#WeekendRead! #MomIsAlwaysMom! Koch, Shenoy et al show @science.org that, in the first 7 days of life, breast milk IgGs (not IgAs!) recognize microbiota & limit, via Fc receptors, Tfh cell and B cell intestinal expansion, protecting against #colitis & #allergy during weaning!
Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens
Maternal antibodies fundamentally regulate gut immunity in the developing infant, yet the mechanisms underlying this process remain elusive. We found that maternal immunoglobulin G (IgG), ingested in ...
doi.org
August 16, 2025 at 2:45 PM
#WeekendRead! #MomIsAlwaysMom! Koch, Shenoy et al show @science.org that, in the first 7 days of life, breast milk IgGs (not IgAs!) recognize microbiota & limit, via Fc receptors, Tfh cell and B cell intestinal expansion, protecting against #colitis & #allergy during weaning!
#WeekendRead! #MomIsAlwaysMom! #EveryCellIsAnImmuneCell! Serhan, Gaudenzio &co show @nature.com that elevated corticosterone in stressed moms alters #skin mast cells & mechanosensing #neurons causing fetal immunedysregulation & eczema after birth. doi.org/10.1038/s415...
Maternal stress triggers early-life eczema through fetal mast cell programming - Nature
Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to otherwise harmless mechanical friction after birth.
doi.org
October 11, 2025 at 3:09 PM
#WeekendRead! #MomIsAlwaysMom! #EveryCellIsAnImmuneCell! Serhan, Gaudenzio &co show @nature.com that elevated corticosterone in stressed moms alters #skin mast cells & mechanosensing #neurons causing fetal immunedysregulation & eczema after birth. doi.org/10.1038/s415...
#WeekendRead! #MomIsAlwaysMom! Dang, Kundu &co show @ CellStemCell that maternal #microbiota imprints the neural and intestinal stem cell compartments of their offsprings via mTOR signaling, leading to long lasting reprogramming of brain & gut functions! Doi.org/10.1016/j.stem.2024.10.003
Redirecting
Doi.org
December 14, 2024 at 4:35 PM
#WeekendRead! #MomIsAlwaysMom! Dang, Kundu &co show @ CellStemCell that maternal #microbiota imprints the neural and intestinal stem cell compartments of their offsprings via mTOR signaling, leading to long lasting reprogramming of brain & gut functions! Doi.org/10.1016/j.stem.2024.10.003
#MomIsAlwaysMom! Pietrasanta, Rescigno &co show @ Cell Host and Microbe that antibiotics treatment of pregnant mice decreases IgAs in the breast milk, causing lower IgA-coated #microbiota, long-lasting dysbiosis & susceptibility to bacterial sepsis!! www.cell.com/cell-host-mi...
Prenatal antibiotics reduce breast milk IgA and induce dysbiosis in mouse offspring, increasing neonatal susceptibility to bacterial sepsis
Up to one-third of women receive antibiotics during pregnancy. Pietrasanta et al.
show that antibiotic treatment of pregnant mice reduces the amount of breast milk
antibodies (SIgA) and alters the neo...
www.cell.com
November 27, 2024 at 5:00 PM
#MomIsAlwaysMom! Pietrasanta, Rescigno &co show @ Cell Host and Microbe that antibiotics treatment of pregnant mice decreases IgAs in the breast milk, causing lower IgA-coated #microbiota, long-lasting dysbiosis & susceptibility to bacterial sepsis!! www.cell.com/cell-host-mi...
#WeekendRead! #MomIsAlwaysMom! Fan Zheng Chen &co show @science.org that a maternal diet-derived fatty acid contained in breast milk potentiates Th1 responses in newborns protecting against bacteria & viruses throughout adulthood!
doi.org/10.1126/scie...
doi.org/10.1126/scie...
Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting
How maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. We report that maternal supplementation with trans-vaccenic acid (TVA), the ...
doi.org
June 27, 2026 at 3:00 PM
#WeekendRead! #MomIsAlwaysMom! Fan Zheng Chen &co show @science.org that a maternal diet-derived fatty acid contained in breast milk potentiates Th1 responses in newborns protecting against bacteria & viruses throughout adulthood!
doi.org/10.1126/scie...
doi.org/10.1126/scie...
#WeekendRead! #MomIsAlwaysMom & #SleepWell! Yao, Itoh &co show @cp-cellmetabolism.bsky.social that mimicking a chronic jet lag in pregnant mice causes decrease fetal size & an offspring that is more susceptible to high fat diet induced #obesity! www.cell.com/cell-metabol...
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring
Yao et al. demonstrate that maternal circadian rhythms during pregnancy impact placental
signature and fetal rhythm. Diet-induced obesity in offspring is exacerbated by in
utero chronodisruption. The ...
www.cell.com
January 25, 2025 at 4:16 PM
#WeekendRead! #MomIsAlwaysMom & #SleepWell! Yao, Itoh &co show @cp-cellmetabolism.bsky.social that mimicking a chronic jet lag in pregnant mice causes decrease fetal size & an offspring that is more susceptible to high fat diet induced #obesity! www.cell.com/cell-metabol...
#WeekendRead! #MomIsAlwaysMom! Huang, Mass &co show @nature.com that obese moms reprogram kupffer cells #KCs of their progeny via glycolysis, favoring lipid uptake by hepatocytes & development of fatty liver disease which can be prevented deleting KCs or HIF1a! www.nature.com/articles/s41...
Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature
In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
www.nature.com
July 6, 2025 at 3:49 PM
#WeekendRead! #MomIsAlwaysMom! Huang, Mass &co show @nature.com that obese moms reprogram kupffer cells #KCs of their progeny via glycolysis, favoring lipid uptake by hepatocytes & development of fatty liver disease which can be prevented deleting KCs or HIF1a! www.nature.com/articles/s41...