Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
onlinelibrary.wiley.com/doi/10.1002/...
"We show for first time widespread abnormalities in the function of unmyelinated somatosensory & autonomic axons that may explain the multiplicity of symptoms in #longCOVID”
onlinelibrary.wiley.com/doi/10.1002/...
"We show for first time widespread abnormalities in the function of unmyelinated somatosensory & autonomic axons that may explain the multiplicity of symptoms in #longCOVID”
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Objective
To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular, g.....
onlinelibrary.wiley.com
September 28, 2025 at 1:22 PM
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
onlinelibrary.wiley.com/doi/10.1002/...
"We show for first time widespread abnormalities in the function of unmyelinated somatosensory & autonomic axons that may explain the multiplicity of symptoms in #longCOVID”
onlinelibrary.wiley.com/doi/10.1002/...
"We show for first time widespread abnormalities in the function of unmyelinated somatosensory & autonomic axons that may explain the multiplicity of symptoms in #longCOVID”
2/
First: the nervous system.
They used microneurography—a tiny needle in the nerve—to measure sympathetic activity.
Long COVID patients had 77% more nerve bursts than controls. That's fight-or-flight mode, stuck on.
First: the nervous system.
They used microneurography—a tiny needle in the nerve—to measure sympathetic activity.
Long COVID patients had 77% more nerve bursts than controls. That's fight-or-flight mode, stuck on.
May 18, 2025 at 1:07 PM
2/
First: the nervous system.
They used microneurography—a tiny needle in the nerve—to measure sympathetic activity.
Long COVID patients had 77% more nerve bursts than controls. That's fight-or-flight mode, stuck on.
First: the nervous system.
They used microneurography—a tiny needle in the nerve—to measure sympathetic activity.
Long COVID patients had 77% more nerve bursts than controls. That's fight-or-flight mode, stuck on.
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Shahrzad Hadavi MD
Shahrzad Hadavi MD
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Objective
To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular, g.....
onlinelibrary.wiley.com
September 23, 2025 at 4:34 AM
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Shahrzad Hadavi MD
Shahrzad Hadavi MD
Ein interessanter Artikel über Pathologie der Small Fibers bei #Fibromyalgie und die Abgrenzung zur klassischen Small Fiber Neuropathie.
Auch bei ME/CFS ist eine reduzierte Faserdichte häufig zu sehen. Leider gibt es dazu noch sehr wenig Forschung.
journals.lww.com/painrpts/ful...
Auch bei ME/CFS ist eine reduzierte Faserdichte häufig zu sehen. Leider gibt es dazu noch sehr wenig Forschung.
journals.lww.com/painrpts/ful...
Small fiber pathology in fibromyalgia syndrome : PAIN Reports
pecial small fiber neurophysiology such as C-fiber microneurography. Microneurography in particular has shown increased spontaneous activity, mechanosensitivity, and enhanced activity-induced slowing ...
journals.lww.com
January 17, 2025 at 2:16 PM
Ein interessanter Artikel über Pathologie der Small Fibers bei #Fibromyalgie und die Abgrenzung zur klassischen Small Fiber Neuropathie.
Auch bei ME/CFS ist eine reduzierte Faserdichte häufig zu sehen. Leider gibt es dazu noch sehr wenig Forschung.
journals.lww.com/painrpts/ful...
Auch bei ME/CFS ist eine reduzierte Faserdichte häufig zu sehen. Leider gibt es dazu noch sehr wenig Forschung.
journals.lww.com/painrpts/ful...
"described for the first time widespread abnormalities in the function of unmyelinated C fibers, both somatosensory and sympathetic, that could represent a common pathophysiological mechanism explaining the multiplicity of symptoms in #longCOVID"
#MECFS
onlinelibrary.wiley.com/doi/10.1002/...
#MECFS
onlinelibrary.wiley.com/doi/10.1002/...
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Objective
To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular, g.....
onlinelibrary.wiley.com
September 23, 2025 at 3:27 AM
"described for the first time widespread abnormalities in the function of unmyelinated C fibers, both somatosensory and sympathetic, that could represent a common pathophysiological mechanism explaining the multiplicity of symptoms in #longCOVID"
#MECFS
onlinelibrary.wiley.com/doi/10.1002/...
#MECFS
onlinelibrary.wiley.com/doi/10.1002/...
King’s College Hospital studied 36 long COVID patients and found 89% had small nerve fiber dysfunction.
Many showed abnormal pain signaling and faulty autonomic nerves, pointing to nerve damage as a key driver of symptoms.
onlinelibrary.wiley.com/doi/10.1002/...
Many showed abnormal pain signaling and faulty autonomic nerves, pointing to nerve damage as a key driver of symptoms.
onlinelibrary.wiley.com/doi/10.1002/...
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Objective To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular, g...
onlinelibrary.wiley.com
September 23, 2025 at 12:58 AM
King’s College Hospital studied 36 long COVID patients and found 89% had small nerve fiber dysfunction.
Many showed abnormal pain signaling and faulty autonomic nerves, pointing to nerve damage as a key driver of symptoms.
onlinelibrary.wiley.com/doi/10.1002/...
Many showed abnormal pain signaling and faulty autonomic nerves, pointing to nerve damage as a key driver of symptoms.
onlinelibrary.wiley.com/doi/10.1002/...
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
#Neurology
onlinelibrary.wiley.com/doi/10.1002/...
#Neurology
onlinelibrary.wiley.com/doi/10.1002/...
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Objective To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular, g...
onlinelibrary.wiley.com
September 23, 2025 at 2:26 PM
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
#Neurology
onlinelibrary.wiley.com/doi/10.1002/...
#Neurology
onlinelibrary.wiley.com/doi/10.1002/...
Preprint alert: Using human microneurography protocols in PatchSeq experiments on pig DRGs we identify the molecular identity of human dermal CMi-fibers (sleeping nociceptors). We provide an integrated pig-human-more transcriptomic atlas and identify OSMR and SST as marker, backed by human expts.
Molecular architecture of human dermal sleeping nociceptors https://www.biorxiv.org/content/10.1101/2024.12.20.629638v1
December 22, 2024 at 5:56 PM
Preprint alert: Using human microneurography protocols in PatchSeq experiments on pig DRGs we identify the molecular identity of human dermal CMi-fibers (sleeping nociceptors). We provide an integrated pig-human-more transcriptomic atlas and identify OSMR and SST as marker, backed by human expts.
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID onlinelibrary.wiley.com/doi/10.1002/...
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Objective To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular, g...
onlinelibrary.wiley.com
September 23, 2025 at 8:51 AM
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID onlinelibrary.wiley.com/doi/10.1002/...
There have been some prior investigations using microneurography by Giuseppe Mancia (PMID: 10411843, PMID: 23552126, and PMID: 34365811)
November 20, 2024 at 7:13 AM
There have been some prior investigations using microneurography by Giuseppe Mancia (PMID: 10411843, PMID: 23552126, and PMID: 34365811)
📢 International Society for Microneurography second hands-on course on 16-27 June 2025 in Prato, Italy.
Week 1 on afferent single unit recordings and week 2 on efferent sympathetic microneurography.
Learn all about microneurography theory and practice, and share experiences! microneurography.org
Week 1 on afferent single unit recordings and week 2 on efferent sympathetic microneurography.
Learn all about microneurography theory and practice, and share experiences! microneurography.org
Home
microneurography.org
April 10, 2025 at 10:11 AM
📢 International Society for Microneurography second hands-on course on 16-27 June 2025 in Prato, Italy.
Week 1 on afferent single unit recordings and week 2 on efferent sympathetic microneurography.
Learn all about microneurography theory and practice, and share experiences! microneurography.org
Week 1 on afferent single unit recordings and week 2 on efferent sympathetic microneurography.
Learn all about microneurography theory and practice, and share experiences! microneurography.org
How microneurography used to be done. Some old photos of #microneurography in Marseille, from the 1990s
December 19, 2023 at 2:12 PM
How microneurography used to be done. Some old photos of #microneurography in Marseille, from the 1990s
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID - Ribeiro - Annals of Neurology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID
Objective To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular, g...
onlinelibrary.wiley.com
September 23, 2025 at 8:02 PM
Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID - Ribeiro - Annals of Neurology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Wonderful and thought provoking for my clinical work! Does your lab have capacity for PNS measures as well? Microneurography, for example?
December 10, 2025 at 8:23 PM
Wonderful and thought provoking for my clinical work! Does your lab have capacity for PNS measures as well? Microneurography, for example?
New #preprint on modeling fingertip mechanoreceptor responses to #touch of varying speed, force & texture using #microneurography where information is represented across mechanoreceptor classes, each contributing differently-weighted inputs with Victoria Lang, Helena Backlund Wasling, Johan Wessberg
Single human fingertip mechanoreceptive afferents simultaneously encode multidimensional aspects of touch
Touch using the hands is essential for recognizing surface features and manipulating objects, where different aspects are encoded by four main types of low-threshold mechanoreceptors (LTMs) in glabrou...
www.biorxiv.org
October 30, 2025 at 10:03 AM
New #preprint on modeling fingertip mechanoreceptor responses to #touch of varying speed, force & texture using #microneurography where information is represented across mechanoreceptor classes, each contributing differently-weighted inputs with Victoria Lang, Helena Backlund Wasling, Johan Wessberg
Johan Wessberg giving a nice historical perspective of microneurography
June 23, 2025 at 8:42 AM
Johan Wessberg giving a nice historical perspective of microneurography
Beisswanger et al. use microneurography to reveal C-nociceptor dysfunction beyond conventional testing, offering insights into the role of C-nociceptors in ongoing neuropathic pain. Learn more in #PAIN bit.ly/4nqvWMG
October 23, 2025 at 12:00 PM
Beisswanger et al. use microneurography to reveal C-nociceptor dysfunction beyond conventional testing, offering insights into the role of C-nociceptors in ongoing neuropathic pain. Learn more in #PAIN bit.ly/4nqvWMG
I have not yet seen a mechanistic study of the decrease in blood pressure that occurs in most people with repeated measurements a minute apart
I wonder if people who do microneurography studies have simply measured BP a few times during one of their studies
I wonder if people who do microneurography studies have simply measured BP a few times during one of their studies
November 20, 2024 at 12:36 AM
I have not yet seen a mechanistic study of the decrease in blood pressure that occurs in most people with repeated measurements a minute apart
I wonder if people who do microneurography studies have simply measured BP a few times during one of their studies
I wonder if people who do microneurography studies have simply measured BP a few times during one of their studies
*Deadline tomorrow!* Register for this year's International Society for Microneurography 3rd hands-on Comprehensive #Microneurography Course & Conference, 15-26 June 2026 in Prato, Italy. For more info, see: lnkd.in/duQTXZNE
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
March 30, 2026 at 11:11 AM
*Deadline tomorrow!* Register for this year's International Society for Microneurography 3rd hands-on Comprehensive #Microneurography Course & Conference, 15-26 June 2026 in Prato, Italy. For more info, see: lnkd.in/duQTXZNE
In fact, the recent Nature Neuro. study Yu et al 2024 (from the labs of Wenqin Luo, Patrick Ernfors, and Håkan Olausson) with single-unit microneurography recordings in humans showed that C-LTMR DRG touch neurons respond to both soft brush and noxious heat ramps.
April 25, 2025 at 11:34 AM
In fact, the recent Nature Neuro. study Yu et al 2024 (from the labs of Wenqin Luo, Patrick Ernfors, and Håkan Olausson) with single-unit microneurography recordings in humans showed that C-LTMR DRG touch neurons respond to both soft brush and noxious heat ramps.
Supervised Spike Sorting Feasibility of Noisy Single-Electrode Extracellular Recordings: Systematic Study of Human C-Nociceptors recorded via Microneurography https://www.biorxiv.org/content/10.1101/2024.12.31.630860v1
December 31, 2024 at 4:16 PM
Supervised Spike Sorting Feasibility of Noisy Single-Electrode Extracellular Recordings: Systematic Study of Human C-Nociceptors recorded via Microneurography https://www.biorxiv.org/content/10.1101/2024.12.31.630860v1
Or is the question whether you can really relate single unit microneurography recordings to actual function? That’s something I ask myself in all my experiments.
January 16, 2025 at 5:16 PM
Or is the question whether you can really relate single unit microneurography recordings to actual function? That’s something I ask myself in all my experiments.