an Organ-On-A-Chip microphysiological system (MPS) counts as a doll if you think about it
December 23, 2024 at 5:40 PM
an Organ-On-A-Chip microphysiological system (MPS) counts as a doll if you think about it
The #intestine's dynamics (environment/movement/stiffness/flow) shapes stem cell fitness and function, shown here via PIEZO channels and is reflected in in-vitro models. So, are static 3D cultures sufficient? Could microphysiological systems #MPS #Organ-on-chip offer a better approach here?
December 1, 2024 at 10:22 AM
The #intestine's dynamics (environment/movement/stiffness/flow) shapes stem cell fitness and function, shown here via PIEZO channels and is reflected in in-vitro models. So, are static 3D cultures sufficient? Could microphysiological systems #MPS #Organ-on-chip offer a better approach here?
Excited to announce my upcoming @snsf.ch Ambizione research group at EPFL on bacteria-host interactions, combining systems approaches and microphysiological models.
🚨 We have an open PhD position! More info on projects and how to apply here: elisabettacacace.github.io/BHI-Lab/
🧪
🚨 We have an open PhD position! More info on projects and how to apply here: elisabettacacace.github.io/BHI-Lab/
🧪
February 6, 2026 at 3:50 PM
Excited to announce my upcoming @snsf.ch Ambizione research group at EPFL on bacteria-host interactions, combining systems approaches and microphysiological models.
🚨 We have an open PhD position! More info on projects and how to apply here: elisabettacacace.github.io/BHI-Lab/
🧪
🚨 We have an open PhD position! More info on projects and how to apply here: elisabettacacace.github.io/BHI-Lab/
🧪
A Review in Nature Reviews Bioengineering discusses pregnancy-associated organs-on-chips, which are microphysiological systems that model gestational tissues to unveil the mechanisms of obstetric conditions and evaluate drug safety and efficacy during pregnancy in vitro. 🔒
Pregnancy-associated organs-on-chips - Nature Reviews Bioengineering
Pregnancy-associated organs-on-chips (PAOOCs) are microphysiological systems that model gestational tissues to unveil the mechanisms of obstetric conditions and evaluate drug safety and efficacy during pregnancy in vitro. In this Review, we discuss the biological and mechanical components of PAOOCs and propose design recommendations to improve their physiological fidelity, reproducibility and accessibility.
go.nature.com
June 28, 2026 at 7:12 PM
A Review in Nature Reviews Bioengineering discusses pregnancy-associated organs-on-chips, which are microphysiological systems that model gestational tissues to unveil the mechanisms of obstetric conditions and evaluate drug safety and efficacy during pregnancy in vitro. 🔒
We have an open postdoc position in our lab using #NAMs!
We are seeking a postdoctoral researcher to work on an NIH-funded R01 project investigating tendon cell-ECM interactions using advanced microphysiological and engineered approaches (including non-animal models).
Apply here! michmed.org/5GV5x
We are seeking a postdoctoral researcher to work on an NIH-funded R01 project investigating tendon cell-ECM interactions using advanced microphysiological and engineered approaches (including non-animal models).
Apply here! michmed.org/5GV5x
RESEARCH FELLOW | U-M Careers
michmed.org
July 10, 2025 at 7:13 PM
We have an open postdoc position in our lab using #NAMs!
We are seeking a postdoctoral researcher to work on an NIH-funded R01 project investigating tendon cell-ECM interactions using advanced microphysiological and engineered approaches (including non-animal models).
Apply here! michmed.org/5GV5x
We are seeking a postdoctoral researcher to work on an NIH-funded R01 project investigating tendon cell-ECM interactions using advanced microphysiological and engineered approaches (including non-animal models).
Apply here! michmed.org/5GV5x
On May 26-29, Dylan Hakken and Dr. Hannes Campo traveled to The Microphysiological Systems (MPS) World Summit in Washington DC.
Dylan presented a poster entitled "Development of a Vascularized Microphysiological System Compatible with Complex 3D Cultures."
Dylan presented a poster entitled "Development of a Vascularized Microphysiological System Compatible with Complex 3D Cultures."
June 2, 2026 at 2:24 PM
On May 26-29, Dylan Hakken and Dr. Hannes Campo traveled to The Microphysiological Systems (MPS) World Summit in Washington DC.
Dylan presented a poster entitled "Development of a Vascularized Microphysiological System Compatible with Complex 3D Cultures."
Dylan presented a poster entitled "Development of a Vascularized Microphysiological System Compatible with Complex 3D Cultures."
A human gut-BBB-brain microphysiological model for studying neurodegenerative diseases https://www.biorxiv.org/content/10.64898/2026.02.24.707716v1
February 26, 2026 at 5:15 AM
A human gut-BBB-brain microphysiological model for studying neurodegenerative diseases https://www.biorxiv.org/content/10.64898/2026.02.24.707716v1
Here’s our latest revision of microphysiological systems in parasitology research, published in @plos.org #plospathogens in collaboration with Jorge de-Carvalho (ITQB-NOVA) and @mariabernabeu.bsky.social. Kudos to @mariazalmeida.bsky.social, PhD student, for the heavy lifting of this work.
Leveraging microphysiological systems to expedite understanding of host–parasite interactions
Microphysiological systems (MPS) replicate the dynamic interactions between cells, tissues, and fluids. They have emerged as transformative tools for biology and have been increasingly applied to host...
journals.plos.org
May 4, 2025 at 9:24 PM
Here’s our latest revision of microphysiological systems in parasitology research, published in @plos.org #plospathogens in collaboration with Jorge de-Carvalho (ITQB-NOVA) and @mariabernabeu.bsky.social. Kudos to @mariazalmeida.bsky.social, PhD student, for the heavy lifting of this work.
Our #UofRBME students are at #MPSWorldSummit 2025 in Brussels🌍presenting cutting-edge tissue chip research & connecting with global leaders. Stop by if you can!👋
🔗 mpsworldsummit.org
#Microphysiological #URochesterResearch @urochestersmd.bsky.social @urengineering.bsky.social @urochester.bsky.social
🔗 mpsworldsummit.org
#Microphysiological #URochesterResearch @urochestersmd.bsky.social @urengineering.bsky.social @urochester.bsky.social
June 9, 2025 at 7:19 PM
Our #UofRBME students are at #MPSWorldSummit 2025 in Brussels🌍presenting cutting-edge tissue chip research & connecting with global leaders. Stop by if you can!👋
🔗 mpsworldsummit.org
#Microphysiological #URochesterResearch @urochestersmd.bsky.social @urengineering.bsky.social @urochester.bsky.social
🔗 mpsworldsummit.org
#Microphysiological #URochesterResearch @urochestersmd.bsky.social @urengineering.bsky.social @urochester.bsky.social
Check out this week's blog from Dr Emily Jones at the @quadraminstitute.bsky.social to hear about her trip to Brussels for the Microphysiological Systems World Summit 2025. Great to see microbiology research in Norwich being shared with international audiences!
www.cmi-norwich.ac.uk/presenting-n...
www.cmi-norwich.ac.uk/presenting-n...
Presenting new research at an international conference: using microphysiological systems (MPS) to study microbial infections
Dr Emily Jones visits Brussels to share her latest findings and network with researchers from around the world.
www.cmi-norwich.ac.uk
August 14, 2025 at 9:51 AM
Check out this week's blog from Dr Emily Jones at the @quadraminstitute.bsky.social to hear about her trip to Brussels for the Microphysiological Systems World Summit 2025. Great to see microbiology research in Norwich being shared with international audiences!
www.cmi-norwich.ac.uk/presenting-n...
www.cmi-norwich.ac.uk/presenting-n...
Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems
Monocytes from Alzheimer’s disease patients induce disease phenotypes in human cortical organoid microphysiological systems.
www.science.org
August 23, 2025 at 10:21 AM
Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
In silico PBPK and in vitro microphysiological systems are useful predictive tools but require in vivo data for validation and species bridging. They are not standalone substitutes /6
May 20, 2026 at 7:17 PM
In silico PBPK and in vitro microphysiological systems are useful predictive tools but require in vivo data for validation and species bridging. They are not standalone substitutes /6
A microphysiological system of sterile injury demonstrates neutrophil reverse migration via macrophage-derived extracellular vesicle crosstalk. https://www.biorxiv.org/content/10.1101/2024.12.30.630550v1
December 30, 2024 at 9:18 PM
A microphysiological system of sterile injury demonstrates neutrophil reverse migration via macrophage-derived extracellular vesicle crosstalk. https://www.biorxiv.org/content/10.1101/2024.12.30.630550v1
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing #Sarcoma Proliferation and Migration
advanced.onlinelibrary.wiley.com/doi/full/10....
advanced.onlinelibrary.wiley.com/doi/full/10....
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularizatio...
advanced.onlinelibrary.wiley.com
September 28, 2025 at 1:24 PM
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing #Sarcoma Proliferation and Migration
advanced.onlinelibrary.wiley.com/doi/full/10....
advanced.onlinelibrary.wiley.com/doi/full/10....
Great to see the European Organ-on-Chip Society represented on @bsky.app. Activity will ramp up in the coming period, but for now, please follow @euroocs.bsky.social #ooc #mps #microphysiological
January 27, 2025 at 11:26 AM
Great to see the European Organ-on-Chip Society represented on @bsky.app. Activity will ramp up in the coming period, but for now, please follow @euroocs.bsky.social #ooc #mps #microphysiological
A microphysiological system (MPS) featuring multicellular human hepatic spheroids physically integrated with self-organized microvascular networks for studies of #insulin resistance www.nature.com/articles/s41...
A vascularized liver microphysiological system captures key features of hepatic insulin resistance and monocyte infiltration - Nature Communications
To humanize models of liver metabolic disease research, authors develop a microfluidic platform leveraging human hepatic spheroids integrated with microvasculature and circulating monocytes to model h...
www.nature.com
February 3, 2026 at 10:56 AM
A microphysiological system (MPS) featuring multicellular human hepatic spheroids physically integrated with self-organized microvascular networks for studies of #insulin resistance www.nature.com/articles/s41...
ICYMI: Should culture media for microphysiological systems be nutritionally physiological?
Should culture media for microphysiological systems be nutritionally physiological?
Nature Reviews Bioengineering, Published online: 25 February 2025; doi:10.1038/s44222-025-00290-wThe incipient use of microphysiological systems (MPSs) in the drug regulatory pathway is based on equivalent or superior predictive value in the evaluation of…
www.nature.com
February 26, 2025 at 11:16 PM
ICYMI: Should culture media for microphysiological systems be nutritionally physiological?
Thrilled to share that a part of my Ph.D. work from
@dukeubme.bsky.social @stemcellengineer.bsky.social Lab is now out in @natbiomedeng.nature.com!
We investigated the impact of CHD-linked SMAD2 variants on kidney development using engineered human iPS cells in a microphysiological system.
@dukeubme.bsky.social @stemcellengineer.bsky.social Lab is now out in @natbiomedeng.nature.com!
We investigated the impact of CHD-linked SMAD2 variants on kidney development using engineered human iPS cells in a microphysiological system.
November 3, 2025 at 11:39 PM
Thrilled to share that a part of my Ph.D. work from
@dukeubme.bsky.social @stemcellengineer.bsky.social Lab is now out in @natbiomedeng.nature.com!
We investigated the impact of CHD-linked SMAD2 variants on kidney development using engineered human iPS cells in a microphysiological system.
@dukeubme.bsky.social @stemcellengineer.bsky.social Lab is now out in @natbiomedeng.nature.com!
We investigated the impact of CHD-linked SMAD2 variants on kidney development using engineered human iPS cells in a microphysiological system.
To investigate neuroinflammation in Alzheimer’s disease pathogenesis, researchers at #IUBloomington, @cityofhope.bsky.social, @uclaanes.bsky.social, & @mayoclinic.org developed a human cortical #organoid microphysiological system to study monocyte-mediated neuroinflammation.
#neuroskyence #alz #MPS
#neuroskyence #alz #MPS
January 2, 2026 at 3:19 PM
To investigate neuroinflammation in Alzheimer’s disease pathogenesis, researchers at #IUBloomington, @cityofhope.bsky.social, @uclaanes.bsky.social, & @mayoclinic.org developed a human cortical #organoid microphysiological system to study monocyte-mediated neuroinflammation.
#neuroskyence #alz #MPS
#neuroskyence #alz #MPS
This new review for oral health researchers explores how #microphysiological culture systems could advance therapies for dental, oral & craniofacial (DOC) diseases. 🧪
By faculty from the @wyssinstitute.bsky.social and @bme-uoft.bsky.social
aiche.onlinelibrary.wiley.com/doi/10.1002/...
By faculty from the @wyssinstitute.bsky.social and @bme-uoft.bsky.social
aiche.onlinelibrary.wiley.com/doi/10.1002/...
Oral tissue spheroid, organoid, and organ‐on chip microphysiological modeling strategies towards enhanced emulation of health and disease
Diseases and disorders of dental, oral, and craniofacial (DOC) tissues represent a significant global health burden and have been found to have the greatest age-standardized prevalence and incidence ...
aiche.onlinelibrary.wiley.com
June 5, 2025 at 2:53 PM
This new review for oral health researchers explores how #microphysiological culture systems could advance therapies for dental, oral & craniofacial (DOC) diseases. 🧪
By faculty from the @wyssinstitute.bsky.social and @bme-uoft.bsky.social
aiche.onlinelibrary.wiley.com/doi/10.1002/...
By faculty from the @wyssinstitute.bsky.social and @bme-uoft.bsky.social
aiche.onlinelibrary.wiley.com/doi/10.1002/...
🔬 Postdoctoral Opportunity in Biomedical Research. #Organoids & #Organs-on-Chip for #IBD and #Personalized #Medicine at #i2mc in #Toulouse, #France at the crossroads of #stem cell biology, #microphysiological systems, and translational medicine.
👉 Apply before Nov. 1rst at audrey.ferrand@inserm.fr
👉 Apply before Nov. 1rst at audrey.ferrand@inserm.fr
October 11, 2025 at 8:03 AM
🔬 Postdoctoral Opportunity in Biomedical Research. #Organoids & #Organs-on-Chip for #IBD and #Personalized #Medicine at #i2mc in #Toulouse, #France at the crossroads of #stem cell biology, #microphysiological systems, and translational medicine.
👉 Apply before Nov. 1rst at audrey.ferrand@inserm.fr
👉 Apply before Nov. 1rst at audrey.ferrand@inserm.fr
In the 2026 reviews issue of Lab on a Chip:
Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function in vitro.
#OpenAccess from Esak Lee & Yansong Peng.
Read now: pubs.rsc.org/en/content/a...
@isaacleelab.bsky.social @cornelluniversity.bsky.social
Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function in vitro.
#OpenAccess from Esak Lee & Yansong Peng.
Read now: pubs.rsc.org/en/content/a...
@isaacleelab.bsky.social @cornelluniversity.bsky.social
Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function in vitro
The lymphatic system—integral to fluid balance, immune surveillance, and lipid absorption—is frequently overlooked despite its vital roles. Traditional research modalities, including static two-dimens...
pubs.rsc.org
March 16, 2026 at 8:55 AM
In the 2026 reviews issue of Lab on a Chip:
Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function in vitro.
#OpenAccess from Esak Lee & Yansong Peng.
Read now: pubs.rsc.org/en/content/a...
@isaacleelab.bsky.social @cornelluniversity.bsky.social
Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function in vitro.
#OpenAccess from Esak Lee & Yansong Peng.
Read now: pubs.rsc.org/en/content/a...
@isaacleelab.bsky.social @cornelluniversity.bsky.social
The agenda for our Nature Conference 'Engineered models of human disease' is taking shape 😍 We have sessions on organoids, microphysiological systems, disease-specific models, women's health, computational approaches and the immune system!
Check it out: go.nature.com/3R4ueSk
Check it out: go.nature.com/3R4ueSk
Engineered Models of Human Disease
SAVE THE DATE!Join biologists, bioengineers, clinical researchers, and industry professionals in Belgrade on 28-29 October for a cutting-edge conference focused on the design of human-relevant disease...
go.nature.com
March 12, 2025 at 12:37 PM
The agenda for our Nature Conference 'Engineered models of human disease' is taking shape 😍 We have sessions on organoids, microphysiological systems, disease-specific models, women's health, computational approaches and the immune system!
Check it out: go.nature.com/3R4ueSk
Check it out: go.nature.com/3R4ueSk
MIMETAS has landed on Bluesky! If you’re into microphysiological systems, 3D human tissue models, and cutting-edge biotech, you’re in the right place. Expect insights, the latest updates and behind-the-scenes research innovation. 👋 Learn about us here: mimetas.com
March 5, 2025 at 2:38 PM
MIMETAS has landed on Bluesky! If you’re into microphysiological systems, 3D human tissue models, and cutting-edge biotech, you’re in the right place. Expect insights, the latest updates and behind-the-scenes research innovation. 👋 Learn about us here: mimetas.com
Drug treatment alters performance in a neural microphysiological system of information processing https://www.biorxiv.org/content/10.1101/2025.01.27.635163v1
January 29, 2025 at 10:15 PM
Drug treatment alters performance in a neural microphysiological system of information processing https://www.biorxiv.org/content/10.1101/2025.01.27.635163v1