Alt: Barry Bonds launches a home run to Right Field at Pqc Bell Park.

Protein quality control (PQC) mechanisms including the ubiquitin (Ub)-proteasome system (UPS), autophagy, and chaperone-mediated refolding are essential to maintain protein homeostasis in cells. Recent studies show that these PQC mechanisms are further modulated by biomolecular condensates that sequester PQC components and compartmentalize reactions. Accumulating evidence points towards the PQC machinery playing a pivotal role in regulating the assembly, disassembly, and viscoelastic properties of several condensates. Here, we discuss how the PQC machinery can form their own condensates and also be recruited to known condensates under physiological or stress-induced conditions. We present molecular insights into how the multivalent architecture of polyUb chains, Ub-binding adaptor proteins, and other PQC machinery contribute to condensate assembly, leading to the regulation of downstream PQC outcomes and therapeutic potential.

Related Jobs

Germ DM now defaults to post-quantum cryptography (PQC), protecting your messages from being harvested now and decrypted later by a quantum computer. We will deprecate non-PQC connections this year, m...

OpenSSL 3.5 is now available for download with

Amazon Web Services (AWS) is migrating to post-quantum cryptography (PQC). Like other security and compliance features in AWS, we will deliver PQC as part of our shared responsibility model. This mean...