Love seeing entirely novel findings about dopamine
Move over G proteins! Dopamine can regulate glutamate/NMDA directly and without second messenger systems: D2R physically couples GluN2B to suppress NMDA current directly 🤯
(congrats to team from Javitch & Ford labs)
www.science.org/doi/10.1126/...
Move over G proteins! Dopamine can regulate glutamate/NMDA directly and without second messenger systems: D2R physically couples GluN2B to suppress NMDA current directly 🤯
(congrats to team from Javitch & Ford labs)
www.science.org/doi/10.1126/...
Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning
Dopamine acts at D2-NMDA receptor heteromers to control glutamatergic transmission and aversive learning.
www.science.org
August 11, 2026 at 2:55 PM
Love seeing entirely novel findings about dopamine
Move over G proteins! Dopamine can regulate glutamate/NMDA directly and without second messenger systems: D2R physically couples GluN2B to suppress NMDA current directly 🤯
(congrats to team from Javitch & Ford labs)
www.science.org/doi/10.1126/...
Move over G proteins! Dopamine can regulate glutamate/NMDA directly and without second messenger systems: D2R physically couples GluN2B to suppress NMDA current directly 🤯
(congrats to team from Javitch & Ford labs)
www.science.org/doi/10.1126/...
🧪🧠 New preprint: helping resolve a decades-long debate in synaptic plasticity
NMDA receptors are central to Hebbian learning. Yet for >30 years, the existence and function of presynaptic NMDA receptors have remained controversial.
📄 doi.org/10.64898/202...
1/6
NMDA receptors are central to Hebbian learning. Yet for >30 years, the existence and function of presynaptic NMDA receptors have remained controversial.
📄 doi.org/10.64898/202...
1/6
doi.org
February 16, 2026 at 8:28 PM
🧪🧠 New preprint: helping resolve a decades-long debate in synaptic plasticity
NMDA receptors are central to Hebbian learning. Yet for >30 years, the existence and function of presynaptic NMDA receptors have remained controversial.
📄 doi.org/10.64898/202...
1/6
NMDA receptors are central to Hebbian learning. Yet for >30 years, the existence and function of presynaptic NMDA receptors have remained controversial.
📄 doi.org/10.64898/202...
1/6
today i got sent to the principles office for antagonizing all the other girls' NMDA receptors :/
June 19, 2026 at 10:02 PM
today i got sent to the principles office for antagonizing all the other girls' NMDA receptors :/
Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements | Science Advances www.science.org/doi/10.1126/...
Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements
Opening of the NMDA receptor involves bending of the helices lining the ion channel gate.
www.science.org
September 24, 2025 at 6:39 PM
Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements | Science Advances www.science.org/doi/10.1126/...
We show that memantine selectively improves neural decoding of attended illusory Kanizsa triangles, revealing NMDA receptor-dependent enhancement of feedback processing.
elifesciences.org/articles/100...
Thanks to Samuel Noorman @fahrenfort.bsky.social @timostein.bsky.social Jasper Zantvoord
elifesciences.org/articles/100...
Thanks to Samuel Noorman @fahrenfort.bsky.social @timostein.bsky.social Jasper Zantvoord
A causal role of the NMDA receptor in recurrent processing during perceptual integration
Memantine selectively improves neural decoding of attended illusory contours, revealing NMDA receptor-dependent enhancement of feedback processing in human visual perception.
elifesciences.org
June 25, 2025 at 9:46 AM
We show that memantine selectively improves neural decoding of attended illusory Kanizsa triangles, revealing NMDA receptor-dependent enhancement of feedback processing.
elifesciences.org/articles/100...
Thanks to Samuel Noorman @fahrenfort.bsky.social @timostein.bsky.social Jasper Zantvoord
elifesciences.org/articles/100...
Thanks to Samuel Noorman @fahrenfort.bsky.social @timostein.bsky.social Jasper Zantvoord
Geoff Gabriel on FB:
Ketamine was derived from PCP as an NMDA receptor antagonist. It’s a schedule III drug classified as a “dissociative anesthetic.” Patients receive it in medical settings before surgery. It’s also utilized by psychiatric patients (in smaller doses) to manage depression.
Ketamine was derived from PCP as an NMDA receptor antagonist. It’s a schedule III drug classified as a “dissociative anesthetic.” Patients receive it in medical settings before surgery. It’s also utilized by psychiatric patients (in smaller doses) to manage depression.
December 22, 2024 at 12:27 AM
Geoff Gabriel on FB:
Ketamine was derived from PCP as an NMDA receptor antagonist. It’s a schedule III drug classified as a “dissociative anesthetic.” Patients receive it in medical settings before surgery. It’s also utilized by psychiatric patients (in smaller doses) to manage depression.
Ketamine was derived from PCP as an NMDA receptor antagonist. It’s a schedule III drug classified as a “dissociative anesthetic.” Patients receive it in medical settings before surgery. It’s also utilized by psychiatric patients (in smaller doses) to manage depression.
It’s not just size and shape. Synaptic properties, especially those governing NMDA receptor dynamics - play a critical role. Human neurons exhibit steeper NMDA nonlinearities, elevating their computational complexity. (7/11)
December 26, 2024 at 5:31 PM
It’s not just size and shape. Synaptic properties, especially those governing NMDA receptor dynamics - play a critical role. Human neurons exhibit steeper NMDA nonlinearities, elevating their computational complexity. (7/11)
Nature research paper: Conformational diversity and fully opening mechanism of native NMDA receptor
go.nature.com/4aA8NlM
go.nature.com/4aA8NlM
Conformational diversity and fully opening mechanism of native NMDA receptor - Nature
Analyses of heterogeneous assemblies of native NMDA receptors from whole-brain tissue of mice reveal new characteristics of conformational diversity and channel opening.
go.nature.com
February 12, 2026 at 1:03 PM
Nature research paper: Conformational diversity and fully opening mechanism of native NMDA receptor
go.nature.com/4aA8NlM
go.nature.com/4aA8NlM
i personally seem to have a bizarre mutant nmda system and nmda antagonists feel like dying
May 30, 2025 at 4:54 PM
i personally seem to have a bizarre mutant nmda system and nmda antagonists feel like dying
NMDA receptor with xenon entering. Xenon acts as an antagonist and can be used as an anasthetic.
🧪⚗️🧶🧬🐡 #CompChemSky #SciComm #mograph #c4d
🧪⚗️🧶🧬🐡 #CompChemSky #SciComm #mograph #c4d
December 5, 2024 at 5:28 PM
NMDA receptor with xenon entering. Xenon acts as an antagonist and can be used as an anasthetic.
🧪⚗️🧶🧬🐡 #CompChemSky #SciComm #mograph #c4d
🧪⚗️🧶🧬🐡 #CompChemSky #SciComm #mograph #c4d
Just out! Expectations modulate stimulus-evoked recurrent, but not feedforward, processing, and this is attention-dependent. NMDA-dependent feedback specifically supports perceptual integration (illusory contours), rather than mediating expectations (base rate). www.jneurosci.org/content/46/1...
Effects of Expectation, Attention, and NMDA Receptor Blockade on Feedforward and Feedback Processing
Perception is increasingly viewed as an inferential process wherein sensory inputs are integrated with prior expectations. We employed time-resolved decoding on electroencephalography (EEG) data ( n ...
www.jneurosci.org
April 7, 2026 at 2:54 PM
Just out! Expectations modulate stimulus-evoked recurrent, but not feedforward, processing, and this is attention-dependent. NMDA-dependent feedback specifically supports perceptual integration (illusory contours), rather than mediating expectations (base rate). www.jneurosci.org/content/46/1...
Also sorry for your loss. Anesthesiologist here, but iruntbamimma is correct. Although it has potent analgesic properties, Ketamine acts primarily on NMDA receptors, not opiate receptors. It is hallucinogenic, differing in chemical structure from LSD by a single methyl group.
December 30, 2024 at 3:20 AM
Also sorry for your loss. Anesthesiologist here, but iruntbamimma is correct. Although it has potent analgesic properties, Ketamine acts primarily on NMDA receptors, not opiate receptors. It is hallucinogenic, differing in chemical structure from LSD by a single methyl group.
Compared to healthy individuals, people with #Alzheimers disease exhibit decreased NMDA receptors in synapses and increased extrasynaptic membranes.
#neuroscience #neurology
#neuroscience #neurology
Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer’s disease patients. - Instituto de Neurociencias de Alicante
An innovative protocol reveals the distribution of NMDA receptors in the brains of individuals with Alzheimer's. This study, led by the Institute for Neurosciences UMH-CSIC, analyzes for the first tim...
in.umh-csic.es
December 10, 2024 at 1:18 AM
Compared to healthy individuals, people with #Alzheimers disease exhibit decreased NMDA receptors in synapses and increased extrasynaptic membranes.
#neuroscience #neurology
#neuroscience #neurology
nmda受体坏了 随时随地体验无药物的解离
October 21, 2024 at 6:17 AM
nmda受体坏了 随时随地体验无药物的解离
Nature research paper: Mechanism of conductance control and neurosteroid binding in NMDA receptors
go.nature.com/48QfMYq
go.nature.com/48QfMYq
Mechanism of conductance control and neurosteroid binding in NMDA receptors - Nature
Ion-channel conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate receptor.
go.nature.com
November 2, 2025 at 5:28 PM
Nature research paper: Mechanism of conductance control and neurosteroid binding in NMDA receptors
go.nature.com/48QfMYq
go.nature.com/48QfMYq
I was recently diagnosed with a rare autoimmune disorder called anti-NMDA receptor encephalitis. It's a "disease of chaos" that completely upturned my life for a couple months.
I wrote a blog about it that goes into more detail and discusses prognosis. :-)
burntsushi.net/encephalitis/
I wrote a blog about it that goes into more detail and discusses prognosis. :-)
burntsushi.net/encephalitis/
Encephalitis - Andrew Gallant's Blog
burntsushi.net
June 3, 2026 at 1:54 PM
I was recently diagnosed with a rare autoimmune disorder called anti-NMDA receptor encephalitis. It's a "disease of chaos" that completely upturned my life for a couple months.
I wrote a blog about it that goes into more detail and discusses prognosis. :-)
burntsushi.net/encephalitis/
I wrote a blog about it that goes into more detail and discusses prognosis. :-)
burntsushi.net/encephalitis/
i always thought NMDA is latin for mu
December 29, 2024 at 5:30 PM
i always thought NMDA is latin for mu
if you like 5-ht2a agonists you are a problem solver and if you like nmda receptor antagonists you are an ontologist. I don’t make the rules. (because I am a problem solver.)
September 20, 2026 at 3:52 PM
if you like 5-ht2a agonists you are a problem solver and if you like nmda receptor antagonists you are an ontologist. I don’t make the rules. (because I am a problem solver.)
fast post to the effect of "some dissociative symptoms are probably neurological injuries stemming from anesthesia" segyges.github.io/posts/dissoc...
Dissociation as Neurological Injury
A hypothesis connecting childhood surgical anesthesia, NMDA-system injury, and long-term dissociative symptoms
segyges.github.io
August 3, 2026 at 12:59 AM
fast post to the effect of "some dissociative symptoms are probably neurological injuries stemming from anesthesia" segyges.github.io/posts/dissoc...
More evidence of NMDA hypo function-like dysfunction during perception in schizophrenia, disconnecting priors from inputs 👇
January 19, 2025 at 3:06 PM
More evidence of NMDA hypo function-like dysfunction during perception in schizophrenia, disconnecting priors from inputs 👇
כן, nmda זה נחמד, אבל ניסיתם להרים את בן השנה ואז הוא יחליט להניח עליכם את הראש ולחבק אתכם חזק חזק?
#פידעוללים
#פידעוללים
June 1, 2025 at 1:43 PM
כן, nmda זה נחמד, אבל ניסיתם להרים את בן השנה ואז הוא יחליט להניח עליכם את הראש ולחבק אתכם חזק חזק?
#פידעוללים
#פידעוללים
🥁🎉The Psychosis Collective proudly presents our first preprint
𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞
𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴
starring Le He & Harriet Feldman
www.biorxiv.org/content/10.6...
We wanted to understand how antipsychotics work. Thread🧵
𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞
𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴
starring Le He & Harriet Feldman
www.biorxiv.org/content/10.6...
We wanted to understand how antipsychotics work. Thread🧵
March 31, 2026 at 2:19 PM
🥁🎉The Psychosis Collective proudly presents our first preprint
𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞
𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴
starring Le He & Harriet Feldman
www.biorxiv.org/content/10.6...
We wanted to understand how antipsychotics work. Thread🧵
𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞
𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴
starring Le He & Harriet Feldman
www.biorxiv.org/content/10.6...
We wanted to understand how antipsychotics work. Thread🧵
Can damage to a specific brain circuit cause psychosis? New paper out today by @andrewpines.bsky.social @shansiddiqi.bsky.social says Yes! Hub of the circuit is in the hippocampus - great alignment with NMDA encephalitis. @braincircuits.bsky.social
What brain regions are involved in causing psychotic symptoms?
Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵
Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵
February 13, 2025 at 1:34 AM
Can damage to a specific brain circuit cause psychosis? New paper out today by @andrewpines.bsky.social @shansiddiqi.bsky.social says Yes! Hub of the circuit is in the hippocampus - great alignment with NMDA encephalitis. @braincircuits.bsky.social
Our most recent preprint: Presynaptically located NMDA receptors that signal non-ionotropically via JNK2 contribute to Spike-Timing-Dependent Plasticity, STDP. This explains the lack of frequency dependence in timing-dependent Long-Term Depression, tLTD. www.biorxiv.org/content/10.1...
Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling
In the textbook view, NMDA receptors (NMDARs) act as coincidence detectors in Hebbian plasticity by fluxing Ca2+ when simultaneously depolarized and glutamate bound. Hebbian coincidence detection requ...
www.biorxiv.org
February 11, 2025 at 4:08 AM
Our most recent preprint: Presynaptically located NMDA receptors that signal non-ionotropically via JNK2 contribute to Spike-Timing-Dependent Plasticity, STDP. This explains the lack of frequency dependence in timing-dependent Long-Term Depression, tLTD. www.biorxiv.org/content/10.1...
Is actually the opposite. It accelerates vitals if anything. It primarily works NMDA pathway and comparing to opioids is nonsensical unless you do molecular pharmacology for a living and can speak to the nuances
December 30, 2024 at 2:57 AM
Is actually the opposite. It accelerates vitals if anything. It primarily works NMDA pathway and comparing to opioids is nonsensical unless you do molecular pharmacology for a living and can speak to the nuances