A transient RNP compartment boosts translation and growth of mammalian oocytes | Science Advances www.science.org/doi/10.1126/...
A transient RNP compartment boosts translation and growth of mammalian oocytes
Mammalian oocytes undergo an extended growth phase, during which transcription gradually declines. To sustain meiotic divisions and early embryonic development, growing oocytes must accumulate materna...
www.science.org
August 30, 2026 at 8:55 AM
A transient RNP compartment boosts translation and growth of mammalian oocytes | Science Advances www.science.org/doi/10.1126/...
Trade off between large volume of oocytes reducing fidelity of chromosome segregation during meiosis and its requirement for developmental competence during early embryonic divisions after fertilization
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Large Cytoplasm Is Linked to the Error-Prone Nature of Oocytes
Chromosome segregation during meiosis in oocytes is error prone. The uniquely large cytoplasmic size of oocytes, which provides support for embryogene…
www.sciencedirect.com
July 27, 2025 at 3:29 AM
Trade off between large volume of oocytes reducing fidelity of chromosome segregation during meiosis and its requirement for developmental competence during early embryonic divisions after fertilization
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
I’m excited to share that our pic of meiotic midbodies in wildtype and mos mutant oocytes made the cover @jcellsci.bsky.social! Congrats to @muhammad-haseeb.bsky.social and @giselacairobaza.bsky.social!
March 28, 2026 at 4:28 PM
I’m excited to share that our pic of meiotic midbodies in wildtype and mos mutant oocytes made the cover @jcellsci.bsky.social! Congrats to @muhammad-haseeb.bsky.social and @giselacairobaza.bsky.social!
Did you know #zebrafish can change sex as adults? Females that no longer produce oocytes can readily convert to a male, both phenotypically and behaviorally. #ZebrafishFunFacts 🧪
November 30, 2024 at 9:46 AM
Did you know #zebrafish can change sex as adults? Females that no longer produce oocytes can readily convert to a male, both phenotypically and behaviorally. #ZebrafishFunFacts 🧪
Another announcement! 📣 Our work on hybrid incompatibility in cohesin protection in 🐭oocytes is published!! Congrats Warif El Yakoubi and Eddie Pan!!🎉 We found hybrids with cohesion errors in two distinct genus.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Hybrid female sterility due to cohesin protection errors in mouse oocytes
Misregulation of chromosome cohesion during female meiosis serves as a reproductive isolating barrier in mice.
www.science.org
February 7, 2026 at 12:51 AM
Another announcement! 📣 Our work on hybrid incompatibility in cohesin protection in 🐭oocytes is published!! Congrats Warif El Yakoubi and Eddie Pan!!🎉 We found hybrids with cohesion errors in two distinct genus.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Marijuana may damage oocytes — unfertilized eggs in female ovaries — in ways researchers worry may lead to infertility, miscarriage and possible genetic defects in babies, new research has found.
Read more: https://cnn.it/4nm8aRp
Read more: https://cnn.it/4nm8aRp
September 9, 2025 at 4:27 PM
Marijuana may damage oocytes — unfertilized eggs in female ovaries — in ways researchers worry may lead to infertility, miscarriage and possible genetic defects in babies, new research has found.
Read more: https://cnn.it/4nm8aRp
Read more: https://cnn.it/4nm8aRp
Here we go again! Our paper on #proteostasis in human oocytes appeared on the latest @embojournal.org cover! A great collaboration with Dexeus Mujer @bokelab.bsky.social ! 🥂👏🏻💪🏻
August 18, 2025 at 12:35 PM
Here we go again! Our paper on #proteostasis in human oocytes appeared on the latest @embojournal.org cover! A great collaboration with Dexeus Mujer @bokelab.bsky.social ! 🥂👏🏻💪🏻
#NCB2024
In June, Schuh & co analyzed #proteostasis in mammalian #oocytes and ovaries: found that the maintenance of oocytes involves exceptional protein #longevity, and many of the extremely long-lived proteins decline as the ovary ages.
www.nature.com/articles/s41...
In June, Schuh & co analyzed #proteostasis in mammalian #oocytes and ovaries: found that the maintenance of oocytes involves exceptional protein #longevity, and many of the extremely long-lived proteins decline as the ovary ages.
www.nature.com/articles/s41...
The maintenance of oocytes in the mammalian ovary involves extreme protein longevity - Nature Cell Biology
Harasimov, Gorry, Welp, Penir, Horokhovskyi et al. analyse proteostasis in mammalian oocytes and ovaries: the maintenance of oocytes involves exceptional protein longevity, and many of the extremely l...
www.nature.com
December 19, 2024 at 2:13 PM
#NCB2024
In June, Schuh & co analyzed #proteostasis in mammalian #oocytes and ovaries: found that the maintenance of oocytes involves exceptional protein #longevity, and many of the extremely long-lived proteins decline as the ovary ages.
www.nature.com/articles/s41...
In June, Schuh & co analyzed #proteostasis in mammalian #oocytes and ovaries: found that the maintenance of oocytes involves exceptional protein #longevity, and many of the extremely long-lived proteins decline as the ovary ages.
www.nature.com/articles/s41...
Thanks for highlighting our recent work in human oocytes! :) -EB
New online: A snapshot of proteostasis in human oocytes
A snapshot of proteostasis in human oocytes
Nature Structural & Molecular Biology, Published online: 09 September 2025; doi:10.1038/s41594-025-01679-2A snapshot of proteostasis in human oocytes
go.nature.com
September 10, 2025 at 4:53 PM
Thanks for highlighting our recent work in human oocytes! :) -EB
Is your child texting about Invertebrates?
LOL: Love Oceanic Larvae
TBH: Tunicate Bed Heaven
SMH: Some Magnificent Helix
WTF: Wuchereria The Filarial
TFW: Tomopteris - Flashy Worms
ROFL: Regarding Oocytes From Limulus
STFU: Specialised Tentacle For Undulation
LOL: Love Oceanic Larvae
TBH: Tunicate Bed Heaven
SMH: Some Magnificent Helix
WTF: Wuchereria The Filarial
TFW: Tomopteris - Flashy Worms
ROFL: Regarding Oocytes From Limulus
STFU: Specialised Tentacle For Undulation
January 26, 2024 at 2:33 AM
Is your child texting about Invertebrates?
LOL: Love Oceanic Larvae
TBH: Tunicate Bed Heaven
SMH: Some Magnificent Helix
WTF: Wuchereria The Filarial
TFW: Tomopteris - Flashy Worms
ROFL: Regarding Oocytes From Limulus
STFU: Specialised Tentacle For Undulation
LOL: Love Oceanic Larvae
TBH: Tunicate Bed Heaven
SMH: Some Magnificent Helix
WTF: Wuchereria The Filarial
TFW: Tomopteris - Flashy Worms
ROFL: Regarding Oocytes From Limulus
STFU: Specialised Tentacle For Undulation
New #ScienceAdvances research finds that mitochondrial DNA in human oocytes do not accumulate age-related mutations.
Learn more: https://scim.ag/3HswrWL
Learn more: https://scim.ag/3HswrWL
August 19, 2025 at 5:14 PM
New #ScienceAdvances research finds that mitochondrial DNA in human oocytes do not accumulate age-related mutations.
Learn more: https://scim.ag/3HswrWL
Learn more: https://scim.ag/3HswrWL
Oocytes store large amounts of proteins to support the earliest developmental stages. In @nature.com, the Leung group describes the structure of the cytoplasmic lattice in unprecedented detail. At least 13 different proteins assemble into a stable storage complex. hubrecht.eu/oocyte-storage-complex/
April 22, 2026 at 7:20 AM
Oocytes store large amounts of proteins to support the earliest developmental stages. In @nature.com, the Leung group describes the structure of the cytoplasmic lattice in unprecedented detail. At least 13 different proteins assemble into a stable storage complex. hubrecht.eu/oocyte-storage-complex/
Xenopus laevis oocytes as lampshades in the hotel restaurant 🙂🐸🧪
August 19, 2024 at 7:05 AM
Xenopus laevis oocytes as lampshades in the hotel restaurant 🙂🐸🧪
What does an ovary actually look like as it ages—one oocyte at a time?
We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan.
And the ovary turned out to be much more organized than we expected. 🧵 1/5
www.nature.com/articles/s43...
We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan.
And the ovary turned out to be much more organized than we expected. 🧵 1/5
www.nature.com/articles/s43...
Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve - Nature Aging
The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou...
www.nature.com
August 12, 2026 at 11:41 AM
What does an ovary actually look like as it ages—one oocyte at a time?
We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan.
And the ovary turned out to be much more organized than we expected. 🧵 1/5
www.nature.com/articles/s43...
We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan.
And the ovary turned out to be much more organized than we expected. 🧵 1/5
www.nature.com/articles/s43...
This is good news for trans women. In addition to this it is possible to create oocytes from the DNA in our cells meaning that all the technology for us to be able to bear our own children now exists. It is only a matter of time…
First baby born in the UK after womb transplant from deceased donor
Transplants from deceased donors can only happen when the family of someone who has died are asked specifically if they wish to donate the person’s uterus
www.independent.co.uk
February 24, 2026 at 10:05 AM
This is good news for trans women. In addition to this it is possible to create oocytes from the DNA in our cells meaning that all the technology for us to be able to bear our own children now exists. It is only a matter of time…
it's always fun to look back at phd data in @heisenbergcplab.bsky.social - here a wave of acentrosomal microtubule asters forming in maturing zebrafish oocytes, bringing the cytoplasm into motion...
February 15, 2026 at 11:26 AM
it's always fun to look back at phd data in @heisenbergcplab.bsky.social - here a wave of acentrosomal microtubule asters forming in maturing zebrafish oocytes, bringing the cytoplasm into motion...
The proteostatic landscape of healthy human oocytes
Elvan Böke and colleagues @bokelab.bsky.social find that mature human oocytes show reduced activity of lysosomes, proteasomes and mitochondria, highlighting reproductive differences between humans and mouse
www.embopress.org/doi/full/10....
Elvan Böke and colleagues @bokelab.bsky.social find that mature human oocytes show reduced activity of lysosomes, proteasomes and mitochondria, highlighting reproductive differences between humans and mouse
www.embopress.org/doi/full/10....
July 16, 2025 at 11:03 AM
The proteostatic landscape of healthy human oocytes
Elvan Böke and colleagues @bokelab.bsky.social find that mature human oocytes show reduced activity of lysosomes, proteasomes and mitochondria, highlighting reproductive differences between humans and mouse
www.embopress.org/doi/full/10....
Elvan Böke and colleagues @bokelab.bsky.social find that mature human oocytes show reduced activity of lysosomes, proteasomes and mitochondria, highlighting reproductive differences between humans and mouse
www.embopress.org/doi/full/10....
Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: marie-helene.verlhac@college-de-france.fr
For more information, please contact: marie-helene.verlhac@college-de-france.fr
August 28, 2025 at 8:23 AM
Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: marie-helene.verlhac@college-de-france.fr
For more information, please contact: marie-helene.verlhac@college-de-france.fr
At birth upwards of 2 million immature reproductive cells known as oocytes are already present in the ovaries.
July 29, 2025 at 7:04 PM
At birth upwards of 2 million immature reproductive cells known as oocytes are already present in the ovaries.
📣 Paper alert!! Excited to share the 2nd research paper from my time in the @bokelab.bsky.social at @crg.eu, out today in the @embojournal.org!
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
1/
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
1/
July 16, 2025 at 11:36 AM
📣 Paper alert!! Excited to share the 2nd research paper from my time in the @bokelab.bsky.social at @crg.eu, out today in the @embojournal.org!
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
1/
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
1/
How do oocytes prepare for life before life begins? 🧬
Our new review in Annual Review of Cell and Developmental Biology @annualreview explores how oocytes store proteins to support development and fertility. (1/5)
🔗 go.shr.lc/4o9hsk8
Our new review in Annual Review of Cell and Developmental Biology @annualreview explores how oocytes store proteins to support development and fertility. (1/5)
🔗 go.shr.lc/4o9hsk8
October 8, 2025 at 12:50 PM
How do oocytes prepare for life before life begins? 🧬
Our new review in Annual Review of Cell and Developmental Biology @annualreview explores how oocytes store proteins to support development and fertility. (1/5)
🔗 go.shr.lc/4o9hsk8
Our new review in Annual Review of Cell and Developmental Biology @annualreview explores how oocytes store proteins to support development and fertility. (1/5)
🔗 go.shr.lc/4o9hsk8
Check out our latest paper in Science Advances, in which we built a constriction-based microfluidic device to measure the deformability of oocytes to assess their mechanical properties with minimal impact.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Noninvasive characterization of oocyte deformability in microconstrictions
A microfluidic measurement method translates oocyte mechanical characterization into oocyte quality assessment.
www.science.org
February 20, 2025 at 7:11 AM
Check out our latest paper in Science Advances, in which we built a constriction-based microfluidic device to measure the deformability of oocytes to assess their mechanical properties with minimal impact.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Gisela Cairo @giselacairobaza.bsky.social, Muhammad Haseeb @muhammad-haseeb.bsky.social, Soni Lacefield @lacefieldlab.bsky.social & team find that the MOS-MAPK pathway regulates polar body fate in mouse oocytes.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
March 12, 2026 at 2:11 PM
Gisela Cairo @giselacairobaza.bsky.social, Muhammad Haseeb @muhammad-haseeb.bsky.social, Soni Lacefield @lacefieldlab.bsky.social & team find that the MOS-MAPK pathway regulates polar body fate in mouse oocytes.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...