Nature research paper: Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer
go.nature.com/48R5k1V
go.nature.com/48R5k1V
Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer - Nature
The Lap-NET1 phase 1b trial reports that combined netrin1 antibody (NP137) plus modified FOLFIRINOX therapy on patients with locally advanced pancreatic cancer was well tolerated and improved progression-free survival and overall survival via inhibition of epithelial–mesenchymal transition.
go.nature.com
April 24, 2026 at 7:46 AM
Nature research paper: Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer
go.nature.com/48R5k1V
go.nature.com/48R5k1V
A summary thread of our Cell Reports paper published last week. In brief, we found a novel activity for netrin1 in the developing spinal cord: it acts as a boundary, to limit Bmp signaling to the dorsal most spinal cord. 1/9 www.sciencedirect.com/science/arti...
Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling
We have identified an unexpected role for netrin1, a canonical axonal guidance cue, as a suppressor of bone morphogenetic protein (Bmp) signaling in t…
www.sciencedirect.com
November 19, 2024 at 12:17 AM
A summary thread of our Cell Reports paper published last week. In brief, we found a novel activity for netrin1 in the developing spinal cord: it acts as a boundary, to limit Bmp signaling to the dorsal most spinal cord. 1/9 www.sciencedirect.com/science/arti...
Vascularized midbrain assembloids
#ParkinsonsDisease
Vascular+Microglia integration⏫endothelial & microglial morphologic complexity (elongation, arborization)
hiPSC LRRK2 G2019S
👉⬆️% Astrocyte Pericyte Netrin1+GPX4+ Dopaminergic neuron
👉Altered microglial inflamm
www.biorxiv.org/content/10.1...
#ParkinsonsDisease
Vascular+Microglia integration⏫endothelial & microglial morphologic complexity (elongation, arborization)
hiPSC LRRK2 G2019S
👉⬆️% Astrocyte Pericyte Netrin1+GPX4+ Dopaminergic neuron
👉Altered microglial inflamm
www.biorxiv.org/content/10.1...
March 17, 2026 at 12:46 PM
Vascularized midbrain assembloids
#ParkinsonsDisease
Vascular+Microglia integration⏫endothelial & microglial morphologic complexity (elongation, arborization)
hiPSC LRRK2 G2019S
👉⬆️% Astrocyte Pericyte Netrin1+GPX4+ Dopaminergic neuron
👉Altered microglial inflamm
www.biorxiv.org/content/10.1...
#ParkinsonsDisease
Vascular+Microglia integration⏫endothelial & microglial morphologic complexity (elongation, arborization)
hiPSC LRRK2 G2019S
👉⬆️% Astrocyte Pericyte Netrin1+GPX4+ Dopaminergic neuron
👉Altered microglial inflamm
www.biorxiv.org/content/10.1...
New on bioRxiv! 🧠🧬
Our work uncovers how modularity in the DCC-ECD shapes axon guidance and neuronal migration.Using mouse lines with mutations in Netrin-1 and Draxin binding sites, we show how distinct DCC modules drive precise circuit assembly
#Neuroscience #AxonGuidance #DCC #Netrin1 #Draxin
Our work uncovers how modularity in the DCC-ECD shapes axon guidance and neuronal migration.Using mouse lines with mutations in Netrin-1 and Draxin binding sites, we show how distinct DCC modules drive precise circuit assembly
#Neuroscience #AxonGuidance #DCC #Netrin1 #Draxin
Modularity in the DCC extracellular domain elicits distinct effects on axon guidance https://www.biorxiv.org/content/10.64898/2025.12.11.693717v1
December 12, 2025 at 11:12 AM
New on bioRxiv! 🧠🧬
Our work uncovers how modularity in the DCC-ECD shapes axon guidance and neuronal migration.Using mouse lines with mutations in Netrin-1 and Draxin binding sites, we show how distinct DCC modules drive precise circuit assembly
#Neuroscience #AxonGuidance #DCC #Netrin1 #Draxin
Our work uncovers how modularity in the DCC-ECD shapes axon guidance and neuronal migration.Using mouse lines with mutations in Netrin-1 and Draxin binding sites, we show how distinct DCC modules drive precise circuit assembly
#Neuroscience #AxonGuidance #DCC #Netrin1 #Draxin
Netrin1 proteini omuriliğin gelişiminde çok önemli bir rol oynarmış.
Araştırmacılar Netrin1 molekülünün omuriliğin gelişiminde beklenmedik bir rol oynadığını keşfetti.
stemcell.ucla.edu/news/scienti...
Araştırmacılar Netrin1 molekülünün omuriliğin gelişiminde beklenmedik bir rol oynadığını keşfetti.
stemcell.ucla.edu/news/scienti...
Scientists discover ‘entirely unanticipated’ role of protein netrin1 in spinal cord development
Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have uncovered an unexpected role for the molecule netrin1 in organizing the developing spinal cor...
stemcell.ucla.edu
November 18, 2024 at 2:12 PM
Netrin1 proteini omuriliğin gelişiminde çok önemli bir rol oynarmış.
Araştırmacılar Netrin1 molekülünün omuriliğin gelişiminde beklenmedik bir rol oynadığını keşfetti.
stemcell.ucla.edu/news/scienti...
Araştırmacılar Netrin1 molekülünün omuriliğin gelişiminde beklenmedik bir rol oynadığını keşfetti.
stemcell.ucla.edu/news/scienti...
New paper from the Butler lab! More evidence that netrin1 has boundary activity, in this case compartmentalizing the spinal cord by limiting Bmp signaling. newsroom.ucla.edu/releases/sci...
Scientists discover ‘entirely unanticipated’ role of protein netrin1 in spinal cord development
Known for its axon guidance properties, new research suggests protein is critical in guiding neural development.
newsroom.ucla.edu
November 18, 2024 at 1:48 AM
New paper from the Butler lab! More evidence that netrin1 has boundary activity, in this case compartmentalizing the spinal cord by limiting Bmp signaling. newsroom.ucla.edu/releases/sci...
Very excited to see this paper out in print!! it was a wonderful collaboration to identify this unexpected role of Netrin1, which is usually known for axon guidance. Check it out!
A summary thread of our Cell Reports paper published last week. In brief, we found a novel activity for netrin1 in the developing spinal cord: it acts as a boundary, to limit Bmp signaling to the dorsal most spinal cord. 1/9 www.sciencedirect.com/science/arti...
Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling
We have identified an unexpected role for netrin1, a canonical axonal guidance cue, as a suppressor of bone morphogenetic protein (Bmp) signaling in t…
www.sciencedirect.com
November 22, 2024 at 4:53 PM
Very excited to see this paper out in print!! it was a wonderful collaboration to identify this unexpected role of Netrin1, which is usually known for axon guidance. Check it out!
Renal Arteriogenesis by
FoxD1+ stromal progenitor-derived #Netrin1
1) Endothelial #BranchingMorphogenesis
2) #MuralCell vessel coverage
3) Timely differentiation of Six2+ nephron progenitors
@ondinecleaver.bsky.social Development 2023
1/5🧵
journals.biologists.com/dev/article/...
FoxD1+ stromal progenitor-derived #Netrin1
1) Endothelial #BranchingMorphogenesis
2) #MuralCell vessel coverage
3) Timely differentiation of Six2+ nephron progenitors
@ondinecleaver.bsky.social Development 2023
1/5🧵
journals.biologists.com/dev/article/...
October 14, 2023 at 7:20 PM
Renal Arteriogenesis by
FoxD1+ stromal progenitor-derived #Netrin1
1) Endothelial #BranchingMorphogenesis
2) #MuralCell vessel coverage
3) Timely differentiation of Six2+ nephron progenitors
@ondinecleaver.bsky.social Development 2023
1/5🧵
journals.biologists.com/dev/article/...
FoxD1+ stromal progenitor-derived #Netrin1
1) Endothelial #BranchingMorphogenesis
2) #MuralCell vessel coverage
3) Timely differentiation of Six2+ nephron progenitors
@ondinecleaver.bsky.social Development 2023
1/5🧵
journals.biologists.com/dev/article/...
Remarkably, Sandy found that the dI1-dI3s were specifically lost when netrin1 was overexpressed in chicken, while dorsal progenitors (dP) 1-dP3 expanded in the absence of netrin1 in mice. These cell fate changes correlated with the loss or gain of Bmp signaling respectively. 6/9
November 19, 2024 at 12:26 AM
Remarkably, Sandy found that the dI1-dI3s were specifically lost when netrin1 was overexpressed in chicken, while dorsal progenitors (dP) 1-dP3 expanded in the absence of netrin1 in mice. These cell fate changes correlated with the loss or gain of Bmp signaling respectively. 6/9
Sandeep Gupta took a bioinformatic approach using our dI stem cell model to assess the mechanism by which netrin1 regulates cell fate. He identified that netrin1 does not appear to act directly as a Bmp inhibitor but rather regulates mRNA processing. 8/9
November 19, 2024 at 12:29 AM
Sandeep Gupta took a bioinformatic approach using our dI stem cell model to assess the mechanism by which netrin1 regulates cell fate. He identified that netrin1 does not appear to act directly as a Bmp inhibitor but rather regulates mRNA processing. 8/9
Together, these results argued that netrin1 acts from the intermediate spinal cord to regionally confine Bmp signaling to the dorsal spinal cord. 7/9
November 19, 2024 at 12:27 AM
Together, these results argued that netrin1 acts from the intermediate spinal cord to regionally confine Bmp signaling to the dorsal spinal cord. 7/9
Netrin1 antibody NP137 blocks EMT, aiding chemo-resistance in pancreatic cancer. Proven in preclinical & clinical trials with new promise! PMID:42020751, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10436-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1038/s41586-026-10436-4
No description available
doi.org
May 23, 2026 at 6:40 AM
Thus, the presence of netrin1 may stabilize the production of Bmp inhibitors, such as the inhibitory Smad, Smad7. Such inhibitors then suppress Bmp signaling and permitting the specification of the intermediate dI4–dI6 fates. In short, a really enjoyable Butler lab collaboration! 9/9
November 19, 2024 at 12:31 AM
Thus, the presence of netrin1 may stabilize the production of Bmp inhibitors, such as the inhibitory Smad, Smad7. Such inhibitors then suppress Bmp signaling and permitting the specification of the intermediate dI4–dI6 fates. In short, a really enjoyable Butler lab collaboration! 9/9
Work from many labs, including the Butler lab, has shown that Bmps act from the dorsal midline to specify the dorsal-most interneurons, dI1, dI2 and dI3. Moreover, there is a boundary of netrin1 expression immediately adjacent to the dorsal-most spinal cord. 5/9
November 19, 2024 at 12:25 AM
Work from many labs, including the Butler lab, has shown that Bmps act from the dorsal midline to specify the dorsal-most interneurons, dI1, dI2 and dI3. Moreover, there is a boundary of netrin1 expression immediately adjacent to the dorsal-most spinal cord. 5/9
However, Sandy rapidly hit a brick wall, because in the presence of high levels of netrin1 after in ovo electroporation, the commissural (dI1) axons disappeared. This is not a small phenotype; the axons completely disappear. 3/9
November 19, 2024 at 12:23 AM
However, Sandy rapidly hit a brick wall, because in the presence of high levels of netrin1 after in ovo electroporation, the commissural (dI1) axons disappeared. This is not a small phenotype; the axons completely disappear. 3/9
This paper grew out of an unexpected observation, by Sandy Alvarez, as part of her thesis work in the Butler lab. She was expressing tagged netrin1 in the chicken spinal cord, with the goal of live imaging the passage of netrin from progenitors -> pial surface -> axons. 2/9
November 19, 2024 at 12:18 AM
This paper grew out of an unexpected observation, by Sandy Alvarez, as part of her thesis work in the Butler lab. She was expressing tagged netrin1 in the chicken spinal cord, with the goal of live imaging the passage of netrin from progenitors -> pial surface -> axons. 2/9
This result was a mystery for months, until Sandy found a 2021 paper that suggested netrin1 could suppress Bmp signaling in vitro. She then set about assessing whether she had identified the same activity in the spinal cord in vivo. 4/9
pubmed.ncbi.nlm.nih.gov/33883596/
pubmed.ncbi.nlm.nih.gov/33883596/
Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling - PubMed
Netrin-1 is a secreted protein that is well known for its involvement in axonal guidance during embryonic development and as an enhancer of cancer cell metastasis. Despite extensive efforts, the molec...
pubmed.ncbi.nlm.nih.gov
November 19, 2024 at 12:24 AM
This result was a mystery for months, until Sandy found a 2021 paper that suggested netrin1 could suppress Bmp signaling in vitro. She then set about assessing whether she had identified the same activity in the spinal cord in vivo. 4/9
pubmed.ncbi.nlm.nih.gov/33883596/
pubmed.ncbi.nlm.nih.gov/33883596/
Avec les précieuses explications d'Elsa Ducrot, astronome-adjointe au @cea.fr et co-première autrice de l'étude parue dans Nature Astronomy ici : www.nature.com/articles/s41...
Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer - Nature
The Lap-NET1 phase 1b trial reports that combined netrin1 antibody (NP137) plus modified FOLFIRINOX therapy on patients with locally advanced pancreatic cancer was well tolerated and improved progress...
www.nature.com
April 27, 2026 at 9:59 AM
Avec les précieuses explications d'Elsa Ducrot, astronome-adjointe au @cea.fr et co-première autrice de l'étude parue dans Nature Astronomy ici : www.nature.com/articles/s41...
One of the cruelest things pancreatic cancer does is develop resistance to chemo. A first-in-class antibody called NP137, published today in Nature, may stop it from happening & add meaningful months of life. www.nature.com/articles/s41... #PancreaticCancer #Chemotherapy #CancerResearch #NP137 #TCSC
Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer - Nature
The Lap-NET1 phase 1b trial reports that combined netrin1 antibody (NP137) plus modified FOLFIRINOX therapy on patients with locally advanced pancreatic cancer was well tolerated and improved progress...
www.nature.com
April 23, 2026 at 9:35 AM
One of the cruelest things pancreatic cancer does is develop resistance to chemo. A first-in-class antibody called NP137, published today in Nature, may stop it from happening & add meaningful months of life. www.nature.com/articles/s41... #PancreaticCancer #Chemotherapy #CancerResearch #NP137 #TCSC
Feed: "BIOENGINEER.ORG"
By: Bioengineer on Thursday, April 23, 2026
By: Bioengineer on Thursday, April 23, 2026
Blocking Netrin1 Overcomes Pancreatic Cancer Chemoresistance
In an unprecedented leap forward for pancreatic cancer treatment, researchers have unveiled NP137, a novel therapeutic agent that appears to disrupt chemotherapy resistance and enhance patient
bioengineer.org
April 23, 2026 at 10:37 AM
Feed: "BIOENGINEER.ORG"
By: Bioengineer on Thursday, April 23, 2026
By: Bioengineer on Thursday, April 23, 2026
Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer
->Nature | More on "Pancreatic cancer chemotherapy resistance treatment" at BigEarthData.ai
->Nature | More on "Pancreatic cancer chemotherapy resistance treatment" at BigEarthData.ai
Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer
The study objectives and design are described in Methods. Between March 2023 and June 2024, a total of 43 patients from 9 centres were enrolled, including 3 in the safety lead-in phase of the study, where the dose of 14 mg kg−1 every 2 weeks for NP137 was confirmed. Demographics of the safety analysis population (n = 43) were consistent with general trends among patients with LAPC: median age was 65, 51% were male, patients had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 (60%) or 1 (40%). Vascular encasement of aorta, mesenteric superior artery and celiac trunk was present in 5%, 58% and 51% of participants, respectively. Patients were considered at baseline as never resectable (54%) or potentially resectable (46%), with baseline CA 19.9 of more than 500 UI ml−1 in 42% of patients (Supplementary Table 1 and Supplementary Information). Of note, two patients were enrolled despite a metastatic disease. Safety is reported in all 43 participants who received at least one dose of treatment. All patients experienced at least one adverse event: 58% experienced at least one adverse event of grade 3 or higher, 47% experienced at least one NP137-related adverse event, including 12% who experienced...
www.nature.com
April 23, 2026 at 4:31 AM
'Netrin1, ..regulator of tumour epithelial-to-mesenchymal transition'
Relating primarily a neurodevelopmental factor to the so-called EMT, something that no one knows what it is yet, is indeed absurd enough.
@nature.com
Relating primarily a neurodevelopmental factor to the so-called EMT, something that no one knows what it is yet, is indeed absurd enough.
@nature.com
April 25, 2026 at 12:16 PM
'Netrin1, ..regulator of tumour epithelial-to-mesenchymal transition'
Relating primarily a neurodevelopmental factor to the so-called EMT, something that no one knows what it is yet, is indeed absurd enough.
@nature.com
Relating primarily a neurodevelopmental factor to the so-called EMT, something that no one knows what it is yet, is indeed absurd enough.
@nature.com
Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling https://www.biorxiv.org/content/10.1101/2023.11.02.565384v1
Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling https://www.biorxiv.org/content/10.1101/2023.11.02.565384v1
We have identified an unexpected role for netrin1 as a suppressor of bone morphogenetic protein (Bmp
www.biorxiv.org
November 5, 2023 at 4:31 AM
Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling https://www.biorxiv.org/content/10.1101/2023.11.02.565384v1
We first tested the role of Netrin-1 in promoting EMT by overexpressing it in our mouse model. Netrin1 overexpression results in an increase in the number of tumours per mouse and the proportion of tumour cells undergoing EMT (6/23)
November 19, 2024 at 1:55 PM
We first tested the role of Netrin-1 in promoting EMT by overexpressing it in our mouse model. Netrin1 overexpression results in an increase in the number of tumours per mouse and the proportion of tumour cells undergoing EMT (6/23)