Newomics developed a direct-infusion ESI-MS platform for shotgun lipidomics of human plasma samples, that achieves high throughput, high sensitivity, and robustness.

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Newomics MEA Chip is "more than a column" as it monolithically integrates an LC column with an ESI emitter and a post-column inlet (PCI) in zero dead volume connections necessary for sample-limited bo...

From Conference Insights to Real-World Skills ! Join Our Post-MSACL Hands-On Workshop! 26-28 SEPTEMBER 2025 As a post-conference event at MSACL, join MRM Proteomics Inc. for our Hands-on MRM Targeted ...

Newomics MnESI-MS Platform is a robust plug-and-play platform, delivering High-Sensitivity and High-Throughput. MnESI Platform = MnESI Source + M3 Emitter.

Are you ready to explore cutting-edge advancements in mass spectrometry and its transformative role in life sciences and drug development? Join us for an exclusive free online symposium designed to sh...

Build for Superior Microflow and Nanoflow LC-MS DuoESI Platform = DuoESI Source + M3 Emitter The DuoESI source empowers the Newomics award-winning M3 multi-nozzle emitter, and MEA chip with a column m...

The Berkeley biotech that makes the mass spectrometer you already own dramatically better.

Microflow porous graphitized carbon liquid chromatography (PGC-LC) combined with negative mode ionization mass spectrometry (MS) provides high resolution separation and identification of reduced nati...

In most bioanalytical laboratories, high-resolution mass spectrometry (HRMS) systems with electrospray ionization (ESI) are hyphenated to liquid chromatography platforms. The latter typically operate under analytical flow (AF; 0.2–1 mL/min) regimes. Hence, AF/ESI-HRMS methods prioritize the detection of analytes of higher abundances or ionizability and tend to suffer from matrix effects or ion suppression. A far higher sensitivity can be obtained with electrospray at nanoflow (10–1000 nL/min) thanks to a better ionization efficiency and significant decrease in matrix effects. Both advantages are crucial to reliably accessing low-abundance compounds or weakly ionizable analytes. This work presents a microflow (μF) chromatographic setup coupled to a novel microfabricated multinozzle electrospray (mnESI) emitter with five nozzles spraying at 600 nL/min per nozzle for untargeted HRMS lipidomic profiling. With a runtime of 19 min, similar to our established analytical flow (AF/ESI) lipidomics platform, μF/mnESI produced a 16-fold median increase across 69 deuterated lipid standards. The performance of this new configuration was also evaluated in the context of the profiling of a 3D clear cell renal cell carcinoma (ccRCC) model exposed to a multidrug combination therapy. The processing of the acquired data resulted in 1270 (μF/mnESI) vs 752 (AF/ESI) MS2-annotated lipids. Among those, 762 achieved <10% variation on pooled QC samples for μF/mnESI compared to only 361 for the AF method. In addition, the measurements of ccRCC samples confirmed the improvements in ionization efficiency and adduct patterns observed with standards, enabling to annotate 79 oxidized triglycerides, 38 cholesterol esters (only five and four detected in AF/ESI, respectively), and 12 sitosterol esters, not yet reported in mammalian cell cultures.

Newomics MnESI-MS Platform is a robust plug-and-play platform, delivering High-Sensitivity and High-Throughput. MnESI Platform = MnESI Source + M3 Emitter.

The MnESI platform for LC-MS analysis of proteomics shows significant improvement over conventional microflow LC-MS.

Newomics M3 Emitter with MnESI-MS platform achieve high throughput, high sensitivity and robustness in bottom-up proteomics analysis.

Newomics MEA Chip is "more than a column" as it monolithically integrates an LC column with an ESI emitter and a post-column inlet (PCI) in zero dead volume connections necessary for sample-limited bo...

The time has finally arrived: our UniESI Source for Waters mass spectrometers is officially launched and ready to ship. The UniESI Source for Waters features the same excellent benefits of our existin...

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