Falling responses, budgets & staff are biting. #BLS will cut 350 #ProducerPriceIndex #inflation sub-indexes.
It'll be harder to gauge effects of #supplychain disruptions, #tariffs, #monetary, #fiscal & #regulatory #policy and more.
www.bls.gov/ppi/notices/...
#econsky #PPI @aaronsojourner.org
It'll be harder to gauge effects of #supplychain disruptions, #tariffs, #monetary, #fiscal & #regulatory #policy and more.
www.bls.gov/ppi/notices/...
#econsky #PPI @aaronsojourner.org
BLS to Discontinue Selected PPIs
BLS to Discontinue Selected PPIs
www.bls.gov
May 22, 2025 at 5:46 PM
Falling responses, budgets & staff are biting. #BLS will cut 350 #ProducerPriceIndex #inflation sub-indexes.
It'll be harder to gauge effects of #supplychain disruptions, #tariffs, #monetary, #fiscal & #regulatory #policy and more.
www.bls.gov/ppi/notices/...
#econsky #PPI @aaronsojourner.org
It'll be harder to gauge effects of #supplychain disruptions, #tariffs, #monetary, #fiscal & #regulatory #policy and more.
www.bls.gov/ppi/notices/...
#econsky #PPI @aaronsojourner.org
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Left: Experimentally validated PPIs
Right: AF3-predicted PPIs
Coevolution is all we've got
Source: threadreaderapp.com/thread/18564...
Right: AF3-predicted PPIs
Coevolution is all we've got
Source: threadreaderapp.com/thread/18564...
November 13, 2024 at 12:37 PM
Left: Experimentally validated PPIs
Right: AF3-predicted PPIs
Coevolution is all we've got
Source: threadreaderapp.com/thread/18564...
Right: AF3-predicted PPIs
Coevolution is all we've got
Source: threadreaderapp.com/thread/18564...
just found out PPIs are BAD for your heart
September 23, 2026 at 9:46 PM
just found out PPIs are BAD for your heart
Protein–protein interactions (PPIs) are key to discovering and interpreting new biological functions.
We’re excited to introduce 𝑭𝒍𝒂𝒔𝒉𝑷𝑷𝑰: a new application of gLM2 that uses genomic language modeling to predict proteome-wide PPIs in microbial genomes in minutes.
We’re excited to introduce 𝑭𝒍𝒂𝒔𝒉𝑷𝑷𝑰: a new application of gLM2 that uses genomic language modeling to predict proteome-wide PPIs in microbial genomes in minutes.
March 3, 2026 at 3:16 PM
Protein–protein interactions (PPIs) are key to discovering and interpreting new biological functions.
We’re excited to introduce 𝑭𝒍𝒂𝒔𝒉𝑷𝑷𝑰: a new application of gLM2 that uses genomic language modeling to predict proteome-wide PPIs in microbial genomes in minutes.
We’re excited to introduce 𝑭𝒍𝒂𝒔𝒉𝑷𝑷𝑰: a new application of gLM2 that uses genomic language modeling to predict proteome-wide PPIs in microbial genomes in minutes.
Reduced capacity forced BLS to end publication of some producer price data series.
www.bls.gov/ppi/notices/...
www.bls.gov/ppi/notices/...
BLS to Discontinue Selected PPIs
BLS to Discontinue Selected PPIs
www.bls.gov
September 9, 2025 at 2:00 AM
Reduced capacity forced BLS to end publication of some producer price data series.
www.bls.gov/ppi/notices/...
www.bls.gov/ppi/notices/...
Tämä ei ole tekoälyn tuotos.
December 25, 2024 at 7:00 AM
Tämä ei ole tekoälyn tuotos.
Budget cuts mean data cuts.
BLS is suspending many producer price indexes:
www.bls.gov/ppi/notices/...
#econsky
BLS is suspending many producer price indexes:
www.bls.gov/ppi/notices/...
#econsky
BLS to Discontinue Selected PPIs
BLS to Discontinue Selected PPIs
www.bls.gov
May 23, 2025 at 9:16 PM
Budget cuts mean data cuts.
BLS is suspending many producer price indexes:
www.bls.gov/ppi/notices/...
#econsky
BLS is suspending many producer price indexes:
www.bls.gov/ppi/notices/...
#econsky
Ppis PpornⓇ
Piss For Pleasure
#polla #orinar #pipi #pis #pissfetish #pisswhereyouwant #publicurination #piss #pissing #publicpee #BlueCollar #urinatinginpublic #dickout #dickoutinpublic #pissforpleasure #wataa
Piss For Pleasure
#polla #orinar #pipi #pis #pissfetish #pisswhereyouwant #publicurination #piss #pissing #publicpee #BlueCollar #urinatinginpublic #dickout #dickoutinpublic #pissforpleasure #wataa
September 17, 2026 at 4:59 AM
Ppis PpornⓇ
Piss For Pleasure
#polla #orinar #pipi #pis #pissfetish #pisswhereyouwant #publicurination #piss #pissing #publicpee #BlueCollar #urinatinginpublic #dickout #dickoutinpublic #pissforpleasure #wataa
Piss For Pleasure
#polla #orinar #pipi #pis #pissfetish #pisswhereyouwant #publicurination #piss #pissing #publicpee #BlueCollar #urinatinginpublic #dickout #dickoutinpublic #pissforpleasure #wataa
TY @mjfree.bsky.social I am going to post this every day until Canada votes a new PM
#IstandWithCANADA
#CANADA
#NeverPoilievre
#PierrePoilievreIsLyingToYou
#NeverVoteConservative
#IstandWithCANADA
#CANADA
#NeverPoilievre
#PierrePoilievreIsLyingToYou
#NeverVoteConservative
January 12, 2025 at 2:01 PM
TY @mjfree.bsky.social I am going to post this every day until Canada votes a new PM
#IstandWithCANADA
#CANADA
#NeverPoilievre
#PierrePoilievreIsLyingToYou
#NeverVoteConservative
#IstandWithCANADA
#CANADA
#NeverPoilievre
#PierrePoilievreIsLyingToYou
#NeverVoteConservative
Ppis hoje venci a fila e fui o 1° para pegar os deliciosos takoyakis da velhinha ✨️🐙
May 18, 2025 at 2:02 PM
Ppis hoje venci a fila e fui o 1° para pegar os deliciosos takoyakis da velhinha ✨️🐙
Fresh blog: PPIs are safe and effective for GI prophylaxis… the end.
😁Review of SUP-ICU, PEPTIC & REVISE
😁PPIs are effective & safe (no increase in PNA or CDiff)
😁Mortality trends are statistical noise (REVISE shows *less* mortality w/ PPIs)
blog: emcrit.org/pulmcrit/rev... #FOAMed #MedSky
😁Review of SUP-ICU, PEPTIC & REVISE
😁PPIs are effective & safe (no increase in PNA or CDiff)
😁Mortality trends are statistical noise (REVISE shows *less* mortality w/ PPIs)
blog: emcrit.org/pulmcrit/rev... #FOAMed #MedSky
June 18, 2024 at 12:24 PM
Fresh blog: PPIs are safe and effective for GI prophylaxis… the end.
😁Review of SUP-ICU, PEPTIC & REVISE
😁PPIs are effective & safe (no increase in PNA or CDiff)
😁Mortality trends are statistical noise (REVISE shows *less* mortality w/ PPIs)
blog: emcrit.org/pulmcrit/rev... #FOAMed #MedSky
😁Review of SUP-ICU, PEPTIC & REVISE
😁PPIs are effective & safe (no increase in PNA or CDiff)
😁Mortality trends are statistical noise (REVISE shows *less* mortality w/ PPIs)
blog: emcrit.org/pulmcrit/rev... #FOAMed #MedSky
A few PPIs we've done recently. #classic #classiccar #classiccars #auto #automotive #automobile #impala #chevelle #restomod #streetrod #hotrod #custom #inspection #chicago #tampa #atlanta #car #cars
July 8, 2026 at 4:53 PM
A few PPIs we've done recently. #classic #classiccar #classiccars #auto #automotive #automobile #impala #chevelle #restomod #streetrod #hotrod #custom #inspection #chicago #tampa #atlanta #car #cars
Should people on PPIs take supplemental b12?
November 18, 2024 at 1:16 AM
Should people on PPIs take supplemental b12?
Excited to see this work now available as a preprint. It has been a rewarding project exploring how TurboID can be adapted to study extracellular PPIs in plants.
Our group's latest preprint shows TurboID can be adapted for studying extracellular elicitor-receptor interactions in plants. Hopefully useful for the apoplastic MPMI community
www.biorxiv.org/content/10.6...
Led by former PhD @abdelrahmanqutb.bsky.social
www.biorxiv.org/content/10.6...
Led by former PhD @abdelrahmanqutb.bsky.social
A TurboID-based proximity labelling method for detecting extracellular protein interactions in plants
The apoplast is a primary location for interactions between plants and invasive pathogens and is the site where many pathogen-secreted effectors are perceived by cell surface immune receptors to activ...
www.biorxiv.org
September 23, 2026 at 7:31 PM
Excited to see this work now available as a preprint. It has been a rewarding project exploring how TurboID can be adapted to study extracellular PPIs in plants.
Predicting protein-protein interactions (PPIs) at proteome scale can take months with co-folding models due to the massive all-vs-all comparisons required.
We are excited to announce FlashPPI, a contrastive learning framework that predicts proteome wide physical interfaces in minutes. 1/🧵
We are excited to announce FlashPPI, a contrastive learning framework that predicts proteome wide physical interfaces in minutes. 1/🧵
March 3, 2026 at 3:07 PM
Predicting protein-protein interactions (PPIs) at proteome scale can take months with co-folding models due to the massive all-vs-all comparisons required.
We are excited to announce FlashPPI, a contrastive learning framework that predicts proteome wide physical interfaces in minutes. 1/🧵
We are excited to announce FlashPPI, a contrastive learning framework that predicts proteome wide physical interfaces in minutes. 1/🧵
And before someone chimes in with "ah but if you lose the weight you don't need the PPIs" actually um, I have EoE, and the PPIs are the only treatment found to be effective, with the mechanism of action not even being well understood
Which is why we don't blanket push drugs like this, normally
Which is why we don't blanket push drugs like this, normally
May 24, 2026 at 5:10 AM
And before someone chimes in with "ah but if you lose the weight you don't need the PPIs" actually um, I have EoE, and the PPIs are the only treatment found to be effective, with the mechanism of action not even being well understood
Which is why we don't blanket push drugs like this, normally
Which is why we don't blanket push drugs like this, normally
They already have: www.bls.gov/ppi/notices/...
BLS to Discontinue Selected PPIs
BLS to Discontinue Selected PPIs
www.bls.gov
June 4, 2025 at 5:46 PM
They already have: www.bls.gov/ppi/notices/...
Kahvia pihalla, aurinko porottaa, onneksi on LI-ppis 😎
July 19, 2025 at 11:57 AM
Kahvia pihalla, aurinko porottaa, onneksi on LI-ppis 😎
Even as we contemplate Congressionally authorized budgets, extracurricular DOGE cuts are starting to affect data collection
www.bls.gov/ppi/notices/...
www.bls.gov/ppi/notices/...
BLS to Discontinue Selected PPIs
BLS to Discontinue Selected PPIs
www.bls.gov
May 22, 2025 at 7:28 PM
Even as we contemplate Congressionally authorized budgets, extracurricular DOGE cuts are starting to affect data collection
www.bls.gov/ppi/notices/...
www.bls.gov/ppi/notices/...
Here is an example list of medications with long-term safety data in pregnancy, helpful for treating common illnesses:
Fever/pain: acetaminophen
GERD: H2 blockers or PPIs
Nausea: Dimenhydrinate, metoclopramide, ondansetron
Hypertension: labetalol, nifedipine, methyldopa
Fever/pain: acetaminophen
GERD: H2 blockers or PPIs
Nausea: Dimenhydrinate, metoclopramide, ondansetron
Hypertension: labetalol, nifedipine, methyldopa
September 23, 2025 at 11:29 PM
Here is an example list of medications with long-term safety data in pregnancy, helpful for treating common illnesses:
Fever/pain: acetaminophen
GERD: H2 blockers or PPIs
Nausea: Dimenhydrinate, metoclopramide, ondansetron
Hypertension: labetalol, nifedipine, methyldopa
Fever/pain: acetaminophen
GERD: H2 blockers or PPIs
Nausea: Dimenhydrinate, metoclopramide, ondansetron
Hypertension: labetalol, nifedipine, methyldopa
#Review 🚨
Can targeting mutant protein-protein interactions (PPIs) lead to new cancer therapies?🤔
Check out our latest Review from Fu, Mo and Ivanov to answer this! They explore the mechanisms by which oncogenic mutations impact PPIs, technologies for studying this & the therapeutic implications.
Can targeting mutant protein-protein interactions (PPIs) lead to new cancer therapies?🤔
Check out our latest Review from Fu, Mo and Ivanov to answer this! They explore the mechanisms by which oncogenic mutations impact PPIs, technologies for studying this & the therapeutic implications.
January 14, 2025 at 3:32 PM
#Review 🚨
Can targeting mutant protein-protein interactions (PPIs) lead to new cancer therapies?🤔
Check out our latest Review from Fu, Mo and Ivanov to answer this! They explore the mechanisms by which oncogenic mutations impact PPIs, technologies for studying this & the therapeutic implications.
Can targeting mutant protein-protein interactions (PPIs) lead to new cancer therapies?🤔
Check out our latest Review from Fu, Mo and Ivanov to answer this! They explore the mechanisms by which oncogenic mutations impact PPIs, technologies for studying this & the therapeutic implications.
If you’re on PPIs please don’t eat the questionable-looking lettuce.
When in doubt, throw it out.
That is all.
When in doubt, throw it out.
That is all.
August 3, 2025 at 12:23 AM
If you’re on PPIs please don’t eat the questionable-looking lettuce.
When in doubt, throw it out.
That is all.
When in doubt, throw it out.
That is all.
The Virtual Cell is biologists' Golem, story-told with whatever the latest technology happens to be.
(PPIs, metabolic networks, ODEs, ChIP-Seq GRNs, LLMs, ...)
(PPIs, metabolic networks, ODEs, ChIP-Seq GRNs, LLMs, ...)
December 27, 2025 at 2:51 PM
The Virtual Cell is biologists' Golem, story-told with whatever the latest technology happens to be.
(PPIs, metabolic networks, ODEs, ChIP-Seq GRNs, LLMs, ...)
(PPIs, metabolic networks, ODEs, ChIP-Seq GRNs, LLMs, ...)
Young adult me decided at like 25 that I was allergic to Prilosec / PPIs
(fast forward two decades)
"Huh, yeah, this PPI is helping, and I feel fine"
... goddammityoungmeganwhatthefuckwaswrongwithyou
(fast forward two decades)
"Huh, yeah, this PPI is helping, and I feel fine"
... goddammityoungmeganwhatthefuckwaswrongwithyou
April 2, 2025 at 9:30 PM
Young adult me decided at like 25 that I was allergic to Prilosec / PPIs
(fast forward two decades)
"Huh, yeah, this PPI is helping, and I feel fine"
... goddammityoungmeganwhatthefuckwaswrongwithyou
(fast forward two decades)
"Huh, yeah, this PPI is helping, and I feel fine"
... goddammityoungmeganwhatthefuckwaswrongwithyou