Lipofuscin accumulation in squeletal muscle in pwME!! compared to LC and control.
Rob Wust
#MEAwarenessDay
#MyalgicEncephalomyelitis
#MECFSConference2025
Rob Wust
#MEAwarenessDay
#MyalgicEncephalomyelitis
#MECFSConference2025
May 12, 2025 at 12:50 PM
Lipofuscin accumulation in squeletal muscle in pwME!! compared to LC and control.
Rob Wust
#MEAwarenessDay
#MyalgicEncephalomyelitis
#MECFSConference2025
Rob Wust
#MEAwarenessDay
#MyalgicEncephalomyelitis
#MECFSConference2025
"There is something in the pwME serum that stresses the mitochondria"
Karl Johan Tronstad
#MECFSConference2025
#MyalgicEncephalomyelitis
#MEAwarenessDay
Karl Johan Tronstad
#MECFSConference2025
#MyalgicEncephalomyelitis
#MEAwarenessDay
May 12, 2025 at 1:35 PM
"There is something in the pwME serum that stresses the mitochondria"
Karl Johan Tronstad
#MECFSConference2025
#MyalgicEncephalomyelitis
#MEAwarenessDay
Karl Johan Tronstad
#MECFSConference2025
#MyalgicEncephalomyelitis
#MEAwarenessDay
Hypoperfusion and reduced systemic oxygen extraction induced microvascular alteration due to red blood cells' deformation in #pwME and LC
Christian Puta
#MECFSConference2025
#MEAwarenessDay
#MyalgicEncephalomyelitis
Christian Puta
#MECFSConference2025
#MEAwarenessDay
#MyalgicEncephalomyelitis
May 12, 2025 at 1:14 PM
Hypoperfusion and reduced systemic oxygen extraction induced microvascular alteration due to red blood cells' deformation in #pwME and LC
Christian Puta
#MECFSConference2025
#MEAwarenessDay
#MyalgicEncephalomyelitis
Christian Puta
#MECFSConference2025
#MEAwarenessDay
#MyalgicEncephalomyelitis
"There is no doubt about brain dissorders in ME"
Dr Yamamura
#MECFSConference2025
#MyalgicEncephalomyelitis
#MEAwarenessDay
Dr Yamamura
#MECFSConference2025
#MyalgicEncephalomyelitis
#MEAwarenessDay
May 12, 2025 at 2:49 PM
"There is no doubt about brain dissorders in ME"
Dr Yamamura
#MECFSConference2025
#MyalgicEncephalomyelitis
#MEAwarenessDay
Dr Yamamura
#MECFSConference2025
#MyalgicEncephalomyelitis
#MEAwarenessDay
Pediatric diagnosis of #MyalgicEncephalomyelitis is very late (5y) and we need to change that.
Kristian Sommerfelt, University of Bergen, Norway
#MECFSConference2025
Kristian Sommerfelt, University of Bergen, Norway
#MECFSConference2025
May 12, 2025 at 10:37 AM
Pediatric diagnosis of #MyalgicEncephalomyelitis is very late (5y) and we need to change that.
Kristian Sommerfelt, University of Bergen, Norway
#MECFSConference2025
Kristian Sommerfelt, University of Bergen, Norway
#MECFSConference2025
"There is a extreme severity of symptoms in Severe and VerySevere ME patients"
"The FUNCAP scale is not good enought to measure VS symptoms"
Kristian Sommerfelt, University of Bergen, Norway
#MyalgicEncephalomyelitis
#MECFSConference2025
"The FUNCAP scale is not good enought to measure VS symptoms"
Kristian Sommerfelt, University of Bergen, Norway
#MyalgicEncephalomyelitis
#MECFSConference2025
May 12, 2025 at 10:33 AM
"There is a extreme severity of symptoms in Severe and VerySevere ME patients"
"The FUNCAP scale is not good enought to measure VS symptoms"
Kristian Sommerfelt, University of Bergen, Norway
#MyalgicEncephalomyelitis
#MECFSConference2025
"The FUNCAP scale is not good enought to measure VS symptoms"
Kristian Sommerfelt, University of Bergen, Norway
#MyalgicEncephalomyelitis
#MECFSConference2025
Significant Increase of NRP1 (neuropilin) in half ME and LC patients.
Dr Yamamura
#MECFSConference2025
#MyalgicEncephalomyelitis
Dr Yamamura
#MECFSConference2025
#MyalgicEncephalomyelitis
May 12, 2025 at 2:52 PM
Significant Increase of NRP1 (neuropilin) in half ME and LC patients.
Dr Yamamura
#MECFSConference2025
#MyalgicEncephalomyelitis
Dr Yamamura
#MECFSConference2025
#MyalgicEncephalomyelitis
Small effects [off label drugs] can make a big difference in quality of life [of the patient].
Dr. Stingl
#MyalgicEncephalomyelitis
#MECFSConference2025
#MEAwarenessDay
Dr. Stingl
#MyalgicEncephalomyelitis
#MECFSConference2025
#MEAwarenessDay
May 12, 2025 at 10:01 AM
Small effects [off label drugs] can make a big difference in quality of life [of the patient].
Dr. Stingl
#MyalgicEncephalomyelitis
#MECFSConference2025
#MEAwarenessDay
Dr. Stingl
#MyalgicEncephalomyelitis
#MECFSConference2025
#MEAwarenessDay
Overview of IgG therapy in ME/CFS and PCS
Today at 11am
Nina Babel
#MECFSConference2025
#MyalgicEncephalomyelitis
Today at 11am
Nina Babel
#MECFSConference2025
#MyalgicEncephalomyelitis
May 13, 2025 at 8:35 AM
Overview of IgG therapy in ME/CFS and PCS
Today at 11am
Nina Babel
#MECFSConference2025
#MyalgicEncephalomyelitis
Today at 11am
Nina Babel
#MECFSConference2025
#MyalgicEncephalomyelitis
What a conference!!
And I missed so much!
Thanks Charité Fatigue Center and Dr Scheibenbogen for this.
See you tomorrow if we can ;)
#MECFSConference2025
#MEAwarenessDay
#MyalgizEncephalomyelitis
And I missed so much!
Thanks Charité Fatigue Center and Dr Scheibenbogen for this.
See you tomorrow if we can ;)
#MECFSConference2025
#MEAwarenessDay
#MyalgizEncephalomyelitis
May 12, 2025 at 4:01 PM
What a conference!!
And I missed so much!
Thanks Charité Fatigue Center and Dr Scheibenbogen for this.
See you tomorrow if we can ;)
#MECFSConference2025
#MEAwarenessDay
#MyalgizEncephalomyelitis
And I missed so much!
Thanks Charité Fatigue Center and Dr Scheibenbogen for this.
See you tomorrow if we can ;)
#MECFSConference2025
#MEAwarenessDay
#MyalgizEncephalomyelitis
Disease severity and Handgripp in pediatric. Mihatsch. POSTER
"Muscular strengh is severily reduced in ME patients.
Handgrip strength predicts ME CFS in 50-56%"
#MECFSConference2025
"Muscular strengh is severily reduced in ME patients.
Handgrip strength predicts ME CFS in 50-56%"
#MECFSConference2025
May 12, 2025 at 10:51 AM
Disease severity and Handgripp in pediatric. Mihatsch. POSTER
"Muscular strengh is severily reduced in ME patients.
Handgrip strength predicts ME CFS in 50-56%"
#MECFSConference2025
"Muscular strengh is severily reduced in ME patients.
Handgrip strength predicts ME CFS in 50-56%"
#MECFSConference2025
Brain connectivity analysis. Poster
Significant functional and connectivity differences in Motor and somatosensory aspects.
Possible altered sensory and motor processing
No structural differences found but possible affectation
#MECFSConference2025
Significant functional and connectivity differences in Motor and somatosensory aspects.
Possible altered sensory and motor processing
No structural differences found but possible affectation
#MECFSConference2025
May 12, 2025 at 10:42 AM
Brain connectivity analysis. Poster
Significant functional and connectivity differences in Motor and somatosensory aspects.
Possible altered sensory and motor processing
No structural differences found but possible affectation
#MECFSConference2025
Significant functional and connectivity differences in Motor and somatosensory aspects.
Possible altered sensory and motor processing
No structural differences found but possible affectation
#MECFSConference2025
"The ability of having a shower separates severe and very severe patients"
Kristian Sommerfelt, University of Bergen, Norway
#MyalgicEncephalomyelitis
#MEAwarenessDay
#MECFSConference2025
Kristian Sommerfelt, University of Bergen, Norway
#MyalgicEncephalomyelitis
#MEAwarenessDay
#MECFSConference2025
May 12, 2025 at 10:29 AM
"The ability of having a shower separates severe and very severe patients"
Kristian Sommerfelt, University of Bergen, Norway
#MyalgicEncephalomyelitis
#MEAwarenessDay
#MECFSConference2025
Kristian Sommerfelt, University of Bergen, Norway
#MyalgicEncephalomyelitis
#MEAwarenessDay
#MECFSConference2025
Gut Bacteria in pwME. POSTER
The compossition of the gut microbiome is altered
afffecting the neuronal system, by tryptophan pathways degradation, with effect in the gut-brain axis.
#MECFSConference2025
The compossition of the gut microbiome is altered
afffecting the neuronal system, by tryptophan pathways degradation, with effect in the gut-brain axis.
#MECFSConference2025
May 12, 2025 at 10:45 AM
Gut Bacteria in pwME. POSTER
The compossition of the gut microbiome is altered
afffecting the neuronal system, by tryptophan pathways degradation, with effect in the gut-brain axis.
#MECFSConference2025
The compossition of the gut microbiome is altered
afffecting the neuronal system, by tryptophan pathways degradation, with effect in the gut-brain axis.
#MECFSConference2025
Low-dose Rapamycin trial in PCS
RAP is mTOR inhibitor at high dose, immunomodulatory effect at low doses. Effects in viral activation, reverses immunosenescence, stabilices inflamatory cytokines.
Dose: single weekly dose of 1mg (2w)+ 2mg (2w)+ 4mg for 2 months
David Putrino
#MECFSConference2025
RAP is mTOR inhibitor at high dose, immunomodulatory effect at low doses. Effects in viral activation, reverses immunosenescence, stabilices inflamatory cytokines.
Dose: single weekly dose of 1mg (2w)+ 2mg (2w)+ 4mg for 2 months
David Putrino
#MECFSConference2025
May 13, 2025 at 10:31 AM
Low-dose Rapamycin trial in PCS
RAP is mTOR inhibitor at high dose, immunomodulatory effect at low doses. Effects in viral activation, reverses immunosenescence, stabilices inflamatory cytokines.
Dose: single weekly dose of 1mg (2w)+ 2mg (2w)+ 4mg for 2 months
David Putrino
#MECFSConference2025
RAP is mTOR inhibitor at high dose, immunomodulatory effect at low doses. Effects in viral activation, reverses immunosenescence, stabilices inflamatory cytokines.
Dose: single weekly dose of 1mg (2w)+ 2mg (2w)+ 4mg for 2 months
David Putrino
#MECFSConference2025
Microvascular dysfunction in MECFS. POSTER
Overexertion and muscle fatigue due to:
Capillaries are clogged (lumen space is thicker, endothelial activation and dysfunction, base mb thickening) in LC and ME patients which affects to oxygen extraction and diffusion.
#MECFSConference2025
#MyalgicE
Overexertion and muscle fatigue due to:
Capillaries are clogged (lumen space is thicker, endothelial activation and dysfunction, base mb thickening) in LC and ME patients which affects to oxygen extraction and diffusion.
#MECFSConference2025
#MyalgicE
May 12, 2025 at 11:00 AM
Microvascular dysfunction in MECFS. POSTER
Overexertion and muscle fatigue due to:
Capillaries are clogged (lumen space is thicker, endothelial activation and dysfunction, base mb thickening) in LC and ME patients which affects to oxygen extraction and diffusion.
#MECFSConference2025
#MyalgicE
Overexertion and muscle fatigue due to:
Capillaries are clogged (lumen space is thicker, endothelial activation and dysfunction, base mb thickening) in LC and ME patients which affects to oxygen extraction and diffusion.
#MECFSConference2025
#MyalgicE
Immunoadsorption trial in ME/CFS
The worstening of VSpwME is due to an outpatient treatment. They are very weak peope.
Elisa Stein
#MECFSConference2025
#MyalgicEncephalomyelitis
The worstening of VSpwME is due to an outpatient treatment. They are very weak peope.
Elisa Stein
#MECFSConference2025
#MyalgicEncephalomyelitis
May 13, 2025 at 8:24 AM
Immunoadsorption trial in ME/CFS
The worstening of VSpwME is due to an outpatient treatment. They are very weak peope.
Elisa Stein
#MECFSConference2025
#MyalgicEncephalomyelitis
The worstening of VSpwME is due to an outpatient treatment. They are very weak peope.
Elisa Stein
#MECFSConference2025
#MyalgicEncephalomyelitis
Transcriptome analysis identifies immune dysregulation in peripheral immune cells of ME/CFS patients.
There are shifts in the monocytes and NK cells, and transcriptomes, between LC and recovered group.
Anna Aschenbrenner
#MECFSConference2025
#MEAwarenessDay
There are shifts in the monocytes and NK cells, and transcriptomes, between LC and recovered group.
Anna Aschenbrenner
#MECFSConference2025
#MEAwarenessDay
May 12, 2025 at 3:54 PM
Transcriptome analysis identifies immune dysregulation in peripheral immune cells of ME/CFS patients.
There are shifts in the monocytes and NK cells, and transcriptomes, between LC and recovered group.
Anna Aschenbrenner
#MECFSConference2025
#MEAwarenessDay
There are shifts in the monocytes and NK cells, and transcriptomes, between LC and recovered group.
Anna Aschenbrenner
#MECFSConference2025
#MEAwarenessDay
Infection type does NOT drive transcriptional shifts: it doesn't matter the virus, there is a shift in the genes transcribed after an infection.
Anna Aschenbrenner
#MECFSConference2025
#MEAwarenessDay
Anna Aschenbrenner
#MECFSConference2025
#MEAwarenessDay
May 12, 2025 at 3:55 PM
Infection type does NOT drive transcriptional shifts: it doesn't matter the virus, there is a shift in the genes transcribed after an infection.
Anna Aschenbrenner
#MECFSConference2025
#MEAwarenessDay
Anna Aschenbrenner
#MECFSConference2025
#MEAwarenessDay
RAMAN spectroscopic profiling of immune cells. POSTER
JENA univ.
We see an upregulation for the patient's immune cells after the test (response to exercise).
#MECFSConference2025
#MEAwarenessDay
#MyalgicEncephalomyelitis
JENA univ.
We see an upregulation for the patient's immune cells after the test (response to exercise).
#MECFSConference2025
#MEAwarenessDay
#MyalgicEncephalomyelitis
May 12, 2025 at 10:55 AM
RAMAN spectroscopic profiling of immune cells. POSTER
JENA univ.
We see an upregulation for the patient's immune cells after the test (response to exercise).
#MECFSConference2025
#MEAwarenessDay
#MyalgicEncephalomyelitis
JENA univ.
We see an upregulation for the patient's immune cells after the test (response to exercise).
#MECFSConference2025
#MEAwarenessDay
#MyalgicEncephalomyelitis
"There is a sereve lack of profound research of medication for #MyalgicEncephalomyelitis"
Bernhard Wörmann, Charité
#MECFSConference2025
Bernhard Wörmann, Charité
#MECFSConference2025
May 12, 2025 at 10:09 AM
"There is a sereve lack of profound research of medication for #MyalgicEncephalomyelitis"
Bernhard Wörmann, Charité
#MECFSConference2025
Bernhard Wörmann, Charité
#MECFSConference2025
Metabolomics & OMICs
Hypothesis: impaired vascular function (less blood in brain) and metabolic changes and energy stress after exercise, that yields in hypoxia and increased lactate, then to metabolic adaptations to energy stress.
Karl Johan Tronstad
#MECFSConference2025
#MyalgicEncephalomyelitis
Hypothesis: impaired vascular function (less blood in brain) and metabolic changes and energy stress after exercise, that yields in hypoxia and increased lactate, then to metabolic adaptations to energy stress.
Karl Johan Tronstad
#MECFSConference2025
#MyalgicEncephalomyelitis
May 12, 2025 at 1:32 PM
Metabolomics & OMICs
Hypothesis: impaired vascular function (less blood in brain) and metabolic changes and energy stress after exercise, that yields in hypoxia and increased lactate, then to metabolic adaptations to energy stress.
Karl Johan Tronstad
#MECFSConference2025
#MyalgicEncephalomyelitis
Hypothesis: impaired vascular function (less blood in brain) and metabolic changes and energy stress after exercise, that yields in hypoxia and increased lactate, then to metabolic adaptations to energy stress.
Karl Johan Tronstad
#MECFSConference2025
#MyalgicEncephalomyelitis
Plasma cell targeting in ME/CFS
Daratumumab, an aab IgGKappa against mieloma, to be used with big expectations in a clinical trial for #MyalgicEncephalomyelitis lacking private Funding (only from a Norwegian ME assoc.)
Øystein Fluge
#MECFSConference2025
#MEAwarenessMonth
Daratumumab, an aab IgGKappa against mieloma, to be used with big expectations in a clinical trial for #MyalgicEncephalomyelitis lacking private Funding (only from a Norwegian ME assoc.)
Øystein Fluge
#MECFSConference2025
#MEAwarenessMonth
May 13, 2025 at 7:45 AM
Plasma cell targeting in ME/CFS
Daratumumab, an aab IgGKappa against mieloma, to be used with big expectations in a clinical trial for #MyalgicEncephalomyelitis lacking private Funding (only from a Norwegian ME assoc.)
Øystein Fluge
#MECFSConference2025
#MEAwarenessMonth
Daratumumab, an aab IgGKappa against mieloma, to be used with big expectations in a clinical trial for #MyalgicEncephalomyelitis lacking private Funding (only from a Norwegian ME assoc.)
Øystein Fluge
#MECFSConference2025
#MEAwarenessMonth
Low-dose Naltrexone (LDN) and Mestinon trial in ME/CFS
Randomized Clinical trial Baby Lift
60 mg (20mg*3 per day) Pyridostigmine and/or mestinon
Target: increase preload after autonomic improvement. Improves exercise tolerance
David Systrom
#MECFSConference2025
#MyalgicEncephalomyelitis
Randomized Clinical trial Baby Lift
60 mg (20mg*3 per day) Pyridostigmine and/or mestinon
Target: increase preload after autonomic improvement. Improves exercise tolerance
David Systrom
#MECFSConference2025
#MyalgicEncephalomyelitis
May 13, 2025 at 10:17 AM
Low-dose Naltrexone (LDN) and Mestinon trial in ME/CFS
Randomized Clinical trial Baby Lift
60 mg (20mg*3 per day) Pyridostigmine and/or mestinon
Target: increase preload after autonomic improvement. Improves exercise tolerance
David Systrom
#MECFSConference2025
#MyalgicEncephalomyelitis
Randomized Clinical trial Baby Lift
60 mg (20mg*3 per day) Pyridostigmine and/or mestinon
Target: increase preload after autonomic improvement. Improves exercise tolerance
David Systrom
#MECFSConference2025
#MyalgicEncephalomyelitis
Immunoadsorption in severely ill ME/CFS patients
HELP apheresis is NOT IAd
Reduces IgG. Used in autoimmune diseases
"a pwME bedriden, yes, but involvement of the brain or the heart is also severe disease"
Georg Schlieper
#MECFSConference2025
#MyalgicEncephalomyelitis
HELP apheresis is NOT IAd
Reduces IgG. Used in autoimmune diseases
"a pwME bedriden, yes, but involvement of the brain or the heart is also severe disease"
Georg Schlieper
#MECFSConference2025
#MyalgicEncephalomyelitis
May 13, 2025 at 8:32 AM
Immunoadsorption in severely ill ME/CFS patients
HELP apheresis is NOT IAd
Reduces IgG. Used in autoimmune diseases
"a pwME bedriden, yes, but involvement of the brain or the heart is also severe disease"
Georg Schlieper
#MECFSConference2025
#MyalgicEncephalomyelitis
HELP apheresis is NOT IAd
Reduces IgG. Used in autoimmune diseases
"a pwME bedriden, yes, but involvement of the brain or the heart is also severe disease"
Georg Schlieper
#MECFSConference2025
#MyalgicEncephalomyelitis