Unveiling a signaling pathway with implications for pediatric cardiovascular diseases associated with right ventricular pressure overload: doi.org/10.1172/jci....
Hu et al. show that RVPO impairs cardiomyocyte maturation via the MEF2D/BIN1 axis & restoring BIN1 rescues the defect
Hu et al. show that RVPO impairs cardiomyocyte maturation via the MEF2D/BIN1 axis & restoring BIN1 rescues the defect
September 24, 2026 at 4:05 PM
Unveiling a signaling pathway with implications for pediatric cardiovascular diseases associated with right ventricular pressure overload: doi.org/10.1172/jci....
Hu et al. show that RVPO impairs cardiomyocyte maturation via the MEF2D/BIN1 axis & restoring BIN1 rescues the defect
Hu et al. show that RVPO impairs cardiomyocyte maturation via the MEF2D/BIN1 axis & restoring BIN1 rescues the defect
🆕 in JMCC: HDAC7 protects against pathological cardiac hypertrophy and remodeling by interacting with and repressing MEF2D. The HDAC7-MEF2D axis highlights a potential epigenetic strategy to prevent heart failure progression 💪🏼
www.jmcc-online.com/article/S002...
www.jmcc-online.com/article/S002...
September 22, 2026 at 12:02 PM
🆕 in JMCC: HDAC7 protects against pathological cardiac hypertrophy and remodeling by interacting with and repressing MEF2D. The HDAC7-MEF2D axis highlights a potential epigenetic strategy to prevent heart failure progression 💪🏼
www.jmcc-online.com/article/S002...
www.jmcc-online.com/article/S002...
MEF2D-fusion BCP-ALL lacks definitive targeted therapies.
This study identifies the CABIN1-derived peptide CB15 as a direct MEF2D-fusion inhibitor that suppresses #Oncogenic transcription and induces #Leukemia cell death.
#STTT #OpenAccess: doi.org/10.1038/s413...
This study identifies the CABIN1-derived peptide CB15 as a direct MEF2D-fusion inhibitor that suppresses #Oncogenic transcription and induces #Leukemia cell death.
#STTT #OpenAccess: doi.org/10.1038/s413...
August 22, 2026 at 6:20 AM
MEF2D-fusion BCP-ALL lacks definitive targeted therapies.
This study identifies the CABIN1-derived peptide CB15 as a direct MEF2D-fusion inhibitor that suppresses #Oncogenic transcription and induces #Leukemia cell death.
#STTT #OpenAccess: doi.org/10.1038/s413...
This study identifies the CABIN1-derived peptide CB15 as a direct MEF2D-fusion inhibitor that suppresses #Oncogenic transcription and induces #Leukemia cell death.
#STTT #OpenAccess: doi.org/10.1038/s413...
migraine pathophysiology.
RESULTS: Eight EDC-related genes were identified as significantly associated with migraine risk, of which MEF2D, OSBPL10, B9D2, HTRA1 and PRDM16 were classified as high- or medium-evidence genes. (🧵 8/14)
RESULTS: Eight EDC-related genes were identified as significantly associated with migraine risk, of which MEF2D, OSBPL10, B9D2, HTRA1 and PRDM16 were classified as high- or medium-evidence genes. (🧵 8/14)
June 9, 2026 at 10:51 AM
migraine pathophysiology.
RESULTS: Eight EDC-related genes were identified as significantly associated with migraine risk, of which MEF2D, OSBPL10, B9D2, HTRA1 and PRDM16 were classified as high- or medium-evidence genes. (🧵 8/14)
RESULTS: Eight EDC-related genes were identified as significantly associated with migraine risk, of which MEF2D, OSBPL10, B9D2, HTRA1 and PRDM16 were classified as high- or medium-evidence genes. (🧵 8/14)
The paper presents the case of a 39-years old woman where Optical Genome Mapping detected a previously undetected chromothripsis-like pattern of chromosome 1 including a cryptic rearrangement which was confirmed by "targeted" RNA sequencing. imagebank.hematology...
4/4
4/4
B-cell acute lymphoblastic leukemia with MEF2D::BCL9 rearrangement mimicking a Burkitt lymphoma
A 39-year-old woman presented with widespread lymphadenopathy, leukocytosis (25.1 × 109/L), anemia (hemoglobin, 9.6 g/dL), thrombocytopenia (23 × 109/
imagebank.hematology.org
November 21, 2024 at 12:31 AM
The paper presents the case of a 39-years old woman where Optical Genome Mapping detected a previously undetected chromothripsis-like pattern of chromosome 1 including a cryptic rearrangement which was confirmed by "targeted" RNA sequencing. imagebank.hematology...
4/4
4/4
The University Hopital of Grenoble, France, publishes a paper titled :
"B-cell acute lymphoblastic leukemia with MEF2D::BCL9 rearrangement mimicking a Burkitt lymphoma"
where they highlight the growing importance of cytogenetic and molecular tools for the critical subclassification of B-ALL
2/4
"B-cell acute lymphoblastic leukemia with MEF2D::BCL9 rearrangement mimicking a Burkitt lymphoma"
where they highlight the growing importance of cytogenetic and molecular tools for the critical subclassification of B-ALL
2/4
November 21, 2024 at 12:31 AM
The University Hopital of Grenoble, France, publishes a paper titled :
"B-cell acute lymphoblastic leukemia with MEF2D::BCL9 rearrangement mimicking a Burkitt lymphoma"
where they highlight the growing importance of cytogenetic and molecular tools for the critical subclassification of B-ALL
2/4
"B-cell acute lymphoblastic leukemia with MEF2D::BCL9 rearrangement mimicking a Burkitt lymphoma"
where they highlight the growing importance of cytogenetic and molecular tools for the critical subclassification of B-ALL
2/4
The muscle specific MEF2Dα2 isoform promotes muscle ketolysis and running capacity in mice
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
The muscle specific MEF2Dα2 isoform promotes muscle ketolysis and running capacity in mice | EMBO reports
imageimageThe muscle specific MEF2Dα2 isoform is produced by regulated postnatal alternative
splicing. Deletion of this exon in mice causes reduced running capacity and muscle
ketolytic gene expressio...
www.embopress.org
September 17, 2025 at 5:30 PM
The muscle specific MEF2Dα2 isoform promotes muscle ketolysis and running capacity in mice
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
詳細詰めてる時が一番夢中になれる 分子学的にどうこう、とか細胞表面抗原とか、そういうお話は私がすることじゃないかなと思うから流すし白血病もM0-7飛ばしてALLだけに絞るつもりなんだけどそれはそれとしてCMLとM2、APL(M3)、M5、ALLの中でもMEF2D-BCL9とかBCP-ABLとかは少しだけまたどこかで出したいな……という気持ちはある
多くの子供たちに関わることをお話ししていきたい気持ちはもちろんあるのだけど どうしても引っ張られちゃうな
多くの子供たちに関わることをお話ししていきたい気持ちはもちろんあるのだけど どうしても引っ張られちゃうな
February 21, 2026 at 3:21 PM
詳細詰めてる時が一番夢中になれる 分子学的にどうこう、とか細胞表面抗原とか、そういうお話は私がすることじゃないかなと思うから流すし白血病もM0-7飛ばしてALLだけに絞るつもりなんだけどそれはそれとしてCMLとM2、APL(M3)、M5、ALLの中でもMEF2D-BCL9とかBCP-ABLとかは少しだけまたどこかで出したいな……という気持ちはある
多くの子供たちに関わることをお話ししていきたい気持ちはもちろんあるのだけど どうしても引っ張られちゃうな
多くの子供たちに関わることをお話ししていきたい気持ちはもちろんあるのだけど どうしても引っ張られちゃうな
RRIDs were included in this paper. Thanks for making your methods matter! #reproducibility #methodsmatter #STMpublishing
MEF2D regulates T-cell function via CD70-CD27 signaling and promotes immune evasion in hepatocellular carcinoma
doi.org
October 8, 2025 at 7:00 AM
RRIDs were included in this paper. Thanks for making your methods matter! #reproducibility #methodsmatter #STMpublishing
RRIDs were included in this Andrology paper. Thanks for making your methods matter! #methodsmatter #accelerateopenscience #RRID
Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk-stimulated mouse MA-10 Leydig cells
doi.org
May 20, 2025 at 7:01 AM
RRIDs were included in this Andrology paper. Thanks for making your methods matter! #methodsmatter #accelerateopenscience #RRID
다중 오믹스 통합 및 차등 유전자 발현 분석을 통해 조절 기전을 규명했다. 마지막으로, 우선순위가 부여된 내분비 교란 물질(EDC)과 편두통 병리생리학에 관여하는 분자 표적 간의 상호작용을 평가하기 위해 분자 도킹 및 분자 역학 시뮬레이션을 수행했다.
결과: 8개의 EDC 관련 유전자가 편두통 위험과 유의미한 관련이 있는 것으로 확인되었으며, 그중 MEF2D, OSBPL10, B9D2, HTRA1 및 PRDM16은 높은 또는 중간 수준의 증거를 가진 유전자로 분류되었다. (🧵 4/7)
결과: 8개의 EDC 관련 유전자가 편두통 위험과 유의미한 관련이 있는 것으로 확인되었으며, 그중 MEF2D, OSBPL10, B9D2, HTRA1 및 PRDM16은 높은 또는 중간 수준의 증거를 가진 유전자로 분류되었다. (🧵 4/7)
June 9, 2026 at 10:57 AM
다중 오믹스 통합 및 차등 유전자 발현 분석을 통해 조절 기전을 규명했다. 마지막으로, 우선순위가 부여된 내분비 교란 물질(EDC)과 편두통 병리생리학에 관여하는 분자 표적 간의 상호작용을 평가하기 위해 분자 도킹 및 분자 역학 시뮬레이션을 수행했다.
결과: 8개의 EDC 관련 유전자가 편두통 위험과 유의미한 관련이 있는 것으로 확인되었으며, 그중 MEF2D, OSBPL10, B9D2, HTRA1 및 PRDM16은 높은 또는 중간 수준의 증거를 가진 유전자로 분류되었다. (🧵 4/7)
결과: 8개의 EDC 관련 유전자가 편두통 위험과 유의미한 관련이 있는 것으로 확인되었으며, 그중 MEF2D, OSBPL10, B9D2, HTRA1 및 PRDM16은 높은 또는 중간 수준의 증거를 가진 유전자로 분류되었다. (🧵 4/7)
B-ALL 分子亞型的預後分層
良好：ETV6::RUNX1〔t(12;21)〕、DUX4-r（即使合併 IKZF1 缺失）、hyperdiploidy（尤其 trisomy 4、10、17）。
高風險：MEF2D-r、TCF3::HLF、BCR::ABL1-like、hypodiploidy、KMT2A-r。
#血液專科
https://hema-2026.hsiehting.com/q/114-014
良好：ETV6::RUNX1〔t(12;21)〕、DUX4-r（即使合併 IKZF1 缺失）、hyperdiploidy（尤其 trisomy 4、10、17）。
高風險：MEF2D-r、TCF3::HLF、BCR::ABL1-like、hypodiploidy、KMT2A-r。
#血液專科
https://hema-2026.hsiehting.com/q/114-014
August 3, 2026 at 7:39 AM
B-ALL 分子亞型的預後分層
良好：ETV6::RUNX1〔t(12;21)〕、DUX4-r（即使合併 IKZF1 缺失）、hyperdiploidy（尤其 trisomy 4、10、17）。
高風險：MEF2D-r、TCF3::HLF、BCR::ABL1-like、hypodiploidy、KMT2A-r。
#血液專科
https://hema-2026.hsiehting.com/q/114-014
良好：ETV6::RUNX1〔t(12;21)〕、DUX4-r（即使合併 IKZF1 缺失）、hyperdiploidy（尤其 trisomy 4、10、17）。
高風險：MEF2D-r、TCF3::HLF、BCR::ABL1-like、hypodiploidy、KMT2A-r。
#血液專科
https://hema-2026.hsiehting.com/q/114-014
Thrilled to share our newest study in @ScienceMagazine. We created Boolean mice and CRISPR screened the heck outta ILC2s
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mef2d potentiates type-2 immune responses and allergic lung inflammation
Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and protective immune responses. Their production depends on the transcription factor GATA3, which is further elevate...
www.science.org
August 14, 2024 at 9:43 PM
Thrilled to share our newest study in @ScienceMagazine. We created Boolean mice and CRISPR screened the heck outta ILC2s
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
MEF2D impairs mitochondrial respiration, glucose-stimulated insulin secretion, and survival in INS-1 β-cells. https://www.biorxiv.org/content/10.64898/2026.03.07.709963v1
March 9, 2026 at 8:31 AM
MEF2D impairs mitochondrial respiration, glucose-stimulated insulin secretion, and survival in INS-1 β-cells. https://www.biorxiv.org/content/10.64898/2026.03.07.709963v1
Hsa_circ_0013729 Drives Gastric Cancer via MEF2D Regulation
Recent advancements in cancer research continue to uncover complex mechanisms influencing the progression of various malignancies. A particularly intriguing study from a team of researchers led by Li, H. et al. delves into the role of…
Recent advancements in cancer research continue to uncover complex mechanisms influencing the progression of various malignancies. A particularly intriguing study from a team of researchers led by Li, H. et al. delves into the role of…
Hsa_circ_0013729 Drives Gastric Cancer via MEF2D Regulation
Recent advancements in cancer research continue to uncover complex mechanisms influencing the progression of various malignancies. A particularly intriguing study from a team of researchers led by Li, H. et al. delves into the role of circular RNAs in gastric cancer. This pivotal research focuses on Hsa_circ_0013729, which emerges as a significant player in promoting the progression of gastric cancer. The study highlights the intricate relationship between Hsa_circ_0013729 and the gene MEF2D, suggesting a multifaceted regulatory role that may provide new therapeutic targets for combating this aggressive cancer.
scienmag.com
August 30, 2025 at 6:01 PM
Hsa_circ_0013729 Drives Gastric Cancer via MEF2D Regulation
Recent advancements in cancer research continue to uncover complex mechanisms influencing the progression of various malignancies. A particularly intriguing study from a team of researchers led by Li, H. et al. delves into the role of…
Recent advancements in cancer research continue to uncover complex mechanisms influencing the progression of various malignancies. A particularly intriguing study from a team of researchers led by Li, H. et al. delves into the role of…
From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells.
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
December 9, 2024 at 5:18 PM
From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells.
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
The muscle specific MEF2Dα2 isoform is generated by postnatal alternative #splicing. It regulates skeletal muscle ketogenic gene expression, blood ketone levels and exercise capacity.
#metabolism
-> www.embopress.org/doi/full/10....
#metabolism
-> www.embopress.org/doi/full/10....
September 16, 2025 at 2:46 PM
The muscle specific MEF2Dα2 isoform is generated by postnatal alternative #splicing. It regulates skeletal muscle ketogenic gene expression, blood ketone levels and exercise capacity.
#metabolism
-> www.embopress.org/doi/full/10....
#metabolism
-> www.embopress.org/doi/full/10....
Researchers identified CUDC-907, a dual PI3K/#HDAC inhibitor, to suppress #MEF2D fusion-driven BCP-ALL, inducing #Apoptosis and disrupting #Oncogenic signaling, highlighting its promise for precision therapy.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
March 31, 2026 at 6:00 PM
Researchers identified CUDC-907, a dual PI3K/#HDAC inhibitor, to suppress #MEF2D fusion-driven BCP-ALL, inducing #Apoptosis and disrupting #Oncogenic signaling, highlighting its promise for precision therapy.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Calcineurin-binding protein 1 (#CABIN1) directly binds to the #MEF2D #FusionProtein, thereby affecting cell survival and modulating the expression of core regulatory factors of BCP-ALL in the MEF2D::HNRNPUL1 cell lines.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
December 29, 2025 at 12:30 PM
Calcineurin-binding protein 1 (#CABIN1) directly binds to the #MEF2D #FusionProtein, thereby affecting cell survival and modulating the expression of core regulatory factors of BCP-ALL in the MEF2D::HNRNPUL1 cell lines.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
CABIN1 effectively targets MEF2D fusion by directly binding the MEF2D fusion protein, thereby affecting #CellSurvival and modulating the expression of core regulatory factors of #BCPALL in the MEF2D::HNRNPUL1 cell lines. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
October 16, 2025 at 10:00 AM
CABIN1 effectively targets MEF2D fusion by directly binding the MEF2D fusion protein, thereby affecting #CellSurvival and modulating the expression of core regulatory factors of #BCPALL in the MEF2D::HNRNPUL1 cell lines. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
CUDC-907 is a highly potent dual PI3K/HDAC inhibitor that exhibits excellent #cytotoxicity and high selectivity against MEF2D fusion–expressing B-cell precursor acute lymphoblastic #leukemia (#BCPALL) cells. #medsky
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
October 13, 2025 at 6:42 AM
CUDC-907 is a highly potent dual PI3K/HDAC inhibitor that exhibits excellent #cytotoxicity and high selectivity against MEF2D fusion–expressing B-cell precursor acute lymphoblastic #leukemia (#BCPALL) cells. #medsky
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
CUDC-907 is a highly potent dual-target PI3K/HDAC inhibitor with excellent cytotoxicity and high-selectivity against MEF2D fusion-expressing B-cell precursor acute lymphoblastic #leukemia (#BCPALL) cells. #medsky
#OpenAccess: www.nature.com/articles/s41...
#OpenAccess: www.nature.com/articles/s41...
August 7, 2025 at 3:04 PM
CUDC-907 is a highly potent dual-target PI3K/HDAC inhibitor with excellent cytotoxicity and high-selectivity against MEF2D fusion-expressing B-cell precursor acute lymphoblastic #leukemia (#BCPALL) cells. #medsky
#OpenAccess: www.nature.com/articles/s41...
#OpenAccess: www.nature.com/articles/s41...
MEF2D impairs mitochondrial respiration, glucose-stimulated insulin secretion, and survival in INS-1 β-cells. https://www.biorxiv.org/content/10.64898/2026.03.07.709963v1
March 9, 2026 at 8:31 AM
MEF2D impairs mitochondrial respiration, glucose-stimulated insulin secretion, and survival in INS-1 β-cells. https://www.biorxiv.org/content/10.64898/2026.03.07.709963v1
Researchers found that MEF2D blocks T-cell–mediated antitumor immunity by regulating the expression of CD70 and activating the CD70-CD27 signaling axis. Manipulating this pathway may improve the efficacy of liver cancer immunotherapy. Learn more: ow.ly/nh8n50XFUxU.
MEF2D regulates T-cell function via CD70-CD27 signaling and promotes immune evasion in hepatocellular carcinoma
Abstract. Hepatocellular carcinoma (HCC) stands as one of the most prevalent and fatal malignancies globally, posing a persistent challenge in its treatmen
ow.ly
December 8, 2025 at 7:37 PM
Researchers found that MEF2D blocks T-cell–mediated antitumor immunity by regulating the expression of CD70 and activating the CD70-CD27 signaling axis. Manipulating this pathway may improve the efficacy of liver cancer immunotherapy. Learn more: ow.ly/nh8n50XFUxU.