Foldseek 10 with 4-27x (1-8 GPUs) faster search through MMseqs2-GPU. Faster ProstT5 protein search w/o structure prediction through multi-GPU/Apple Metal, new BFVD/BFMD databases and multimer clustering (preview).
💾 github.com/steineggerla...
📄 www.biorxiv.org/content/10.1...
🐍 available in bioconda
💾 github.com/steineggerla...
📄 www.biorxiv.org/content/10.1...
🐍 available in bioconda
January 20, 2025 at 2:56 PM
Foldseek 10 with 4-27x (1-8 GPUs) faster search through MMseqs2-GPU. Faster ProstT5 protein search w/o structure prediction through multi-GPU/Apple Metal, new BFVD/BFMD databases and multimer clustering (preview).
💾 github.com/steineggerla...
📄 www.biorxiv.org/content/10.1...
🐍 available in bioconda
💾 github.com/steineggerla...
📄 www.biorxiv.org/content/10.1...
🐍 available in bioconda
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
doi.org
January 3, 2025 at 7:18 PM
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Pangolin 1.23 introduces self-service HA and clustering, alongside CLI improvements, multi-admin support, and organization management updates.
linuxiac.com/pangolin-1-2...
#OpenSource #VPN
linuxiac.com/pangolin-1-2...
#OpenSource #VPN
Pangolin 1.23 Tunneled Reverse Proxy Makes High Availability Easier to Deploy
Pangolin 1.23 introduces self-service HA and clustering, alongside CLI improvements, multi-admin support, and organization management updates.
linuxiac.com
September 19, 2026 at 7:08 PM
Pangolin 1.23 introduces self-service HA and clustering, alongside CLI improvements, multi-admin support, and organization management updates.
linuxiac.com/pangolin-1-2...
#OpenSource #VPN
linuxiac.com/pangolin-1-2...
#OpenSource #VPN
Stat-Arb Is a Clustering Problem: Multi-View Spectral > Any Signal [Aligrithm]
Stat-Arb Is a Clustering Problem: Multi-View Spectral > Any Signal [Aligrithm]
On S&P 500 names from 2000 to 2022, the best book in Raymond Leung's grid is multi-view co-regularized spectral clustering with 25 clusters, a plain long-short spread, and an Ornstein-Uhlenbeck entry and exit. After a 5 basis point charge on each leg at entry and again at exit, that book has an annualized Sharpe ratio of 0.830, a mean excess return of 2.7% a year, and a maximum drawdown
aligrithm.com
September 26, 2026 at 11:29 PM
Stat-Arb Is a Clustering Problem: Multi-View Spectral > Any Signal [Aligrithm]
Today in Nature Genetics:
Analysis of multi-condition single-cell data with latent embedding multivariate regression
www.nature.com/articles/s41...
Analysis of multi-condition single-cell data with latent embedding multivariate regression
www.nature.com/articles/s41...
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
www.nature.com
January 3, 2025 at 8:19 PM
Today in Nature Genetics:
Analysis of multi-condition single-cell data with latent embedding multivariate regression
www.nature.com/articles/s41...
Analysis of multi-condition single-cell data with latent embedding multivariate regression
www.nature.com/articles/s41...
Thrilled to have this work published! Thanks to some awesome teamwork, we've demonstrated improvements in multi-crystal data clustering by automatically separating 🐮🐷🧑🔬 #multicrystal #clustering #crystallography doi.org/10.1107/S205...
Enhanced intensity-based clustering of isomorphous multi-crystal data sets in the presence of subtle variations
Bovine, porcine and human insulin data sets are isomorphous in terms of unit cell and symmetry. Through enhancements to the multi-crystal clustering methods in DIALS, species-pure data sets are automa...
doi.org
May 30, 2025 at 10:26 AM
Thrilled to have this work published! Thanks to some awesome teamwork, we've demonstrated improvements in multi-crystal data clustering by automatically separating 🐮🐷🧑🔬 #multicrystal #clustering #crystallography doi.org/10.1107/S205...
🔥 New Version of Free Google Search Console Report tool featuring Search and Discover Multi-domain reporting, keyword and pages clustering, keywords opportunities and cluster comparisons among, full data export without limits 👌 Take a look at mydomain.dev by the awesome @errioxa.bsky.social
November 28, 2024 at 8:09 PM
🔥 New Version of Free Google Search Console Report tool featuring Search and Discover Multi-domain reporting, keyword and pages clustering, keywords opportunities and cluster comparisons among, full data export without limits 👌 Take a look at mydomain.dev by the awesome @errioxa.bsky.social
Giotto Suite: a multiscale and technology-agnostic spatial multiomics analysis ecosystem
giottosuite.com
Multi-slice/-modal registration
Joint cell type annotation⬅️ multiple segmentation
Integrated modalities-based Leiden clustering
@natmethods.nature.com 2025
www.nature.com/articles/s41...
giottosuite.com
Multi-slice/-modal registration
Joint cell type annotation⬅️ multiple segmentation
Integrated modalities-based Leiden clustering
@natmethods.nature.com 2025
www.nature.com/articles/s41...
October 2, 2025 at 7:05 PM
Giotto Suite: a multiscale and technology-agnostic spatial multiomics analysis ecosystem
giottosuite.com
Multi-slice/-modal registration
Joint cell type annotation⬅️ multiple segmentation
Integrated modalities-based Leiden clustering
@natmethods.nature.com 2025
www.nature.com/articles/s41...
giottosuite.com
Multi-slice/-modal registration
Joint cell type annotation⬅️ multiple segmentation
Integrated modalities-based Leiden clustering
@natmethods.nature.com 2025
www.nature.com/articles/s41...
fritei a cabeça hj mas vamos as conclusões
- vou trocar de mongo pra cassandra (talvez scylla)
- posts ficarão em uma table mesmo, nada "table-per-user" muito menos multi-clustering *sinal da cruz*
- por enquanto vou me preocupar só com a timeline de "following" usando "fan in technique"
- vou trocar de mongo pra cassandra (talvez scylla)
- posts ficarão em uma table mesmo, nada "table-per-user" muito menos multi-clustering *sinal da cruz*
- por enquanto vou me preocupar só com a timeline de "following" usando "fan in technique"
October 25, 2024 at 3:42 AM
fritei a cabeça hj mas vamos as conclusões
- vou trocar de mongo pra cassandra (talvez scylla)
- posts ficarão em uma table mesmo, nada "table-per-user" muito menos multi-clustering *sinal da cruz*
- por enquanto vou me preocupar só com a timeline de "following" usando "fan in technique"
- vou trocar de mongo pra cassandra (talvez scylla)
- posts ficarão em uma table mesmo, nada "table-per-user" muito menos multi-clustering *sinal da cruz*
- por enquanto vou me preocupar só com a timeline de "following" usando "fan in technique"
I’ve tried and failed to get them from him/Lange, but you can use my best shot at replicating it in our upcoming study that extends the model (and inference framework, associated accelerations) for multiallelic data + missing data: github.com/arunsethuram...
GitHub - arunsethuraman/multiclust: Multinomial clustering of multi-allelic, multi-locus population genomic data to assign population structure.
Multinomial clustering of multi-allelic, multi-locus population genomic data to assign population structure. - GitHub - arunsethuraman/multiclust: Multinomial clustering of multi-allelic, multi-lo...
github.com
August 8, 2025 at 12:03 AM
I’ve tried and failed to get them from him/Lange, but you can use my best shot at replicating it in our upcoming study that extends the model (and inference framework, associated accelerations) for multiallelic data + missing data: github.com/arunsethuram...
Pangolin 1.23 Tunneled Reverse Proxy Makes High Availability Easier to Deploy
Pangolin 1.23 introduces self-service HA and clustering, alongside CLI improvements, multi-admin support, and organization management updates.
#Linux
Pangolin 1.23 introduces self-service HA and clustering, alongside CLI improvements, multi-admin support, and organization management updates.
#Linux
Pangolin 1.23 Tunneled Reverse Proxy Makes High Availability Easier to Deploy
Pangolin 1.23 introduces self-service HA and clustering, alongside CLI improvements, multi-admin support, and organization management updates.
linuxiac.com
September 20, 2026 at 5:58 AM
Pangolin 1.23 Tunneled Reverse Proxy Makes High Availability Easier to Deploy
Pangolin 1.23 introduces self-service HA and clustering, alongside CLI improvements, multi-admin support, and organization management updates.
#Linux
Pangolin 1.23 introduces self-service HA and clustering, alongside CLI improvements, multi-admin support, and organization management updates.
#Linux
MULTICLUST is written in C (yes, I know that I’m old school), open source, and can be accessed on my Git page: github.com/arunsethuram... Comments welcome!
GitHub - arunsethuraman/multiclust: Multinomial clustering of multi-allelic, multi-locus population genomic data to assign population structure.
Multinomial clustering of multi-allelic, multi-locus population genomic data to assign population structure. - GitHub - arunsethuraman/multiclust: Multinomial clustering of multi-allelic, multi-lo...
github.com
August 8, 2025 at 4:45 AM
MULTICLUST is written in C (yes, I know that I’m old school), open source, and can be accessed on my Git page: github.com/arunsethuram... Comments welcome!
Chrysalidocarpus lutescens is a fast-growing, clustering palm. It would be great as a source of hearts-of-palm (“palm cabbage”), EXCEPT the growing point (the “heart”) is loaded with cyanogenic glycosides + enzyme. Do not eat it! ☠️ #HCN #Arecaceae #TropicalBotany #Botany 🌾🧪🌱
August 23, 2025 at 11:24 AM
Chrysalidocarpus lutescens is a fast-growing, clustering palm. It would be great as a source of hearts-of-palm (“palm cabbage”), EXCEPT the growing point (the “heart”) is loaded with cyanogenic glycosides + enzyme. Do not eat it! ☠️ #HCN #Arecaceae #TropicalBotany #Botany 🌾🧪🌱
Amy Herring (Duke University) will present the COPSS Elizabeth L. Scott Award Lecture, “Informed Clustering of Multi-View Data,” at 2:05 p.m. in Room CC-210A. tinyurl.com/mrt5482r #STATSSKY #JSM2026
August 4, 2026 at 4:49 PM
Amy Herring (Duke University) will present the COPSS Elizabeth L. Scott Award Lecture, “Informed Clustering of Multi-View Data,” at 2:05 p.m. in Room CC-210A. tinyurl.com/mrt5482r #STATSSKY #JSM2026
3/ Franca brings 2 novel SSL techniques:
(1) A parameter-efficient multi-head clustering projector using nested Matryoshka representations. It refines features into finer clusters, addressing semantic ambiguity, improving performance & memory efficiency
(1) A parameter-efficient multi-head clustering projector using nested Matryoshka representations. It refines features into finer clusters, addressing semantic ambiguity, improving performance & memory efficiency
July 21, 2025 at 2:50 PM
3/ Franca brings 2 novel SSL techniques:
(1) A parameter-efficient multi-head clustering projector using nested Matryoshka representations. It refines features into finer clusters, addressing semantic ambiguity, improving performance & memory efficiency
(1) A parameter-efficient multi-head clustering projector using nested Matryoshka representations. It refines features into finer clusters, addressing semantic ambiguity, improving performance & memory efficiency
Anthony Couthures, Gustave Bainier, Vineeth Satheeskumar Varma, Samson Lasaulce, Irinel-Constantin Morarescu: From Consensus to Robust Clustering: Multi-Agent Systems with Nonlinear Interactions https://hal.science/hal-05763901v1 [spi.auto]
September 28, 2026 at 3:01 AM
Anthony Couthures, Gustave Bainier, Vineeth Satheeskumar Varma, Samson Lasaulce, Irinel-Constantin Morarescu: From Consensus to Robust Clustering: Multi-Agent Systems with Nonlinear Interactions https://hal.science/hal-05763901v1 [spi.auto]
I am proud to share our latest paper📜 “The multi-scale complexity of human genetic variation beyond continental groups”, just pre-printed on @biorxivpreprint.bsky.social !
Link Here ➡️ www.biorxiv.org/content/10.1...
Link Here ➡️ www.biorxiv.org/content/10.1...
The multi-scale complexity of human genetic variation beyond continental groups
Traditional clustering and visualization approaches in human genetics often operate under frameworks that assume inherent, discrete groupings1,2. These methods can inadvertently simplify multifaceted ...
www.biorxiv.org
December 18, 2024 at 4:18 AM
I am proud to share our latest paper📜 “The multi-scale complexity of human genetic variation beyond continental groups”, just pre-printed on @biorxivpreprint.bsky.social !
Link Here ➡️ www.biorxiv.org/content/10.1...
Link Here ➡️ www.biorxiv.org/content/10.1...
New work from @mashaals.bsky.social's group! We develop network-based pipeline & visualization tool that takes some genetic similarity metrics, builds a network, & identifies network communities at multiple resolutions. We then used it on the 1KGP/HGDP datasets for a richer view of human variation.
The multi-scale complexity of human genetic variation beyond continental groups
Traditional clustering and visualization approaches in human genetics often operate under frameworks that assume inherent, discrete groupings1,2. These methods can inadvertently simplify multifaceted ...
www.biorxiv.org
December 17, 2024 at 9:07 PM
New work from @mashaals.bsky.social's group! We develop network-based pipeline & visualization tool that takes some genetic similarity metrics, builds a network, & identifies network communities at multiple resolutions. We then used it on the 1KGP/HGDP datasets for a richer view of human variation.
As we were celebrating psychophysics the other day, here is a fun example in the multi-source auditory domain. So beautiful. So clean. Bayes all the way. journals.plos.org/ploscompbiol...
Perceptual clustering in auditory streaming
Author summary Perceiving the world requires humans to organize perceptual stimuli according to the likely sources that generated them, requiring inference about these sources and their relationship w...
journals.plos.org
January 22, 2026 at 1:12 AM
As we were celebrating psychophysics the other day, here is a fun example in the multi-source auditory domain. So beautiful. So clean. Bayes all the way. journals.plos.org/ploscompbiol...
3/6 The clustering and timing suggest a sustained acceleration in new work intake — the kind of multi-day contract drumbeat that historically signals a shift in backlog composition or a major client ramp.
September 28, 2026 at 1:25 PM
3/6 The clustering and timing suggest a sustained acceleration in new work intake — the kind of multi-day contract drumbeat that historically signals a shift in backlog composition or a major client ramp.
…that "multi-billion" number is exactly 0x7FFFFFFF, or 1111111111111111111111111111111—
Does this mean "literally off the charts", data sources getting cut off outright, or some kind of less horrid explanation? In any case, that's, uh. Quite the number to be clustering at.
Does this mean "literally off the charts", data sources getting cut off outright, or some kind of less horrid explanation? In any case, that's, uh. Quite the number to be clustering at.
Louisville, Kentucky banned masks and, as a result, last week all three of their wastewater monitoring sites were in the top 10 nationwide for multi-billion percent COVID increases (# shown in the righthand column).
Why are people so determined to get sick??
Why are people so determined to get sick??
January 23, 2025 at 1:38 AM
…that "multi-billion" number is exactly 0x7FFFFFFF, or 1111111111111111111111111111111—
Does this mean "literally off the charts", data sources getting cut off outright, or some kind of less horrid explanation? In any case, that's, uh. Quite the number to be clustering at.
Does this mean "literally off the charts", data sources getting cut off outright, or some kind of less horrid explanation? In any case, that's, uh. Quite the number to be clustering at.
Riffing on the recent Jepsen report, I took a look at MariaDB's open-source multi-master clustering database, Galera.
I was impressed both by the work MariaDB has done to make REPEATABLE READ more in line with the literature and also with Galera itself.
theconsensus.dev/p/2026/03/29...
I was impressed both by the work MariaDB has done to make REPEATABLE READ more in line with the literature and also with Galera itself.
theconsensus.dev/p/2026/03/29...
March 29, 2026 at 6:26 PM
Riffing on the recent Jepsen report, I took a look at MariaDB's open-source multi-master clustering database, Galera.
I was impressed both by the work MariaDB has done to make REPEATABLE READ more in line with the literature and also with Galera itself.
theconsensus.dev/p/2026/03/29...
I was impressed both by the work MariaDB has done to make REPEATABLE READ more in line with the literature and also with Galera itself.
theconsensus.dev/p/2026/03/29...
CRISP: Clustering Multi-Vector Representations for Denoising and Pruning
Google introduces a multi-vector training method that learns inherently clusterable representations, outperforming post-hoc clustering methods while reducing vector count.
📝 arxiv.org/abs/2505.11471
Google introduces a multi-vector training method that learns inherently clusterable representations, outperforming post-hoc clustering methods while reducing vector count.
📝 arxiv.org/abs/2505.11471
CRISP: Clustering Multi-Vector Representations for Denoising and Pruning
Multi-vector models, such as ColBERT, are a significant advancement in neural information retrieval (IR), delivering state-of-the-art performance by representing queries and documents by multiple cont...
arxiv.org
May 19, 2025 at 6:15 AM
CRISP: Clustering Multi-Vector Representations for Denoising and Pruning
Google introduces a multi-vector training method that learns inherently clusterable representations, outperforming post-hoc clustering methods while reducing vector count.
📝 arxiv.org/abs/2505.11471
Google introduces a multi-vector training method that learns inherently clusterable representations, outperforming post-hoc clustering methods while reducing vector count.
📝 arxiv.org/abs/2505.11471
Fairy: fast approximate coverage for multi-sample metagenomic binning microbiomejournal.biomedcentral.com/articles/10.... #jcampubs
Fairy: fast approximate coverage for multi-sample metagenomic binning - Microbiome
Background Metagenomic binning, the clustering of assembled contigs that belong to the same genome, is a crucial step for recovering metagenome-assembled genomes (MAGs). Contigs are linked by exploiti...
microbiomejournal.biomedcentral.com
August 16, 2024 at 1:55 PM
Fairy: fast approximate coverage for multi-sample metagenomic binning microbiomejournal.biomedcentral.com/articles/10.... #jcampubs
Paper describing clustering methods to separate subtle structural differences in populations of protein crystals - with application to polymorphs, ligand binding.. - led by Amy Thompson @amyjayyyne.bsky.social with VMXi,I24 and Data Analysis at @ddiamond.bsky.social journals.iucr.org/d/issues/202...
Enhanced intensity-based clustering of isomorphous multi-crystal data sets in the presence of subtle variations
Bovine, porcine and human insulin data sets are isomorphous in terms of unit cell and symmetry. Through enhancements to the multi-crystal clustering methods in DIALS, species-pure data sets are automa...
journals.iucr.org
June 2, 2025 at 7:41 AM
Paper describing clustering methods to separate subtle structural differences in populations of protein crystals - with application to polymorphs, ligand binding.. - led by Amy Thompson @amyjayyyne.bsky.social with VMXi,I24 and Data Analysis at @ddiamond.bsky.social journals.iucr.org/d/issues/202...