Peroxisomes are imp in blood cell differentiation & proposes a role for peroxisomes for structural integrity of hematopoietic stem cell niches in Drosophila. @rohankhadilkar.bsky.social ACTREC-TMC #OBMT26
March 14, 2026 at 1:28 PM
Peroxisomes are imp in blood cell differentiation & proposes a role for peroxisomes for structural integrity of hematopoietic stem cell niches in Drosophila. @rohankhadilkar.bsky.social ACTREC-TMC #OBMT26
Probes to quantitatively measure membrane fluidity of intracellular organeller membranes. More fluid mitochondrial inner-membranes are more respiratory. Gaurav Singh, Sunil Laxman lab, inStem #OBMT26
March 16, 2026 at 12:59 PM
Probes to quantitatively measure membrane fluidity of intracellular organeller membranes. More fluid mitochondrial inner-membranes are more respiratory. Gaurav Singh, Sunil Laxman lab, inStem #OBMT26
Golgi organization is altered on loss of adhesion. Axl inhibition leads to AMPK activation that controls golgi organization through Arf1 activation. Shared talk w/ student Vaishnavi Raut who presents link between autophagy & golgi organization. Nagaraj Balasubramanian, IISER Pune #OBMT26
March 15, 2026 at 3:51 AM
Golgi organization is altered on loss of adhesion. Axl inhibition leads to AMPK activation that controls golgi organization through Arf1 activation. Shared talk w/ student Vaishnavi Raut who presents link between autophagy & golgi organization. Nagaraj Balasubramanian, IISER Pune #OBMT26
Several kinases stabilize and influence septin remodeling in budding yeast to facilitate cytokinesis. These kinases have a kinase-independent role in actomyosin ring organization & dynamics. @syncellbiolab.bsky.social IISc #OBMT26
March 15, 2026 at 6:14 AM
Several kinases stabilize and influence septin remodeling in budding yeast to facilitate cytokinesis. These kinases have a kinase-independent role in actomyosin ring organization & dynamics. @syncellbiolab.bsky.social IISc #OBMT26
Centrosome is a hub for cell cycle regulation & DNA damage signaling. Mapping the functional roles of oncogenic mutations in STIL via BRCA mediated AuroraA centrosomal homeostasis. Priyanka Singh, IIT-Jodhpur #OBMT26
March 15, 2026 at 11:29 AM
Centrosome is a hub for cell cycle regulation & DNA damage signaling. Mapping the functional roles of oncogenic mutations in STIL via BRCA mediated AuroraA centrosomal homeostasis. Priyanka Singh, IIT-Jodhpur #OBMT26
Conventional view: treadmilling actin, barbed ends grow & pointed-ends dont grow/shrink. Profilin inhibits actin pointed-end polymerization. In muscles, old expt suggests pointed-ends can grow. Leiomodin facilitates elongation at the pointed-end. Shashank Shekhar, Emory Univ #OBMT26
March 15, 2026 at 5:47 AM
Conventional view: treadmilling actin, barbed ends grow & pointed-ends dont grow/shrink. Profilin inhibits actin pointed-end polymerization. In muscles, old expt suggests pointed-ends can grow. Leiomodin facilitates elongation at the pointed-end. Shashank Shekhar, Emory Univ #OBMT26
Syntaxin 11 deficiency impaires cell-intrinsic host defence by enhancing Coxiella & Salmonella replication in monocytes & leads to immune disorders. Nisha Singh, Sandhya Ganesan lab, IISER-Trivandrum #OBMT26
March 15, 2026 at 1:51 PM
Syntaxin 11 deficiency impaires cell-intrinsic host defence by enhancing Coxiella & Salmonella replication in monocytes & leads to immune disorders. Nisha Singh, Sandhya Ganesan lab, IISER-Trivandrum #OBMT26
Synaptic release is customized for speed and the amount of secretion & regulation may matter more for insulin/immune cell cargo. Synaptobrevin makes dimers and only a few molecules are needed for fusion, although 70 molecules are present/vesicle. Debasis Das @tifr.res.in #OBMT26
March 16, 2026 at 4:56 AM
Synaptic release is customized for speed and the amount of secretion & regulation may matter more for insulin/immune cell cargo. Synaptobrevin makes dimers and only a few molecules are needed for fusion, although 70 molecules are present/vesicle. Debasis Das @tifr.res.in #OBMT26
Cilia maintenance occurs despite dynamic ciliary composition & ciliary tubulin. Conditional PCM knockdowns after cilia formation leads to cilia defects that is reversible on restoring PCM components. Swadhin Jana @ncbsbangalore.bsky.social #OBMT26
March 15, 2026 at 12:26 PM
Cilia maintenance occurs despite dynamic ciliary composition & ciliary tubulin. Conditional PCM knockdowns after cilia formation leads to cilia defects that is reversible on restoring PCM components. Swadhin Jana @ncbsbangalore.bsky.social #OBMT26
Viruses usurp centrosomes & subvert their function. Flavivirus helicase target to centrosomes, a minimal fragment can target JEV proteins to centrosomes. Centrosomes are proviral in JEV infection. Karthigeyan Dhanasekaran, RCB-UNESCO #OBMT26
March 15, 2026 at 7:28 AM
Viruses usurp centrosomes & subvert their function. Flavivirus helicase target to centrosomes, a minimal fragment can target JEV proteins to centrosomes. Centrosomes are proviral in JEV infection. Karthigeyan Dhanasekaran, RCB-UNESCO #OBMT26
Identifies common players in multiple organisms in making & moving autophagosome. Presents role of the exocyst complex and myosin5 in autophagy. Ravi Manjithaya, JNCASR #OBMT26
March 14, 2026 at 1:04 PM
Identifies common players in multiple organisms in making & moving autophagosome. Presents role of the exocyst complex and myosin5 in autophagy. Ravi Manjithaya, JNCASR #OBMT26
Chromogranin plays roles in dense core vesicle maturation & subcellular distribution, also on golgi organization without widespread trafficking defects. Bhavani Sahu, DBT-NBRC #OBMT26
March 15, 2026 at 5:12 AM
Chromogranin plays roles in dense core vesicle maturation & subcellular distribution, also on golgi organization without widespread trafficking defects. Bhavani Sahu, DBT-NBRC #OBMT26
Vimlesh Kumar IISER-Bhopal introduces the lab. Student Priyabrata: Prefoldin is imp in tracheal luminal physiology & plasticity thru the cytoskeleton. Student Srikanth: Highwire undergoes LLPS & forms condensates in endocytic mutants. #OBMT26
March 15, 2026 at 12:48 PM
Vimlesh Kumar IISER-Bhopal introduces the lab. Student Priyabrata: Prefoldin is imp in tracheal luminal physiology & plasticity thru the cytoskeleton. Student Srikanth: Highwire undergoes LLPS & forms condensates in endocytic mutants. #OBMT26
EVs & lipid droplets both facilitate virus transmission. Immature JEV egress non-lytically via EVs from neuronal cells. Lipid droplets may be used to form multi vesicular bodies and EVs. Sourish Ghosh, IICB-CSIR #OBMT26
March 16, 2026 at 7:28 AM
EVs & lipid droplets both facilitate virus transmission. Immature JEV egress non-lytically via EVs from neuronal cells. Lipid droplets may be used to form multi vesicular bodies and EVs. Sourish Ghosh, IICB-CSIR #OBMT26
Insep/IER3IP1 loss leads to cell division defects & Rab11 vesicle accumulation in Drosophila neuroblasts/human cells. Insep interacts w/ Yip1d1, whose loss leads to cytokinesis failure & Rab11 vesicle accumulation. Sonal Jaiswal, CCMB-CSIR #OBMT26
March 15, 2026 at 1:27 PM
Insep/IER3IP1 loss leads to cell division defects & Rab11 vesicle accumulation in Drosophila neuroblasts/human cells. Insep interacts w/ Yip1d1, whose loss leads to cytokinesis failure & Rab11 vesicle accumulation. Sonal Jaiswal, CCMB-CSIR #OBMT26
Coarse grain Martini molecular model of Caveolin-binding shows that Caveolin both induces and senses membrane curvature. Caveolin binding induced curvature shows that cholesterol & PS are found in the neck. Durba Sengupta, NCL #OBMT26
March 16, 2026 at 12:03 PM
Coarse grain Martini molecular model of Caveolin-binding shows that Caveolin both induces and senses membrane curvature. Caveolin binding induced curvature shows that cholesterol & PS are found in the neck. Durba Sengupta, NCL #OBMT26
Introduces how Stat Mech can be used to study biological systems. Sandeep Choubey, IMSc. Student Prakash Dey presents a theory-expt dialogue showing multi-state actin-binding protein model to account for actin-dynamics. #OBMT26
March 15, 2026 at 7:07 AM
Introduces how Stat Mech can be used to study biological systems. Sandeep Choubey, IMSc. Student Prakash Dey presents a theory-expt dialogue showing multi-state actin-binding protein model to account for actin-dynamics. #OBMT26
Trainee Uma: ATG18 catalyzes a budding process that could be directly involved in regulating morphology. Thomas Pucadyil, IISER-Pune: EHD1 is an ATP dependent cutter. Dynamin is involved in retromer trafficking & differentially regulated by EHD family members. #OBMT26
March 16, 2026 at 2:06 PM
Trainee Uma: ATG18 catalyzes a budding process that could be directly involved in regulating morphology. Thomas Pucadyil, IISER-Pune: EHD1 is an ATP dependent cutter. Dynamin is involved in retromer trafficking & differentially regulated by EHD family members. #OBMT26
Sunando Dutta, IISER-Bhopal introduces 2 roads to metastasis-single cell or collective invasion. Trainee Amrita: HGF/MET facilitates the invadopodia led charge of cell migration thru the ECM. KIF16B drives MET to invadopodia surface delivery #OBMT26
March 16, 2026 at 1:27 PM
Sunando Dutta, IISER-Bhopal introduces 2 roads to metastasis-single cell or collective invasion. Trainee Amrita: HGF/MET facilitates the invadopodia led charge of cell migration thru the ECM. KIF16B drives MET to invadopodia surface delivery #OBMT26
Lysosomes are not only trash cans but also control centers in cell health/disease. Has identified several Arl8 effectors for lysosome motility/distribution. Mechanistic understanding of Arl8's role in osteoclast mediated bone remodeling. Amit Tuli, CSIR-IMTECH #OBMT26
March 14, 2026 at 12:38 PM
Lysosomes are not only trash cans but also control centers in cell health/disease. Has identified several Arl8 effectors for lysosome motility/distribution. Mechanistic understanding of Arl8's role in osteoclast mediated bone remodeling. Amit Tuli, CSIR-IMTECH #OBMT26
Deep dive into how fusion is mediated by viral fusogen proteins w/ pre-fusion, extension & post-fusion confirmations. A fusion loop tryptophan that inserts in the membrane & is enough to cause membrane structure disruption. Tirumala Kumar Chowdary, NISER #OBMT26
March 16, 2026 at 7:49 AM
Deep dive into how fusion is mediated by viral fusogen proteins w/ pre-fusion, extension & post-fusion confirmations. A fusion loop tryptophan that inserts in the membrane & is enough to cause membrane structure disruption. Tirumala Kumar Chowdary, NISER #OBMT26
Suchismita: -vely charged nanoparticles are intracellularly retained more than +vely charged NP. The intracellular compartment of +ve & -ve NPs varies as do their mobility & directionality. Content/type of NP inside vesicle may organize membrane surface compsition. Nitin Mohan lab,IIT-Kanpur #OBMT26
March 16, 2026 at 12:26 PM
Suchismita: -vely charged nanoparticles are intracellularly retained more than +vely charged NP. The intracellular compartment of +ve & -ve NPs varies as do their mobility & directionality. Content/type of NP inside vesicle may organize membrane surface compsition. Nitin Mohan lab,IIT-Kanpur #OBMT26
The luminal domain (LD) region of Seipin/Fld1 is dispensable for lipid droplet biogenesis & function. Fld1-∆LD has gain of function activity but the LD is imp for TAG levels in the cell. Amit Khatri, Vineet Choudhary lab, AIIMS-New Delhi #OBMT26
March 15, 2026 at 4:12 AM
The luminal domain (LD) region of Seipin/Fld1 is dispensable for lipid droplet biogenesis & function. Fld1-∆LD has gain of function activity but the LD is imp for TAG levels in the cell. Amit Khatri, Vineet Choudhary lab, AIIMS-New Delhi #OBMT26
Clathrin heavy chains mutants associated with intellectual disability. Disease CHC mutants over-expressed in Dm ⬇️ ligand uptake on heat stress, no structural or functional defects at the pre-synapse NMJ but alters post-synaptic architecture and impaired learning. Deepa Subramanyam, NCCS #OBMT26
March 16, 2026 at 11:35 AM
Clathrin heavy chains mutants associated with intellectual disability. Disease CHC mutants over-expressed in Dm ⬇️ ligand uptake on heat stress, no structural or functional defects at the pre-synapse NMJ but alters post-synaptic architecture and impaired learning. Deepa Subramanyam, NCCS #OBMT26
Allosteric activation switches of AP2. Akshay: Levels of Muniscin family members influence clathrin mediated Transferrin endocytosis. Sarvesh: Phosphorylation of AP2 via BMPK2 & AAK1 regulates clathrin-mediated endocytosis Umasankar Perunthottam lab, NCCS-DBT #OBMT26
March 16, 2026 at 11:15 AM
Allosteric activation switches of AP2. Akshay: Levels of Muniscin family members influence clathrin mediated Transferrin endocytosis. Sarvesh: Phosphorylation of AP2 via BMPK2 & AAK1 regulates clathrin-mediated endocytosis Umasankar Perunthottam lab, NCCS-DBT #OBMT26