Midkine is known to accumulate in Alzheimer’s patients, but rather than accelerate the disease, it seems to prevent a second, sticky protein from clumping together—the chief hallmark in this form of dementia.
www.goodnewsnetwork.org/tiny-protein...
www.goodnewsnetwork.org/tiny-protein...
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease
Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in Alzheimer’s disease. Midkine is known to accumulate in Al...
www.goodnewsnetwork.org
September 10, 2025 at 11:52 PM
Midkine is known to accumulate in Alzheimer’s patients, but rather than accelerate the disease, it seems to prevent a second, sticky protein from clumping together—the chief hallmark in this form of dementia.
www.goodnewsnetwork.org/tiny-protein...
www.goodnewsnetwork.org/tiny-protein...
Moving forward in the fight against Alzheimer's disease.
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease
Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in Alzheimer’s disease. Midkine is known to accumulate in Al...
www.goodnewsnetwork.org
September 14, 2025 at 7:50 PM
Moving forward in the fight against Alzheimer's disease.
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease - Good News Network www.goodnewsnetwork.org/tiny-protein...
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease
Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in Alzheimer’s disease. Midkine is known to accumulate in Al...
www.goodnewsnetwork.org
September 8, 2025 at 10:37 PM
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease - Good News Network www.goodnewsnetwork.org/tiny-protein...
Cool paper by the group of @msmelanoma.bsky.social in @naturecancer.bsky.social showing that tumor secreted growth factor midkine rewires DCs toward a tolerogenic state and promotes tumor immune escape.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade - Nature Cancer
Catena et al. report that melanoma-secreted midkine impairs differentiation and function of dendritic cells, limiting antitumor immunity and response to immune checkpoint blockade.
www.nature.com
April 4, 2025 at 12:53 PM
Cool paper by the group of @msmelanoma.bsky.social in @naturecancer.bsky.social showing that tumor secreted growth factor midkine rewires DCs toward a tolerogenic state and promotes tumor immune escape.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Important findings from the @soledadsosalab.bsky.social at the @cdi-einstein.bsky.social at Montefiore Einstein Comprehensive Cancer Center on the mechanisms of dormant cutaneous melanoma awakening via midkine dependent signaling. Congrats on this story!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Midkine inhibits dormancy of disseminated melanoma cells
A significant factor in cancer-related mortality in melanoma is the appearance of intrinsically aggressive distal metastases. This recurrence frequently results from the awakening of dormant dissemina...
www.biorxiv.org
June 8, 2025 at 2:55 PM
Important findings from the @soledadsosalab.bsky.social at the @cdi-einstein.bsky.social at Montefiore Einstein Comprehensive Cancer Center on the mechanisms of dormant cutaneous melanoma awakening via midkine dependent signaling. Congrats on this story!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
I feel bad for midkine. Just the name. It’s like a promise that it’s not special.
December 17, 2024 at 8:07 PM
I feel bad for midkine. Just the name. It’s like a promise that it’s not special.
A study led by @stjuderesearch.bsky.social & VAI scientists, published in @natsmb.nature.com, reports a protein called midkine may help prevent brain plaques that contribute to Alzheimer’s disease. www.vai.org/article/midk...
Midkine proteins prevent Alzheimer’s-related plaques – Van Andel Institute
Read about Midkine proteins prevent Alzheimer’s-related plaques on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.
www.vai.org
October 23, 2025 at 7:41 PM
A study led by @stjuderesearch.bsky.social & VAI scientists, published in @natsmb.nature.com, reports a protein called midkine may help prevent brain plaques that contribute to Alzheimer’s disease. www.vai.org/article/midk...
what about the other family members, mehkine, midkine-like, and IL-6?
December 17, 2024 at 8:50 PM
what about the other family members, mehkine, midkine-like, and IL-6?
www.goodnewsnetwork.org/tiny-protein... Advances in Alzheimers research could lead to a breakthrough in how to treat it some day. That would be a very #goodthing! #positivity #positivevibes
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease
Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in Alzheimer’s disease. Midkine is known to accumulate in Al...
www.goodnewsnetwork.org
November 8, 2025 at 7:19 AM
www.goodnewsnetwork.org/tiny-protein... Advances in Alzheimers research could lead to a breakthrough in how to treat it some day. That would be a very #goodthing! #positivity #positivevibes
Yan et al. from @dfcibreastonc.bsky.social show that aging of the mammary gland fosters tumorigenesis by midkine-driven epigenetic shifts and increased epithelial proliferation. Targeting midkine may reduce age-related breast cancer risk. 🧪 https://buff.ly/4iAwqh8 @CellPress.bsky.social
December 16, 2024 at 9:54 AM
Yan et al. from @dfcibreastonc.bsky.social show that aging of the mammary gland fosters tumorigenesis by midkine-driven epigenetic shifts and increased epithelial proliferation. Targeting midkine may reduce age-related breast cancer risk. 🧪 https://buff.ly/4iAwqh8 @CellPress.bsky.social
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease www.goodnewsnetwork.org/tiny-protein...
Hope.
Hope.
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease
Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in Alzheimer’s disease. Midkine is known to accumulate in Al...
www.goodnewsnetwork.org
September 8, 2025 at 11:10 PM
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease www.goodnewsnetwork.org/tiny-protein...
Hope.
Hope.
Tiny Protein Dismantles the Toxic Clumps Behind #Alzheimer’s | ScienceDaily 😮
St. Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. 👍
St. Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. 👍
Tiny protein dismantles the toxic clumps behind Alzheimer’s
St. Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. The finding...
www.sciencedaily.com
August 23, 2025 at 2:53 PM
Tiny Protein Dismantles the Toxic Clumps Behind #Alzheimer’s | ScienceDaily 😮
St. Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. 👍
St. Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. 👍
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease
https://www.goodnewsnetwork.org/tiny-protein-confirmed-to-dismantle-the-toxic-clumps-linked-to-alzheimers-disease/ #goodnews
https://www.goodnewsnetwork.org/tiny-protein-confirmed-to-dismantle-the-toxic-clumps-linked-to-alzheimers-disease/ #goodnews
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimerâs Disease
Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in Alzheimer’s disease. Midkine is known to accumulate in Alzheimer’s patients, but rather than accelerate the disease, it seems to prevents a second, sticky protein from clumping togetherâthe chief hallmark in this form of […]
www.goodnewsnetwork.org
September 8, 2025 at 5:00 PM
Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease
https://www.goodnewsnetwork.org/tiny-protein-confirmed-to-dismantle-the-toxic-clumps-linked-to-alzheimers-disease/ #goodnews
https://www.goodnewsnetwork.org/tiny-protein-confirmed-to-dismantle-the-toxic-clumps-linked-to-alzheimers-disease/ #goodnews
Game-changer in Alzheimer's research! Scientists have identified a tiny protein, Midkine, that breaks down the toxic clumps causing the disease. 🎉 #Alzheimers #MedicalBreakthrough #HopeForAlzheimers
New discovery: tiny protein called Midkine dismantles the toxic clumps behind Alzheimer’s
Summary:
St. Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. The finding could inspire new drugs that harness midkine’s protective power.
Here is a different link to the academic journal publication of the study:
http://dx.doi.org/10.1038/s41594-025-01657-8
Published on August 21, 2025.
Journal: Nature Structural and Molecular Biology
www.sciencedaily.com
September 1, 2025 at 10:00 PM
Game-changer in Alzheimer's research! Scientists have identified a tiny protein, Midkine, that breaks down the toxic clumps causing the disease. 🎉 #Alzheimers #MedicalBreakthrough #HopeForAlzheimers
@healthcare-europe.bsky.social, thanks for highlighting our paper in @naturecancer.bsky.social. Quite excited indeed about identifying a prometastatic factor (Midkine) that tricks the immune system (dendritic cells in this case) to compromise prognosis and immune response
@cniostopcancer.bsky.social
@cniostopcancer.bsky.social
Researchers led by @msmelanoma.bsky.social from 🇪🇸 @cniostopcancer.bsky.social discovered a key mechanism by which #melanomas and other aggressive #tumours prevent the #immune system from detecting and attacking them – one of the greatest challenges in #oncology today.
How midkine helps tumours evade immunotherapy
Cutaneous melanoma, the most aggressive form of skin cancer, is characterised by its accumulation of a large number of mutations.
dlvr.it
April 5, 2025 at 7:31 AM
@healthcare-europe.bsky.social, thanks for highlighting our paper in @naturecancer.bsky.social. Quite excited indeed about identifying a prometastatic factor (Midkine) that tricks the immune system (dendritic cells in this case) to compromise prognosis and immune response
@cniostopcancer.bsky.social
@cniostopcancer.bsky.social
Researchers led by @msmelanoma.bsky.social from 🇪🇸 @cniostopcancer.bsky.social discovered a key mechanism by which #melanomas and other aggressive #tumours prevent the #immune system from detecting and attacking them – one of the greatest challenges in #oncology today.
How midkine helps tumours evade immunotherapy
Cutaneous melanoma, the most aggressive form of skin cancer, is characterised by its accumulation of a large number of mutations.
dlvr.it
April 5, 2025 at 6:31 AM
Researchers led by @msmelanoma.bsky.social from 🇪🇸 @cniostopcancer.bsky.social discovered a key mechanism by which #melanomas and other aggressive #tumours prevent the #immune system from detecting and attacking them – one of the greatest challenges in #oncology today.
#ScienceSaturday 🧵
➡️ Melanoma secretes a protein called midkine (MDK), which plays a key role in reprogramming dendritic cells in the tumor microenvironment.
❓ How can this impact immune responses?
➡️ Melanoma secretes a protein called midkine (MDK), which plays a key role in reprogramming dendritic cells in the tumor microenvironment.
❓ How can this impact immune responses?
March 29, 2025 at 1:41 PM
#ScienceSaturday 🧵
➡️ Melanoma secretes a protein called midkine (MDK), which plays a key role in reprogramming dendritic cells in the tumor microenvironment.
❓ How can this impact immune responses?
➡️ Melanoma secretes a protein called midkine (MDK), which plays a key role in reprogramming dendritic cells in the tumor microenvironment.
❓ How can this impact immune responses?
Melanoma cells, the most aggressive form of skin cancer, produce a protein that blocks the recognition and removal of the tumour by the immune system, the body’s natural defences
The protein, called Midkine, allows melanoma to “hide” in different organs and increases resistance to immunotherapy
/2
The protein, called Midkine, allows melanoma to “hide” in different organs and increases resistance to immunotherapy
/2
October 31, 2025 at 6:24 AM
Melanoma cells, the most aggressive form of skin cancer, produce a protein that blocks the recognition and removal of the tumour by the immune system, the body’s natural defences
The protein, called Midkine, allows melanoma to “hide” in different organs and increases resistance to immunotherapy
/2
The protein, called Midkine, allows melanoma to “hide” in different organs and increases resistance to immunotherapy
/2
I’m thrilled to announce our project on skin melanoma dormancy. Congratulations to all the authors! Now, let’s embark on the journey to get our work published in a journal! www.biorxiv.org/cgi/content/...
@einsteinmededu.bsky.social @cdi-einstein.bsky.social
@einsteinmededu.bsky.social @cdi-einstein.bsky.social
Midkine inhibits dormancy of disseminated melanoma cells
A significant factor in cancer-related mortality in melanoma is the appearance of intrinsically aggressive distal metastases. This recurrence frequently results from the awakening of dormant dissemina...
www.biorxiv.org
June 2, 2025 at 2:34 PM
I’m thrilled to announce our project on skin melanoma dormancy. Congratulations to all the authors! Now, let’s embark on the journey to get our work published in a journal! www.biorxiv.org/cgi/content/...
@einsteinmededu.bsky.social @cdi-einstein.bsky.social
@einsteinmededu.bsky.social @cdi-einstein.bsky.social
Midkine inhibits dormancy of disseminated melanoma cells https://www.biorxiv.org/content/10.1101/2025.05.27.656365v1
June 1, 2025 at 5:49 AM
Midkine inhibits dormancy of disseminated melanoma cells https://www.biorxiv.org/content/10.1101/2025.05.27.656365v1
Midkine inhibits dormancy of disseminated melanoma cells https://www.biorxiv.org/content/10.1101/2025.05.27.656365v1
June 1, 2025 at 5:49 AM
Midkine inhibits dormancy of disseminated melanoma cells https://www.biorxiv.org/content/10.1101/2025.05.27.656365v1