Safety and efficacy of staged, bilateral magnetic resonance-guided focused ultrasound pallidothalamic tractotomy for motor complications of Parkinson's disease: a prospective, multicentre, single-arm trial

www.thelancet.com/journals/lan...

New publication using Lead-DBS:
In this article by Mazurek et al., the authors tested whether ICD‑10‑derived frailty (RAI) and age predicted outcomes after unilateral MRgFUS thalamotomy for essential tremor in 481 patients, finding ne...

Check out the paper here 👇👇
https://doi.org/10.1002/mds.70435

Tremor Control and Patient Reported Outcomes after Bilateral Focused Ultrasound Thalamotomy for Essential Tremor

Authors:Nathan J. Pertsch MD, Kazuki Sakakura MD, PhD, Julia M. Mueller BS, Dustin Kim BA, Yoo Jin Ahn BS, Lucinda T. Chiu MD, Jesus Roberto Varela MD, Havish Gattu BS, Shama Patel NP,…

With more on bilateral MRgFUS pallidothalamic tractotomy for Parkinson's disease in a linked Comment: www.thelancet.com/journals/lan...

ICYMI in our July issue: staged bilateral magnetic resonance-guided focused ultrasound (MRgFUS) pallidothalamic tractotomy for Parkinson's disease, investigated in a multicentre trial: www.thelancet.com/journals/lan...

Classic publication using Lead-DBS:
In this article by Germann et al., the authors compared DBS and MRgFUS targeting in 118 essential tremor patients via stimulation/lesion mapping, probabilistic efficacy...

Check out the paper here 👇👇
https://jnnp.bmj.com/content/early/2023/09/18/jnnp-2022-330795

Science Briefing

Unilateral MRgFUS Tractotomy Shows Risk-Benefit Trade-off in Parkinson's Personalized briefing Discovery of the day · Neurology Safety and efficacy of staged, bilateral magnetic resonance-guided focused ultrasound pallidothalamic tractotomy for motor complications of Parkinson's…

Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is a non-invasive, incisionless procedure that uses high-intensity sound waves to precisely destroy problematic brain tissue causing Parkinson's symptoms. It is generally used for patients with medication-resistant tremors or severe dyskinesia.

In our July issue: a muticentre trial of staged bilateral magnetic resonance-guided focused ultrasound (MRgFUS) pallidothalamic tractotomy for Parkinson's disease www.thelancet.com/journals/lan...

Breakthrough Study Reveals Focused Ultrasound as Effective Treatment for Parkinson's Disease Relief#USA#Miami#Parkinson's_Disease#MRgFUS#Insightec

bilateral procedures demand rigorous patient selection and counselling regarding cumulative risks.

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Post-bilateral treatment complications in speech, gait & balance are consistent with historical data for bilateral ablative procedures for movement disorders. Although unilateral MRgFUS pallidothalamic tractotomy was beneficial in the study,

#Medsky🧪 #neurosky #publichealth @thelancetneuro.bsky.social Unilateral MRgFUS pallidothalamic tractotomy demonstrated safety & efficacy for #Parkinson'sdisease motor complications; however, bilateral treatment offered small motor gains while increasing persistent moderate or severe adverse events.

Unilateral MRgFUS pallidothalamic tractotomy=safe & efficacious, but bilateral treatment offered small motor gains while increasing persistent moderate or severe adverse events. Post-bilateral treatment complications (speech, gait, & balance) consistent with historical data

Results of a prospective, multicentre, single-arm trial assessing safety & efficacy of staged, bilateral magnetic resonance-guided focused ultrasound (MRgFUS) pallidothalamic tractotomy for motor complications of #Parkinsons have been published
www.thelancet.com/journals/lan...

predominantly by right-sided headaches and unresponsive to multiple preventive and acute treatments, underwent MRgFUS VIM thalamotomy for severe ET. After the procedure, her tremor resolved, and her chronic migraines were no longer reported during long-term follow-up. (🧵 3/7)

MR-guided focused ultrasound (MRgFUS) ventral intermediate nucleus (VIM) thalamotomy is an incisionless treatment for medication-refractory essential tremor (ET).

OBSERVATIONS: A 76-year-old woman with a 40-year history of chronic migraine with near-daily attacks, characterized (🧵 2/7)

Resolution of chronic refractory migraine and development of burning mouth syndrome after focused ultrasound thalamotomy: illustrative case
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📚 Source: Journal of neurosurgery. Case lessons
👤 Creator: Shachar Zion Shemesh et al.
📅 Date: 2026-05-25

#MigrainePapertag/MigrainePaper" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#MigrainePaper #Migraine/hashtag/Migraine" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#Migraine #PubMed="/hashtag/PubMed" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#PubMed

관찰 결과: 40년 동안 거의 매일 발작이 있었던 만성 편두통을 앓아온 76세 여성 환자는 주로 우측 두통을 호소했으며, 여러 예방 및 급성 치료에 반응하지 않았으나, 중증 본태성 진전(ET)으로 인해 MRgFUS VIM 시상 절제술을 받았다. 시술 후 진전은 소실되었으며, 장기 추적 관찰 기간 동안 만성 편두통 증상은 더 이상 보고되지 않았다. (🧵 2/4)

배경: 만성 편두통은 일상생활에 심각한 지장을 주는 신경계 질환이다. 일부 환자들은 모든 표준 치료에 반응하지 않는 만성 일일 두통을 겪게 된다. MR 유도 집중 초음파(MRgFUS)를 이용한 복측 중간핵(VIM) 시상 절제술은 약물 치료에 반응하지 않는 본태성 진전(ET)에 대한 비수술적 치료법이다. (🧵 1/4)

집중 초음파 시상 절제술 후 만성 난치성 편두통의 호전과 구강 작열감 증후군의 발생: 사례 보고
▶️ 논문읽기

📚 출처: Journal of neurosurgery. Case lessons
👤 저자: Shachar Zion Shemesh et al.
📅 날짜: 2026년 05월 25일

🆔 PMID: 42184431
🔗 DOI: 10.3171/CASE251040

#편두통논문g/%ED%8E%B8%EB%91%90%ED%86%B5%EB%85%BC%EB%AC%B8" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#편두통논문 #편두통hashtag/%ED%8E%B8%EB%91%90%ED%86%B5" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#편두통 #펍메드hashtag/%ED%8E%8D%EB%A9%94%EB%93%9C" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#펍메드

link.springer.com/article/10.1... (Xuhui Fan et al.)

🔹 Noninvasive treatment providing rapid pain relief and local tumour control
🔹 Fewer systemic side effects compared to opioids, radiation, or chemotherapy
🔹 Clear guidance on patient selection, workflow, and safety
🔹 Future focus on AI and global data to optimise outcome