An adult female neotropical otter was rescued from a water well near a Barrackpore home on Friday and released into a branch of the Oropouche River.

To synthesize current evidence on Oropouche virus infection during pregnancy, with particular emphasis on transmission dynamics, clinical presentation, diagnostic challenges, and emerging data on v...

Using a mouse model of congenital infection, researchers show that Oropouche virus causes severe brain damage and developmental defects in the fetus, highlighting its potential to cause congenital dis...

Bannerman et al. demonstrate that OROV causes severe neurodevelopmental pathology in human brain models and has the potential for congenital infection in murine models.

#Oropouche virus disrupts #neurodevelopment and exhibits #congenital infection potential, https://etidiohnew.blogspot.com/2026/09/oropouche-virus-disrupts.html

Remédios serão destinados ao tratamento de sintomas de dengue, chikungunya, zika e febre do Oropouche

CONCLUSION: OROV emergence in Asia is not inevitable but remains a credible preparedness concern. Proactive surveillance, diagnostic readiness, vector competence studies, and regional preparedness are needed to enable early detection and reduce the risk of introduction and establishment.

Oropouche virus (OROV), an emerging arbovirus of the genus Orthobunyavirus, has become a growing public health concern following its recent expansion across the Americas and its potential to cause severe clinical outcomes in maternal and child health. Although Oropouche fever has classically been described as an acute self-limited febrile illness, accumulating evidence indicates that OROV is associated with meningitis and fatal infection, as well as evidence of vertical transmission associated...

The Oropouche virus (OROV) is an emerging orthobunyavirus responsible for significant outbreaks in South America. Its nonstructural protein, NSs, serves as a principal virulence factor by modulating host antiviral responses.MethodsWe investigated whether OROV NSs suppresses type I interferon (IFN-I) signaling downstream of IFNAR activation and examined its effects on host transcription. The function of NSs was analyzed by assessing RNA polymerase II (RNAPII) levels, phosphorylation, transcriptional activity, nucleolar localization, the effects of proteasome inhibition, and the characterization of NoLS-like basic residue motifs.ResultsOROV NSs was found to attenuate IFN-I signaling in human cells without affecting the abundance, phosphorylation, or nuclear localization of STAT1/2. NSs significantly reduced RNAPII protein levels and RNAPII-driven transcription, with this reduction being reversed by proteasome inhibition, indicating proteasome-dependent degradation. NSs partially localized to the nucleolus and disrupted the nucleolar protein fibrillarin. Mutations in two basic residue clusters abolished nucleolar disruption, restored RNAPII abundance, and rescued transcriptional activity.ConclusionsOROV NSs suppresses host transcription through nucleolar targeting and RNAPII degradation, thereby impairing IFN-I signaling downstream of IFNAR. These findings provide mechanistic insights into OROV immune evasion and underscore NSs-mediated transcriptional repression as a critical determinant of viral pathogenesis.

We describe 5 cases of human Oropouche virus infection detected in rural Venezuela in 2025. All isolates belonged to the OROVBr2015-2024 reassortant lineage linked to the 2024-2025 epidemic. Our re...

As cases surged in 2024 in Brazil, reports also emerged of deaths and babies born with microcephaly and other congenital malformations linked to Oropouche virus infection.