Computer-based study: Fisetin binds Superoxide Dismutase 1 (#SOD1) E100K mutant, stabilizes structure, reduces β-sheets, changes Free Energy Landscape (FEL) → lowers aggregation risk in amyotrophic lateral sclerosis. #ALS #NaturalPolyphenols www.frontiersin.org/journals/che...
Frontiers | Inhibitory effect of Fisetin against the aggregation process of SOD1 E100K mutant: computer-based drug design as a potential therapeutic for ALS disease
Protein misfolding and aggregation in superoxide dismutase 1 (SOD1) are linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). SOD1 mut...
www.frontiersin.org
August 12, 2025 at 5:27 AM
Computer-based study: Fisetin binds Superoxide Dismutase 1 (#SOD1) E100K mutant, stabilizes structure, reduces β-sheets, changes Free Energy Landscape (FEL) → lowers aggregation risk in amyotrophic lateral sclerosis. #ALS #NaturalPolyphenols www.frontiersin.org/journals/che...