Out today... From Bowman lab, MpARF2 is the first essential transcription factor to be described for meristem maintenance in Marchantia. Glad to have contributed to another paper with Eduardo. #plantsciences #evodevo www.sciencedirect.com/science/arti...

📢 New publication 'The B-class #auxin response factor MpARF2 is essential for #meristem organization in free-living #plant gametophytes' by Eduardo Flores-Sandoval et al. in Current Biology 🧪🌱

doi.org/10.1016/j.cu...

So it is likely that the gain of F2 turned the ancestral A-ARF into an activator. We recreated this evolutionary innovation by engineering F2 into the B repressor MpARF2 and lo and behold: it turns into an activator, gains MED15 interaction and loses TPL interaction!!! (13/17)

Using the plant transcription factor MpARF2, we found exactly that.

Rather than existing only as monomers or condensates, MpARF2 forms nanoscopic clusters.

These are not simply small condensates.

Nanoclusters represent a distinct thermodynamic assembly state with unique DNA-binding behavior.

植物の成長を支える転写因子MpARF2の役割を解明した研究成果#東京理科大学#MpARF2#植物ホルモン

東京理科大学の研究チームが、植物の成長点における転写因子MpARF2の重要な役割を解明しました。この発見が植物の未来に与える影響に迫ります。

Both ARFs and MED15 have large Intrinsically Disordered Regions (IDR) and by teaming up with @alexholehouse.bsky.social we found that these IDRs likely mediate multivalent MpARF1-MpMED15 interactions. An MpARF1/MpARF2 knock-in line revealed that both ARFs localize to small, nuclear clusters (10/17)

Eduardo Flores-Sandoval and colleagues propose that the gene MpARF2 and the hormone auxin work together to providing signalling information to surrounding differentiating cells—a game changer for embryophyte evolution doi.org/10.1016/j.cu...

Unlocking the Molecular Mechanisms Behind Continuous Plant Growth#Japan#Tokyo#stem_cells#MpARF2#Plant_Growth

植物の成長を支える転写因子MpARF2の重要な役割を解明#転写因子#ゼニゴケ#植物成長

植物の永続的成長を支える鍵となる転写因子MpARF2の役割を解明。コケ植物ゼニゴケを通じて、成長点のメカニズムを深く探求した。研究の成果は新しい植物育成技術に繋がる可能性も。