➡️ Nocturnin drives mitochondrial NADP(H)/NAD(H) rhythms to regulate steroid rhythm amplitude and time metabolism

➡️ Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease

This review highlights how NAD⁺/NADH and NADP⁺/NADPH homeostasis—regulated by NAD kinases, MESH1, NOCT, and circadian control—governs cellular metabolism and redox balance, with dysregulation linked to #cancer and #MetabolicDisease. #Nocturnin

#OpenAccess: doi.org/10.1016/j.ge...

Nocturnin drives mitochondrial NADP(H)/NAD(H) rhythms to regulate steroid rhythm amplitude and time metabolism https://www.biorxiv.org/content/10.64898/2026.07.24.740574v1

Nocturnin drives mitochondrial NADP(H)/NAD(H) rhythms to regulate steroid rhythm amplitude and time metabolism https://www.biorxiv.org/content/10.64898/2026.07.24.740574v1