Abstract. Consumption of a western diet and high body mass index (BMI) are risk factors for progression from pre-malignant phenotypes to multiple myeloma, a hematologic cancer. In the NUTRIVENTION tri...

Nutrivention is using dietary interventions to impact response to cancer treatment. Increasing fiber intake can improve response rates for patients undergoing immunotherapy treatment for melanoma because fiber is a food source for beneficial bacteria in our gut microbiome. Increasing fiber intake to even just 30 grams per day may lead to positive changes.

Learn more about how a clinical trial at MSK revealed important connections between the foods we eat and our cancer risk.

YouTube video by HealthTree Foundation for Multiple Myeloma

IntroductionPoor diet quality, elevated body mass index (BMI), insulin resistance, microbiome dysbiosis, inflammation as well as immune dysfunction ha…

Can’t access it apparently so not able to look in more detail at the moment

Short answer: yes! Inappropriate use of single arm designs (and over-interpretation of results from them) is a major problem in cancer, that seems to be very under-appreciated. The other issues you mention are kind-of secondary to this. I’ll try to take a look at the study and comment in more detail.

Shah et al. recently published in Cancer Discovery results from the NUTRIVENTION trial, a single-arm dietary intervention study in patients with myeloma precursor disorders. While the research question is clinically important and the comprehensive biomarker assessment commendable, several methodological limitations warrant careful consideration before interpreting the findings as evidence for dietary intervention efficacy. Concerns regarding the single-arm design precluding causal inference, inadequate control for multiplicity across dozens of endpoints, inappropriate dichotomization of continuous outcomes, post-hoc subgroup analyses, and regression to the mean in trajectory analyses. Am I thinking right about this study? Please advise. We can design better studies in my opinion. I am a novice, so seeking opinions from the group here

IntroductionPoor diet quality, elevated body mass index (BMI), insulin resistance, microbiome dysbiosis, inflammation as well as immune dysfunction ha…

IntroductionPoor diet quality, elevated body mass index (BMI), insulin resistance, microbiome dysbiosis, inflammation as well as immune dysfunction ha…

A plant-based diet slashed multiple myeloma risk in NUTRIVENTION trials, while exercise cut colon cancer recurrence by 28% in the CHALLENGE study. Restrictiv...

A plant-based diet slashed multiple myeloma risk in NUTRIVENTION trials, while exercise cut colon cancer recurrence by 28% in the CHALLENGE study. Restrictiv...

A plant-based diet slashed multiple myeloma risk in NUTRIVENTION trials, while exercise cut colon cancer recurrence by 28% in the CHALLENGE study. Restrictiv...

A plant-based diet slashed multiple myeloma risk in NUTRIVENTION trials, while exercise cut colon cancer recurrence by 28% in the CHALLENGE study. Restrictiv...