#mitochondrialdisease papers from last week:
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoworld.bsky.social
Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoworld.bsky.social
Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance
December 15, 2024 at 2:56 PM
#mitochondrialdisease papers from last week:
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoworld.bsky.social
Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoworld.bsky.social
Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance
Now in print: tour de force mitonuclear epistasis study in C. elegans.
Start to finish, vision and execution, 100% Tuc Nguyen @tuchmnguyen.bsky.social
Start to finish, vision and execution, 100% Tuc Nguyen @tuchmnguyen.bsky.social
Nguyen et al. used C. elegans as a model to study mitonuclear epistasis, leveraging genetic and phenotypic data to show that mitonuclear epistasis contributed significantly to phenotypic variance across all tested conditions.
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans
Abstract. Coordinated genetic and physical interactions between mitochondrial and nuclear gene products regulate ATP production in the mitochondria. Linkin
doi.org
December 14, 2025 at 12:53 AM
Now in print: tour de force mitonuclear epistasis study in C. elegans.
Start to finish, vision and execution, 100% Tuc Nguyen @tuchmnguyen.bsky.social
Start to finish, vision and execution, 100% Tuc Nguyen @tuchmnguyen.bsky.social
Although it feels bizarre to be posting about research with what has been going on in the US this week, I want to highlight new work from graduate student @nemovrobles.bsky.social whose first-first author paper on mitonuclear incompatibilities in swordtails just posted on bioRxiv. shorturl.at/gC71V
Admixture mapping reveals evidence for multiple mitonuclear incompatibilities in swordtail fish hybrids
How barriers to gene flow arise between closely related species is one of the oldest questions in evolutionary biology. Classic models in evolutionary biology predict that negative epistatic interacti...
shorturl.at
February 1, 2025 at 11:17 PM
Although it feels bizarre to be posting about research with what has been going on in the US this week, I want to highlight new work from graduate student @nemovrobles.bsky.social whose first-first author paper on mitonuclear incompatibilities in swordtails just posted on bioRxiv. shorturl.at/gC71V
Very proud of this little contribution we have made to the field.
Check out our latest @pnas.org paper on mitonuclear ageing
Check out our latest @pnas.org paper on mitonuclear ageing
How far do intergenomic compatibility shape ageing trajectories? 🦠🧬🪰
Our latest study in PNAS @pnas.org, explores this. Check it out! doi.org/10.1073/pnas...
Thanks to an amazing team: @fcamus.bsky.social, @dk-dowling.bsky.social, Avi & Finley.
#mitochondria #mitonuclear #ageing #diet #hormesis
Our latest study in PNAS @pnas.org, explores this. Check it out! doi.org/10.1073/pnas...
Thanks to an amazing team: @fcamus.bsky.social, @dk-dowling.bsky.social, Avi & Finley.
#mitochondria #mitonuclear #ageing #diet #hormesis
Mitonuclear discordance modulates mitochondrial ageing dynamics in natural Drosophila populations | PNAS
Mitochondrial decline is a hallmark of ageing, yet the role of intergenomic compatibility
in shaping ageing trajectories remains poorly understood,...
doi.org
July 8, 2026 at 3:44 PM
Very proud of this little contribution we have made to the field.
Check out our latest @pnas.org paper on mitonuclear ageing
Check out our latest @pnas.org paper on mitonuclear ageing
Reproductive barriers can evolve despite gene flow. A combination of genomics and behavioural assays shows two mitonuclear incompatibilities originated via ancient hybridization that underlie hybrid inviability in a pair of closely related swordtail fishes www.nature.com/articles/s41...
Pervasive gene flow despite strong and varied reproductive barriers in swordtails - Nature Ecology & Evolution
Reproductive barriers can evolve despite gene flow. A combination of genomics and behavioural assays shows two mitonuclear incompatibilities originated via ancient hybridization that underlie hybrid i...
www.nature.com
March 26, 2025 at 2:32 PM
Reproductive barriers can evolve despite gene flow. A combination of genomics and behavioural assays shows two mitonuclear incompatibilities originated via ancient hybridization that underlie hybrid inviability in a pair of closely related swordtail fishes www.nature.com/articles/s41...
Nguyen et al. used C. elegans as a model to study mitonuclear epistasis, leveraging genetic and phenotypic data to show that mitonuclear epistasis contributed significantly to phenotypic variance across all tested conditions.
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans
Abstract. Coordinated genetic and physical interactions between mitochondrial and nuclear gene products regulate ATP production in the mitochondria. Linkin
doi.org
December 12, 2025 at 11:50 AM
Nguyen et al. used C. elegans as a model to study mitonuclear epistasis, leveraging genetic and phenotypic data to show that mitonuclear epistasis contributed significantly to phenotypic variance across all tested conditions.
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
There's loads more molecular population genetics and quantitative genetics in the paper, which represents (imho) the most rigorous factorial analysis of mitonuclear epistasis to date. It's nice to work with terrific people!
Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans
Coordinated genetic and physical interactions between mitochondrial and nuclear gene products regulate ATP production in the mitochondria. Linking mitochondrial genotypes and mitonuclear genetic inter...
www.biorxiv.org
April 25, 2025 at 8:44 PM
There's loads more molecular population genetics and quantitative genetics in the paper, which represents (imho) the most rigorous factorial analysis of mitonuclear epistasis to date. It's nice to work with terrific people!
How far do intergenomic compatibility shape ageing trajectories? 🦠🧬🪰
Our latest study in PNAS @pnas.org, explores this. Check it out! doi.org/10.1073/pnas...
Thanks to an amazing team: @fcamus.bsky.social, @dk-dowling.bsky.social, Avi & Finley.
#mitochondria #mitonuclear #ageing #diet #hormesis
Our latest study in PNAS @pnas.org, explores this. Check it out! doi.org/10.1073/pnas...
Thanks to an amazing team: @fcamus.bsky.social, @dk-dowling.bsky.social, Avi & Finley.
#mitochondria #mitonuclear #ageing #diet #hormesis
Mitonuclear discordance modulates mitochondrial ageing dynamics in natural Drosophila populations | PNAS
Mitochondrial decline is a hallmark of ageing, yet the role of intergenomic compatibility
in shaping ageing trajectories remains poorly understood,...
doi.org
July 8, 2026 at 12:15 PM
How far do intergenomic compatibility shape ageing trajectories? 🦠🧬🪰
Our latest study in PNAS @pnas.org, explores this. Check it out! doi.org/10.1073/pnas...
Thanks to an amazing team: @fcamus.bsky.social, @dk-dowling.bsky.social, Avi & Finley.
#mitochondria #mitonuclear #ageing #diet #hormesis
Our latest study in PNAS @pnas.org, explores this. Check it out! doi.org/10.1073/pnas...
Thanks to an amazing team: @fcamus.bsky.social, @dk-dowling.bsky.social, Avi & Finley.
#mitochondria #mitonuclear #ageing #diet #hormesis
When sex chromosomes turnover, they can reset the rules of genomic conflict.
New preprint exploring how turnover reshapes barriers to gene flow through an “escape-hatch” model for mitonuclear conflict.
Any feedback would be welcome! ecoevorxiv.org/repository/v...
New preprint exploring how turnover reshapes barriers to gene flow through an “escape-hatch” model for mitonuclear conflict.
Any feedback would be welcome! ecoevorxiv.org/repository/v...
Resetting the rules: Sex chromosome turnover as an escape hatch for mitonuclear conflict
ecoevorxiv.org
October 10, 2025 at 3:54 PM
When sex chromosomes turnover, they can reset the rules of genomic conflict.
New preprint exploring how turnover reshapes barriers to gene flow through an “escape-hatch” model for mitonuclear conflict.
Any feedback would be welcome! ecoevorxiv.org/repository/v...
New preprint exploring how turnover reshapes barriers to gene flow through an “escape-hatch” model for mitonuclear conflict.
Any feedback would be welcome! ecoevorxiv.org/repository/v...
Hot of the press #mitochondria paper!! 🎉 @jevbio.bsky.social
New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝
@fcamus.bsky.social @dk-dowling.bsky.social et al.,
academic.oup.com/jeb/advance-...
New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝
@fcamus.bsky.social @dk-dowling.bsky.social et al.,
academic.oup.com/jeb/advance-...
Mitonuclear interactions and early-life diet shape adult nutritional behaviour
Abstract. Mitochondrial function relies on close coordination between the mitochondrial and nuclear genomes. Disruption to this coordination—via mitonuclea
academic.oup.com
October 20, 2025 at 9:13 AM
Hot of the press #mitochondria paper!! 🎉 @jevbio.bsky.social
New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝
@fcamus.bsky.social @dk-dowling.bsky.social et al.,
academic.oup.com/jeb/advance-...
New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝
@fcamus.bsky.social @dk-dowling.bsky.social et al.,
academic.oup.com/jeb/advance-...
Mitonuclear divergence predicts gradual speciation in animal hybrid zones 🧪
ecoevorxiv.org/repository/v...
Collectively, this data synthesis in the early stage of animal speciation reveals a gradual development of reproductive isolation with mitonuclear genetic divergence.
ecoevorxiv.org/repository/v...
Collectively, this data synthesis in the early stage of animal speciation reveals a gradual development of reproductive isolation with mitonuclear genetic divergence.
September 11, 2025 at 3:31 PM
Mitonuclear divergence predicts gradual speciation in animal hybrid zones 🧪
ecoevorxiv.org/repository/v...
Collectively, this data synthesis in the early stage of animal speciation reveals a gradual development of reproductive isolation with mitonuclear genetic divergence.
ecoevorxiv.org/repository/v...
Collectively, this data synthesis in the early stage of animal speciation reveals a gradual development of reproductive isolation with mitonuclear genetic divergence.
Zhao et al. analysed phylogenetic signal in OXPHOS genes, mtDNA genes and nuclear genes in 53 beetle species, detecting two major cases of mitonuclear discordance caused by introgressive hybridization and incomplete lineage sorting.
🔗 doi.org/10.1093/molbev/msaf291
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf291
#evobio #molbio
December 1, 2025 at 9:36 AM
Zhao et al. analysed phylogenetic signal in OXPHOS genes, mtDNA genes and nuclear genes in 53 beetle species, detecting two major cases of mitonuclear discordance caused by introgressive hybridization and incomplete lineage sorting.
🔗 doi.org/10.1093/molbev/msaf291
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf291
#evobio #molbio
Your daily Avian Hybrids story!
Mitonuclear discordance in a rapid radiation of Kingfishers
avianhybrids.wordpress.com/2023/11/08/m...
#ornithology
Mitonuclear discordance in a rapid radiation of Kingfishers
avianhybrids.wordpress.com/2023/11/08/m...
#ornithology
Mitonuclear discordance in a rapid radiation of Kingfishers
What evolutionary process can explain this genomic mismatch?
avianhybrids.wordpress.com
June 26, 2026 at 1:04 PM
Your daily Avian Hybrids story!
Mitonuclear discordance in a rapid radiation of Kingfishers
avianhybrids.wordpress.com/2023/11/08/m...
#ornithology
Mitonuclear discordance in a rapid radiation of Kingfishers
avianhybrids.wordpress.com/2023/11/08/m...
#ornithology
🎉New paper out!🎉 @evolletters.bsky.social
Interested in #mitochondria and how #mitonuclear compatibility shapes fitness in insect populations? Check this out! 🦠🪰
A big thanks to all the authors: @fcamus.bsky.social @dk-dowling.bsky.social, Enrique, Nick, Marion et al
#MSCA
doi.org/10.1093/evle...
Interested in #mitochondria and how #mitonuclear compatibility shapes fitness in insect populations? Check this out! 🦠🪰
A big thanks to all the authors: @fcamus.bsky.social @dk-dowling.bsky.social, Enrique, Nick, Marion et al
#MSCA
doi.org/10.1093/evle...
Assessing the role of mitonuclear interactions on mitochondrial function and organismal fitness in natural Drosophila populations
Abstract. Mitochondrial function depends on the effective interactions between proteins and RNA encoded by the mitochondrial and nuclear genomes. Evidence
doi.org
December 1, 2024 at 9:13 AM
🎉New paper out!🎉 @evolletters.bsky.social
Interested in #mitochondria and how #mitonuclear compatibility shapes fitness in insect populations? Check this out! 🦠🪰
A big thanks to all the authors: @fcamus.bsky.social @dk-dowling.bsky.social, Enrique, Nick, Marion et al
#MSCA
doi.org/10.1093/evle...
Interested in #mitochondria and how #mitonuclear compatibility shapes fitness in insect populations? Check this out! 🦠🪰
A big thanks to all the authors: @fcamus.bsky.social @dk-dowling.bsky.social, Enrique, Nick, Marion et al
#MSCA
doi.org/10.1093/evle...
Just out in @journal-evo.bsky.social: "Testing for age- and sex- specific mitonuclear epistasis in Drosophila"
academic.oup.com/evolut/advan...
academic.oup.com/evolut/advan...
Testing for age- and sex- specific mitonuclear epistasis in Drosophila
Abstract. The need for efficient ATP production is predicted to result in the evolution of cooperation between the mitochondrial and nuclear encoded compon
academic.oup.com
May 14, 2025 at 10:00 AM
Just out in @journal-evo.bsky.social: "Testing for age- and sex- specific mitonuclear epistasis in Drosophila"
academic.oup.com/evolut/advan...
academic.oup.com/evolut/advan...
Fantastic seminar from UCL Genetics Institute PhD student Finley Grover-Thomas describing his ongoing work on mitonuclear evolution in human populations of Latin America.
June 2, 2026 at 1:56 PM
Fantastic seminar from UCL Genetics Institute PhD student Finley Grover-Thomas describing his ongoing work on mitonuclear evolution in human populations of Latin America.
Effects of mating system and adaptedness on the evolution of fitness and mtDNA copy number in mitonuclear mismatched C. elegans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Effects of mating system and adaptedness on the evolution of fitness and mtDNA copy number in mitonuclear mismatched C. elegans - Heredity
Heredity - Effects of mating system and adaptedness on the evolution of fitness and mtDNA copy number in mitonuclear mismatched C. elegans
www.nature.com
July 31, 2025 at 1:45 PM
Effects of mating system and adaptedness on the evolution of fitness and mtDNA copy number in mitonuclear mismatched C. elegans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Admixture mapping reveals evidence for multiple mitonuclear incompatibilities in swordtail fish hybrids https://www.biorxiv.org/content/10.1101/2025.01.30.635158v1
February 1, 2025 at 12:32 AM
Admixture mapping reveals evidence for multiple mitonuclear incompatibilities in swordtail fish hybrids https://www.biorxiv.org/content/10.1101/2025.01.30.635158v1
Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans
academic.oup.com/mbe/article/...
academic.oup.com/mbe/article/...
Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans
Abstract. Coordinated genetic and physical interactions between mitochondrial and nuclear gene products regulate ATP production in the mitochondria. Linkin
academic.oup.com
December 12, 2025 at 9:09 PM
Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans
academic.oup.com/mbe/article/...
academic.oup.com/mbe/article/...
A post over a decade in the making… 🙌beyond excited to share our work out today in @science.org. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. Here, we report that dysfunctiona...
www.science.org
February 6, 2025 at 9:22 PM
A post over a decade in the making… 🙌beyond excited to share our work out today in @science.org. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
New publication about the Atlantic bluefin tuna and ancient DNA: with Emma Eriksen, Adam Andrews, Oliver Kersten, Giada Ferrari, Lane Atmore and Bastiaan Star from @unioslo-cees.bsky.social and @biovitenskap.bsky.social published in Heredity by @nature.com
#AncientDNA
www.nature.com/articles/s41...
#AncientDNA
www.nature.com/articles/s41...
Five millennia of mitonuclear discordance in Atlantic bluefin tuna identified using ancient DNA - Heredity
Heredity - Five millennia of mitonuclear discordance in Atlantic bluefin tuna identified using ancient DNA
www.nature.com
February 10, 2025 at 2:34 PM
New publication about the Atlantic bluefin tuna and ancient DNA: with Emma Eriksen, Adam Andrews, Oliver Kersten, Giada Ferrari, Lane Atmore and Bastiaan Star from @unioslo-cees.bsky.social and @biovitenskap.bsky.social published in Heredity by @nature.com
#AncientDNA
www.nature.com/articles/s41...
#AncientDNA
www.nature.com/articles/s41...
Genetic and environmental interactions outweigh mitonuclear coevolution for complex traits in Drosophila https://www.biorxiv.org/content/10.1101/2025.11.24.689096v1
November 26, 2025 at 5:32 AM
Genetic and environmental interactions outweigh mitonuclear coevolution for complex traits in Drosophila https://www.biorxiv.org/content/10.1101/2025.11.24.689096v1
New story on the #AvianHybrids blog!
Mitonuclear discordance in a rapid radiation of Kingfishers
avianhybrids.wordpress.com/2023/11/08/m...
Based on the Molecular Ecology paper by Devon DeRaad and his colleagues | #ornithology
Mitonuclear discordance in a rapid radiation of Kingfishers
avianhybrids.wordpress.com/2023/11/08/m...
Based on the Molecular Ecology paper by Devon DeRaad and his colleagues | #ornithology
Mitonuclear discordance in a rapid radiation of Kingfishers
What evolutionary process can explain this genomic mismatch?
avianhybrids.wordpress.com
November 8, 2023 at 8:09 AM
New story on the #AvianHybrids blog!
Mitonuclear discordance in a rapid radiation of Kingfishers
avianhybrids.wordpress.com/2023/11/08/m...
Based on the Molecular Ecology paper by Devon DeRaad and his colleagues | #ornithology
Mitonuclear discordance in a rapid radiation of Kingfishers
avianhybrids.wordpress.com/2023/11/08/m...
Based on the Molecular Ecology paper by Devon DeRaad and his colleagues | #ornithology
@ltgoncalves.bsky.social @pedropezzi.bsky.social @mdepra.bsky.social @francosoe.bsky.social analyzed mitonuclear coevolution in 55 bumblebee species, finding strong evolutionary rate correlations between mitochondrial and nuclear-interacting genes.
🔗 doi.org/10.1093/gbe/evaf123
#genome #bees
🔗 doi.org/10.1093/gbe/evaf123
#genome #bees
July 9, 2025 at 7:22 AM
@ltgoncalves.bsky.social @pedropezzi.bsky.social @mdepra.bsky.social @francosoe.bsky.social analyzed mitonuclear coevolution in 55 bumblebee species, finding strong evolutionary rate correlations between mitochondrial and nuclear-interacting genes.
🔗 doi.org/10.1093/gbe/evaf123
#genome #bees
🔗 doi.org/10.1093/gbe/evaf123
#genome #bees