Definitions and explanations of MR terms and sequences.

Leaders from Toronto’s academic health research community today launched the greatest multi-site collaboration and advancement in clinical imaging research the city has seen…

Interpretation of numerous MRI data may be incorrect: blood flow is not a reliable indicator of brain activity.

Prof Peter zu Eulenburg from the Institute of Neuroradiology at the LMU Hospital in Munich, in collaboration with French and Italian polar researchers, has put the first mobile magnetic resonance imag...

Neuroimaging enables rich noninvasive measurements of human brain activity, but translating such data into neuroscientific insights and clinical applications requires complex analyses and collaboratio...

Bruker honors researchers in the field of preclinical imaging with our MRI Award which is presented at the ISMRM Conference.

Bruker honors researchers in the field of preclinical imaging with our MRI Award which is presented at the ISMRM Conference.

FDA clears next-gen Swoop® MRI system with Optive AI™ software, bringing a transformative leap in image quality with enhanced usability and comfort.

Lactate is a key metabolic driver in oncology and immunology. Even in the presence of physiological oxygen levels, most cancer cells upregulate anaerobic glycolysis, resulting in abnormal lactate production and accumulation in the tumor microenvironment. The development of more effective, sensitive, and safe probes for detecting extracellular lactate holds the potential to significantly impact cancer metabolic profiling and staging significantly. Macrocyclic-based PARACEST agents have been reported to act as shift reagents (SRs) and detect extracellular lactate via chemical exchange saturation transfer (CEST) MRI. Here, we introduce a new family of SRs based on the PCTA ligand, an inherently stable and kinetically inert group of molecules with the potential for (pre)clinical translation. We observed that Yb-PCTA and Eu-PCTA can significantly shift lactate –OH signals in the CEST spectra. In vitro, CEST MRI experiments proved that imaging extracellular lactate specifically with these complexes is feasible even in the presence of competing small metabolites in blood and in the tumor microenvironment. In vivo preclinical imaging showed that Yb-PCTA can be safely administered intravenously in mice to detect extracellular lactate noninvasively. This work contributes to the field of precision imaging in medicine and provides evidence that the PCTA-ligand is a valuable scaffold for developing molecular and metabolic imaging sensors.

The FDA is amplifying a recall effort underway at Siemens Healthineers related to several of its MRI machines, linked to their helium containment and the potential for a dangerous rupture | The FDA is...

Bruker honors researchers in the field of preclinical imaging with our MRI Award which is presented at the ISMRM Conference.

Something you don't see everyday... | 72 comments on LinkedIn