#PBVAB17
#PBVAB17 @aschier1 @vvirdi Right, you two, I’m closing so you have to tweet the bitter end of the conference 😎
November 21, 2024 at 6:47 PM
#PBVAB17 Steinmetz: Can image via NMR at 400x lower dose of contrast agent normally used.
November 21, 2024 at 6:47 PM
#PBVAB17 Steinmetz: Label TMV exterior with targetting ligands via Tyr 139, interior cavity with contrast agents.
November 21, 2024 at 6:47 PM
#PBVAB17 Yongjik Lee: points out that molecular farming is attracting lots attention in Korea from big industry.
November 21, 2024 at 6:47 PM
#PBVAB17 Barry Holtz, iBio: he says “We make antibodies” – not plant-made antibodies. A CDMO - commercial development manufac organisation
November 21, 2024 at 6:46 PM
#PBVAB17 Schaaf: use ways of making biologics same as CHO cells to largest extent, so as to preserve similarities in processing & equip
November 21, 2024 at 6:46 PM
#PBVAB17 Vikram Virdi: putting the AS in GRAS - showing that edible seed homogenates containing sIgA protect the Ab through to faeces 😎
November 21, 2024 at 6:46 PM
#PBVAB17 Greta Besenyei
Using microalga Phaeodactylum tricornutum proprietary vectors etc Excellent technoeconomic models and protocols
November 21, 2024 at 6:46 PM
#PBVAB17 Steinmetz: Cowpea mosaic virus VLPs are excellent elicitors of anti-tumour responses all by themselves
November 21, 2024 at 6:46 PM
#PBVAB17 Nicole Steinmetz
Plant virus-based nanotech – exploits natural role as experts in self-assembly and delivery of cargoes into cells
November 21, 2024 at 6:46 PM
#PBVAB17 Ahmad Ibrahim:
Lettuce necrotic yellows virus-derived minireplicon as recombinant expression vector - Rhabdo-like.
November 21, 2024 at 6:46 PM
Mi-Young Kim: increased immgenicity of plant-made DENV EDIII domain by fusing with Ig Fc, and got x-neut of all 4 dengue subtypes #PBVAB17
November 21, 2024 at 6:46 PM
#PBVAB17 Reza Saberianfar: achieved 350 mg/kg FW content of secretory camellid VHH-IgA hybrid anti-Shiga toxin
November 21, 2024 at 6:46 PM
#PBVAB17 Steinkellner: can get plant-made HIV neut PG9 Abs to do ADCC by glycoengineering and sulphation - new activity for these Abs!
November 21, 2024 at 6:46 PM
#PBVAB17 Herta Steinkellner: sulphation of anti-HIV NAb in plants achieved using engineered human enzyme - got signif inc neut activity
November 21, 2024 at 6:46 PM
#PBVAB17 Only Yuri Gleba could get away with calling a company Nambawan 😀
November 21, 2024 at 6:46 PM
#PBVAB17 Orzaez: successful in making effective pluribody camellid VHH Abs in plants against snake venom! Plant-made PolymAbs are here 😀
November 21, 2024 at 6:46 PM
#pbvab17 Stefan Warner: can get more uniform N-glycosylation and more complete sialylation of Abs in engineered plants
November 21, 2024 at 6:46 PM
#PBVAB17 Depicker: Abs in transgenic seeds stable for 5 yrs at room temp - and can be delivered in seeds.
November 21, 2024 at 6:46 PM
#PBVAB17 I noted that an anally appled antimicrobial could be said to have ASS status, rather than GRAS 😎
November 21, 2024 at 6:46 PM
#PBVAB17 Gleba: Got FDA approval for plant-made colicin treatment for vegetables in 2015, and in 2017 from USDA as well for meat products
November 21, 2024 at 6:45 PM
#PBVAB17: Gleba: “Your burger is a bigger threat than radical Islam”. Organic veg too - bacterial contamination a big and growing problem.
November 21, 2024 at 6:45 PM
#PBVAB17 Gleba: “A group for whom time horizon is not compatible with long-term product development”. I’m in that group 😟
November 21, 2024 at 6:45 PM
#PBVAB17 Michael Pauly: relied on Nature paper for anti-HIV Neut Ab sequence that turned out to be wrong….
November 21, 2024 at 6:45 PM
#PBVAB17 Shaaltiel: can dramatically improve plant-made biosimilars into biobetter therapeutics using clever chemistry
November 21, 2024 at 6:45 PM