Lots of fluid studies are observational. She is suspicious of this data. Then she show us more observational data.

#NKFClincials

On to how much fluid
CLOVERS after initial resuscitation pressors or fluids?
No difference in primary outcome

#NKFClincials

We give less fluid than Rivers (about half) but we still give a lot and giving that fluid early is better than late.
#NKFClincials

She then showed two different models of sub phenotyping giving very different outcomes. It matters who's you define them. She feels this is the future of AKI.

Now she is going to switch gears and talk about fluid management in sepsis.

#NKFClincials

AKI Subphenotyping

Use this phenotype AKI in the norepinephrine v vasopressin trial

differential response to therapy based on phenotype.

Also seen in CLOVERS trial of fluid management strategies, again differential response to intervention.

#NKFClincials

Subphenotyping has been successful in ARDS. They divided it into hypo- and hyper-inflammatory phenotypes.

These phenotypes respond to therapy differently.

#NKFClincials

Welcome to #NKFClincials! Stay tuned for more info on new innovation in the nephrology community.

Welcome to #NKFClincials! Stay tuned for more info on new innovation in the nephrology community. #KidneyDisease #CKD #healthcare #nephrology

Part 1 of a 2 part CME series on Hep C and CKD now available from the NKF! Take it for FREE online and come to #NKFClincials in Austin for Part 2!