Nature Communications - The communication hinge, found in type IV ABC transporters, forms a bidirectional communication between ATP- and substrate-binding sites. This is an unexplored allosteric...

We analyzed resting-state functional magnetic resonance imaging (fMRI) data from the BioFINDER-2 cohort (973 participants) with complete data (cerebrospinal fluid (CSF) Aβ42/40, tau PET and fMRI scans; see Table 1 for participant characteristics). After parcellating the cortex into 1,000 regions33, FC was quantified using nodal affinity, the parcel-wise average of connectivity similarity to all other parcels. Henceforth, we focus on this FCS as our central FC measure of interest (Fig. 1a and Methods). Nodal affinity was used as the outcome in parcel-wise regression models (Methods), with the t-values of the terms of interest mapped onto the cortical surface, resulting in ‘t-maps’ (Fig. 1a,c). Our goal was to assess the degree to which these t-maps aligned with the principal axes (that is, gradients) of functional organization (Fig. 1c). The gradients of interest were defined as the first three principal components of the averaged connectomes from healthy controls (Fig. 1b; see Extended Data Fig. 10 for comparisons of different methods to derive gradients, and explained variance of the derived components). Supplementary analyses (Supplementary Table 1) with gradients derived using several methods (including the traditional diffusion map embedding from Margulies and colleagues20) confirmed that this methodological choice did not substantially impact the results...