This observation others w/ #gastruloids on how Matrigel elicits the emergence of somites morphogenesis where somite GRNs are in place or on how spinal cord can refine the patterning of somites. All about higher order organizing interactions between cell populations. #Codevelopment #NotInTheGenes
September 29, 2026 at 7:47 AM
This observation others w/ #gastruloids on how Matrigel elicits the emergence of somites morphogenesis where somite GRNs are in place or on how spinal cord can refine the patterning of somites. All about higher order organizing interactions between cell populations. #Codevelopment #NotInTheGenes
one for the #notinthegenes crowd... 😈
What's wrong with the selfish gene view of evolution? Not much, it turns out (with caveats) 🧵1/6 www.newscientist.com/article/2525...
The Selfish Gene at 50: Why Dawkins’s evolution classic still holds up
When Richard Dawkins’s first blockbuster book was published half a century ago, few genes had ever been sequenced or studied in detail. Yet the book’s gene-centred view of evolution still has much to ...
www.newscientist.com
May 21, 2026 at 9:46 AM
one for the #notinthegenes crowd... 😈
? #NotInTheGenes ?
Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).
Biophysicists are realizing that there is an undervalued element at play in early development: Aside from genes, mechanical forces also steer the growth of embryos. @annademming.bsky.social reports: www.quantamagazine.org/genes-have-h...
October 11, 2025 at 9:13 AM
? #NotInTheGenes ?
Loved it!! And would recommend to all my scientist friends.
#NotInTheGenes
#NotInTheGenes
I wrote something on developmental biology and disability and put it up on the node last night:
thenode.biologists.com/developmenta...
I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!
thenode.biologists.com/developmenta...
I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!
Developmental Biology and Disability - the Node
Hopeful monsters. Morphospace. Mutation. Natural variation. Mutagenesis screens. Polymorphism. Deformity. Phenotype. Disease. Adaptation. Anomaly.
thenode.biologists.com
September 30, 2025 at 3:14 PM
Loved it!! And would recommend to all my scientist friends.
#NotInTheGenes
#NotInTheGenes
In this beautiful system, we could show uncoupling of gene expression profiles, morphology and patterning… #NotInTheGenes 😉 (also includes a method to do long term 🔬 of elongating gastruloids)
Thank you to all involved @jeromewongng.bsky.social @thomasgregor.bsky.social @alexandremayran.bsky.social
Thank you to all involved @jeromewongng.bsky.social @thomasgregor.bsky.social @alexandremayran.bsky.social
Modifying mechanical constraint guides gastruloid patterning
This Research Highlight showcases the work from Judith Pineau @judithpineau.bsky.social, Jerome Wong-Ng @jeromewongng.bsky.social, Thomas Gregor @thomasgregor.bsky.social and colleagues:
journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Judith Pineau @judithpineau.bsky.social, Jerome Wong-Ng @jeromewongng.bsky.social, Thomas Gregor @thomasgregor.bsky.social and colleagues:
journals.biologists.com/dev/article/...
October 3, 2025 at 8:18 AM
In this beautiful system, we could show uncoupling of gene expression profiles, morphology and patterning… #NotInTheGenes 😉 (also includes a method to do long term 🔬 of elongating gastruloids)
Thank you to all involved @jeromewongng.bsky.social @thomasgregor.bsky.social @alexandremayran.bsky.social
Thank you to all involved @jeromewongng.bsky.social @thomasgregor.bsky.social @alexandremayran.bsky.social
These specific polarity defects are challenging to explain by direct transcriptional regulation alone.
While Stat3 transcriptional regulation likely contributes...
#NotInTheGenes
>
While Stat3 transcriptional regulation likely contributes...
#NotInTheGenes
>
February 28, 2025 at 4:20 PM
These specific polarity defects are challenging to explain by direct transcriptional regulation alone.
While Stat3 transcriptional regulation likely contributes...
#NotInTheGenes
>
While Stat3 transcriptional regulation likely contributes...
#NotInTheGenes
>
Our findings highlight non-transcriptional functions of Stat3, propose an overlooked feature in cell polarity – the polarization competence (see below), and advance our understanding of female reproduction.
#NotInTheGenes
>
#NotInTheGenes
>
February 28, 2025 at 4:20 PM
Our findings highlight non-transcriptional functions of Stat3, propose an overlooked feature in cell polarity – the polarization competence (see below), and advance our understanding of female reproduction.
#NotInTheGenes
>
#NotInTheGenes
>
Interesting www.science.org/doi/10.1126/.... Yet the underlaying assumption that one can go from DNA sequence all the way to a full organism deserves some critical discussion in view of Martinez-Arias motto #NotIntheGenes www.science.org/doi/10.1126/... & P Ball's disgressions on causal emergence
Sequence modeling and design from molecular to genome scale with Evo
The genome is a sequence that encodes the DNA, RNA, and proteins that orchestrate an organism’s function. We present Evo, a long-context genomic foundation model with a frontier architecture trained o...
www.science.org
November 15, 2024 at 9:07 AM
Interesting www.science.org/doi/10.1126/.... Yet the underlaying assumption that one can go from DNA sequence all the way to a full organism deserves some critical discussion in view of Martinez-Arias motto #NotIntheGenes www.science.org/doi/10.1126/... & P Ball's disgressions on causal emergence
Check out our lab's latest publication - cells that make waves! We also tell a cautionary tale for those trying to engineer tissues with synthetic gene circuits: tissue physics, such as cellular crowding, may affect circuit behaviour #NotInTheGenes. See Jos's summary for details. More to come soon!
November 26, 2024 at 12:16 AM
Check out our lab's latest publication - cells that make waves! We also tell a cautionary tale for those trying to engineer tissues with synthetic gene circuits: tissue physics, such as cellular crowding, may affect circuit behaviour #NotInTheGenes. See Jos's summary for details. More to come soon!
Then we wondered, how would this impact transcription, would it reflect gastruloid's temporality or morphology? In contrast with morphology, the emergence of a Mesp2 pole was incredibly tight between different sizes #NotintheGenes?
December 24, 2024 at 3:47 PM
Then we wondered, how would this impact transcription, would it reflect gastruloid's temporality or morphology? In contrast with morphology, the emergence of a Mesp2 pole was incredibly tight between different sizes #NotintheGenes?
Then we wondered, how would this impact transcription, would it reflect gastruloid's temporality or morphology? In contrast with morphology, the emergence of a Mesp2 pole was incredibly tight between different sizes #NotintheGenes?
December 24, 2024 at 2:35 PM
Then we wondered, how would this impact transcription, would it reflect gastruloid's temporality or morphology? In contrast with morphology, the emergence of a Mesp2 pole was incredibly tight between different sizes #NotintheGenes?
Then we wondered, how would this impact transcription, would it reflect gastruloid's temporality or morphology? In contrast with morphology, the emergence of a Mesp2 pole was incredibly tight between different sizes #NotintheGenes?
December 24, 2024 at 1:36 PM
Then we wondered, how would this impact transcription, would it reflect gastruloid's temporality or morphology? In contrast with morphology, the emergence of a Mesp2 pole was incredibly tight between different sizes #NotintheGenes?
In the midst of foundational models of the cell (or should I say pseudocell), seen as an “bag”, this www.cell.com/cell/fulltex... is a great antidote, and one that anyone who knows that a cell is more than its genes, can relate to and understand
#RealCellsRUs #NotInTheGenes
#RealCellsRUs #NotInTheGenes
Establishing a conceptual framework for holistic cell states and state transitions
Technological advances have brought “big data” to the cellular level. Rafelski and
Theriot share their vision of defining a cell's state in a holistic way that reflects
all molecular, organizational, ...
www.cell.com
July 14, 2026 at 7:03 AM
In the midst of foundational models of the cell (or should I say pseudocell), seen as an “bag”, this www.cell.com/cell/fulltex... is a great antidote, and one that anyone who knows that a cell is more than its genes, can relate to and understand
#RealCellsRUs #NotInTheGenes
#RealCellsRUs #NotInTheGenes
Because #gastruloids allow measurements, they can teach us about quantitative traits. Exploring #CellCompetiion @joshifrenster.bsky.social et al
www.nature.com/articles/s41...
Biology as a matter of #Genes #Cells and #Numbers but of much that is #NotInTheGenes
www.nature.com/articles/s41...
Biology as a matter of #Genes #Cells and #Numbers but of much that is #NotInTheGenes
Mosaic gastruloids reveal a temporal restriction for developmental cell competition - Nature Cell Biology
Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...
www.nature.com
April 4, 2026 at 3:38 PM
Because #gastruloids allow measurements, they can teach us about quantitative traits. Exploring #CellCompetiion @joshifrenster.bsky.social et al
www.nature.com/articles/s41...
Biology as a matter of #Genes #Cells and #Numbers but of much that is #NotInTheGenes
www.nature.com/articles/s41...
Biology as a matter of #Genes #Cells and #Numbers but of much that is #NotInTheGenes
December 17, 2025 at 8:04 AM
@campaslab.bsky.social @jesseveenvliet.bsky.social labs use #gastruloids to explore axial extension in mammalian embryos
www.biorxiv.org/content/10.1...
They find novel mechanisms involving and interplay of proliferation and mechanical constraining.
#NotInTheGenes #CellsRUs
www.biorxiv.org/content/10.1...
They find novel mechanisms involving and interplay of proliferation and mechanical constraining.
#NotInTheGenes #CellsRUs
November 6, 2025 at 6:40 AM
@campaslab.bsky.social @jesseveenvliet.bsky.social labs use #gastruloids to explore axial extension in mammalian embryos
www.biorxiv.org/content/10.1...
They find novel mechanisms involving and interplay of proliferation and mechanical constraining.
#NotInTheGenes #CellsRUs
www.biorxiv.org/content/10.1...
They find novel mechanisms involving and interplay of proliferation and mechanical constraining.
#NotInTheGenes #CellsRUs
Looking forward to discussing why “genetics is not that simple” tomorrow in Lisboa. Thank you Fundacao Francisco Manues do Santos and GIMM for the opportunity
ffms.pt/en/agenda/al...
#NotInTheGenes #CellsRUs #Gastrulation
ffms.pt/en/agenda/al...
#NotInTheGenes #CellsRUs #Gastrulation
November 3, 2025 at 5:37 AM
Looking forward to discussing why “genetics is not that simple” tomorrow in Lisboa. Thank you Fundacao Francisco Manues do Santos and GIMM for the opportunity
ffms.pt/en/agenda/al...
#NotInTheGenes #CellsRUs #Gastrulation
ffms.pt/en/agenda/al...
#NotInTheGenes #CellsRUs #Gastrulation
October 16, 2025 at 10:13 PM
Today is a special day, some would call it the first of the rest of my life.
I look forward to doing the same as before, from a different vantage point, trying to use what I have learnt to keep on learning. Thank you to all who have taught me.
#NotInTheGenes #CellsRUs
I look forward to doing the same as before, from a different vantage point, trying to use what I have learnt to keep on learning. Thank you to all who have taught me.
#NotInTheGenes #CellsRUs
October 1, 2025 at 4:56 PM
Today is a special day, some would call it the first of the rest of my life.
I look forward to doing the same as before, from a different vantage point, trying to use what I have learnt to keep on learning. Thank you to all who have taught me.
#NotInTheGenes #CellsRUs
I look forward to doing the same as before, from a different vantage point, trying to use what I have learnt to keep on learning. Thank you to all who have taught me.
#NotInTheGenes #CellsRUs
THANK YOU for many years of friendship, support and for sharing your great Science
La Pedrera #Barcelona
#NotInTheGenes #CellsRUs #Cambridge
La Pedrera #Barcelona
#NotInTheGenes #CellsRUs #Cambridge
September 22, 2025 at 9:01 PM
THANK YOU for many years of friendship, support and for sharing your great Science
La Pedrera #Barcelona
#NotInTheGenes #CellsRUs #Cambridge
La Pedrera #Barcelona
#NotInTheGenes #CellsRUs #Cambridge
With the group that came together @upf.edu in #Barcelona, celebrating 5 years of exploring, dreaming and discovering. Grateful #NotInTheGenes #CellsRUs
September 22, 2025 at 2:40 PM
With the group that came together @upf.edu in #Barcelona, celebrating 5 years of exploring, dreaming and discovering. Grateful #NotInTheGenes #CellsRUs
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
September 4, 2025 at 8:52 AM
Need to put an effort to understand cells, the interpreters and users of the genes
#CellsRUs #NotInTheGenes
#CellsRUs #NotInTheGenes
September 4, 2025 at 8:45 AM
Need to put an effort to understand cells, the interpreters and users of the genes
#CellsRUs #NotInTheGenes
#CellsRUs #NotInTheGenes
Hablando con @adrian_science sobre ‘el dia 14. Como las células diseñan la vida’ y sus cuitas con los #genes
shorturl.at/oZcyf
en castellano.
Mas en @EdicionesPaidos “Las arquitectas de la vida’
#NotInTheGenes #CellsRUs
shorturl.at/oZcyf
en castellano.
Mas en @EdicionesPaidos “Las arquitectas de la vida’
#NotInTheGenes #CellsRUs
August 6, 2025 at 11:13 AM
Hablando con @adrian_science sobre ‘el dia 14. Como las células diseñan la vida’ y sus cuitas con los #genes
shorturl.at/oZcyf
en castellano.
Mas en @EdicionesPaidos “Las arquitectas de la vida’
#NotInTheGenes #CellsRUs
shorturl.at/oZcyf
en castellano.
Mas en @EdicionesPaidos “Las arquitectas de la vida’
#NotInTheGenes #CellsRUs
Just heard @wcratcliff.bsky.social on the origin of #multicellularity www.youtube.com/watch?v=MsvD...
Great to hear that cells harnessing physics was a significant step & to have a proper discussion of the question not led by the ‘power’ of genes. Well worth a listen.
#NotInTheGenes #CellsRus
Great to hear that cells harnessing physics was a significant step & to have a proper discussion of the question not led by the ‘power’ of genes. Well worth a listen.
#NotInTheGenes #CellsRus
How Did Multicellular Life Evolve? | Podcast: The Joy of Why
YouTube video by Quanta Magazine
www.youtube.com
August 1, 2025 at 8:11 AM
Just heard @wcratcliff.bsky.social on the origin of #multicellularity www.youtube.com/watch?v=MsvD...
Great to hear that cells harnessing physics was a significant step & to have a proper discussion of the question not led by the ‘power’ of genes. Well worth a listen.
#NotInTheGenes #CellsRus
Great to hear that cells harnessing physics was a significant step & to have a proper discussion of the question not led by the ‘power’ of genes. Well worth a listen.
#NotInTheGenes #CellsRus