There’s a lot of really good research going on right now in orexin replacement, for both N1 and N2!
In the meantime though, we’ve just gotta keep managing how we can.
In the meantime though, we’ve just gotta keep managing how we can.
January 21, 2026 at 3:41 AM
There’s a lot of really good research going on right now in orexin replacement, for both N1 and N2!
In the meantime though, we’ve just gotta keep managing how we can.
In the meantime though, we’ve just gotta keep managing how we can.
Researchers in South Korea found that SARS-CoV-2 selectively disrupts the brain’s orexin system, leading to lasting cortical neuron damage.
Boosting orexin levels reversed this effect, revealing a possible root of Long COVID fatigue and brain fog.
www.biorxiv.org/content/10.6...
Boosting orexin levels reversed this effect, revealing a possible root of Long COVID fatigue and brain fog.
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 24, 2026 at 5:30 AM
Researchers in South Korea found that SARS-CoV-2 selectively disrupts the brain’s orexin system, leading to lasting cortical neuron damage.
Boosting orexin levels reversed this effect, revealing a possible root of Long COVID fatigue and brain fog.
www.biorxiv.org/content/10.6...
Boosting orexin levels reversed this effect, revealing a possible root of Long COVID fatigue and brain fog.
www.biorxiv.org/content/10.6...
“The discovery of orexins & their link to narcolepsy became central for understanding sleep–wake regulation itself.” 🧪Sebastiaan Overeem & Birgitte R. Kornum report in @nejm.org on the pivotal roles that #LaskerAward winners Mignot & Yanagisawa had in the discovery of orexin:
buff.ly/T3CPftu
buff.ly/T3CPftu
September 24, 2026 at 10:05 PM
“The discovery of orexins & their link to narcolepsy became central for understanding sleep–wake regulation itself.” 🧪Sebastiaan Overeem & Birgitte R. Kornum report in @nejm.org on the pivotal roles that #LaskerAward winners Mignot & Yanagisawa had in the discovery of orexin:
buff.ly/T3CPftu
buff.ly/T3CPftu
Orexin system disruption may be driving Long COVID symptoms and chronic health issues
www.thailandmedical.news/news/orexin-...
www.thailandmedical.news/news/orexin-...
Orexin system disruption may be driving Long COVID symptoms and chronic health issues - Thailand Medical News
www.thailandmedical.news
March 29, 2025 at 3:24 AM
Orexin system disruption may be driving Long COVID symptoms and chronic health issues
www.thailandmedical.news/news/orexin-...
www.thailandmedical.news/news/orexin-...
ME Research UK:
Orexin is a chemical messenger produced in the brain. Disruptions in the orexin system produce symptoms that overlap with long COVID and ME/CFS. A review discusses whether it is feasible that disruptions relating to orexin could be linked to #longCOVID. tinyurl.com/5b34px25
#mecfs
Orexin is a chemical messenger produced in the brain. Disruptions in the orexin system produce symptoms that overlap with long COVID and ME/CFS. A review discusses whether it is feasible that disruptions relating to orexin could be linked to #longCOVID. tinyurl.com/5b34px25
#mecfs
June 14, 2026 at 2:02 PM
ME Research UK:
Orexin is a chemical messenger produced in the brain. Disruptions in the orexin system produce symptoms that overlap with long COVID and ME/CFS. A review discusses whether it is feasible that disruptions relating to orexin could be linked to #longCOVID. tinyurl.com/5b34px25
#mecfs
Orexin is a chemical messenger produced in the brain. Disruptions in the orexin system produce symptoms that overlap with long COVID and ME/CFS. A review discusses whether it is feasible that disruptions relating to orexin could be linked to #longCOVID. tinyurl.com/5b34px25
#mecfs
for some reason down a rabbit hole of mid-80s-mid 2000s discoveries (Leptin, Orexin, Growth Hormone production, cold receptor, p21 KO mouse, human iPSCs, etc) and realizing that they were all accepted less than two week after submission. Orexin in 4 days! Those were the days....
January 1, 2025 at 2:48 AM
for some reason down a rabbit hole of mid-80s-mid 2000s discoveries (Leptin, Orexin, Growth Hormone production, cold receptor, p21 KO mouse, human iPSCs, etc) and realizing that they were all accepted less than two week after submission. Orexin in 4 days! Those were the days....
A cat will sleep for around 16 hours a day, given the chance. Labradors lack the appetite regulator orexin. I think I must be a good 40% cat, 40% labrador.
January 11, 2025 at 4:12 PM
A cat will sleep for around 16 hours a day, given the chance. Labradors lack the appetite regulator orexin. I think I must be a good 40% cat, 40% labrador.
In a new editorial, Clifford B. Saper, MD, PhD, describes the scientific foundations of a trial of an orexin agonist to treat narcolepsy. Read the full editorial: nej.md/4jUOItD
#MedSky #ScienceSky
#MedSky #ScienceSky
Targeting Orexin Receptors to Treat Narcolepsy | NEJM
The author describes the scientific foundations of a trial of an orexin agonist to treat narcolepsy.
nej.md
May 14, 2025 at 10:04 PM
In a new editorial, Clifford B. Saper, MD, PhD, describes the scientific foundations of a trial of an orexin agonist to treat narcolepsy. Read the full editorial: nej.md/4jUOItD
#MedSky #ScienceSky
#MedSky #ScienceSky
Patients with narcolepsy type 1 have hypersomnolence caused by a loss of orexin-producing neurons. Research findings from the TAK-861-2001 trial on oveporexton, a highly selective oral orexin receptor 2 agonist, in these patients are summarized in a new Quick Take video. nej.md/4mdFZUS
#MedSky
#MedSky
May 24, 2025 at 12:01 PM
Patients with narcolepsy type 1 have hypersomnolence caused by a loss of orexin-producing neurons. Research findings from the TAK-861-2001 trial on oveporexton, a highly selective oral orexin receptor 2 agonist, in these patients are summarized in a new Quick Take video. nej.md/4mdFZUS
#MedSky
#MedSky
The sleep need reduction proposal with @niplav.bsky.social and nomagicpill is up!!
manifund.org/projects/ore...
manifund.org/projects/ore...
Orexin Pilot Experiment for Reducing Sleep Need
Testing intranasal orexin-A administration for sleep need reduction: a 2-3 participant self-blinded randomized controlled trial
manifund.org
May 22, 2025 at 7:04 PM
The sleep need reduction proposal with @niplav.bsky.social and nomagicpill is up!!
manifund.org/projects/ore...
manifund.org/projects/ore...
“The discovery of orexins & their link to narcolepsy became central for understanding sleep–wake regulation itself.” 🧪Sebastiaan Overeem & Birgitte R. Kornum report in @nejm.org on the pivotal roles that #LaskerAward winners Mignot & Yanagisawa had in the discovery of orexin:
buff.ly/T3CPftu
buff.ly/T3CPftu
September 13, 2026 at 10:25 PM
“The discovery of orexins & their link to narcolepsy became central for understanding sleep–wake regulation itself.” 🧪Sebastiaan Overeem & Birgitte R. Kornum report in @nejm.org on the pivotal roles that #LaskerAward winners Mignot & Yanagisawa had in the discovery of orexin:
buff.ly/T3CPftu
buff.ly/T3CPftu
🎥 Watch for an explainer of the science behind the 2026 Albert Lasker Basic Medical Research Award.
#Lasker2026 #LaskerAward Stanford Medicine 🧪
#Lasker2026 #LaskerAward Stanford Medicine 🧪
Unlocking a Secret to Sleep and Wakefulness
The 2026 Lasker Basic Medical Research Award honors Emmanuel Mignot and Masashi Yanagisawa for identification of orexin, a brain peptide that maintains wakefulness, and the discovery that orexin deficiency causes uncontrolled sleep in narcolepsy—revealing a key insight into the nature of sleep.
youtu.be
September 25, 2026 at 9:50 PM
🎥 Watch for an explainer of the science behind the 2026 Albert Lasker Basic Medical Research Award.
#Lasker2026 #LaskerAward Stanford Medicine 🧪
#Lasker2026 #LaskerAward Stanford Medicine 🧪
Hello! I’m presenting a poster at #ACNP2024 from the lab Monday night on opioid use and orexin/dynorphin modulation of VTA firing. Come talk to me!
We are officially on the ground in Phoenix so it's time for the #ACNP2024 role call 📣
Introduce yourself, your science, tell us if you're a veteran or first-timer, promote your poster/talk/favorite social - whatever you want, this is your space to say it ⬇️
Introduce yourself, your science, tell us if you're a veteran or first-timer, promote your poster/talk/favorite social - whatever you want, this is your space to say it ⬇️
a poster of a witch and a girl with the words say something
ALT: a poster of a witch and a girl with the words say something
media.tenor.com
December 7, 2024 at 3:19 AM
Hello! I’m presenting a poster at #ACNP2024 from the lab Monday night on opioid use and orexin/dynorphin modulation of VTA firing. Come talk to me!
🧬Science Wednesdays: Orexin
Orexin is a peptide in the brain that is a major regulator of sleep/wake cycles. When its levels are abnormal, it can have notable impacts on a person’s health. (1/4)
Orexin is a peptide in the brain that is a major regulator of sleep/wake cycles. When its levels are abnormal, it can have notable impacts on a person’s health. (1/4)
April 16, 2025 at 4:29 PM
🧬Science Wednesdays: Orexin
Orexin is a peptide in the brain that is a major regulator of sleep/wake cycles. When its levels are abnormal, it can have notable impacts on a person’s health. (1/4)
Orexin is a peptide in the brain that is a major regulator of sleep/wake cycles. When its levels are abnormal, it can have notable impacts on a person’s health. (1/4)
"neurons ... in hypothalamus secrete the neuropeptide orexin simultaneously control both food intake and energy expenditure. → orexin neurons influence the decision between eating and exercising, rather than influencing how much the mice move or eat" www.the-scientist.com/how-the-brai...
How the Brain Chooses to Eat or Exercise
Neurons that secrete the neuropeptide orexin help mice decide between exercise and snacking.
www.the-scientist.com
February 8, 2025 at 10:17 PM
"neurons ... in hypothalamus secrete the neuropeptide orexin simultaneously control both food intake and energy expenditure. → orexin neurons influence the decision between eating and exercising, rather than influencing how much the mice move or eat" www.the-scientist.com/how-the-brai...
Excited to share new research from my lab in final published form! By deleting hypocretin (orexin) receptors from CRF neurons, we uncovered neuropeptide mechanisms linking alcohol drinking and negative emotional hyperarousal through BNST neuronal excitability.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 3, 2025 at 5:19 PM
Excited to share new research from my lab in final published form! By deleting hypocretin (orexin) receptors from CRF neurons, we uncovered neuropeptide mechanisms linking alcohol drinking and negative emotional hyperarousal through BNST neuronal excitability.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
🧪 Watch Emmanuel Mignot’s & Masashi Yanasigawa’s dobermans and mice with narcolepsy (see mouse in lower right-hand corner).
They won a 2026 #LaskerAward for identifying the brain peptide orexin & discovering that orexin deficiency causes uncontrolled sleep in narcolepsy: https://ow.ly/JECv50ZNtsV
They won a 2026 #LaskerAward for identifying the brain peptide orexin & discovering that orexin deficiency causes uncontrolled sleep in narcolepsy: https://ow.ly/JECv50ZNtsV
September 15, 2026 at 11:35 PM
🧪 Watch Emmanuel Mignot’s & Masashi Yanasigawa’s dobermans and mice with narcolepsy (see mouse in lower right-hand corner).
They won a 2026 #LaskerAward for identifying the brain peptide orexin & discovering that orexin deficiency causes uncontrolled sleep in narcolepsy: https://ow.ly/JECv50ZNtsV
They won a 2026 #LaskerAward for identifying the brain peptide orexin & discovering that orexin deficiency causes uncontrolled sleep in narcolepsy: https://ow.ly/JECv50ZNtsV
An integrative review on the orexin system and hypothalamic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: implications for precision medicine
www.explorationpub.com/Journals/ent...
Screenshot from latest Science for ME weekly update
#MEcfs #CFS #PwME
www.explorationpub.com/Journals/ent...
Screenshot from latest Science for ME weekly update
#MEcfs #CFS #PwME
August 25, 2025 at 2:37 AM
An integrative review on the orexin system and hypothalamic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: implications for precision medicine
www.explorationpub.com/Journals/ent...
Screenshot from latest Science for ME weekly update
#MEcfs #CFS #PwME
www.explorationpub.com/Journals/ent...
Screenshot from latest Science for ME weekly update
#MEcfs #CFS #PwME
Orexin-A ordered, arrives in two days
July 7, 2025 at 3:49 PM
Orexin-A ordered, arrives in two days
My RU colleague, Morgan James, and I are gonna do some fun science for the next two years studying how bisphenol A screws up orexin neurons.
February 9, 2024 at 4:46 PM
My RU colleague, Morgan James, and I are gonna do some fun science for the next two years studying how bisphenol A screws up orexin neurons.
4) Something similar has been reported in type I narcolepsy, a rare autoimmune disease that targets orexin neurons. Due to a lack of orexin, these patients fall asleep uncontrollably during the day and suffer from sudden muscle weakness.
December 29, 2025 at 4:05 PM
4) Something similar has been reported in type I narcolepsy, a rare autoimmune disease that targets orexin neurons. Due to a lack of orexin, these patients fall asleep uncontrollably during the day and suffer from sudden muscle weakness.
I wouldn't say they're entirely unrelated. There's increasing evidence ADHD involves orexin dysregulation to some degree, and narcolepsy is caused by orexin deficiency.
September 16, 2026 at 9:14 PM
I wouldn't say they're entirely unrelated. There's increasing evidence ADHD involves orexin dysregulation to some degree, and narcolepsy is caused by orexin deficiency.
Congratulations to 2026 #LaskerAward winners Emmanuel Mignot and Masashi Yanagisawa! For identification of orexin, a brain peptide that maintains wakefulness, and the discovery that orexin deficiency causes uncontrolled sleep in #narcolepsy — revealing a key insight into the nature of sleep. 🧪
September 9, 2026 at 12:40 PM
Congratulations to 2026 #LaskerAward winners Emmanuel Mignot and Masashi Yanagisawa! For identification of orexin, a brain peptide that maintains wakefulness, and the discovery that orexin deficiency causes uncontrolled sleep in #narcolepsy — revealing a key insight into the nature of sleep. 🧪
45% of those with #LongCOVID suffer from a sleep disorder.
It's so prevalent it's dubbed 'coronasomnia'.
Overall, CSF orexin-A levels are crucial for diagnosing and understanding various sleep disorders and neurological conditions.
pubmed.ncbi.nlm.nih.gov/11756606/
It's so prevalent it's dubbed 'coronasomnia'.
Overall, CSF orexin-A levels are crucial for diagnosing and understanding various sleep disorders and neurological conditions.
pubmed.ncbi.nlm.nih.gov/11756606/
CSF hypocretin/orexin levels in narcolepsy and other neurological conditions - PubMed
Undetectable CSF hypocretin-1 levels are highly specific to narcolepsy and rare cases of GBS. Measuring hypocretin-1 levels in the CSF of patients suspected of narcolepsy is a useful diagnostic proced...
pubmed.ncbi.nlm.nih.gov
September 13, 2025 at 9:01 PM
45% of those with #LongCOVID suffer from a sleep disorder.
It's so prevalent it's dubbed 'coronasomnia'.
Overall, CSF orexin-A levels are crucial for diagnosing and understanding various sleep disorders and neurological conditions.
pubmed.ncbi.nlm.nih.gov/11756606/
It's so prevalent it's dubbed 'coronasomnia'.
Overall, CSF orexin-A levels are crucial for diagnosing and understanding various sleep disorders and neurological conditions.
pubmed.ncbi.nlm.nih.gov/11756606/
Translational Psychiatry
An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour
www.nature.com/articles/s41...
An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour
www.nature.com/articles/s41...
An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour - Translational Psychiatry
Translational Psychiatry - An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour
www.nature.com
April 15, 2025 at 2:16 PM
Translational Psychiatry
An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour
www.nature.com/articles/s41...
An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour
www.nature.com/articles/s41...