimen, to delay or reverse MDR1 activation and enhance tumor sensitivity to SOC chemotherapies.
🐕⚠️ Der MDR1-Gendefekt kann insbesondere bei einigen Hunderassen zu einer erhöhten Empfindlichkeit gegenüber bestimmten Tierarzneimitteln führen. Das BVL empfiehlt Tierhalterinnen und -haltern, im Verdachtsfall einen Tierarzt aufzusuchen.
➡️ sohub.io/jmw5
➡️ sohub.io/jmw5
July 30, 2025 at 9:34 AM
🐕⚠️ Der MDR1-Gendefekt kann insbesondere bei einigen Hunderassen zu einer erhöhten Empfindlichkeit gegenüber bestimmten Tierarzneimitteln führen. Das BVL empfiehlt Tierhalterinnen und -haltern, im Verdachtsfall einen Tierarzt aufzusuchen.
➡️ sohub.io/jmw5
➡️ sohub.io/jmw5
MDR1 mutasyonuna sahip kediler yaygın kullanılan ilaçlara karşı ciddi reaksiyon riski altındymış.
news.wsu.edu/press-releas...
news.wsu.edu/press-releas...
March 28, 2024 at 3:33 PM
MDR1 mutasyonuna sahip kediler yaygın kullanılan ilaçlara karşı ciddi reaksiyon riski altındymış.
news.wsu.edu/press-releas...
news.wsu.edu/press-releas...
🐶🐱 Bei Verdacht zum Tierarzt:
Der MDR1-Gendefekt kann vor allem bei einigen Hütehunden und Windhundrassen – aber vereinzelt auch bei Mischlingshunden und Katzen – zu einer höheren Empfindlichkeit gegenüber bestimmten Tierarzneimitteln führen.
👉 bvl.bund.de/MDR1-Defekt
Der MDR1-Gendefekt kann vor allem bei einigen Hütehunden und Windhundrassen – aber vereinzelt auch bei Mischlingshunden und Katzen – zu einer höheren Empfindlichkeit gegenüber bestimmten Tierarzneimitteln führen.
👉 bvl.bund.de/MDR1-Defekt
July 30, 2025 at 12:22 PM
🐶🐱 Bei Verdacht zum Tierarzt:
Der MDR1-Gendefekt kann vor allem bei einigen Hütehunden und Windhundrassen – aber vereinzelt auch bei Mischlingshunden und Katzen – zu einer höheren Empfindlichkeit gegenüber bestimmten Tierarzneimitteln führen.
👉 bvl.bund.de/MDR1-Defekt
Der MDR1-Gendefekt kann vor allem bei einigen Hütehunden und Windhundrassen – aber vereinzelt auch bei Mischlingshunden und Katzen – zu einer höheren Empfindlichkeit gegenüber bestimmten Tierarzneimitteln führen.
👉 bvl.bund.de/MDR1-Defekt
Danke für den Hinweis. Hatten wir bei Tiffi, die es nur knapp überlebt hat - Collie Mix mit MDR1, was man natürlich nicht weiß, wenn es ein Tierheimhund ist.
November 18, 2025 at 11:46 AM
Danke für den Hinweis. Hatten wir bei Tiffi, die es nur knapp überlebt hat - Collie Mix mit MDR1, was man natürlich nicht weiß, wenn es ein Tierheimhund ist.
Similarly, evolving cancer cells in chemotherapy causes MDR1 upregulation and resistance to a broad range of anti-cancer. But, these evolved drug-resistant cells exhibited significant collateral sensitivity to PAC-1.
December 1, 2025 at 9:30 PM
Similarly, evolving cancer cells in chemotherapy causes MDR1 upregulation and resistance to a broad range of anti-cancer. But, these evolved drug-resistant cells exhibited significant collateral sensitivity to PAC-1.
Excitingly, PAC-1 has entered clinical testing, where it has been well-tolerated and resulted in multiple patient responses. However, no biomarker capable of predicting sensitive tumors was reported. We think that MDR1 expression could be the missing biomarker.
December 1, 2025 at 9:30 PM
Excitingly, PAC-1 has entered clinical testing, where it has been well-tolerated and resulted in multiple patient responses. However, no biomarker capable of predicting sensitive tumors was reported. We think that MDR1 expression could be the missing biomarker.
Dogbook pisses me off sometimes lmao me saying that some dog ppl are too into fear mongering about flea and tick treatment isn't denying that pets with mdr1 are getting seizures from some flea meds holy fuck??? Of course I don't tell ppl to use hartz oh my god???
July 21, 2025 at 8:43 PM
Dogbook pisses me off sometimes lmao me saying that some dog ppl are too into fear mongering about flea and tick treatment isn't denying that pets with mdr1 are getting seizures from some flea meds holy fuck??? Of course I don't tell ppl to use hartz oh my god???
Es ist übrigens nur im Interesse der Tiere, da zB. selbst Parasitenprophylaxe bei nem Hund mit MDR1-Defekt problematisch sein kann (je nach Präparat). Und was bringt die gutgemeinte Entwurmung, wenn das Tier eigentlich einen Magen-Darm-Infekt hat und ggf noch Fieber? Das kann man nicht erraten.
February 20, 2026 at 5:03 PM
Es ist übrigens nur im Interesse der Tiere, da zB. selbst Parasitenprophylaxe bei nem Hund mit MDR1-Defekt problematisch sein kann (je nach Präparat). Und was bringt die gutgemeinte Entwurmung, wenn das Tier eigentlich einen Magen-Darm-Infekt hat und ggf noch Fieber? Das kann man nicht erraten.