How can defective NAA60-mediated N-terminal acetylation cause brain calcification? New perspectives from @henrietteaksnes.bsky.social lab in Brain @oxfordacademic.bsky.social #NAA60 @ispt-proteinterm.bsky.social doi.org/10.1093/brai...
Understanding brain calcification via N-terminal acetylation at the Golgi apparatus
Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder marked by bilateral calcium deposition in the brain parenchyma. Siggerv
doi.org
May 10, 2025 at 7:23 PM
How can defective NAA60-mediated N-terminal acetylation cause brain calcification? New perspectives from @henrietteaksnes.bsky.social lab in Brain @oxfordacademic.bsky.social #NAA60 @ispt-proteinterm.bsky.social doi.org/10.1093/brai...
Uptake of anti-cancer drugs depends on N-terminally acetylated anion channels | @ispt-proteinterm.bsky.social www.nature.com/articles/s42...
NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake - Communications Biology
Genome-wide CRISPR/Cas9 screening identifies the N-terminal acetyltransferase NAA60 to facilitate cis- and carboplatin drug sensitivity, most likely by neutralizing Nt acetylation of the LRRC8A/D VRAC subunits regulating substrate permeability.
www.nature.com
October 7, 2025 at 11:03 AM
Uptake of anti-cancer drugs depends on N-terminally acetylated anion channels | @ispt-proteinterm.bsky.social www.nature.com/articles/s42...
What happens if your transmembrane proteins are not properly N-terminally acetylated? -> Brain calcification. NAA60 variants cause primary familial brain calcifications. Great collab with UCL Chelban and Houlden lab and Aksnes UiB. www.nature.com/articles/s41...
Biallelic NAA60 variants with impaired N-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications - Nature Communications
Most individuals with primary familial brain calcification (PFBC) remain genetically unsolved. Here the authors show that NAA60 biallelic variants cause PFBC, likely via reduced N-terminal acetylation...
www.nature.com
November 21, 2024 at 3:15 PM
What happens if your transmembrane proteins are not properly N-terminally acetylated? -> Brain calcification. NAA60 variants cause primary familial brain calcifications. Great collab with UCL Chelban and Houlden lab and Aksnes UiB. www.nature.com/articles/s41...
RRIDs were included in this paper. Thanks for making your methods matter! #RRID #accelerateopenscience #OpenScience
NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake
doi.org
November 27, 2025 at 8:03 AM
RRIDs were included in this paper. Thanks for making your methods matter! #RRID #accelerateopenscience #OpenScience
Beynin kireçlenmesi hareket bozukluklarına ve bilişsel bozulmaya yol açabilir. Şimdi bu kireçlenmelerin nasıl geliştiğine dair yeni bilgiler sağlayan bir gen tanımlamışlar. NAA60
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 14, 2024 at 5:48 PM
Beynin kireçlenmesi hareket bozukluklarına ve bilişsel bozulmaya yol açabilir. Şimdi bu kireçlenmelerin nasıl geliştiğine dair yeni bilgiler sağlayan bir gen tanımlamışlar. NAA60
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder marked by bilateral calcium deposition in the brain parenchyma. Siggervåg et al. review the role of the Golgi-localized protein NAA60 in PFBC. tinyurl.com/2tnyp37z
May 21, 2025 at 10:41 AM
Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder marked by bilateral calcium deposition in the brain parenchyma. Siggervåg et al. review the role of the Golgi-localized protein NAA60 in PFBC. tinyurl.com/2tnyp37z
Indeed, most Nt-acetylation events occur co-translationally in eukaryotes. Likely to assure an immediate and proper protein maturation, incl. folding, targeting & protection from Ubiquitin E3s. Also post-translational Nt-acetylation: actin (NAA80), transmembrane proteins (NAA60),++ & more to come🤓
December 11, 2025 at 10:34 AM
Indeed, most Nt-acetylation events occur co-translationally in eukaryotes. Likely to assure an immediate and proper protein maturation, incl. folding, targeting & protection from Ubiquitin E3s. Also post-translational Nt-acetylation: actin (NAA80), transmembrane proteins (NAA60),++ & more to come🤓
September 5, 2025 at 7:00 AM