Finally, a SMART approach for the PDA?
One of the thorniest topics in neonatology currently. Some experts seem certain that we can define PDAs that benefit from early treatment. In contrast, the recent trials don't show any clinical benefit in early treated groups compared to controls, and indeed…
One of the thorniest topics in neonatology currently. Some experts seem certain that we can define PDAs that benefit from early treatment. In contrast, the recent trials don't show any clinical benefit in early treated groups compared to controls, and indeed…
Finally, a SMART approach for the PDA?
One of the thorniest topics in neonatology currently. Some experts seem certain that we can define PDAs that benefit from early treatment. In contrast, the recent trials don't show any clinical benefit in early treated groups compared to controls, and indeed usually show an increase in BPD with early treatment, and an increase in mortality with very early treatment. I have posted many times over the last few years about trials of PDA closure. See here and here and here and here Bedside echocardiography has been used to try and define characteristics of the baby and the ductus that might benefit from treatment, but the difficulties in interpretation mean that most of the trials have either just confirmed patency, or have just measured ductus diameter (which isn't much above the limits of resolution of the devices) as a criterion for entry into the trial.
neonatalresearch.org
July 3, 2026 at 9:28 PM
Desperately sad case. We need multidisciplinary teams that use EHRs in NICU/PICU settings to step through their processes & come up with short, medium and long term risk reduction strategies/system-based interventions to prevent future cases #MedSafety #NICUMeds www.judiciary.uk/prevention-o...
February 2, 2026 at 6:20 PM
Desperately sad case. We need multidisciplinary teams that use EHRs in NICU/PICU settings to step through their processes & come up with short, medium and long term risk reduction strategies/system-based interventions to prevent future cases #MedSafety #NICUMeds www.judiciary.uk/prevention-o...
Acute kidney injury affects 1 in 3 NICU infants with prem babies at higher risk. A PDA can compromise organ perfusion, increasing AKI risk. Read more about this in our latest article.
@mijkboyle.bsky.social supervised & Dermot Wildes led the work.
link.springer.com/article/10.1...
@mijkboyle.bsky.social supervised & Dermot Wildes led the work.
link.springer.com/article/10.1...
A Systematic Review of the Incidence of Acute Kidney Injury in Infants with Patent Ductus Arteriosus - Current Pediatrics Reports
Purpose of Review Acute kidney injury (AKI) is common and associated with poor clinical outcomes in neonates, affecting nearly a third of infants admitted to a neonatal intensive care unit (NICU). Pre...
link.springer.com
January 17, 2025 at 9:02 AM